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eLife, ISSN 2050-084X, 08/2014, Volume 3, Issue 2014, pp. 1 - 17
The Cdc45/Mcm2-7/GINS ( CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains... 
replication fork | DNA replication | helicase | motor proteins | AAA+ ATPase | Mcm2-7 | MCM2-7 HELICASE | HEXAMERIC HELICASE | MINICHROMOSOME MAINTENANCE PROTEIN | ARCHAEAL MCM | BUDDING YEAST | STRUCTURAL BASIS | BIOLOGY | REPLICATIVE HELICASE | ELECTRON-MICROSCOPY | 26S PROTEASOME | CRYO-EM STRUCTURE | Minichromosome Maintenance Proteins - metabolism | Protein Multimerization | Eukaryotic Cells - metabolism | Drosophila Proteins - metabolism | Minichromosome Maintenance Proteins - chemistry | Protein Subunits - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Multiprotein Complexes - metabolism | Adenosine Triphosphate - metabolism | Protein Structure, Quaternary | Repressor Proteins - metabolism | Protein Structure, Tertiary | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | DNA, Single-Stranded - metabolism | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | RNA Splicing Factors | Adenosine Triphosphatases - metabolism | Models, Molecular | DNA Replication | DNA - metabolism | Drosophila Proteins - chemistry | Microscopy, Electron | DNA-Binding Proteins - chemistry | Adenosine Triphosphate - analogs & derivatives | DNA, Single-Stranded - chemistry | Multiprotein Complexes - ultrastructure | DNA - chemistry | Multiprotein Complexes - chemistry | Animals | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Subunits - chemistry | Adenosine Triphosphate - chemistry | Chromosomal Proteins, Non-Histone - chemistry | RNA-Binding Proteins - metabolism | Medical research | Single-stranded DNA | Hexamers | Electron microscopy | DNA biosynthesis | DNA helicase | Handedness | Microscopy | Insects | Cdc45 protein | Cell cycle | Polarity | Dimerization | Deoxyribonucleic acid--DNA | Adenosine triphosphatase
Journal Article
Molecular cell, ISSN 1097-2765, 2009, Volume 36, Issue 1, pp. 39 - 50
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination... 
PROTEINS | ACTIVATION | PROTEIN | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | ADAPTER | DEGRADATION | KEAP1 | DIMERIZATION | BTB DOMAIN | HEDGEHOG | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Crystallography, X-Ray | Drosophila Proteins - metabolism | Mutation - physiology | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Ubiquitination - physiology | Peptide Fragments - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Peptide Fragments - chemistry | Phosphoprotein Phosphatases - genetics | Consensus Sequence - physiology | Recombinant Fusion Proteins - genetics | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Phosphoprotein Phosphatases - chemistry | Protein Binding - physiology | Adaptor Proteins, Signal Transducing - chemistry | Histones - chemistry | Protein Interaction Domains and Motifs - physiology | Phosphoprotein Phosphatases - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cullin Proteins - metabolism | Nuclear Proteins - genetics | Peptide Fragments - metabolism | Repressor Proteins - chemistry | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Adaptor Proteins, Signal Transducing - genetics | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Chromatin | Phosphatases | Ligases | CHROMATIN | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | FLEXIBILITY | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | LIGASES | DIMERS | PHOSPHATASES
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2011, Volume 145, Issue 1, pp. 54 - 66
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 3, pp. 1402 - 1414
...: We studied the chaperone activity of Hsp70 combined with four different NEFs and four J proteins... 
Protein Complexes | Protein Misfolding | Cochaperones | HIGH-THROUGHPUT SCREEN | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUALITY-CONTROL | Hsp40 | Protein Folding | HSP110 CHAPERONES | HEAT-SHOCK-PROTEIN | NEGATIVE REGULATOR | Isothermal Titration Calorimetry | J-DOMAIN | ATP HYDROLYSIS | STRUCTURAL BASIS | Molecular Chaperone | HSC70 CHAPERONE | ATPases | Protein-Protein Interactions | Adaptor Proteins, Signal Transducing - chemistry | Molecular Chaperones - metabolism | Transcription Factors - chemistry | Humans | Multiprotein Complexes - genetics | Molecular Chaperones - chemistry | DNA-Binding Proteins - metabolism | HSP110 Heat-Shock Proteins - chemistry | Multiprotein Complexes - metabolism | HSP70 Heat-Shock Proteins - chemistry | HSP40 Heat-Shock Proteins - chemistry | Recombinant Proteins - metabolism | HSP40 Heat-Shock Proteins - metabolism | HSP40 Heat-Shock Proteins - genetics | Molecular Chaperones - genetics | Recombinant Proteins - chemistry | HSP70 Heat-Shock Proteins - genetics | Recombinant Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | HSP110 Heat-Shock Proteins - genetics | Multiprotein Complexes - chemistry | Apoptosis Regulatory Proteins | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | HSP110 Heat-Shock Proteins - metabolism | Protein Binding - physiology | Protein Synthesis and Degradation
Journal Article
Molecular cell, ISSN 1097-2765, 2019, Volume 74, Issue 6, pp. 1175 - 1188.e9
The condensin protein complex plays a key role in the structural organization of genomes... 
condensin | cohesin | SMC protein complex | ABC ATPase | genome organization | mitotic chromosome | structural biology | DNA loop extrusion | MOLECULAR-REPLACEMENT | FULLY-AUTOMATIC CHARACTERIZATION | STRUCTURE REFINEMENT | DATA-COLLECTION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COHESIN RING | CHROMOSOME CONDENSATION | PROTEIN COMPLEXES | CRYSTALLOGRAPHY | DNA EXIT GATE | CELL BIOLOGY | Humans | Crystallography, X-Ray | Multiprotein Complexes - genetics | Saccharomyces cerevisiae - metabolism | Multiprotein Complexes - metabolism | Adenosine Triphosphate - metabolism | Binding Sites | Protein Subunits - genetics | Amino Acid Sequence | Gene Expression | Chromosomal Proteins, Non-Histone - metabolism | Adenosine Triphosphatases - metabolism | Models, Molecular | DNA - metabolism | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | DNA - chemistry | Multiprotein Complexes - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Adenosine Triphosphatases - genetics | HeLa Cells | Saccharomyces cerevisiae Proteins - chemistry | Saccharomyces cerevisiae - genetics | Protein Multimerization | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Chromosomes - metabolism | Carrier Proteins - chemistry | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Protein Conformation, alpha-Helical | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Chaetomium - genetics | Chromosomal Proteins, Non-Histone - genetics | DNA - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Chaetomium - metabolism | Chromosomes - ultrastructure | Sequence Alignment | Carrier Proteins - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Subunits - chemistry | Adenosine Triphosphate - chemistry | Chromosomal Proteins, Non-Histone - chemistry | Proteins | Atoms | Genomics | Cells | Adenosine triphosphatase
Journal Article
Biochemical journal, ISSN 1470-8728, 2017, Volume 474, Issue 8, pp. 1417 - 1438
Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low-complexity domains that possess a similar amino acid... 
EUKARYOTIC STRESS GRANULES | MUTANT FUS PROTEINS | MULTISYSTEM PROTEINOPATHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-TRANSITION | TARDBP MUTATIONS | HNRNP A1 | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS | NEURODEGENERATIVE DISEASES | Proteostasis Deficiencies - metabolism | RNA-Binding Proteins - genetics | TATA-Binding Protein Associated Factors - metabolism | Humans | Prion Proteins - metabolism | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | RNA-Binding Protein FUS - chemistry | TDP-43 Proteinopathies - genetics | Protein Domains | TDP-43 Proteinopathies - pathology | Prion Proteins - chemistry | Prion Proteins - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics | Frontotemporal Dementia - pathology | Calmodulin-Binding Proteins - genetics | Frontotemporal Dementia - genetics | Cytoplasmic Granules | Neurodegenerative Diseases - pathology | Amyotrophic Lateral Sclerosis - genetics | RNA-Binding Proteins - chemistry | TDP-43 Proteinopathies - metabolism | Proteostasis Deficiencies - pathology | RNA-Binding Protein FUS - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | Neurodegenerative Diseases - genetics | Calmodulin-Binding Proteins - chemistry | Calmodulin-Binding Proteins - metabolism | RNA-Binding Protein FUS - metabolism | Neurodegenerative Diseases - metabolism | TATA-Binding Protein Associated Factors - chemistry | DNA-Binding Proteins - genetics | TATA-Binding Protein Associated Factors - genetics | DNA-Binding Proteins - chemistry | Heterogeneous Nuclear Ribonucleoprotein A1 | Proteostasis Deficiencies - genetics | Amyotrophic Lateral Sclerosis - pathology | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - chemistry | Amyotrophic Lateral Sclerosis - metabolism | Mutation | RNA-Binding Proteins - metabolism | RNA-Binding Protein EWS
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 1, p. e52908
.... Nevertheless, some of these organisms show predicted classical zinc fingers motifs of the C2H2 type, which are almost exclusively found in proteins of eukaryotes and most often associated with transcription regulators... 
BACKBONE DYNAMICS | DOMAIN | IMPROVED SENSITIVITY | CHEMICAL-SHIFTS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GENOMIC ANALYSIS | NMR EXPERIMENTS | REGULATORY PROTEIN | RECOGNITION MOTIFS | RNA-POLYMERASE | Oligonucleotides - genetics | Acidianus - genetics | Archaeal Proteins - chemistry | Molecular Sequence Data | Phylogeny | Viral Proteins - metabolism | Solutions - chemistry | DNA-Binding Proteins - metabolism | Archaeal Proteins - genetics | Archaeal Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Viral Proteins - chemistry | Models, Molecular | Viral Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | DNA-Binding Proteins - classification | Sequence Homology, Amino Acid | Oligonucleotides - metabolism | Eukaryota - genetics | Protein Binding | Zinc Fingers - genetics | Acidianus - virology | Histidine | Cladistic analysis | DNA | Zinc finger proteins | DNA binding proteins | Nucleotide sequencing | Protein binding | DNA sequencing | DNA structure | Glutamic acid | Regulators | Transcription factors | Nuclear magnetic resonance--NMR | Viruses | Homology | Genomes | Proteins | Eukaryotes | Mathematical analysis | Protein folding | Fingers | Zinc finger | Bacteria | Deoxyribonucleic acid--DNA | Crystal structure | Binding | Nucleotide sequence | Archaea | Amino acid sequence | Hyperthermophilic archaea | Gene expression | Zinc | Binding sites | Analytical chemistry | Zinc Fingers | Biochemistry, Molecular Biology | Oligonucleotides | Viral Proteins | Acidianus | Chemical Sciences | Life Sciences | Eukaryota | Solutions | Biomolecules | Archaeal Proteins | DNA-Binding Proteins | Deoxyribonucleic acid | Nuclear magnetic resonance | NMR
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2009, Volume 106, Issue 37, pp. 15628 - 15632
...Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins Jun-Sub Im a,1 , Sang-Hee Ki a,1 , Andrea Farina b... 
Cdc7-Dbf4 kinase | Cyclin-dependent kinase | Cdc45-Mcm-GINS complex | Bimolecular fluorescence complementation | BUDDING YEAST | INITIATION | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC DNA-REPLICATION | POLYMERASE-ALPHA | SACCHAROMYCES-CEREVISIAE | CDC45 | ROTHMUND-THOMSON-SYNDROME | S-PHASE | TOPBP1 | bimolecular fluorescence complementation | cyclin-dependent kinase | PROGRESSION | Minichromosome Maintenance Proteins | Cyclin-Dependent Kinases - metabolism | RecQ Helicases - metabolism | Humans | Multiprotein Complexes | Bacterial Proteins - chemistry | RecQ Helicases - genetics | Minichromosome Maintenance Complex Component 7 | Minichromosome Maintenance Complex Component 2 | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Cell Cycle Proteins - genetics | Luminescent Proteins - chemistry | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Bacterial Proteins - genetics | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - metabolism | Cell Cycle | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | RecQ Helicases - chemistry | HeLa Cells | Chromosomal Proteins, Non-Histone - chemistry | Luminescent Proteins - metabolism | Proteins | DNA replication | HeLa cells | Physiological aspects | Genetic aspects | Research | Molecular biology | Biological Sciences
Journal Article