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Journal of the National Cancer Institute, ISSN 0027-8874, 04/2011, Volume 103, Issue 8, pp. 645 - 661
Background Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant cancer cells survive and cause... 
STEM-CELLS | IN-VITRO | ONCOLOGY | TYROSINE KINASE | HGF | CELL INVASION | RECEPTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | NF-KAPPA-B | SCATTER-FACTOR | PROTOONCOGENE | Humans | Neoplasm Invasiveness - prevention & control | Radiation Tolerance | Receptors, Growth Factor - antagonists & inhibitors | NF-kappa B - metabolism | RNA, Messenger - metabolism | NF-kappa B - radiation effects | Receptors, Growth Factor - genetics | Proto-Oncogene Proteins c-met - radiation effects | Signal Transduction - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - radiation effects | Receptors, Growth Factor - radiation effects | Proto-Oncogene Proteins c-met - drug effects | Ataxia Telangiectasia Mutated Proteins | Phosphorylation - radiation effects | Cell Line, Tumor | Mice | RNA, Small Interfering | Tumor Suppressor Proteins - radiation effects | Receptors, Growth Factor - metabolism | Neoplasms - metabolism | Proto-Oncogene Proteins c-met - metabolism | Apoptosis - radiation effects | Up-Regulation - radiation effects | Transcription, Genetic - radiation effects | Transplantation, Heterologous | Sulfones - pharmacology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | Protein-Serine-Threonine Kinases - radiation effects | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Cell Cycle Proteins - genetics | Indoles - pharmacology | Neoplasms - radiotherapy | Gene Expression Regulation, Neoplastic - drug effects | In Situ Nick-End Labeling | Enzyme-Linked Immunosorbent Assay | Radiation-Sensitizing Agents - pharmacology | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Cell Survival - radiation effects | Cell Movement - radiation effects | Proto-Oncogene Proteins c-met - genetics | Blotting, Northern | Animals | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Receptors, Growth Factor - drug effects | DNA Damage - radiation effects | Mitogen-Activated Protein Kinases - metabolism | Ionizing radiation | Physiological aspects | Genetic aspects | Cancer invasiveness | Research | Gene expression | Radiotherapy | Health aspects | Oncology | Radiation therapy | Kinases | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 668 - 679
DNA damage induced by ionizing radiation activates the ATM kinase, which subsequently stabilizes and activates the p53 tumor suppressor protein. Although... 
INDUCED TUMORIGENESIS | PATHWAYS | APOPTOSIS | DEPENDENT PHOSPHORYLATION | MDM2-DEFICIENT MICE | P53-DEFICIENT MICE | ONCOLOGY | P53 ACTIVATION | IN-VIVO | TUMOR-SUPPRESSOR | EMBRYONIC LETHALITY | CELL BIOLOGY | Phosphorylation | Proto-Oncogene Proteins c-mdm2 - genetics | Intestine, Small - pathology | Apoptosis - radiation effects | Radiation Tolerance | Serine | Mice, 129 Strain | Mutation, Missense | Thymus Gland - enzymology | Intestine, Small - enzymology | DNA-Binding Proteins - metabolism | Spleen - enzymology | Thymus Gland - radiation effects | Time Factors | Protein-Serine-Threonine Kinases - radiation effects | Thymus Gland - pathology | Intestine, Small - radiation effects | Protein Stability | Spleen - pathology | Proto-Oncogene Proteins c-mdm2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - radiation effects | Tumor Suppressor Protein p53 - metabolism | Ataxia Telangiectasia Mutated Proteins | Animals | Spleen - radiation effects | Mice | DNA Damage | Enzyme Activation | Tumor Suppressor Proteins - radiation effects | Automated teller machines | Tumor proteins | Nuclear radiation | DNA repair | DNA | DNA damage | Index Medicus | mouse models | Mdm2 | ATM | tumorigenesis | DNA damage response | p53
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 32, pp. 14205 - 14210
Journal Article
Human Pathology, ISSN 0046-8177, 2014, Volume 45, Issue 10, pp. 2029 - 2036
Summary Immunohistochemistry (IHC) testing for mismatch repair proteins (MMRP) is currently being used primarily in colorectal cancer resection specimens. We... 
Pathology | Lynch | HNPCC | Neoadjuvant | Immunohistochemical staining | Reliability | Chemoradiation | LYNCH-SYNDROME | PREMM1,2,6 | NONPOLYPOSIS COLORECTAL-CANCER | RESECTION | MICROSATELLITE INSTABILITY | GUIDELINES | RISK | PATHOLOGY | IDENTIFICATION | MUTATIONS | CARCINOMA | MutL Protein Homolog 1 | Nuclear Proteins - analysis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Adenosine Triphosphatases - drug effects | DNA-Binding Proteins - analysis | Male | Chemoradiotherapy | Immunohistochemistry - standards | DNA Repair Enzymes - radiation effects | Neoplasm Proteins - drug effects | Colorectal Neoplasms - therapy | Adenosine Triphosphatases - analysis | DNA Mismatch Repair | Female | MutS Homolog 2 Protein - radiation effects | Neoadjuvant Therapy | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - drug effects | Reproducibility of Results | DNA-Binding Proteins - radiation effects | MutS Homolog 2 Protein - drug effects | DNA-Binding Proteins - drug effects | Nuclear Proteins - radiation effects | Adaptor Proteins, Signal Transducing - radiation effects | DNA Repair Enzymes - analysis | Adaptor Proteins, Signal Transducing - analysis | Neoplasm Proteins - radiation effects | Neoplasm Proteins - analysis | Aged | MutS Homolog 2 Protein - analysis | Adaptor Proteins, Signal Transducing - drug effects | Adenosine Triphosphatases - radiation effects | DNA Repair Enzymes - drug effects | Proteins | Immunohistochemistry | DNA | Colorectal cancer | Cancer therapies | Surgery | Cloning | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 41, pp. 16669 - 16674
The evolutionarily conserved CONSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1) is a RING and WD40 protein that functions as a substrate receptor of CULLIN4–DAMAGED DNA... 
Yeasts | Hypocotyls | Genetic vectors | Quantification | Gene expression regulation | Biochemistry | Plants | Open reading frames | Seedlings | Plant cells | Protein complex | Light signaling | Posttranscriptional regulation | light signaling | HY5 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | protein complex | SUPPRESSION | posttranscriptional regulation | PERCEPTION | LIGHT CONTROL | INTERACTS | GROWTH | ARABIDOPSIS | CONSTITUTIVELY PHOTOMORPHOGENIC1 | PROTEINS | Arabidopsis Proteins - physiology | Basic-Leucine Zipper Transcription Factors - metabolism | Immunoprecipitation | Chromosomal Proteins, Non-Histone - metabolism | Arabidopsis | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Immunoblotting | Nuclear Proteins - metabolism | Multiprotein Complexes - radiation effects | Arabidopsis Proteins - radiation effects | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Plant Development - radiation effects | Two-Hybrid System Techniques | Ultraviolet Rays | Cullin Proteins - metabolism | Light Signal Transduction - physiology | Real-Time Polymerase Chain Reaction | Plant Development - physiology | Morphogenesis | Physiological aspects | Transcription factors | Research | Photosynthesis | Proteins | Ultraviolet radiation | Flowers & plants | Plant growth | Index Medicus | Biological Sciences
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2010, Volume 397, Issue 2, pp. 350 - 354
Proteins are folded properly in the endoplasmic reticulum (ER). Various stress such as hypoxia, ischemia and starvation interfere with the ER function, causing... 
ER stress | Environmental UVB | HaCaT cells | ATF6 | CELLS | INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | JNK1 | INDUCTION | BIOPHYSICS | ENDOPLASMIC-RETICULUM | TRANSCRIPTION FACTOR | EXPRESSION | TRANSMEMBRANE PROTEIN | Membrane Proteins - radiation effects | Keratinocytes - radiation effects | eIF-2 Kinase - metabolism | Humans | Stress, Physiological | Endoplasmic Reticulum - metabolism | X-Box Binding Protein 1 | Endoribonucleases - radiation effects | DNA-Binding Proteins - metabolism | Ubiquitination | Cell Nucleus - metabolism | Ultraviolet Rays | Cell Nucleus - radiation effects | Protein-Serine-Threonine Kinases - radiation effects | Membrane Proteins - metabolism | Signal Transduction - radiation effects | Protein Folding - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Transcription Factors - radiation effects | DNA-Binding Proteins - radiation effects | Endoribonucleases - metabolism | Environmental Exposure | Activating Transcription Factor 6 - radiation effects | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Keratinocytes - metabolism | Active Transport, Cell Nucleus - drug effects | Endoplasmic Reticulum - radiation effects | Ubiquitin | Stress (Psychology) | Index Medicus | APOPTOSIS | IRRADIATION | ENDOPLASMIC RETICULUM | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | ANOXIA | ULTRAVIOLET RADIATION | BIOLOGICAL RADIATION EFFECTS | ISCHEMIA | RADIATION DOSES | PROTEINS
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2013, Volume 433, Issue 1, pp. 36 - 39
► Protein microarray shows the differential expression of 27 proteins induced by RFR. ► RPA32 related to DNA repair is down-regulated in Western blot. ► p73... 
Protein microarray | Replication Protein A | DNA repair | p73 | Radiofrequency radiation | Apoptosis | P73 | SYSTEM | ACTIVATION | INDUCED APOPTOSIS | CASPASE-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ELECTROMAGNETIC-FIELDS | CANCER | MOBILE PHONE | REPAIR | REPLICATION | BIOPHYSICS | Cell Transformation, Neoplastic - radiation effects | Apoptosis - radiation effects | Humans | Precursor Cells, B-Lymphoid - metabolism | Precursor Cells, B-Lymphoid - radiation effects | Up-Regulation - radiation effects | DNA Repair - radiation effects | Down-Regulation - radiation effects | DNA-Binding Proteins - metabolism | Radio Waves - adverse effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Replication Protein A - radiation effects | Cell Line | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Cell Cycle - radiation effects | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Nuclear Proteins - radiation effects | Tumor Protein p73 | Proteins - metabolism | Proteins - radiation effects | Protein Array Analysis | Hypoxia-Inducible Factor 1, alpha Subunit - radiation effects | Tumor Suppressor Proteins - radiation effects | Cell Proliferation - radiation effects | Proteins | Mobile communication systems | Wireless communication systems | Nuclear radiation | GSM (Global System for Mobile Communications) | Genomics | Genetic research | Telecommunications services industry | Communications industry | Index Medicus | APOPTOSIS | BIOLOGICAL EFFECTS | DNA REPAIR | CELL PROLIFERATION | CELL CYCLE | ABSORPTION | PROTEINS | 60 APPLIED LIFE SCIENCES | RADIOWAVE RADIATION | DNA DAMAGES
Journal Article