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CANCER RESEARCH, ISSN 0008-5472, 12/2007, Volume 67, Issue 24, pp. 11481 - 11486
CpG island promoter hypermethylation of tumor suppressor genes is a common hallmark of human cancer, and new large-scale epigenomic technologies might be... 
DNMT1 | ONCOLOGY
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2018, Volume 32, Issue 7, pp. 3536 - 3546
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 645 - 652
PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dram 1 [DNA... 
DNA methylation | Epigenetics | Poly(ADP-ribosyl)ation (PARylation) | DNA methyltranferase 1 (Dnmt1) | CCCTC-binding factor (Ctcf) | Poly(ADP-ribose) polymerase 1 (Parp1) | POLY(ADP-RIBOSYL)ATION REACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | poly(ADP-ribosyl)ation (PARylation) | epigenetics | HUMAN GENOME | GENE | EMBRYONIC STEM-CELLS | INSULATOR PROTEIN CTCF | UNMETHYLATED STATE | TUMOR-SUPPRESSOR | poly(ADP-ribose) polymerase 1 (Parp1) | CPG ISLANDS | BINDING | DNA (Cytosine-5-)-Methyltransferases - metabolism | Multiprotein Complexes - metabolism | DNA Methylation | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | CCCTC-Binding Factor | Epigenesis, Genetic | CpG Islands - physiology | Repressor Proteins - metabolism | poly(ADP-ribose) polymerase 1 | DNMT1 protein | genomics | Promoters | ADP-ribosylation | CpG islands | Life Sciences | Poly(ADP-ribose) Polymerases | DNA (Cytosine-5-)-Methyltransferase | Multiprotein Complexes | Repressor Proteins | Biochemistry, Molecular Biology | CpG Islands | Poly Adenosine Diphosphate Ribose | Molecular biology | DMR1, differentially methylated region 1 | Ab, antibody | poly(ADPribosyl)ation (PARylation) | H2B, histone 2B | PARG, poly(ADP-ribose) glycohydrolase | Ctcf, CCCTC-binding factor | IP, immunoprecipitation | DTT, dithiothreitol | ChIP, chromatin immunoprecipitation | TBST, Tris-buffered saline plus 0.05% Tween 20 | Dnmt1, DNA (cytosine-5)-methyltransferase 1 | Parp1, poly(ADP-ribose) polymerase 1 | H1, histone 1 | CGI, CpG island | dsDNA, double-stranded DNA | PARylation, poly(ADP-ribosyl)ation | PARs, poly(ADP-ribose) polymers | RE-ChIP, sequential ChIP
Journal Article
BMB Reports, ISSN 1976-6696, 2019, Volume 52, Issue 5, pp. 342 - 347
Methylation is a primary epigenetic mechanism regulating gene expression. 5-aza-2'-deoxycytidine is an FDA-approved drug prescribed for treatment of cancer by... 
DNMT1 | Anti-cancer | Centrosome | CEP131
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 01/2018, Volume 22, Issue 1, pp. 600 - 612
Berberine (BBR), one of active alkaloid found in the rhizome, exhibited anti‐cancer properties. We have showed that BBR inhibited growth of non‐small cell lung... 
Berberine | DNMT1 | Metformin | NSCLC | PDPK1 | SP1 | MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED-APOPTOSIS | REGULATING DNMT1 | EP4 EXPRESSION | CHINESE HERBAL MEDICINE | LUNG-CANCER CELLS | CELL BIOLOGY | DNA METHYLTRANSFERASE 1 | HEPATOCELLULAR-CARCINOMA | GASTRIC-CANCER | QUALITY-OF-LIFE | NF-KAPPA-B | Cell Proliferation - genetics | Neoplasm Invasiveness | Humans | Metformin - pharmacology | Sp1 Transcription Factor - metabolism | 3-Phosphoinositide-Dependent Protein Kinases - metabolism | Cell Movement - genetics | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | Drug Synergism | Berberine - pharmacology | Cell Movement - drug effects | DNA (Cytosine-5-)-Methyltransferase 1 - genetics | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Cycle Checkpoints - genetics | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Genetic research | Hypoglycemic agents | Methyltransferases | Lung cancer, Non-small cell | Gene expression | Genes | Cell proliferation | Lung cancer | DNMT1 protein | Non-small cell lung carcinoma | MAP kinase | Kinases | Sp1 protein | Anticancer properties | Proteins | Protein kinase | Cell cycle | Dnmt1 gene | Forkhead protein | DNA methyltransferase | Inhibition | Cell migration | Deoxyribonucleic acid--DNA | FOXO3 protein | Cancer | Original
Journal Article
Phytomedicine, ISSN 0944-7113, 10/2019, Volume 63, p. 153058
Sulforaphane (SFN), a natural compound present in cruciferous vegetable, has been shown to possess anti-cancer activities. Cancer stem cell (CSC) in bulk tumor... 
Nasopharyngeal carcinoma | DNMT1 | WIF1 | Sulforaphane
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2012, Volume 264, Issue 1, pp. 13 - 22
Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10 (PTEN), a... 
DNA methylation | DNA methyltransferase 1 (DNMT1) | Hepatic stellate cell (HSC) | Phosphatase and tension homolog deleted on chromosome 10 (PTEN) | Liver fibrosis | FIBROSIS | PROMOTER HYPERMETHYLATION | SIGNALING PATHWAYS | TGF-BETA | HUMAN CANCER-CELLS | CPG METHYLATION | EPIGENETIC REGULATION | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | Cell Line | Promoter Regions, Genetic | Up-Regulation | DNA (Cytosine-5-)-Methyltransferase 1 | Gene Silencing | Hepatic Stellate Cells - metabolism | PTEN Phosphohydrolase - metabolism | Rats | Azacitidine - analogs & derivatives | Male | Phosphatidylinositol 3-Kinases - metabolism | Rats, Sprague-Dawley | Gene Knockdown Techniques | MAP Kinase Signaling System | DNA (Cytosine-5-)-Methyltransferases - metabolism | Azacitidine - pharmacology | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA Methylation | Animals | Liver Cirrhosis, Experimental - pathology | Proto-Oncogene Proteins c-akt - metabolism | Liver diseases | Phosphatases | Methyltransferases | RNA | Liver | Genes | DNA | Genetic transcription | Transforming growth factors | Muscle proteins | Methylation | Index Medicus | DNMT1 protein | Extracellular signal-regulated kinase | stellate cells | AKT protein | Promoters | epigenetics | 1-Phosphatidylinositol 3-kinase | Cell activation | Hepatocytes | chromosome 10 | Fibrosis | Dnmt1 gene | DNA methyltransferase | Tumor suppressor genes | PTEN protein | 5-aza-2'-deoxycytidine | Tumors | METHYLATION | COLLAGEN | ACTIN | NEOPLASMS | TRANSCRIPTION | RATS | CHROMOSOMES | 60 APPLIED LIFE SCIENCES | GROWTH FACTORS | PROMOTERS | DEOXYCYTIDINE | GENES | LIVER | METHYL TRANSFERASES | MUSCLES
Journal Article
Pharmacology & Therapeutics, ISSN 0163-7258, 09/2019, p. 107406
Journal Article
Oncotarget, 2016, Volume 7, Issue 52, pp. 87081 - 87090
Journal Article
Atherosclerosis, ISSN 0021-9150, 02/2019, Volume 281, pp. 168 - 179
Underlying mechanisms of cardiovascular diseases (CVD) have been investigated for over 100 years and novel molecular level mechanisms in the pathophysiology... 
DNA methylation | TET2 | Cardiovascular disease | DNMT1 | Atherosclerosis | DNMT3A
Journal Article
Cancer Management and Research, ISSN 1179-1322, 09/2019, Volume 11, pp. 8589 - 8602
Haiyan Zhang,1 Zhuo Zhang,2 Dayu Wang1 1Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun,... 
lncRNA KCNK15-AS1 DNMT1 HDAC1 gastric cancer miR-21
Journal Article
Medical Journal of Wuhan University, ISSN 1671-8852, 01/2019, Volume 40, Issue 1, pp. 11 - 16
Journal Article
Free Radical Research, ISSN 1071-5762, 03/2019, Volume 53, Issue 3, pp. 335 - 347
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyses the conversion of prostaglandin E 2 to a keto metabolite. The expression of... 
breast cancer | DNMT1 | 15-PGDH | methylation | 15d-PGJ
Journal Article
Cancer Science, ISSN 1347-9032, 10/2015, Volume 106, Issue 10, pp. 1333 - 1340
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2014, Volume 26, Issue 4, pp. 577 - 590
DNA methylation in promoters is well known to silence genes and is the presumed therapeutic target of methylation inhibitors. Gene body methylation is... 
DECITABINE | EPIGENOMIC ANALYSIS |