X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (55) 55
drug discovery (44) 44
chemistry, medicinal (40) 40
chemistry, multidisciplinary (33) 33
inhibitors (32) 32
discovery (31) 31
dna-encoded libraries (28) 28
ligands (28) 28
dna - chemistry (27) 27
deoxyribonucleic acid--dna (26) 26
dna (26) 26
libraries (25) 25
design (24) 24
dna-encoded chemical libraries (24) 24
combinatorial chemistry (23) 23
identification (23) 23
selection (22) 22
small molecule libraries - chemistry (21) 21
biochemistry & molecular biology (20) 20
dna-encoded library (20) 20
humans (20) 20
proteins (20) 20
chemistry, applied (19) 19
in-vitro selection (18) 18
organic chemistry (16) 16
technology (14) 14
coding (13) 13
display (13) 13
high-throughput screening (13) 13
chemical libraries (12) 12
combinatorial chemistry techniques (12) 12
dna - metabolism (12) 12
potent (12) 12
affinity (11) 11
article (11) 11
small-molecule libraries (11) 11
binding (10) 10
genetic research (10) 10
pharmacology & pharmacy (10) 10
combinatorial analysis (9) 9
protein binding (9) 9
binding-molecules (8) 8
chemistry (8) 8
dna-encoded chemical library (8) 8
dna‐encoded library (8) 8
protein (8) 8
animals (7) 7
biochemical research methods (7) 7
chemical synthesis (7) 7
combinatorial libraries (7) 7
dna sequencing (7) 7
dna‐encoded chemical libraries (7) 7
gene library (7) 7
molecular structure (7) 7
peptide library (7) 7
small molecule libraries - chemical synthesis (7) 7
small molecule libraries - metabolism (7) 7
small molecules (7) 7
templated organic-synthesis (7) 7
affinität (6) 6
analysis (6) 6
cancer (6) 6
chemistry, organic (6) 6
dna-encoded library technology (6) 6
dna‐encoded libraries (6) 6
enrichment (6) 6
small molecule libraries (6) 6
technology elt (6) 6
anreicherung (5) 5
antagonists (5) 5
binders (5) 5
biology (5) 5
biophysics (5) 5
cell biology (5) 5
enzymes (5) 5
gene sequencing (5) 5
high-throughput (5) 5
kinase inhibitors (5) 5
ligand (5) 5
ligand-target pairs (5) 5
microfluidics (5) 5
nucleotide sequencing (5) 5
oligonucleotides - chemistry (5) 5
optimization (5) 5
peptides (5) 5
polymerase chain reaction (5) 5
research article (5) 5
screening (5) 5
small molecule libraries - pharmacology (5) 5
solid-phase synthesis (5) 5
affinity selection (4) 4
agent-development (4) 4
binding sites (4) 4
biotechnology & applied microbiology (4) 4
chemistry, analytical (4) 4
combinatorial chemistry techniques - methods (4) 4
dna biosynthesis (4) 4
dna-encoded chemistry (4) 4
drug discovery - methods (4) 4
elt (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Drug Discovery Today, ISSN 1359-6446, 11/2016, Volume 21, Issue 11, pp. 1828 - 1834
DNA-encoded chemical libraries have emerged as a powerful tool for hit identification in the pharmaceutical industry and in academia. Similar to biological... 
IN-VITRO | DISPLAY | POTENT | COMBINATORIAL CHEMISTRY | SMALL-MOLECULE LIBRARIES | TARGETS | PHARMACOLOGY & PHARMACY | TEMPLATED SYNTHESIS | INHIBITORS | SELECTION | IDENTIFICATION | Small Molecule Libraries | Drug Discovery | DNA | Proteins | Genetic research | Pharmaceutical industry | DNA-encoded chemical libraries | affinity selections | hit identification
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2019, Volume 58, Issue 28, pp. 9570 - 9574
Here we show a seven‐step chemical synthesis of a DNA‐encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide‐polyketide natural... 
chemical libraries | DNA chemistry | DNA-encoded libraries | Lipinski rules | macrocycles | DESIGN | PERMEABILITY | DRUG DISCOVERY | TEMPLATED SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | SOLUBILITY | DISPLAY | SELECTION | BINDING | Genetic research | Chemical synthesis | DNA | DNA biosynthesis | Organic chemistry | Libraries | Natural products | Deoxyribonucleic acid--DNA
Journal Article
ACS Combinatorial Science, ISSN 2156-8952, 02/2019, Volume 21, Issue 2, pp. 75 - 82
DNA-encoded chemical libraries (DELs) provide a high-throughput and cost-effective route for screening billions of unique molecules for binding affinity for... 
DNA-encoded libraries | data analysis | drug discovery | affinity selection | CHEMISTRY, MEDICINAL | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | POTENT | BINDING-MOLECULES | INHIBITORS | CHEMISTRY, APPLIED | TECHNOLOGY
Journal Article
FEBS Letters, ISSN 0014-5793, 06/2018, Volume 592, Issue 12, pp. 2168 - 2180
Journal Article
Journal Article
ACS COMBINATORIAL SCIENCE, ISSN 2156-8952, 10/2019, Volume 21, Issue 10, pp. 650 - 655
DNA-encoded chemical library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the... 
CHEMISTRY, MEDICINAL | DNA-encoded chemical libraries (DECLs) | FIDELITY | DNA damage | on-DNA chemistry | CHEMISTRY, APPLIED | TECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | quantitative PCR (qPCR)
Journal Article
Journal Article