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1. Full Text Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
by Yin, Wanchao and Mao, Chunyou and Luan, Xiaodong and Shen, Dan-Dan and Shen, Qingya and Su, Haixia and Wang, Xiaoxi and Zhou, Fulai and Zhao, Wenfeng and Gao, Minqi and Chang, Shenghai and Xie, Yuan-Chao and Tian, Guanghui and Jiang, He-Wei and Tao, Sheng-Ce and Shen, Jingshan and Jiang, Yi and Jiang, Hualiang and Xu, Yechun and Zhang, Shuyang and Zhang, Yan and Xu, H. Eric
Science (American Association for the Advancement of Science), ISSN 0036-8075, 06/2020, Volume 368, Issue 6498, pp. 1499 - 1504
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenosine Monophosphate - chemistry | Betacoronavirus - enzymology | Alanine - chemistry | Antiviral Agents - metabolism | Alanine - analogs & derivatives | SARS-CoV-2 | Viral Nonstructural Proteins - chemistry | Antiviral Agents - chemistry | Betacoronavirus - physiology | Enzyme Inhibitors - chemistry | Adenosine Monophosphate - pharmacology | RNA, Viral - metabolism | Alanine - pharmacology | RNA-Dependent RNA Polymerase - chemistry | Antiviral Agents - pharmacology | Catalytic Domain | Enzyme Inhibitors - metabolism | Adenosine Monophosphate - metabolism | Betacoronavirus - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | RNA-Dependent RNA Polymerase - metabolism | Alanine - metabolism | Coronavirus RNA-Dependent RNA Polymerase | Cryoelectron Microscopy | RNA-Dependent RNA Polymerase - antagonists & inhibitors | Multiprotein Complexes - chemistry | RNA, Viral - chemistry | Virus Replication | Adenosine Monophosphate - analogs & derivatives | Protein Conformation | Viral Nonstructural Proteins - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Pandemics | Transcription | Severe acute respiratory syndrome | Double-stranded RNA | Viral diseases | Viruses | RNA polymerase | Coronaviruses | Nucleotides | Electron microscopy | Drug development | DNA-directed RNA polymerase | RNA-directed RNA polymerase | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Replicating | Elongated structure | Respiratory diseases | Replication | Index Medicus
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2. Full Text Structure of the RNA-dependent RNA polymerase from COVID-19 virus
by Gao, Yan and Yan, Liming and Huang, Yucen and Liu, Fengjiang and Zhao, Yao and Cao, Lin and Wang, Tao and Sun, Qianqian and Ming, Zhenhua and Zhang, Lianqi and Ge, Ji and Zheng, Litao and Zhang, Ying and Wang, Haofeng and Zhu, Yan and Zhu, Chen and Hu, Tianyu and Hua, Tian and Zhang, Bing and Yang, Xiuna and Li, Jun and Yang, Haitao and Liu, Zhijie and Xu, Wenqing and Guddat, Luke W and Wang, Quan and Lou, Zhiyong and Rao, Zihe
Science (American Association for the Advancement of Science), ISSN 0036-8075, 05/2020, Volume 368, Issue 6492, pp. 779 - 782
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Dependent RNA Polymerase - ultrastructure | Betacoronavirus - enzymology | Antiviral Agents - metabolism | Alanine - analogs & derivatives | Multiprotein Complexes - metabolism | SARS-CoV-2 | Viral Nonstructural Proteins - chemistry | Drug Design | Protein Domains | Adenosine Monophosphate - pharmacology | Viral Nonstructural Proteins - ultrastructure | Alanine - pharmacology | RNA-Dependent RNA Polymerase - chemistry | Antiviral Agents - pharmacology | Catalytic Domain | Adenosine Monophosphate - metabolism | Models, Molecular | RNA-Dependent RNA Polymerase - metabolism | Alanine - metabolism | Coronavirus RNA-Dependent RNA Polymerase | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | RNA-Dependent RNA Polymerase - antagonists & inhibitors | Multiprotein Complexes - chemistry | Protein Conformation, beta-Strand | Adenosine Monophosphate - analogs & derivatives | Viral Nonstructural Proteins - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Coronaviruses | RNA | Health aspects | Analysis | Severe acute respiratory syndrome | RNA viruses | Pandemics | Transcription | Viral diseases | Viruses | RNA polymerase | Nucleotides | Electron microscopy | DNA-directed RNA polymerase | RNA-directed RNA polymerase | Cofactors | Nucleotide analogs | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Microscopy | Respiratory diseases | Replication | Comparative analysis | Chemical synthesis | Index Medicus
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3. PCR protocols
: a guide to methods and applications
by Innis, Michael A
1990, ISBN 9780123721808, xviii, 482
Polymerase chain reaction | Gene amplification | DNA Polymerases | Genetic Engineering | RNA Polymerases | methods
Book
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4. Full Text Arabidopsis RNA-Dependent RNA Polymerases and Dicer-Like Proteins in Antiviral Defense and Small Interfering RNA Biogenesis during Turnip Mosaic Virus Infection
by Hernan Garcia-Ruiz and Atsushi Takeda and Elisabeth J. Chapman and Christopher M. Sullivan and Noah Fahlgren and Katherine J. Brempelis and James C. Carrington
The Plant cell, ISSN 1040-4651, 2/2010, Volume 22, Issue 2, pp. 481 - 496
Leaves | RNA interference | Double stranded RNA | RNA | Inflorescences | Antivirals | Small interfering RNA | Viruses | Infections | Nucleotides | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Cell Biology | Arabidopsis - genetics | RNA, Small Interfering - genetics | Arabidopsis - enzymology | Ribonuclease III - genetics | Plant Viruses - genetics | Mutation | DNA-Directed RNA Polymerases - metabolism | Arabidopsis thaliana | Turnips | Diseases and pests | Virus diseases of plants | Genetic aspects | Biosynthesis | Properties | Plant viruses | RNA polymerases | Index Medicus | s
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5. Full Text Structure of replicating SARS-CoV-2 polymerase
by Hillen, Hauke S and Kokic, Goran and Farnung, Lucas and Dienemann, Christian and Tegunov, Dimitry and Cramer, Patrick
Nature (London), ISSN 0028-0836, 08/2020, Volume 584, Issue 7819, pp. 154 - 156
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Dependent RNA Polymerase - genetics | RNA-Dependent RNA Polymerase - ultrastructure | RNA, Viral - biosynthesis | Betacoronavirus - drug effects | Betacoronavirus - enzymology | Models, Molecular | RNA-Dependent RNA Polymerase - metabolism | Viral Nonstructural Proteins - genetics | Betacoronavirus - ultrastructure | Coronavirus RNA-Dependent RNA Polymerase | Cryoelectron Microscopy | Alanine - analogs & derivatives | SARS-CoV-2 | Viral Nonstructural Proteins - chemistry | RNA, Viral - chemistry | Adenosine Monophosphate - analogs & derivatives | Protein Conformation | Viral Nonstructural Proteins - metabolism | Adenosine Monophosphate - pharmacology | RNA, Viral - metabolism | Viral Nonstructural Proteins - ultrastructure | Betacoronavirus - genetics | Alanine - pharmacology | RNA-Dependent RNA Polymerase - chemistry | Poles | Enzymes | Transcription | Genes | Medical treatment | Severe acute respiratory syndrome | Cloning | Viral diseases | Sliding | Genomes | RNA polymerase | Coronaviruses | Electron microscopy | DNA-directed RNA polymerase | RNA-directed RNA polymerase | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Proteins | Replicating | Microscopy | Antiviral activity | Fingers & toes | Binding sites | Index Medicus
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6. Full Text Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit
by Feklistov, Andrey and Darst, Seth A
Cell (Cambridge), ISSN 0092-8674, 2011, Volume 147, Issue 6, pp. 1257 - 1269
Promoter Regions, Genetic | Sigma Factor - chemistry | Sigma Factor - metabolism | DNA, Single-Stranded - metabolism | Bacterial Proteins - chemistry | Models, Molecular | Crystallography, X-Ray | Escherichia coli Proteins - metabolism | DNA, Single-Stranded - chemistry | Base Pairing | Base Sequence | Escherichia coli - metabolism | Hydrophobic and Hydrophilic Interactions | Bacterial Proteins - metabolism | DNA-Directed RNA Polymerases - chemistry | DNA-Directed RNA Polymerases - metabolism | Escherichia coli Proteins - chemistry | Thermus - metabolism | Index Medicus
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7. Full Text Structural insight into cap-snatching and RNA synthesis by influenza polymerase
by Reich, Stefan and Reich, Stefan and Guilligay, Delphine and Pflug, Alexander and Malet, Helene and Berger, Imre and Crepin, Thibaut and Hart, Darren and Lunardi, Thomas and Nanao, Max and Ruigrok, Rob W. H and Cusack, Stephen
Nature (London), ISSN 0028-0836, 12/2014, Volume 516, Issue 7531, pp. 361 - 366
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Structure, Tertiary | Influenza A virus - chemistry | Influenza B virus - enzymology | Promoter Regions, Genetic | Catalytic Domain | RNA, Viral - biosynthesis | Crystallization | Models, Molecular | Influenza A virus - enzymology | RNA Caps - metabolism | RNA, Viral - chemistry | Virus Replication | Gene Expression Regulation, Viral | Protein Binding | RNA Caps - chemistry | Influenza B virus - chemistry | DNA-Directed RNA Polymerases - chemistry | DNA-Directed RNA Polymerases - metabolism | Influenza viruses | Synthesis | RNA | Analysis | Crystals | Research | Structure | Health aspects | RNA polymerases | Ribonucleic acid--RNA | Influenza | Binding sites | Crystal structure | Index Medicus | Biochemistry, Molecular Biology | RNA Caps | Influenza B virus | Life Sciences | DNA-Directed RNA Polymerases | Influenza A virus | RNA, Viral | Biomolecules
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8. Full Text Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
by Tchesnokov, Egor P and Feng, Joy Y and Porter, Danielle P and Gotte, Matthias
Viruses, ISSN 1999-4915, 04/2019, Volume 11, Issue 4, p. 326
Life Sciences & Biomedicine | Science & Technology | Virology | Ribonucleotides - chemistry | Humans | RNA Replicase - metabolism | Substrate Specificity | Alanine - chemistry | RNA Replicase - antagonists & inhibitors | Antiviral Agents - metabolism | Viral Proteins - metabolism | Ribonucleotides - pharmacology | Alanine - analogs & derivatives | Antiviral Agents - chemistry | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | Respiratory Syncytial Virus, Human - enzymology | Adenosine - chemistry | Molecular Structure | Alanine - pharmacology | Ebolavirus - enzymology | Antiviral Agents - pharmacology | Ribonucleotides - metabolism | Prodrugs | Respiratory Syncytial Virus, Human - drug effects | Enzyme Inhibitors - metabolism | RNA, Viral - biosynthesis | Enzyme Inhibitors - pharmacology | Alanine - metabolism | Viral Proteins - antagonists & inhibitors | Adenosine - pharmacology | Adenosine - analogs & derivatives | Respiratory Syncytial Virus, Human - physiology | Adenosine - metabolism | Kinetics | DNA-Directed RNA Polymerases - metabolism | Index Medicus | Ebola virus | RdRp | RNA polymerase | GS-5734 | remdesivir | respiratory syncytial virus | delayed chain termination
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9. Full Text The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase
by Lung, Jrhau and Lin, Yu‐Shih and Yang, Yao‐Hsu and Chou, Yu‐Lun and Shu, Li‐Hsin and Cheng, Yu‐Ching and Liu, Hung Te and Wu, Ching‐Yuan
Journal of medical virology, ISSN 0146-6615, 06/2020, Volume 92, Issue 6, pp. 693 - 697
RNA‐dependent RNA polymerase | SARS‐CoV‐2 | theaflavin | traditional Chinese medicinal compounds | Life Sciences & Biomedicine | Science & Technology | Virology | Biflavonoids - pharmacology | Biflavonoids - chemistry | Humans | Betacoronavirus - enzymology | Drugs, Chinese Herbal - pharmacology | Viral Proteins - metabolism | Thermodynamics | SARS-CoV-2 | SARS Virus - genetics | Antiviral Agents - chemistry | Middle East Respiratory Syndrome Coronavirus - enzymology | Protein Interaction Domains and Motifs | Catechin - pharmacology | RNA-Dependent RNA Polymerase - chemistry | Amino Acid Sequence | Antiviral Agents - pharmacology | Catalytic Domain | Computational Biology - methods | Gene Expression | RNA-Dependent RNA Polymerase - genetics | Protein Structure, Secondary | Viral Proteins - chemistry | Betacoronavirus - drug effects | Middle East Respiratory Syndrome Coronavirus - drug effects | RNA-Dependent RNA Polymerase - metabolism | SARS Virus - drug effects | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | Sequence Homology, Amino Acid | RNA-Dependent RNA Polymerase - antagonists & inhibitors | Sequence Alignment | Hydrogen Bonding | Drugs, Chinese Herbal - chemistry | Middle East Respiratory Syndrome Coronavirus - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Molecular Docking Simulation | Betacoronavirus - genetics | SARS Virus - enzymology | Catechin - chemistry | Therapeutic applications | Severe acute respiratory syndrome | Viral diseases | RNA polymerase | Coronaviruses | Hydrophobicity | DNA-directed RNA polymerase | Hydrogen bonding | Middle East respiratory syndrome | Molecular docking | COVID-19 | Docks | Inhibitors | Hydrogen bonds | Binding energy | Respiratory diseases | Antiviral activity | Index Medicus
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10. Full Text An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II
by Searle, Iain and Jones, Alexandra M E and Vogler, Hannes and Patel, Kanu and Hubner, Nina C and Baulcombe, David C and Huang, Linfeng
Nature structural & molecular biology, ISSN 1545-9993, 01/2009, Volume 16, Issue 1, pp. 91 - 93
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | DNA Polymerase beta - chemistry | DNA - metabolism | RNA Polymerase II - metabolism | DNA-Binding Proteins - chemistry | Protein Subunits - metabolism | DNA - genetics | DNA-Binding Proteins - metabolism | Phenotype | RNA Interference | DNA-Directed RNA Polymerases - chemistry | Protein Subunits - chemistry | DNA Polymerase beta - metabolism | DNA-Directed RNA Polymerases - metabolism | DNA Polymerase beta - genetics | RNA Polymerase II - chemistry | RNA, Small Interfering - metabolism | Physiological aspects | Gene silencing | Research | Structure | RNA polymerases | Genetics | RNA polymerase | Molecular biology | Deoxyribonucleic acid--DNA | Botany | Index Medicus
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11. Full Text RNA polymerase molecular beacon as tool for studies of RNA polymerase–promoter interactions
by Mekler, Vladimir and Severinov, Konstantin
Methods (San Diego, Calif.), ISSN 1046-2023, 09/2015, Volume 86, pp. 19 - 26
Fluorescence spectroscopy | RNA polymerase–promoter interactions | RNA polymerase | Transcription initiation | Transcription regulation | RNA polymerase-promoter interactions | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Promoter Regions, Genetic | Escherichia coli - enzymology | Models, Molecular | Protein Binding | Transcription, Genetic | DNA-Directed RNA Polymerases - chemistry | DNA-Directed RNA Polymerases - genetics | Fluorometry | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | RNA | Fluorescence | Genetic transcription | Escherichia coli | RNA polymerases | Index Medicus | transcription regulation | fluorescence spectroscopy | transcription initiation
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