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Clinical Cancer Research, ISSN 1078-0432, 05/2007, Volume 13, Issue 9, pp. 2728 - 2737
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2009, Volume 8, Issue 11, pp. 2992 - 3000
Journal Article
Haematologica, ISSN 0390-6078, 01/2018, Volume 103, Issue 1, pp. 80 - 90
Journal Article
Cancer Biology and Therapy, ISSN 1538-4047, 04/2010, Volume 9, Issue 7, pp. 514 - 522
MK-1775 is a potent and selective small molecule Wee1 inhibitor. Previously we have shown that it abrogated DNA damaged checkpoints induced by gemcitabine,... 
Checkpoint | DNA-damaging agents | Wee1 | Kinase inhibitor | 5-FU | MK-1775 | checkpoint | PHOSPHORYLATION | THYMIDYLATE SYNTHASE | KINASE | SENSITIVITY | MECHANISMS | G CHECKPOINT | kinase inhibitor | CHK1 | ONCOLOGY | CANCER CELL-LINES | CHECKPOINT ABROGATION | CYCLE
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2015, Volume 33, Issue 30, pp. 3409 - 3415
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2013, Volume 12, Issue 8, pp. 1442 - 1452
Inhibition of the DNA damage checkpoint kinase WEE1 potentiates genotoxic chemotherapies by abrogating cell-cycle arrest and proper DNA repair. However, WEE1... 
CYCLIN-DEPENDENT KINASES | CANCER-CELLS | DNA-DAMAGING AGENTS | GROWTH-INHIBITION | IN-VITRO | CHK1 | ONCOLOGY | GENOME INTEGRITY | GENE-EXPRESSION | S-PHASE | ANTITUMOR-ACTIVITY | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Antineoplastic Agents - administration & dosage | Gene Knockdown Techniques | Cell Cycle Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Drug Evaluation, Preclinical | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Pyrazoles - pharmacology | DNA Damage - drug effects | Membrane Proteins - genetics | Pyrimidines - administration & dosage | Protein-Serine-Threonine Kinases - genetics | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Pyrazoles - administration & dosage | Animals | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
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Journal Article