X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1084) 1084
animals (696) 696
dna-activated protein kinase (603) 603
index medicus (597) 597
dna-activated protein kinase - metabolism (576) 576
dna repair (528) 528
dna-binding proteins - metabolism (474) 474
dna damage (461) 461
protein-serine-threonine kinases - metabolism (448) 448
phosphorylation (443) 443
biochemistry & molecular biology (439) 439
mice (430) 430
dependent protein-kinase (416) 416
nuclear proteins - metabolism (375) 375
dna-activated protein kinase - genetics (332) 332
dna (329) 329
vj recombination (328) 328
cell biology (324) 324
dna-binding proteins - genetics (324) 324
nuclear proteins (314) 314
ku autoantigen (313) 313
catalytic subunit (309) 309
oncology (300) 300
protein-serine-threonine kinases - genetics (295) 295
dna-binding proteins (279) 279
nuclear proteins - genetics (274) 274
cell line (255) 255
double-strand breaks (233) 233
cell line, tumor (231) 231
repair (222) 222
ionizing-radiation (217) 217
hela cells (197) 197
apoptosis (185) 185
strand break repair (185) 185
dna breaks, double-stranded (182) 182
cancer (180) 180
genetics & heredity (178) 178
enzymes and coenzymes (175) 175
proteins (174) 174
dna-pk (173) 173
ataxia telangiectasia mutated proteins (171) 171
mutation (170) 170
female (169) 169
dna - metabolism (162) 162
dna-dependent protein kinase (161) 161
dna helicases (157) 157
male (149) 149
mammalian-cells (148) 148
protein kinases (145) 145
molecular sequence data (144) 144
research (142) 142
dna repair - genetics (136) 136
homologous recombination (136) 136
antigens, nuclear (135) 135
cells (134) 134
dna-pkcs (130) 130
dna-activated protein kinase - antagonists & inhibitors (129) 129
article (127) 127
recombination, genetic (126) 126
atm (122) 122
damage (122) 122
mice, scid (122) 122
cell cycle (119) 119
kinases (118) 118
protein binding (117) 117
antigens, nuclear - metabolism (116) 116
genetic aspects (116) 116
cells, cultured (115) 115
multidisciplinary sciences (115) 115
amino acid sequence (111) 111
cell cycle proteins - metabolism (111) 111
cricetinae (111) 111
signal transduction (110) 110
base sequence (109) 109
protein-serine-threonine kinases - physiology (108) 108
radiation (106) 106
deoxyribonucleic acid--dna (103) 103
tumor suppressor protein p53 - metabolism (103) 103
histones - metabolism (101) 101
transfection (101) 101
activation (100) 100
biology (100) 100
dna-binding proteins - physiology (99) 99
dna repair - drug effects (95) 95
tumor cells, cultured (95) 95
ionizing radiation (94) 94
p53 (93) 93
in-vitro (92) 92
radiation, ionizing (92) 92
mice, knockout (91) 91
expression (90) 90
research article (90) 90
biological phenomena, cell phenomena, and immunity (89) 89
toxicology (87) 87
dna - genetics (85) 85
analysis (84) 84
ataxia-telangiectasia (83) 83
blotting, western (82) 82
complex (82) 82
cho cells (81) 81
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 2, pp. 197 - 207
The signaling cascade initiated in response to DNA double-strand breaks (DSBs) has been extensively investigated in interphase cells. Here, we show that... 
Phosphorylation | Chromatin | Mitosis | DNA damage | Ubiquitins | Cell cycle | Cell lines | Histones | Antibodies | Reports | Chromosomes | REPAIR PROTEINS | RECRUITMENT | PHOSPHORYLATION | HUMAN-CELLS | 53BP1 | HISTONE H2AX | ATM | CHECKPOINT | IONIZING-RADIATION | RNF8 UBIQUITIN LIGASE | CELL BIOLOGY | Humans | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Histones - genetics | Mitosis - physiology | DNA Repair | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Ubiquitin-Protein Ligases - genetics | DNA | Research
Journal Article
eLife, ISSN 2050-084X, 12/2012, Volume 2012, Issue 1, p. e00047
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory... 
NEUTROPHIL EXTRACELLULAR TRAPS | INTRACELLULAR DNA | DAI DLM-1/ZBP1 | MAMMALIAN DNA | IN-VIVO | BIOLOGY | V(D)J RECOMBINATION | DEPENDENT PROTEIN-KINASE | CYTOSOLIC DNA | AUTOIMMUNE-DISEASE | CYTOPLASMIC DNA | Embryo, Mammalian | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | DNA-Binding Proteins - deficiency | Vaccinia virus - immunology | DNA-Activated Protein Kinase - genetics | Nuclear Proteins - deficiency | Herpesvirus 1, Human - immunology | Influenza A virus - immunology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Fibroblasts - virology | DNA-Binding Proteins - immunology | Signal Transduction | Gene Expression Regulation - immunology | Membrane Proteins - genetics | DNA, Viral - metabolism | Protein-Serine-Threonine Kinases - genetics | V(D)J Recombination | Membrane Proteins - immunology | DNA-Binding Proteins - genetics | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | DNA, Viral - immunology | Animals | DNA Repair - immunology | Interferon Type I - genetics | Fibroblasts - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Primary Cell Culture | DNA-Activated Protein Kinase - immunology | Cytokines - biosynthesis | Protein kinase C | Severe combined immunodeficiency | Transcription | Genes | Viruses | Innate immunity | Infections | Kinases | DNA repair | Proteins | Fibroblasts | Sensors | Localization | Deoxyribonucleic acid--DNA | RNA viruses | Fractionation | Statistical analysis | Cytokines | V(D)J recombination | Inflammation | RNA polymerase | Pattern recognition | DNA viruses | DNA-dependent protein kinase | Interferon regulatory factor 3 | Cytoplasm | Chemokines
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2014, Volume 54, Issue 1, pp. 119 - 132
The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM.... 
CASEIN KINASE-2 | DNA-PKCS | APOPTOSIS | COMPLEX | DAMAGE-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | GENE DELETION | HEXAKISPHOSPHATE KINASE-2 | P53 | ATR | CELL BIOLOGY | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Proto-Oncogene Proteins c-ets - genetics | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Serine | Casein Kinase II - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Telomere-Binding Proteins - genetics | Transfection | Neoplasms - genetics | RNA Interference | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | HEK293 Cells | Proto-Oncogene Proteins c-ets - metabolism | B-Lymphocytes - pathology | Inositol Phosphates - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Binding Sites | B-Lymphocytes - enzymology | Signal Transduction | HCT116 Cells | Enzyme Stability | Tumor Suppressor Protein p53 - metabolism | Neoplasms - enzymology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Neoplasms - pathology | Casein Kinase II - metabolism | Apoptosis | Medical colleges | Inositol | Neurosciences | Cell death | DNA | Automated teller machines | Biochemistry | Tumor proteins | Phosphotransferases | B cells
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2013, Volume 51, Issue 2, pp. 185 - 199
Chromatin immunoprecipitation studies have mapped protein occupancies at many genomic loci. However, a detailed picture of the complexity of coregulators... 
CELLS | TRANSCRIPTIONAL ACTIVATION | REGULATED TRANSCRIPTION | PHOSPHORYLATION | COACTIVATOR COMPLEX | NUCLEAR RECEPTORS | MEDIATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | DEPENDENT PROTEIN-KINASE | CELL BIOLOGY | Sialoglycoproteins - genetics | Phosphorylation | Estrogens - pharmacology | Humans | Sialoglycoproteins - metabolism | Transcriptional Activation | E1A-Associated p300 Protein - genetics | Gene Expression Regulation, Neoplastic | Multiprotein Complexes - genetics | E1A-Associated p300 Protein - metabolism | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Chromatin Immunoprecipitation | MCF-7 Cells | Forkhead Transcription Factors - metabolism | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Estrogen Receptor alpha - metabolism | Female | Transcription, Genetic | Response Elements - genetics | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Nuclear Proteins - genetics | Peptide Fragments - genetics | Promoter Regions, Genetic | Peptide Fragments - metabolism | Trans-Activators | Nucleosomes - metabolism | Nuclear Proteins - metabolism | Nuclear Receptor Coactivator 3 - genetics | Nucleosomes - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | DNA - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Nuclear Receptor Coactivator 3 - metabolism | Proteomics | Forkhead Box Protein O1 | HeLa Cells
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, p. e11397
Background: Radiotherapy kills tumor-cells by inducing DNA double strand breaks (DSBs). However, the efficient repair of tumors frequently prevents successful... 
RECOMBINATION | STRAND BREAK REPAIR | GLIOMA | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | MIR-31 | EXPRESSION | MICRORNA-101 | SUBUNIT | Cell Transformation, Neoplastic - radiation effects | Humans | Protein-Serine-Threonine Kinases - genetics | 3' Untranslated Regions - genetics | Up-Regulation - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Animals | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Base Sequence | DNA-Activated Protein Kinase - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line, Tumor | Neoplasms - radiotherapy | Mice | MicroRNAs - genetics | Neoplasms - pathology | Nuclear Proteins - genetics | Ionizing radiation | MicroRNA | Genes | DNA | Online searching | Internet/Web search services | Database searching | Tumors | Protein kinase C | DNA damage | Homologous recombination | Cytotoxicity | Oncology | Homology | mRNA | Metastasis | Neurosurgery | Cancer therapies | DNA repair | Homologous recombination repair | Liver cancer | Angiogenesis | Tumorigenesis | Repair | Background radiation | Deoxyribonucleic acid--DNA | Sensitizing | Tumor cells | Radiation therapy | Gene expression | Double-strand break repair | Medicine | Bone cancer | DNA-dependent protein kinase | 3' Untranslated regions | MicroRNAs | Non-homologous end joining | Binding sites | Deoxyribonucleic acid
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 26987 - 27006
DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by... 
REPAIR PROTEINS | STRUCTURAL INSIGHTS | DAMAGE RESPONSE | BIOLOGICAL MACROMOLECULES | SMALL-ANGLE SCATTERING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS | X-RAY-SCATTERING | IONIZING-RADIATION | Phosphorylation | Immunoprecipitation | Humans | DNA Breaks, Double-Stranded | DNA-Activated Protein Kinase - chemistry | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Ku Autoantigen - genetics | DNA Ligase ATP - genetics | X-Ray Diffraction | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | DNA Ligase ATP - metabolism | Nuclear Proteins - genetics | Cross-Linking Reagents | DNA End-Joining Repair - genetics | Ku Autoantigen - chemistry | Models, Molecular | Scattering, Small Angle | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Blotting, Western | DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | DNA Ligase ATP - chemistry | Protein Binding | Protein Conformation | HeLa Cells | DNA-dependent serine/threonine protein kinase (DNA-PK) | small-angle x-ray scattering (SAXS) | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | intrinsically disordered protein | XRCC4 | BASIC BIOLOGICAL SCIENCES | APLF | DNA ligase IV | non-homologous end joining | Ku | protein complex | DNA repair | DNA and Chromosomes | small-angle X-ray scattering (SAXS) | DNA-dependent serine | threonine protein kinase (DNA-PK)
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2015, Volume 28, Issue 1, pp. 97 - 113
Journal Article
Cancer Discovery, ISSN 2159-8274, 11/2013, Volume 3, Issue 11, pp. 1254 - 1271
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2015, Volume 58, Issue 1, pp. 172 - 185
Journal Article