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1. Full Text Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
by Yin, Wanchao and Mao, Chunyou and Luan, Xiaodong and Shen, Dan-Dan and Shen, Qingya and Su, Haixia and Wang, Xiaoxi and Zhou, Fulai and Zhao, Wenfeng and Gao, Minqi and Chang, Shenghai and Xie, Yuan-Chao and Tian, Guanghui and Jiang, He-Wei and Tao, Sheng-Ce and Shen, Jingshan and Jiang, Yi and Jiang, Hualiang and Xu, Yechun and Zhang, Shuyang and Zhang, Yan and Xu, H. Eric
Science (American Association for the Advancement of Science), ISSN 0036-8075, 06/2020, Volume 368, Issue 6498, pp. 1499 - 1504
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenosine Monophosphate - chemistry | Betacoronavirus - enzymology | Alanine - chemistry | Antiviral Agents - metabolism | Alanine - analogs & derivatives | SARS-CoV-2 | Viral Nonstructural Proteins - chemistry | Antiviral Agents - chemistry | Betacoronavirus - physiology | Enzyme Inhibitors - chemistry | Adenosine Monophosphate - pharmacology | RNA, Viral - metabolism | Alanine - pharmacology | RNA-Dependent RNA Polymerase - chemistry | Antiviral Agents - pharmacology | Catalytic Domain | Enzyme Inhibitors - metabolism | Adenosine Monophosphate - metabolism | Betacoronavirus - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | RNA-Dependent RNA Polymerase - metabolism | Alanine - metabolism | Coronavirus RNA-Dependent RNA Polymerase | Cryoelectron Microscopy | RNA-Dependent RNA Polymerase - antagonists & inhibitors | Multiprotein Complexes - chemistry | RNA, Viral - chemistry | Virus Replication | Adenosine Monophosphate - analogs & derivatives | Protein Conformation | Viral Nonstructural Proteins - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Pandemics | Transcription | Severe acute respiratory syndrome | Double-stranded RNA | Viral diseases | Viruses | RNA polymerase | Coronaviruses | Nucleotides | Electron microscopy | Drug development | DNA-directed RNA polymerase | RNA-directed RNA polymerase | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Replicating | Elongated structure | Respiratory diseases | Replication | Index Medicus
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2. Full Text Chloroplast RNA polymerases: Role in chloroplast biogenesis
by Börner, Thomas and Aleynikova, Anastasia Yu and Zubo, Yan O and Kusnetsov, Victor V
Biochimica et biophysica acta. Bioenergetics, ISSN 0005-2728, 09/2015, Volume 1847, Issue 9, pp. 761 - 769
Chloroplast biogenesis | Chloroplast RNA polymerase | Chloroplast RNA | Chloroplast development | Photosynthesis | Chloroplast transcription | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Chloroplasts - physiology | Promoter Regions, Genetic | Transcription, Genetic | DNA-Directed RNA Polymerases - genetics | Chloroplasts - genetics | DNA-Directed RNA Polymerases - physiology | Arabidopsis thaliana | Biosynthesis | RNA | Phytochemistry | RNA polymerases
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3. Full Text The RNA polymerase II core promoter — the gateway to transcription
by Juven-Gershon, Tamar and Hsu, Jer-Yuan and Theisen, Joshua WM and Kadonaga, James T
Current opinion in cell biology, ISSN 0955-0674, 2008, Volume 20, Issue 3, pp. 253 - 259
Internal Medicine | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Messenger - biosynthesis | Base Sequence - genetics | Transcriptional Activation - genetics | Animals | Humans | RNA, Messenger - genetics | TATA Box - genetics | DNA-Directed RNA Polymerases - genetics | Transcription, Genetic - genetics | Promoter Regions, Genetic - genetics | Evolution, Molecular | Transcription Initiation Site - physiology | RNA | Promoters (Genetics) | Index Medicus
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4. Full Text Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase
by Akichika, Shinichiro and Hirano, Seiichi and Shichino, Yuichi and Suzuki, Takeo and Nishimasu, Hiroshi and Ishitani, Ryuichiro and Sugita, Ai and Hirose, Yutaka and Iwasaki, Shintaro and Nureki, Osamu and Suzuki, Tsutomu
Science (American Association for the Advancement of Science), ISSN 0036-8075, 01/2019, Volume 363, Issue 6423, p. eaav0080
Oxidative stress | Yeast | Adenosylmethionine | Profiling | Molecular structure | Transcription | Serine | Biosynthesis | DNA-directed RNA polymerase | Gene sequencing | Proteins | DNA methylation | Genetics | Physiology | Elongation | Crystal structure | Adenosine | Translation | Mass spectroscopy | Roles | RNA polymerase | Metabolism | Gene expression | Ribonucleic acid--RNA | Substrates | S-Adenosylmethionine | Domains | Vertebrates | Organic chemistry | Initiation factor eIF-4E | Methylation | Mass spectrometry | RNA polymerase II | Structural analysis
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5. Full Text Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
by Tchesnokov, Egor P and Feng, Joy Y and Porter, Danielle P and Gotte, Matthias
Viruses, ISSN 1999-4915, 04/2019, Volume 11, Issue 4, p. 326
Life Sciences & Biomedicine | Science & Technology | Virology | Ribonucleotides - chemistry | Humans | RNA Replicase - metabolism | Substrate Specificity | Alanine - chemistry | RNA Replicase - antagonists & inhibitors | Antiviral Agents - metabolism | Viral Proteins - metabolism | Ribonucleotides - pharmacology | Alanine - analogs & derivatives | Antiviral Agents - chemistry | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | Respiratory Syncytial Virus, Human - enzymology | Adenosine - chemistry | Molecular Structure | Alanine - pharmacology | Ebolavirus - enzymology | Antiviral Agents - pharmacology | Ribonucleotides - metabolism | Prodrugs | Respiratory Syncytial Virus, Human - drug effects | Enzyme Inhibitors - metabolism | RNA, Viral - biosynthesis | Enzyme Inhibitors - pharmacology | Alanine - metabolism | Viral Proteins - antagonists & inhibitors | Adenosine - pharmacology | Adenosine - analogs & derivatives | Respiratory Syncytial Virus, Human - physiology | Adenosine - metabolism | Kinetics | DNA-Directed RNA Polymerases - metabolism | Index Medicus | Ebola virus | RdRp | RNA polymerase | GS-5734 | remdesivir | respiratory syncytial virus | delayed chain termination
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6. Full Text The Primary Transcriptome of Barley Chloroplasts: Numerous Noncoding RNAs and the Dominating Role of the Plastid-Encoded RNA Polymerase
by Petya Zhelyazkova and Cynthia M. Sharma and Konrad U. Förstner and Karsten Liere and Jörg Vogel and Thomas Börner
The Plant cell, ISSN 1040-4651, 1/2012, Volume 24, Issue 1, pp. 123 - 136
Datasets | Barley | RNA | Chloroplasts | Complementary DNA | Genes | Libraries | Genomes | Nucleotides | Plastids | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Cell Biology | Gene Expression Regulation, Plant - genetics | DNA-Directed RNA Polymerases - genetics | Transcriptome - genetics | RNA, Untranslated - genetics | Plant Proteins - genetics | Plastids - enzymology | Hordeum - enzymology | Gene Expression Regulation, Plant - physiology | Plastids - genetics | Plant Proteins - metabolism | DNA-Directed RNA Polymerases - metabolism | Hordeum - genetics | Chloroplasts - genetics | Plant genetics | Physiological aspects | Genetic aspects | Research | Genetic transcription | Gene expression | Index Medicus
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7. Full Text RNA polymerase III limits longevity downstream of TORC1
by Filer, Danny and Thompson, Maximillian A and Takhaveev, Vakil and Dobson, Adam J and Kotronaki, Ilektra and Green, James W. M and Heinemann, Matthias and Tullet, Jennifer M. A and Alic, Nazif
Nature (London), ISSN 0028-0836, 12/2017, Volume 552, Issue 7684, pp. 263 - 267
LIFE-SPAN EXTENSION | RAPAMYCIN | SYSTEM | CELLS | MICROFLUIDIC DISSECTION PLATFORM | DROSOPHILA-MELANOGASTER | BUDDING YEAST | TRANSCRIPTION | C-ELEGANS | EXPRESSION | To be checked by Faculty | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Biosynthesis | Drosophila melanogaster - physiology | Longevity - drug effects | Aging - drug effects | Male | Saccharomyces cerevisiae - drug effects | Stem Cells - cytology | Caenorhabditis elegans - physiology | Stem Cells - enzymology | Female | Food | Saccharomyces cerevisiae - physiology | RNA Polymerase III - metabolism | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | RNA Polymerase III - deficiency | Drosophila melanogaster - drug effects | Mechanistic Target of Rapamycin Complex 1 - metabolism | Animals | Caenorhabditis elegans - drug effects | Aging - physiology | Drosophila melanogaster - enzymology | Saccharomyces cerevisiae - enzymology | Longevity - physiology | Caenorhabditis elegans - enzymology | Evolution, Molecular | Intestines - cytology | Intestines - enzymology | RNA Polymerase III - antagonists & inhibitors | Physiological aspects | RNA polymerases | Longevity | TOR protein | Yeast | Genes | Genomes | Kinases | DNA-directed RNA polymerase | Nuclei | Proteins | Intestine | Evolutionary conservation | Aging | Inhibition | Digestive tract | Worms | Transfer RNA | Digestive system | Cell division | Protein biosynthesis | Rapamycin | Gene expression | Ribonucleic acid--RNA | Signaling | Life span | Insects | Protein synthesis | Stem cells | rRNA 5S | Flies | Index Medicus
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8. Full Text Eukaryotic core promoters and the functional basis of transcription initiation
by Haberle, Vanja and Stark, Alexander
Nature reviews. Molecular cell biology, ISSN 1471-0072, 10/2018, Volume 19, Issue 10, pp. 621 - 637
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Chromatin | Gene Expression Regulation - genetics | Humans | Gene Expression Regulation - physiology | RNA Polymerase II - physiology | RNA Polymerase II - metabolism | Transcription Factors - genetics | Eukaryota - metabolism | Promoter Regions, Genetic - genetics | Transcription Factors - metabolism | Transcription, Genetic - physiology | Animals | Eukaryota - genetics | Promoter Regions, Genetic - physiology | DNA | Transcription Initiation, Genetic - physiology | Transcription, Genetic - genetics | Genetic research | Promoters (Genetics) | Genetic transcription | Research | RNA polymerases | Transcription factors | Nucleotide sequence | Genes | RNA polymerase | Ribonucleic acid--RNA | DNA-directed RNA polymerase | Promoters | Cofactors | Gene sequencing | Proteins | Enhancers | Molecular modelling | Transcription initiation | Deoxyribonucleic acid--DNA | RNA polymerase II | Regulatory proteins | Index Medicus
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