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1. Full Text Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
by Ntziachristos, Panagiotis and Ntziachristos, Panagiotis and Tsirigos, Aristotelis and Welstead, G. Grant and Trimarchi, Thomas and Bakogianni, Sofia and Xu, Luyao and Loizou, Evangelia and Holmfeldt, Linda and Strikoudis, Alexandros and King, Bryan and Mullenders, Jasper and Becksfort, Jared and Nedjic, Jelena and Paietta, Elisabeth and Tallman, Martin S and Rowe, Jacob M and Tonon, Giovanni and Satoh, Takashi and Kruidenier, Laurens and Prinjha, Rab and Akira, Shizuo and Van Vlierberghe, Pieter and Ferrando, Adolfo A and Jaenisch, Rudolf and Mullighan, Charles G and Aifantis, Iannis
Nature (London), ISSN 0028-0836, 10/2014, Volume 514, Issue 7523, pp. 513 - 517
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tumor Suppressor Proteins - metabolism | Histones - chemistry | Benzazepines - pharmacology | Pyrimidines - pharmacology | Histone Demethylases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Histone Demethylases - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Methylation - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Epigenesis, Genetic - drug effects | Lysine - metabolism | Mice | Histones - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Jumonji Domain-Containing Histone Demethylases - metabolism | Histones | Genetic aspects | Lymphocytic leukemia | Methyltransferases | Lysine | Health aspects | Studies | Proteins | Genomes | Genes | Leukemia | Binding sites | Index Medicus
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2. Full Text MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease
by Zhou, Yan and Lu, Ming and Du, Ren-Hong and Qiao, Chen and Jiang, Chun-Yi and Zhang, Ke-Zhong and Ding, Jian-Hua and Hu, Gang
Molecular neurodegeneration, ISSN 1750-1326, 04/2016, Volume 11, Issue 1, pp. 28 - 28
microRNA-7 | α-Synuclein | Neuroinflammation | Parkinson's disease | NLRP3 inflammasome | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - metabolism | Parkinson Disease - pathology | Animals | Carrier Proteins - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Dopaminergic Neurons - metabolism | MicroRNAs - genetics | Parkinson Disease - metabolism | Disease Models, Animal | Mice, Knockout | Complications and side effects | Care and treatment | MicroRNA | Influence | Inflammation | Research | Risk factors | Index Medicus
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3. Full Text Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage
by Ren, Honglei and Kong, Ying and Liu, Zhijia and Zang, Dongyun and Yang, Xiaoxia and Wood, Kristofer and Li, Minshu and Liu, Qiang
Stroke (1970), ISSN 0039-2499, 12/2017, Volume 49, Issue 1, pp. 184 - 192
Neuroprotection | Brain edema | Inflammation | Cell death | Clinical Neurology | Peripheral Vascular Disease | Neurosciences & Neurology | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | Index Medicus | brain edema | 10177 | cell death | inflammation | Original Contributions | neuroprotection
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4. Full Text NLRP3 inflammasome activation drives tau pathology
by Ising, Christina and Venegas, Carmen and Zhang, Shuangshuang and Scheiblich, Hannah and Schmidt, Susanne V and Vieira-Saecker, Ana and Schwartz, Stephanie and Albasset, Shadi and McManus, Roisin M and Tejera, Dario and Griep, Angelika and Santarelli, Francesco and Brosseron, Frederic and Opitz, Sabine and Stunden, James and Merten, Maximilian and Kayed, Rakez and Golenbock, Douglas T and Blum, David and Latz, Eicke and Buee, Luc and Heneka, Michael T
Nature (London), ISSN 0028-0836, 11/2019, Volume 575, Issue 7784, pp. 669 - 673
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation | Inflammasomes - metabolism | Gene Expression Regulation - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | tau Proteins - metabolism | Inflammasomes - genetics | Cyclin-Dependent Kinase 5 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | tau Proteins - genetics | Microglia - pathology | Mice | Protein Aggregation, Pathological - physiopathology | Diagnosis | NLRP proteins | Analysis | Tau proteins | Dementia | Neurodegenerative diseases | Pathogenesis | Interleukin | Cognitive ability | Activation | Agglomeration | Inflammation | Kinases | Gene expression | Caspase-1 | Microglia | Pathology | Neurofibrillary tangles | Tau protein | Neurodegeneration | Transgenic animals | Morphology | Alzheimers disease | Alzheimer's disease | Plaques | Index Medicus | Life Sciences | Neuroscience | Cognitive science | Neurons and Cognition
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5. Full Text Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice
by Tang, Ge and Duan, Fengqi and Li, Weixuan and Wang, Yiqin and Zeng, Cheng and Hu, Jia and Li, Hongyu and Zhang, Xuanhong and Chen, Yanming and Tan, Hongmei
Biomedicine & pharmacotherapy, ISSN 0753-3322, 11/2019, Volume 119, pp. 109410 - 109410
NLRP3 inflammasomes | Atherosclerosis | Metformin | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Hyperlipidemias - blood | Inflammasomes - metabolism | Metformin - therapeutic use | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Hyperglycemia - complications | Male | Apolipoproteins E - metabolism | Atherosclerosis - etiology | Adenylate Kinase - metabolism | Lipids - blood | Hyperglycemia - pathology | Thioredoxins - metabolism | Hyperlipidemias - complications | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Hyperlipidemias - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Diabetes Mellitus - drug therapy | Enzyme Activation - drug effects | Aorta - pathology | Atherosclerosis - blood | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Hyperglycemia - blood | Hyperlipidemias - pathology | Macrophages - drug effects | Blood Glucose - metabolism | Index Medicus
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6. Full Text Placental inflammation in pre‐eclampsia by Nod‐like receptor protein (NLRP)3 inflammasome activation in trophoblasts
by Stødle, G. S and Silva, G. B and Tangerås, L. H and Gierman, L. M and Nervik, I and Dahlberg, U. E and Sun, C and Aune, M. H and Thomsen, L. C. V and Bjørge, L and Iversen, A.‐C
Clinical and experimental immunology, ISSN 0009-9104, 07/2018, Volume 193, Issue 1, pp. 84 - 94
cholesterol | NLRP3 | placenta | pre‐eclampsia | inflammation | pre-eclampsia | Life Sciences & Biomedicine | Immunology | Science & Technology | Inflammation - pathology | Trophoblasts - metabolism | Uric Acid - metabolism | Placenta - immunology | Complement Membrane Attack Complex - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cholesterol - blood | Humans | Alarmins - metabolism | Caspase 1 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Cholesterol - metabolism | Pre-Eclampsia - pathology | Pregnancy | C-Reactive Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Interleukin-1beta - metabolism | Inflammasomes - immunology | Pre-Eclampsia - blood | Placenta - pathology | Female | Uric Acid - blood | Complement C5a - immunology | Pre-Eclampsia - immunology | Tyrosine | Interleukins | Analysis | Preeclampsia | Inflammation | Uric acid | Explants | Complement component C5a | Interleukin | Crystals | Caspase | Priming | Activation | Complement | Hazards | Pattern recognition | IL-1β | Kinases | Cholesterol | Proteins | Receptors | Trophoblasts | Placenta | Acids | Protein-tyrosine kinase | Index Medicus | Original
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7. Full Text Negative regulation of Nod‐like receptor protein 3 inflammasome activation by T cell Ig mucin‐3 protects against peritonitis
by Wang, Wei and Shi, Qingzhu and Dou, Shuaijie and Li, Ge and Shi, Xinhui and Jiang, Xingwei and Wang, Zhiding and Yu, Dandan and Chen, Guojiang and Wang, Renxi and Xiao, He and Hou, Chunmei and Feng, Jiannan and Shen, Beifen and Ma, Yuanfang and Han, Gencheng
Immunology, ISSN 0019-2805, 01/2018, Volume 153, Issue 1, pp. 71 - 83
NLRP3 inflammasome | macrophage | Tim‐3 | Tim-3 | Life Sciences & Biomedicine | Immunology | Science & Technology | Potassium - metabolism | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Hepatitis A Virus Cellular Receptor 2 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Adenosine Triphosphate - biosynthesis | Case-Control Studies | Young Adult | Peritonitis - pathology | Interleukin-1beta - metabolism | Adult | Female | Caspase 1 | Protein Interaction Domains and Motifs | Macrophages - immunology | Disease Models, Animal | Hepatitis A Virus Cellular Receptor 2 - chemistry | Cell Line | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Peritonitis - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Peritonitis - immunology | Macrophages - metabolism | Animals | Inflammasomes - immunology | Protein Binding | Mice | Interleukins | Genetic engineering | T cells | Macrophages | Mitogens | Peritonitis | Efflux | Immunoglobulins | Reactive oxygen species | Interleukin | Aluminum sulfate | Transgenic | Priming | Lymphocytes T | Cell activation | Mucin | Immune checkpoint | Rodents | Interleukin 1 | Alum | ATP | Index Medicus | Original
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8. Full Text The myeloid heat shock transcription factor 1/β‐catenin axis regulates NLR family, pyrin domain‐containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury
by Yue, Shi and Zhu, Jianjun and Zhang, Ming and Li, Changyong and Zhou, Xingliang and Zhou, Min and Ke, Michael and Busuttil, Ronald W and Ying, Qi‐Long and Kupiec‐Weglinski, Jerzy W and Xia, Qiang and Ke, Bibo
Hepatology (Baltimore, Md.), ISSN 0270-9139, 11/2016, Volume 64, Issue 5, pp. 1683 - 1698
Inflammasomes - physiology | Reperfusion Injury - etiology | DNA-Binding Proteins - physiology | Liver - blood supply | Transcription Factors - physiology | Animals | Signal Transduction | Mice | beta Catenin - physiology | NLR Family, Pyrin Domain-Containing 3 Protein - physiology | Heat Shock Transcription Factors | Index Medicus
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9. Full Text Patatin-like phospholipase domain-containing 3 ( PNPLA3 ) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
by Pirazzi, Carlo and Adiels, Martin and Burza, Maria Antonella and Mancina, Rosellina Margherita and Levin, Malin and Ståhlman, Marcus and Taskinen, Marja-Riitta and Orho-Melander, Marju and Perman, Jeanna and Pujia, Arturo and Andersson, Linda and Maglio, Cristina and Montalcini, Tiziana and Wiklund, Olov and Borén, Jan and Romeo, Stefano and Naturvetenskapliga fakulteten and Institute of Medicine, Department of Molecular and Clinical Medicine and Faculty of Sciences and Wallenberg Laboratory and Göteborgs universitet and Gothenburg University and Department of Mathematical Sciences and Sahlgrenska Academy and Sahlgrenska akademin and Institutionen för matematiska vetenskaper and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Wallenberglaboratoriet
Journal of hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 6, pp. 1276 - 1282
Gastroenterology and Hepatology | VLDL secretion | Apolipoprotein B | Liver fat content | Genetic variant | Lipolysis | Patatin-like phospholipase domain-containing 3 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Membrane Proteins - genetics | Humans | Liver - metabolism | Middle Aged | Cells, Cultured | Lipase - physiology | Rats | Genotype | Lipid Metabolism | Animals | Membrane Proteins - physiology | Lipoproteins, VLDL - secretion | Apolipoproteins B - secretion | Adult | Lipase - genetics | Index Medicus | triacylglycerol | triglyceride hydrolysis | apolipoprotein-b | fatty liver-disease | obese subjects | low-density lipoprotein | Kardiologi | Cardiac and Cardiovascular Systems | adiponutrin | hypobetalipoproteinemia | cell-line | b-containing lipoproteins
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