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1. Full Text Hypomorphic function and somatic reversion of DOCK8 cause combined immunodeficiency without hyper-IgE
by Kienzler, Anne-Kathrin and van Schouwenburg, Pauline A and Taylor, John and Marwah, Ishita and Sharma, Richa U and Noakes, Charlotte and Thomson, Kate and Sadler, Ross and Segal, Shelley and Ferry, Berne and Taylor, Jenny C and Blair, Edward and Chapel, Helen and Patel, Smita Y
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 2015, Volume 163, pp. 17 - 21
Allergy and Immunology | Hyper-IgE syndrome | Phenotypic variability | Combined immunodeficiency | Whole exome sequencing | DOCK8 | Life Sciences & Biomedicine | Immunology | Science & Technology | Recurrence | Guanine Nucleotide Exchange Factors - genetics | Immunologic Deficiency Syndromes - complications | Humans | Bronchiectasis - immunology | Immunoglobulin M - immunology | Immunoglobulin E - immunology | Immunoglobulin G - immunology | Respiratory Tract Infections - immunology | Immunologic Deficiency Syndromes - genetics | Female | Heterozygote | Respiratory Tract Infections - etiology | Mutation | Immunologic Deficiency Syndromes - immunology | Child | Bronchiectasis - etiology | Immunoglobulin E | Immunodeficiency | Index Medicus | EBV, Epstein–Barr-Virus | DHR1 | Mut, Mutated DOCK8 transcript (referring to c.6019dupT) | HC, Healthy control | CFSE, Carboxyfluorescein diacetate, succinimidyl ester | 2, DOCK homology region | PBMC, Peripheral blood mononuclear cell | PHA, Phytohemagglutinin | Pt, Patient | Brief Communication | DOCK8, Dedicator of cytokinesis 8 | Trunc, Truncated DOCK8 protein
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2. Full Text A set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitis
by Kasap, Nurhan and Celik, Velat and Isik, Sakine and Cennetoglu, Pakize and Kiykim, Ayca and Eltan, Sevgi Bilgic and Nain, Ercan and Ogulur, Ismail and Baser, Dilek and Akkelle, Emre and Celiksoy, Mehmet Halil and Kocamis, Burcu and Cipe, Funda Erol and Yucelten, Ayse Deniz and Karakoc-Aydiner, Elif and Ozen, Ahmet and Baris, Safa
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 02/2021, Volume 223, pp. 108645 - 108645
Hyper-IgE syndrome | STAT3 deficiency | DOCK8 deficiency | Severe atopic dermatitis | Index Medicus
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3. Full Text Haploidentical Related Donor Hematopoietic Stem Cell Transplantation for Dedicator-of-Cytokinesis 8 Deficiency Using Post-Transplantation Cyclophosphamide
by Shah, Nirali N and Freeman, Alexandra F and Su, Helen and Cole, Kristen and Parta, Mark and Moutsopoulos, Niki M and Baris, Safa and Karakoc-Aydiner, Elif and Hughes, Thomas E and Kong, Heidi H and Holland, Steve M and Hickstein, Dennis D
Biology of blood and marrow transplantation, ISSN 1083-8791, 06/2017, Volume 23, Issue 6, pp. 980 - 990
Immune reconstitution | Dedicator-of-cytokinesis-8 (DOCK8) deficiency | Haploidentical transplantation | Transplantation | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Immunologic Deficiency Syndromes - therapy | Humans | Survival Rate | Treatment Outcome | Hematopoietic Stem Cell Transplantation - mortality | Transplantation, Haploidentical - mortality | Cyclophosphamide - therapeutic use | Transplantation, Haploidentical - methods | Immunologic Deficiency Syndromes - mortality | Graft vs Host Disease - prevention & control | Hematopoietic Stem Cell Transplantation - methods | Transplantation Conditioning - methods | Guanine Nucleotide Exchange Factors - deficiency | Cyclophosphamide | Hematopoietic stem cells | Stem cells | Usage | Bone marrow | Mycophenolate mofetil | Index Medicus | Dedicator-of-cytokinesis-8 | (DOCK8) deficiency
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4. Full Text Dedicator of cytokinesis 8 mutation related combined immune deficiency: A single centre experience from India
by Thakkar, Dhwanee and Jain, Naresh and Ramzan, Mohammed and Katewa, Satyendra and Yadav, Satya Prakash
Pediatric hematology oncology journal, ISSN 2468-1245, 10/2017, Volume 2, Issue 3, pp. 55 - 58
Combined immunodeficiency | DOCK8 | Children
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5. Full Text Identification of a T follicular helper cell subset that drives anaphylactic IgE
by Gowthaman, Uthaman and Chen, Jennifer S and Zhang, Biyan and Flynn, William F and Lu, Yisi and Song, Wenzhi and Joseph, Julie and Gertie, Jake A and Xu, Lan and Collet, Magalie A and Grassmann, Jessica D. S and Simoneau, Tregony and Chiang, David and Berin, M. Cecilia and Craft, Joseph E and Weinstein, Jason S and Williams, Adam and Eisenbarth, Stephanie C
Science (American Association for the Advancement of Science), ISSN 0036-8075, 08/2019, Volume 365, Issue 6456, p. 883
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Guanine Nucleotide Exchange Factors - genetics | Humans | Mice, Inbred C57BL | Interleukin-13 - metabolism | Interleukin-13 - genetics | Animals | Immunoglobulin E - immunology | Guanine Nucleotide Exchange Factors - metabolism | Mice, Mutant Strains | T-Lymphocytes, Helper-Inducer - immunology | Proto-Oncogene Proteins c-bcl-6 - metabolism | Adolescent | Anaphylaxis - immunology | Mice | Child | GATA3 Transcription Factor - metabolism | Allergens | Interleukin | Antibodies | Immunoglobulin E | Allergic diseases | Infections | Parasites | Lymph nodes | Gene sequencing | Receptors | Anaphylaxis | Lymphocytes | Population | Worms | Food | Immunization | Immunoglobulins | Peanuts | Cytokines | Crosslinking | Ablation | Allergies | Switching | Affinity | Index Medicus | Helminth | T Follicular Helper Cells | IgE | DOCK8 | IL-4 | IL-13 | GATA3 | Allergen
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6. Full Text DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients
by Aydin, Susanne E and Kilic, Sara Sebnem and Aytekin, Caner and Kumar, Ashish and Porras, Oscar and Kainulainen, Leena and Kostyuchenko, Larysa and Genel, Ferah and Kütükcüler, Necil and Karaca, Neslihan and Gonzalez-Granado, Luis and Abbott, Jordan and Al-Zahrani, Daifulah and Rezaei, Nima and Baz, Zeina and Thiel, Jens and Ehl, Stephan and Marodi, László and Orange, Jordan S and Sawalle-Belohradsky, Julie and Keles, Sevgi and Holland, Steven M and Sanal, Özden and Ayvaz, Deniz C and Tezcan, Ilhan and Al-Mousa, Hamoud and Alsum, Zobaida and Hawwari, Abbas and Metin, Ayse and Matthes-Martin, Susanne and Hönig, Manfred and Schulz, Ansgar and Picard, Capucine and Barlogis, Vincent and Gennery, Anew and Ifversen, Marianne and van Montfrans, Joris and Kuijpers, Taco and Bredius, Robbert and Dückers, Gregor and Al-Herz, Waleed and Pai, Sung-Yun and Geha, Raif and Notheis, Gundula and Schwarze, Carl-Philipp and Tavil, Betül and Azik, Fatih and Bienemann, Kirsten and Grimbacher, Bodo and Heinz, Valerie and Gaspar, H. Bobby and Aydin, Roland and Hagl, Beate and Gathmann, Benjamin and Belohradsky, Bernd H and Ochs, Hans D and Chatila, Talal and Renner, Ellen D and Su, Helen and Freeman, Alexana F and Engelhardt, Karin and Albert, Michael H and inborn errors working party of EBMT and On behalf of the inborn errors working party of EBMT
Journal of clinical immunology, ISSN 0271-9142, 2015, Volume 35, Issue 2, pp. 189 - 198
hyper-IgE syndrome | DOCK8 deficiency | natural outcome | combined immunodeficiency | Life Sciences & Biomedicine | Immunology | Science & Technology | Job Syndrome - immunology | Job Syndrome - genetics | Neoplasms - etiology | Follow-Up Studies | Job Syndrome - mortality | Job Syndrome - therapy | Humans | Middle Aged | Child, Preschool | Infant | Male | Immunoglobulin E - blood | Infection - etiology | Lymphocyte Subsets - immunology | Incidence | Young Adult | Lymphocyte Subsets - metabolism | Immunoglobulin E - immunology | Infection - epidemiology | Infection - diagnosis | Adult | Female | Child | Guanine Nucleotide Exchange Factors - deficiency | Guanine Nucleotide Exchange Factors - genetics | Genetic Association Studies | Job Syndrome - diagnosis | Phenotype | Job Syndrome - complications | Adolescent | Lymphocyte Count | Mutation | Neoplasms - epidemiology | Cohort Studies | Index Medicus
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7. Full Text IL-21 alleviates allergic asthma in DOCK8-knockout mice
by Wu, Jiabin and Zhang, Suqian and Qin, Tao and Jiang, Jinqiu and Liu, Qiao and Zhang, Liang and Zhao, Xiaodong and Dai, Jihong
Biochemical and biophysical research communications, ISSN 0006-291X, 06/2018, Volume 501, Issue 1, pp. 92 - 99
Allergic asthma | Ovalbumin | DOCK8 gene | IL-21 | Murine model | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Index Medicus
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8. Full Text Atopic dermatitis, STAT3- and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern
by Boos, A.C and Hagl, B and Schlesinger, A and Halm, B.E and Ballenberger, N and Pinarci, M and Heinz, V and Kreilinger, D and Spielberger, B.D and Schimke-Marques, L.F and Sawalle-Belohradsky, J and Belohradsky, B.H and Przybilla, B and Schaub, B and Wollenberg, A and Renner, E.D
Allergy (Copenhagen), ISSN 0105-4538, 2014, Volume 69, Issue 7, pp. 943 - 953
atopic dermatitis | STAT3-hyper-IgE syndrome | IgE-based sensitization pattern | hyper-IgE syndromes | DOCK8 deficiency | Immunoglobulin E | Food allergy | Allergens | T cells | Atopic dermatitis | Immunodeficiency | Food allergies | Immunology | Dermatitis | Eczema | Index Medicus
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9. Full Text S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches
by Kunimura, Kazufumi and Sakata, Daiji and Tun, Xin and Uruno, Takehito and Ushijima, Miho and Katakai, Tomoya and Shiraishi, Akira and Aihara, Ryosuke and Kamikaseda, Yasuhisa and Matsubara, Keisuke and Kanegane, Hirokazu and Sawa, Shinichiro and Eberl, Gérard and Ohga, Shouichi and Yoshikai, Yasunobu and Fukui, Yoshinori
Cell reports (Cambridge), ISSN 2211-1247, 11/2019, Volume 29, Issue 9, pp. 2823 - 2834.e7
S100A4-producing cells | intestinal immunity | Peyer's patch | M cell maturation | DOCK8 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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10. Full Text ILC3 deficiency and generalized ILC abnormalities in DOCK8‐deficient patients
by Eken, Ahmet and Cansever, Murat and Okus, Fatma Zehra and Erdem, Serife and Nain, Ercan and Azizoglu, Zehra Busra and Haliloglu, Yesim and Karakukcu, Musa and Ozcan, Alper and Devecioglu, Omer and Aksu, Guzide and Arikan Ayyildiz, Zeynep and Topal, Erdem and Karakoc Aydiner, Elif and Kiykim, Ayca and Metin, Ayse and Cipe, Funda and Kaya, Aysenur and Artac, Hasibe and Reisli, Ismail and Guner, Sukru N and Uygun, Vedat and Karasu, Gulsun and Dönmez Altuntas, Hamiyet and Canatan, Halit and Oukka, Mohamed and Ozen, Ahmet and Chatila, Talal A and Keles, Sevgi and Baris, Safa and Unal, Ekrem and Patiroglu, Turkan
Allergy (Copenhagen), ISSN 0105-4538, 04/2020, Volume 75, Issue 4, pp. 921 - 932
ILC | ILC3 | Hyper‐IgE syndrome (HIES) | DOCK8 | STAT3 | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Flow cytometry | Cell culture | Peripheral blood | Stat3 protein | Immunoglobulin E | Cytokinesis | Mutants | Apoptosis | Index Medicus
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11. Full Text Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency
by Al-Zahrani, Daifulah and Raddadi, Ali and Massaad, Michel and Keles, Sevgi and Jabara, Haifa H and Chatila, Talal A and Geha, Raif
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 2014, Volume 153, Issue 1, pp. 104 - 108
Allergy and Immunology | Warts | Interferon–α 2b | Hyper -immunoglobulin E syndrome | Papilloma Virus | DOCK8 deficiency | Interferon-α 2b | Papilloma virus | Life Sciences & Biomedicine | Immunology | Science & Technology | Recombinant Proteins - therapeutic use | Leukocytes, Mononuclear - metabolism | Job Syndrome - genetics | Job Syndrome - diagnosis | Humans | Interferon-alpha - therapeutic use | Immunophenotyping | Male | Warts - drug therapy | Warts - etiology | Job Syndrome - complications | DNA Mutational Analysis | Pedigree | Leukocytes, Mononuclear - immunology | Mutation | Child | Guanine Nucleotide Exchange Factors - deficiency | Skin - pathology | Immunologic Factors - therapeutic use |