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Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7454, pp. 376 - 379
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2012, Volume 40, Issue 21, pp. 10780 - 10794
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2014, Volume 54, Issue 1, pp. 119 - 132
The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM.... 
CASEIN KINASE-2 | DNA-PKCS | APOPTOSIS | COMPLEX | DAMAGE-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | GENE DELETION | HEXAKISPHOSPHATE KINASE-2 | P53 | ATR | CELL BIOLOGY | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Proto-Oncogene Proteins c-ets - genetics | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Serine | Casein Kinase II - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Telomere-Binding Proteins - genetics | Transfection | Neoplasms - genetics | RNA Interference | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | HEK293 Cells | Proto-Oncogene Proteins c-ets - metabolism | B-Lymphocytes - pathology | Inositol Phosphates - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Binding Sites | B-Lymphocytes - enzymology | Signal Transduction | HCT116 Cells | Enzyme Stability | Tumor Suppressor Protein p53 - metabolism | Neoplasms - enzymology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Neoplasms - pathology | Casein Kinase II - metabolism | Apoptosis | Medical colleges | Inositol | Neurosciences | Cell death | DNA | Automated teller machines | Biochemistry | Tumor proteins | Phosphotransferases | B cells
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 2, pp. 197 - 207
The signaling cascade initiated in response to DNA double-strand breaks (DSBs) has been extensively investigated in interphase cells. Here, we show that... 
Phosphorylation | Chromatin | Mitosis | DNA damage | Ubiquitins | Cell cycle | Cell lines | Histones | Antibodies | Reports | Chromosomes | REPAIR PROTEINS | RECRUITMENT | PHOSPHORYLATION | HUMAN-CELLS | 53BP1 | HISTONE H2AX | ATM | CHECKPOINT | IONIZING-RADIATION | RNF8 UBIQUITIN LIGASE | CELL BIOLOGY | Humans | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Histones - genetics | Mitosis - physiology | DNA Repair | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Ubiquitin-Protein Ligases - genetics | DNA | Research
Journal Article
Aging, ISSN 1945-4589, 01/2009, Volume 1, Issue 1, pp. 109 - 121
The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span extension in yeast. The mammalian Sir2 family member SIRT6 has been... 
LIFE-SPAN | SIR2-LIKE PROTEINS | genomic stability | DNA damage | DEACETYLASE | POLYMERASE | SIRT6 | SIRTUINS | DNA repair | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | GENOMIC INSTABILITY | Sir2 | LONGEVITY | GENE-EXPRESSION | aging | CALORIE RESTRICTION
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2010, Volume 30, Issue 14, pp. 3582 - 3595
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ACETYLTRANSFERASE COMPLEX | ATM FUNCTION | TELOMERE STABILITY | GENOMIC STABILITY | DROSOPHILA MSL COMPLEX | DOSAGE COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATAXIA-TELANGIECTASIA CELLS | IONIZING-RADIATION | MAMMALIAN-CELLS | DEFICIENT CELLS | CELL BIOLOGY | Chromatin - metabolism | RNA, Small Interfering - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Histones - chemistry | Humans | DNA Repair - physiology | Histone Acetyltransferases - genetics | Male | DNA Breaks, Double-Stranded | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | RNA Interference | Base Sequence | DNA-Activated Protein Kinase - metabolism | Histone Acetyltransferases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Acetylation | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Synaptonemal Complex - metabolism | Chromatin - radiation effects | Histone Acetyltransferases - antagonists & inhibitors | HL-60 Cells | Histone Deacetylase Inhibitors - pharmacology | DNA Damage | Histones - metabolism | Lysine - chemistry | Index Medicus | Life Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 26987 - 27006
DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by... 
REPAIR PROTEINS | STRUCTURAL INSIGHTS | DAMAGE RESPONSE | BIOLOGICAL MACROMOLECULES | SMALL-ANGLE SCATTERING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS | X-RAY-SCATTERING | IONIZING-RADIATION | Phosphorylation | Immunoprecipitation | Humans | DNA Breaks, Double-Stranded | DNA-Activated Protein Kinase - chemistry | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Ku Autoantigen - genetics | DNA Ligase ATP - genetics | X-Ray Diffraction | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | DNA Ligase ATP - metabolism | Nuclear Proteins - genetics | Cross-Linking Reagents | DNA End-Joining Repair - genetics | Ku Autoantigen - chemistry | Models, Molecular | Scattering, Small Angle | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Blotting, Western | DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | DNA Ligase ATP - chemistry | Protein Binding | Protein Conformation | HeLa Cells | Index Medicus | DNA-dependent serine/threonine protein kinase (DNA-PK) | small-angle x-ray scattering (SAXS) | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | intrinsically disordered protein | XRCC4 | BASIC BIOLOGICAL SCIENCES | APLF | DNA ligase IV | non-homologous end joining | Ku | protein complex | DNA repair | DNA and Chromosomes | small-angle X-ray scattering (SAXS) | DNA-dependent serine | threonine protein kinase (DNA-PK)
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 2, pp. 425 - 440
Background We reported that DNA-dependent protein kinase (DNA-PK) is critical for the expression of nuclear factor κB–dependent genes in TNF-α–treated... 
Allergy and Immunology | T-cell receptor | DNA-dependent protein kinase | adhesion molecules | severe combined immunodeficiency disease | eosinophilia | asthma | GATA-3 | TH2 cytokines | 2 cytokines | POLY(ADP-RIBOSE) POLYMERASE | V(D)J RECOMBINATION | T(H)2 cytokines | ALLERGIC AIRWAY INFLAMMATION | IMMUNOLOGY | ALLERGY | GROWTH | NF-KAPPA-B | EXPRESSION | DNA-Activated Protein Kinase - antagonists & inhibitors | Spleen - immunology | Bronchial Hyperreactivity - immunology | Ovalbumin - immunology | Humans | Male | Th2 Cells - immunology | Eosinophils - immunology | CD4-Positive T-Lymphocytes - immunology | Allergens - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Plasma Cells - metabolism | GATA3 Transcription Factor - metabolism | Disease Models, Animal | Gene Expression | Receptors, Antigen, T-Cell - metabolism | Lymphocyte Activation | Cell Adhesion | Genetic Heterogeneity | Mice, Knockout | Bronchial Hyperreactivity - pathology | Phenotype | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Asthma - pathology | GATA3 Transcription Factor - genetics | T-Lymphocyte Subsets - immunology | Tumor Necrosis Factor-alpha - metabolism | Asthma - metabolism | Eosinophils - metabolism | Epithelial Cells - metabolism | Adoptive Transfer | Respiratory Mucosa - pathology | Immunoglobulin E - immunology | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Ovalbumin - adverse effects | Bronchial Hyperreactivity - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Cytokines - metabolism | Organ Size | Th2 Cells - metabolism | Animals | Spleen - anatomy & histology | T-Lymphocyte Subsets - metabolism | Severe Combined Immunodeficiency | Respiratory Mucosa - metabolism | Plasma Cells - immunology | Pyroglyphidae - immunology | Kinases | Laboratories | Rodents | Asthma
Journal Article