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International Journal of Molecular Sciences, ISSN 1422-0067, 07/2019, Volume 20, Issue 15, p. 3700
Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in... 
Index Medicus | neuroblastoma | ATM | DNA-PK | checkpoint abrogation | CHK1
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2019, Volume 380, pp. 114646 - 114646
Glioblastomas are the most aggressive of malignant brain cancers with a median patient survival of approximately 18 months. We recently demonstrated that Tet... 
TET1 | Ionizing radiation | DNA-PK | Human glioma | Non homologous DNA repair | Index Medicus
Journal Article
Tetrahedron, ISSN 0040-4020, 01/2019, Volume 75, Issue 3, pp. 374 - 380
Benzoxazine derivatives are useful building blocks and display various biological activities. We serendipitously discovered and subsequently developed a new... 
4H-1,3-benzoxazin-4-ones | N-Formylamine solvent as reactant | m-CPBA | DOMINO REACTION | DNA-PK | CHEMISTRY, ORGANIC | PI3K INHIBITION
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 11, pp. 9618 - 9631
Tudor domain containing protein 9 (TDRD9) is a RNA helicase normally expressed in the germline, where it is involved in the biosynthesis of PIWI-interacting... 
DNA methylation | DNA-PK | PiRNA | DNA damage | Cancer
Journal Article
Cancers, ISSN 2072-6694, 08/2019, Volume 11, Issue 8, p. 1104
Expression of DNA repair genes was studied in uveal melanoma (UM) in order to identify genes that may play a role in metastases formation. We searched for... 
DNA-PK | PRKDC | uveal melanoma | DNA repair | prognosis | oncology | BAP1
Journal Article
DNA Repair, ISSN 1568-7864, 06/2019, Volume 78, pp. 114 - 127
The bulk of DNA damage caused by ionizing radiation (IR) is generally repaired within hours, yet a subset of DNA lesions may persist even for long periods of... 
Super-resolution microscopy | Ionizing radiation | DNA-PK and PARP/olaparib | Homologous recombination | Cellular senescence
Journal Article
International Journal of Radiation Biology, ISSN 0955-3002, 09/2019, Volume 95, Issue 9, pp. 1205 - 1219
Purpose: To evaluate the effect of NU7026, a specific inhibitor of DNA-PKcs, on DNA-double strand break (DSB) repair in a cell cycle specific manner, on the... 
H2AX | apoptosis | DNA-PK | mitotic catastrophe | cell cycle | radiation sensitivity | Index Medicus | Space life sciences
Journal Article
Genes & development, ISSN 0890-9369, 06/2019, Volume 33, Issue 11-12, pp. 684 - 704
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to inhibition of transcription. The DNA-dependent protein kinase (DNA-PK)... 
Index Medicus | transcription silencing | DNA double-strand break repair | Research Paper | DNA-PK | WWP2 HECT E3 ubiquitin ligase | RNAPII ubiquitylation
Journal Article
Molekuliarnaia biologiia, ISSN 0026-8984, 05/2019, Volume 53, Issue 3, pp. 355 - 366
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 07/2006, Volume 8, Issue 7, pp. 668 - U54
The DExD/H-box ATPase Dbp5 is essential for nuclear mRNA export, although its precise role in this process remains poorly understood. Here, we identify the... 
YEAST | INOSITOL HEXAKISPHOSPHATE | DNA-PK | POLY(A)(+) RNA | NUCLEOPORIN RIP1P | PHOSPHOLIPASE-C | CYTOPLASMIC FIBRILS | HEAT-SHOCK | SACCHAROMYCES-CEREVISIAE | TELOMERE LENGTH | CELL BIOLOGY
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 4/2017, Volume 23, Issue 8, pp. 2050 - 2060
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2018, Volume 818, pp. 364 - 370
Notch signaling pathway has been demonstrated to mediate radioresistance of several tumors. Our study aims to explore the function of Notch1/HES1 pathway in... 
Radiosensitiviy | γ-H2AX | DNA-PK | Notch1 | Colorectal cancer | gamma-H2AX | DOWN-REGULATION | NOTCH | RADIATION | ENHANCES RADIOSENSITIVITY | LUNG-CANCER | REPAIR | THERAPY | RADIORESISTANCE | PHARMACOLOGY & PHARMACY | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 40, pp. 25833 - 25841
DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We demonstrate the selectivity of... 
DNA-PK | Radiation therapy | Double-strand break repair | DNA repair | Non-homologous end joining
Journal Article
Oncogene, ISSN 0950-9232, 08/2010, Volume 29, Issue 34, pp. 4826 - 4837
Recurrence is frequently associated with the acquisition of radioresistance by tumors and resulting failures in radiotherapy. We report, in this study, that... 
AKT | cyclin D1 | DNA-PK | fractionated-radiation | radioresistance | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | NUCLEAR EXPORT | MAMMALIAN-CELLS | CANCER STEM-CELLS | CELL BIOLOGY | REPAIR | REPLICATION | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | STRAND BREAK RESPONSE
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 05/2019, Volume 93, Issue 10
The adenovirus (Ad) E4orf4 protein contributes to virus-induced inhibition of the DNA damage response (DDR) by reducing ATM and ATR signaling. Consequently,... 
DNA-PK | STRAND BREAK REPAIR | PHOSPHATASE 2A | DNA damage response | SACCHAROMYCES-CEREVISIAE | E4orf4 | CELL-DEATH | DAMAGE RESPONSE | VIROLOGY | GROWTH ARREST | KINASE CATALYTIC SUBUNIT | EARLY REGION-4 | adenoviruses | P53-INDEPENDENT APOPTOSIS | ATM ACTIVATION
Journal Article
Journal Article