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Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 43, Issue 3, pp. 451 - 462
Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through... 
LISTERIA-MONOCYTOGENES | CYTOCHROME-C | MESSENGER-RNA | BRUCELLA-ABORTUS | INDUCED APOPTOSIS | ER STRESS | THIOREDOXIN-INTERACTING PROTEIN | SECRETION | IMMUNOLOGY | TRANSCRIPTION FACTOR | CELL-DEATH | Caspase 2 - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Brucella abortus - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Caspase 2 - metabolism | Mitochondria - immunology | Endoplasmic Reticulum Stress - genetics | Endoplasmic Reticulum Stress - immunology | Caspase 2 - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Brucella abortus - immunology | Interleukin-1beta - metabolism | Reactive Oxygen Species - immunology | HEK293 Cells | Transcription Factors - immunology | BH3 Interacting Domain Death Agonist Protein - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | RNA Interference - immunology | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | BH3 Interacting Domain Death Agonist Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Endoribonucleases - immunology | Medical colleges | Stress (Physiology) | Mitochondrial DNA | Analysis | Cytochrome | Bacterial infections | Dehydrogenases | Infections | Inflammation | Proteins | Studies | Mitochondria | Rodents | Ligands | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Nature immunology, ISSN 1529-2916, 2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2007, Volume 204, Issue 5, pp. 1119 - 1130
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 462, Issue 7269, pp. 99 - 103
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2009, Volume 183, Issue 8, pp. 4879 - 4886
...) in the receptor's cytoplasmic region. The adaptor protein downstream of tyrosine kinase 2 (Dok2) bound directly to the phosphorylated NPLY motif with a 10-fold higher affinity... 
STEM-CELLS | ACTIVATION | PROGNOSTIC-FACTOR | INHIBITION | DOCKING PROTEIN | PHOSPHORYLATION | NEGATIVE REGULATION | MACROPHAGES | DOWN-REGULATION | SURFACE-PROTEINS | IMMUNOLOGY | Phosphoproteins - immunology | Antigens, CD - immunology | p120 GTPase Activating Protein - metabolism | Humans | Glycoproteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Matrilin Proteins | Signal Transduction - immunology | ras GTPase-Activating Proteins - genetics | Interleukin-4 - pharmacology | RNA, Small Interfering - immunology | Myeloid Cells - immunology | Adaptor Proteins, Signal Transducing - immunology | Antigens, Surface - metabolism | Myeloid Cells - drug effects | Interleukin-8 - metabolism | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | ras GTPase-Activating Proteins - metabolism | DNA-Binding Proteins - immunology | Cartilage Oligomeric Matrix Protein | RNA-Binding Proteins - immunology | Antigens, Surface - genetics | Rats | Receptors, Cell Surface - metabolism | Phosphoproteins - genetics | Receptors, Cell Surface - immunology | Glycoproteins - immunology | Macrophages - metabolism | Animals | Extracellular Matrix Proteins - immunology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Myeloid Cells - metabolism | Macrophages - drug effects | Mice | ras GTPase-Activating Proteins - immunology | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-8 - immunology | Antigens, Surface - immunology | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 23, pp. 16225 - 16234
Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate... 
IFN-BETA | CELLS | ACTIVATION | PROTEIN | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEGRADATION | SEPSIS | TRIGGERED INFLAMMATORY RESPONSES | INNATE IMMUNITY | Interferon-beta - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Intracellular Signaling Peptides and Proteins - immunology | Male | Monocytes - immunology | Lipopolysaccharides - immunology | Gene Knockdown Techniques | Ubiquitin-Protein Ligases - immunology | Sepsis - pathology | Reactive Oxygen Species - immunology | Monocytes - pathology | Tumor Necrosis Factor-alpha - immunology | Interferon-beta - genetics | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | Hydro-Lyases - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Immune Tolerance - drug effects | Cysteine Endopeptidases | Sepsis - immunology | DNA-Binding Proteins - immunology | Lipopolysaccharides - toxicity | Histones - immunology | Immunity, Innate - drug effects | Interleukin-6 - genetics | Macrophages - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Proteins - immunology | Sepsis - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Animals | Histones - genetics | Interleukin-6 - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Hydro-Lyases - immunology | Toll-like Receptors (TLR) | Immunology | Reactive Oxygen Species (ROS) | Innate Immunity | Endotoxin Tolerance | ROS | Inflammation | Macrophages | A20 | Immune Responsive Gene 1
Journal Article
Nature immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 800 - 812
An imbalance in the lineages of immunosuppressive regulatory T cells (T cells) and the inflammatory T 17 subset of helper T cells leads to the development of... 
Forkhead Transcription Factors - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Sjogren's Syndrome - immunology | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | Flow Cytometry | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | HEK293 Cells | Adaptor Proteins, Signal Transducing - immunology | Acetylation | Colitis - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | DNA-Binding Proteins - immunology | Smad Proteins - immunology | Mice, Transgenic | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - immunology | Microscopy, Confocal | Animals | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Trans-Activators - metabolism | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | Smad Proteins - metabolism | Microscopy, Fluorescence
Journal Article
European journal of immunology, ISSN 0014-2980, 2013, Volume 43, Issue 5, pp. 1147 - 1152
Journal Article
Nature (London), ISSN 0028-0836, 05/2017, Volume 545, Issue 7655, pp. 491 - 494
Journal Article
PLoS pathogens, ISSN 1553-7366, 10/2008, Volume 4, Issue 10, pp. e1000176 - e1000176
.... Host responses to these toxins are complex and poorly understood. We find that the endoplasmic reticulum unfolded protein response (UPR... 
PATHWAYS | CAENORHABDITIS-ELEGANS | MESSENGER-RNA | ER STRESS | KINASE | RESISTANCE | MICROBIOLOGY | C-ELEGANS | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | UP-REGULATION | PARASITOLOGY | Endoribonucleases - genetics | Activating Transcription Factor 6 - immunology | Escherichia coli | Humans | Immunity, Innate - genetics | Endoplasmic Reticulum - metabolism | Activating Transcription Factor 6 - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Bacterial Infections - genetics | Bacterial Proteins - toxicity | Bacterial Infections - immunology | Hemolysin Proteins - toxicity | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Transcription Factors - immunology | Protein-Serine-Threonine Kinases - metabolism | Caenorhabditis elegans - metabolism | DNA-Binding Proteins - immunology | Endoplasmic Reticulum - genetics | Endoribonucleases - metabolism | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Membrane Proteins - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Caenorhabditis elegans - immunology | Regulatory Factor X Transcription Factors | Protein Folding | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Animals | Endoplasmic Reticulum - immunology | Protein-Serine-Threonine Kinases - immunology | HeLa Cells | Endotoxins - toxicity | Bacterial Infections - metabolism | Endoribonucleases - immunology | Index Medicus | Proteins | Enzymes | Signal transduction | Statistical analysis | E coli | Toxins | Kinases | Stress response | Experiments
Journal Article