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Publication DateNature, ISSN 0028-0836, 10/2014, Volume 514, Issue 7523, pp. 513 - 517
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly...
ACTIVATION | H3K27 DEMETHYLASE | INITIATING CELL-ACTIVITY | MULTIDISCIPLINARY SCIENCES | JMJD3 CONTRIBUTES | UTX | STEM-CELL | ACUTE MYELOID-LEUKEMIA | EXPRESSION PROFILES | MUTATIONS | GENOME | Tumor Suppressor Proteins - metabolism | Histones - chemistry | Benzazepines - pharmacology | Pyrimidines - pharmacology | Histone Demethylases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Histone Demethylases - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Methylation - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Epigenesis, Genetic - drug effects | Lysine - metabolism | Mice | Histones - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Jumonji Domain-Containing Histone Demethylases - metabolism | Histones | Genetic aspects | Lymphocytic leukemia | Methyltransferases | Lysine | Health aspects | Studies | Proteins | Genomes | Genes | Leukemia | Binding sites
ACTIVATION | H3K27 DEMETHYLASE | INITIATING CELL-ACTIVITY | MULTIDISCIPLINARY SCIENCES | JMJD3 CONTRIBUTES | UTX | STEM-CELL | ACUTE MYELOID-LEUKEMIA | EXPRESSION PROFILES | MUTATIONS | GENOME | Tumor Suppressor Proteins - metabolism | Histones - chemistry | Benzazepines - pharmacology | Pyrimidines - pharmacology | Histone Demethylases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Histone Demethylases - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Methylation - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Epigenesis, Genetic - drug effects | Lysine - metabolism | Mice | Histones - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Jumonji Domain-Containing Histone Demethylases - metabolism | Histones | Genetic aspects | Lymphocytic leukemia | Methyltransferases | Lysine | Health aspects | Studies | Proteins | Genomes | Genes | Leukemia | Binding sites
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 44, pp. 36560 - 36566
Rip1 is required for I kappa B kinase activation in response to tumor necrosis factor alpha (TNF-alpha) and has been implicated in the Toll-like receptor 3...
TRANSCRIPTION FACTORS | DOMAIN-CONTAINING ADAPTER | RECRUITMENT | SIGNALING PATHWAY | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IFN-BETA PROMOTER | TNF RECEPTOR-1 | CUTTING EDGE | A20
TRANSCRIPTION FACTORS | DOMAIN-CONTAINING ADAPTER | RECRUITMENT | SIGNALING PATHWAY | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IFN-BETA PROMOTER | TNF RECEPTOR-1 | CUTTING EDGE | A20
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Loading RightsArteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and...
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
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Loading RightsJournal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 4, pp. 1054 - 1067.e10
Background The Nod-like receptor NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and...
Allergy and Immunology | ibrutinib | Bruton tyrosine kinase | IL-1 | inflammation | inflammasome | NLRP3 | macrophage | X-linked agammaglobulinemia | Muckle-Wells syndrome | Staphylococcus aureus | IMMUNITY | ACTIVATION | IMMUNOLOGY | MASS-SPECTROMETRY | NALP3 INFLAMMASOME | B-CELL | ALLERGY | IN-VIVO | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSION | Inflammasomes - metabolism | Agammaglobulinemia - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Leukocidins - immunology | Molecular Targeted Therapy | Protein-Tyrosine Kinases - genetics | Genetic Diseases, X-Linked - genetics | Bacterial Proteins - immunology | Adaptive Immunity | Cryopyrin-Associated Periodic Syndromes - genetics | Nigericin - immunology | Staphylococcal Infections - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | Immunity, Innate | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Apoptosis Regulatory Proteins | Pyrin Domain - genetics | Agammaglobulinaemia Tyrosine Kinase | Proteomics | Staphylococcus aureus - immunology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Tyrosine | Phenols | Cells | Immunodeficiency | Regulators | Identification methods | Activation | Arthritis | Kinases | Immunity | Caspase-1 | Genotype & phenotype | Bacteria | Protein-tyrosine kinase | Immune system | Cytokines | Secretion | Agammaglobulinemia | Neutrophils | Caspase | Pharmacology | Adaptive immunity | FDA approval | IL-1β | Patients | Ablation | Bruton's tyrosine kinase | Human subjects | Nigericin | Speck | Mutation | Leukocidin | Cancer | Apoptosis
Allergy and Immunology | ibrutinib | Bruton tyrosine kinase | IL-1 | inflammation | inflammasome | NLRP3 | macrophage | X-linked agammaglobulinemia | Muckle-Wells syndrome | Staphylococcus aureus | IMMUNITY | ACTIVATION | IMMUNOLOGY | MASS-SPECTROMETRY | NALP3 INFLAMMASOME | B-CELL | ALLERGY | IN-VIVO | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSION | Inflammasomes - metabolism | Agammaglobulinemia - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Leukocidins - immunology | Molecular Targeted Therapy | Protein-Tyrosine Kinases - genetics | Genetic Diseases, X-Linked - genetics | Bacterial Proteins - immunology | Adaptive Immunity | Cryopyrin-Associated Periodic Syndromes - genetics | Nigericin - immunology | Staphylococcal Infections - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | Immunity, Innate | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Apoptosis Regulatory Proteins | Pyrin Domain - genetics | Agammaglobulinaemia Tyrosine Kinase | Proteomics | Staphylococcus aureus - immunology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Tyrosine | Phenols | Cells | Immunodeficiency | Regulators | Identification methods | Activation | Arthritis | Kinases | Immunity | Caspase-1 | Genotype & phenotype | Bacteria | Protein-tyrosine kinase | Immune system | Cytokines | Secretion | Agammaglobulinemia | Neutrophils | Caspase | Pharmacology | Adaptive immunity | FDA approval | IL-1β | Patients | Ablation | Bruton's tyrosine kinase | Human subjects | Nigericin | Speck | Mutation | Leukocidin | Cancer | Apoptosis
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Loading RightsJournal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 6, pp. 1276 - 1282
Background & Aims The robust association between non-alcoholic fatty liver disease (NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely...
Gastroenterology and Hepatology | VLDL secretion | Apolipoprotein B | Liver fat content | Genetic variant | Lipolysis | Patatin-like phospholipase domain-containing 3 | OBESE SUBJECTS | HYPOBETALIPOPROTEINEMIA | FATTY LIVER-DISEASE | B-CONTAINING LIPOPROTEINS | LOW-DENSITY LIPOPROTEIN | TRIACYLGLYCEROL | APOLIPOPROTEIN-B | TRIGLYCERIDE HYDROLYSIS | GASTROENTEROLOGY & HEPATOLOGY | CELL-LINE | ADIPONUTRIN | Membrane Proteins - genetics | Humans | Liver - metabolism | Middle Aged | Cells, Cultured | Lipase - physiology | Rats | Genotype | Lipid Metabolism | Animals | Membrane Proteins - physiology | Lipoproteins, VLDL - secretion | Apolipoproteins B - secretion | Adult | Lipase - genetics | triacylglycerol | triglyceride hydrolysis | apolipoprotein-b | fatty liver-disease | obese subjects | low-density lipoprotein | Kardiologi | Cardiac and Cardiovascular Systems | adiponutrin | hypobetalipoproteinemia | cell-line | b-containing lipoproteins
Gastroenterology and Hepatology | VLDL secretion | Apolipoprotein B | Liver fat content | Genetic variant | Lipolysis | Patatin-like phospholipase domain-containing 3 | OBESE SUBJECTS | HYPOBETALIPOPROTEINEMIA | FATTY LIVER-DISEASE | B-CONTAINING LIPOPROTEINS | LOW-DENSITY LIPOPROTEIN | TRIACYLGLYCEROL | APOLIPOPROTEIN-B | TRIGLYCERIDE HYDROLYSIS | GASTROENTEROLOGY & HEPATOLOGY | CELL-LINE | ADIPONUTRIN | Membrane Proteins - genetics | Humans | Liver - metabolism | Middle Aged | Cells, Cultured | Lipase - physiology | Rats | Genotype | Lipid Metabolism | Animals | Membrane Proteins - physiology | Lipoproteins, VLDL - secretion | Apolipoproteins B - secretion | Adult | Lipase - genetics | triacylglycerol | triglyceride hydrolysis | apolipoprotein-b | fatty liver-disease | obese subjects | low-density lipoprotein | Kardiologi | Cardiac and Cardiovascular Systems | adiponutrin | hypobetalipoproteinemia | cell-line | b-containing lipoproteins
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Loading RightsMolecular Neurodegeneration, ISSN 1750-1326, 04/2016, Volume 11, Issue 1, p. 28
Background: alpha-Synuclein (alpha-Syn), a pathological hallmark of Parkinson's disease (PD), has been recognized to induce the production of interleukin-1...
microRNA-7 | α-Synuclein | Neuroinflammation | Parkinson's disease | NLRP3 inflammasome | CELLS | ACTIVATION | ALZHEIMERS-DISEASE | MODEL | NEUROSCIENCES | DEGENERATION | ALPHA-SYNUCLEIN EXPRESSION | MICE | ATP | CONTRIBUTES | alpha-Synuclein | Microglia - metabolism | Parkinson Disease - pathology | Animals | Carrier Proteins - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Dopaminergic Neurons - metabolism | MicroRNAs - genetics | Parkinson Disease - metabolism | Disease Models, Animal | Mice, Knockout | Complications and side effects | Care and treatment | MicroRNA | Influence | Inflammation | Research | Risk factors
microRNA-7 | α-Synuclein | Neuroinflammation | Parkinson's disease | NLRP3 inflammasome | CELLS | ACTIVATION | ALZHEIMERS-DISEASE | MODEL | NEUROSCIENCES | DEGENERATION | ALPHA-SYNUCLEIN EXPRESSION | MICE | ATP | CONTRIBUTES | alpha-Synuclein | Microglia - metabolism | Parkinson Disease - pathology | Animals | Carrier Proteins - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Dopaminergic Neurons - metabolism | MicroRNAs - genetics | Parkinson Disease - metabolism | Disease Models, Animal | Mice, Knockout | Complications and side effects | Care and treatment | MicroRNA | Influence | Inflammation | Research | Risk factors
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Loading RightsProceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 45, pp. 19449 - 19454
Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO₂,...
Nanoparticles | Asbestos | Lungs | Secretion | Neutrophils | Keratinocytes | Mice | Inflammation | Neutrophil infiltration | Macrophages | Titanium dioxide | Silica dioxide | Caspase-1 | silica dioxide | PARTICLES | MICE DEFICIENT | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | NALP3 INFLAMMASOME | RESPONSES | PATHWAY | CRYSTALS | titanium dioxide | SECRETION | TITANIUM-DIOXIDE | PROTEINS | caspase-1 | Inflammasomes - metabolism | Pneumonia - etiology | NLR Family, Pyrin Domain-Containing 3 Protein | Interleukin-1alpha - metabolism | Carrier Proteins - drug effects | Nanoparticles - toxicity | Inhalation | Receptors, Interleukin-1 - metabolism | Titanium - toxicity | Signal Transduction - immunology | Animals | Carrier Proteins - metabolism | Silicon Dioxide - toxicity | Inflammasomes - drug effects | Keratinocytes - drug effects | Interleukin-1beta - metabolism | Keratinocytes - metabolism | Zinc Oxide | Biological Sciences
Nanoparticles | Asbestos | Lungs | Secretion | Neutrophils | Keratinocytes | Mice | Inflammation | Neutrophil infiltration | Macrophages | Titanium dioxide | Silica dioxide | Caspase-1 | silica dioxide | PARTICLES | MICE DEFICIENT | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | NALP3 INFLAMMASOME | RESPONSES | PATHWAY | CRYSTALS | titanium dioxide | SECRETION | TITANIUM-DIOXIDE | PROTEINS | caspase-1 | Inflammasomes - metabolism | Pneumonia - etiology | NLR Family, Pyrin Domain-Containing 3 Protein | Interleukin-1alpha - metabolism | Carrier Proteins - drug effects | Nanoparticles - toxicity | Inhalation | Receptors, Interleukin-1 - metabolism | Titanium - toxicity | Signal Transduction - immunology | Animals | Carrier Proteins - metabolism | Silicon Dioxide - toxicity | Inflammasomes - drug effects | Keratinocytes - drug effects | Interleukin-1beta - metabolism | Keratinocytes - metabolism | Zinc Oxide | Biological Sciences
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Loading RightsProceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 7, pp. 2400 - 2405
Understanding the mechanisms of epigenetic remodeling that follow fertilization is a fundamental step toward understanding the bases of early embryonic...
Zygotes | Messenger RNA | Ungulates | Blastocyst | Stem cells | Histones | Small interfering RNA | Embryonic stem cells | Embryos | Oocytes | RNA-POLYMERASE-II | MOUSE DEVELOPMENT | CHROMATIN | DEMETHYLASE JMJD3 | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | UTX | OOCYTES | MAMMALIAN-CELLS | POLYCOMB | Animals | Cattle | Histones - chemistry | Jumonji Domain-Containing Histone Demethylases - physiology | Lysine - metabolism | Histones - metabolism | Methylation | Proteins | Embryonic development | Physiological aspects | Research | Health aspects | Biological Sciences
Zygotes | Messenger RNA | Ungulates | Blastocyst | Stem cells | Histones | Small interfering RNA | Embryonic stem cells | Embryos | Oocytes | RNA-POLYMERASE-II | MOUSE DEVELOPMENT | CHROMATIN | DEMETHYLASE JMJD3 | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | UTX | OOCYTES | MAMMALIAN-CELLS | POLYCOMB | Animals | Cattle | Histones - chemistry | Jumonji Domain-Containing Histone Demethylases - physiology | Lysine - metabolism | Histones - metabolism | Methylation | Proteins | Embryonic development | Physiological aspects | Research | Health aspects | Biological Sciences
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Loading RightsStroke, ISSN 0039-2499, 12/2017, Volume 49, Issue 1, pp. 184 - 192
BACKGROUND AND PURPOSE—Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. As a key component of the innate immune system, the...
Neuroprotection | Brain edema | Inflammation | Cell death | brain edema | ACTIVATION | cell death | RAT | DEPLETION | MECHANISMS | MODEL | TRANSLATION | CLINICAL NEUROLOGY | STROKE | inflammation | neuroprotection | PERIPHERAL VASCULAR DISEASE | MICE | CELL | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | 10177 | Original Contributions
Neuroprotection | Brain edema | Inflammation | Cell death | brain edema | ACTIVATION | cell death | RAT | DEPLETION | MECHANISMS | MODEL | TRANSLATION | CLINICAL NEUROLOGY | STROKE | inflammation | neuroprotection | PERIPHERAL VASCULAR DISEASE | MICE | CELL | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | 10177 | Original Contributions
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Loading RightsImmunology, ISSN 0019-2805, 01/2018, Volume 153, Issue 1, pp. 71 - 83
The Nod‐like receptor protein 3 ( NLRP 3) inflammasome plays roles in host defence against invading pathogens and in the development of autoimmune damage....
NLRP | macrophage | 3 inflammasome | Tim‐3 | NLRP3 inflammasome | Tim-3 | HOMEOSTASIS | INHIBITION | IMMUNE-RESPONSES | MACROPHAGES | DISEASE | SECRETION | IMMUNOLOGY | SUPPRESSION | EXPRESSION | Potassium - metabolism | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Hepatitis A Virus Cellular Receptor 2 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Adenosine Triphosphate - biosynthesis | Case-Control Studies | Young Adult | Peritonitis - pathology | Interleukin-1beta - metabolism | Adult | Female | Caspase 1 | Protein Interaction Domains and Motifs | Macrophages - immunology | Disease Models, Animal | Hepatitis A Virus Cellular Receptor 2 - chemistry | Cell Line | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Peritonitis - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Peritonitis - immunology | Macrophages - metabolism | Animals | Inflammasomes - immunology | Protein Binding | Mice | Interleukins | Genetic engineering | T cells | Macrophages | Mitogens | Peritonitis | Efflux | Immunoglobulins | Reactive oxygen species | Interleukin | Aluminum sulfate | Transgenic | Priming | Lymphocytes T | Activation | Cell activation | Mucin | Immune checkpoint | Rodents | Interleukin 1 | Alum | ATP | Original
NLRP | macrophage | 3 inflammasome | Tim‐3 | NLRP3 inflammasome | Tim-3 | HOMEOSTASIS | INHIBITION | IMMUNE-RESPONSES | MACROPHAGES | DISEASE | SECRETION | IMMUNOLOGY | SUPPRESSION | EXPRESSION | Potassium - metabolism | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Hepatitis A Virus Cellular Receptor 2 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Adenosine Triphosphate - biosynthesis | Case-Control Studies | Young Adult | Peritonitis - pathology | Interleukin-1beta - metabolism | Adult | Female | Caspase 1 | Protein Interaction Domains and Motifs | Macrophages - immunology | Disease Models, Animal | Hepatitis A Virus Cellular Receptor 2 - chemistry | Cell Line | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Peritonitis - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Peritonitis - immunology | Macrophages - metabolism | Animals | Inflammasomes - immunology | Protein Binding | Mice | Interleukins | Genetic engineering | T cells | Macrophages | Mitogens | Peritonitis | Efflux | Immunoglobulins | Reactive oxygen species | Interleukin | Aluminum sulfate | Transgenic | Priming | Lymphocytes T | Activation | Cell activation | Mucin | Immune checkpoint | Rodents | Interleukin 1 | Alum | ATP | Original
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Loading RightsFASEB Journal, ISSN 0892-6638, 08/2012, Volume 26, Issue 8, pp. 3575 - 3586
Death receptor 3 (DR3, TNFRSF25), the closest family relative to tumor necrosis factor receptor 1, promotes CD4(+) T-cell-driven inflammatory disease. We...
Vaccinia virus | Murine cytomegalovirus | LATENT INFECTION | MURINE CYTOMEGALOVIRUS-INFECTION | VIRUS | TNF-LIKE LIGAND | DR3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALLERGIC LUNG INFLAMMATION | vaccinia virus | TL1A | CELL BIOLOGY | DOMAIN-CONTAINING RECEPTOR | RESPONSES | murine cytomegalovirus | TUMOR-NECROSIS-FACTOR | BIOLOGY | Apoptosis - drug effects | Adoptive Transfer | Viral Load | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Muromegalovirus - immunology | Animals | Receptors, Tumor Necrosis Factor, Member 25 - physiology | Tumor Necrosis Factor Ligand Superfamily Member 15 - physiology | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Herpesviridae Infections - immunology
Vaccinia virus | Murine cytomegalovirus | LATENT INFECTION | MURINE CYTOMEGALOVIRUS-INFECTION | VIRUS | TNF-LIKE LIGAND | DR3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALLERGIC LUNG INFLAMMATION | vaccinia virus | TL1A | CELL BIOLOGY | DOMAIN-CONTAINING RECEPTOR | RESPONSES | murine cytomegalovirus | TUMOR-NECROSIS-FACTOR | BIOLOGY | Apoptosis - drug effects | Adoptive Transfer | Viral Load | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Muromegalovirus - immunology | Animals | Receptors, Tumor Necrosis Factor, Member 25 - physiology | Tumor Necrosis Factor Ligand Superfamily Member 15 - physiology | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Herpesviridae Infections - immunology
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Loading RightsJournal of Oral Pathology & Medicine, ISSN 0904-2512, 04/2018, Volume 47, Issue 4, pp. 434 - 439
BackgroundRecurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be...
NLRP | polymorphism | recurrent aphthous stomatitis | NOD‐like receptor | NOD-like receptor | NLRP3 | CYTOKINE PROFILES | POLYMORPHISMS | DENTISTRY, ORAL SURGERY & MEDICINE | MUTATIONS | PATHOLOGY | TYPE-1 | CELIAC-DISEASE | Genetic Variation | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Stomatitis, Aphthous - genetics | Czech Republic | Humans | Middle Aged | Adult | Female | Male | Case-Control Studies | Medical research | Stomatitis | Genes | Genetic research | Medicine, Experimental | Stomatitis, Aphthous | Single nucleotide polymorphisms | Polymerase chain reaction | Haplotypes | Aphthous stomatitis | Statistical analysis | Gene frequency | Single-nucleotide polymorphism | Nuclease | Gene polymorphism | Genotypes | Polymorphism
NLRP | polymorphism | recurrent aphthous stomatitis | NOD‐like receptor | NOD-like receptor | NLRP3 | CYTOKINE PROFILES | POLYMORPHISMS | DENTISTRY, ORAL SURGERY & MEDICINE | MUTATIONS | PATHOLOGY | TYPE-1 | CELIAC-DISEASE | Genetic Variation | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Stomatitis, Aphthous - genetics | Czech Republic | Humans | Middle Aged | Adult | Female | Male | Case-Control Studies | Medical research | Stomatitis | Genes | Genetic research | Medicine, Experimental | Stomatitis, Aphthous | Single nucleotide polymorphisms | Polymerase chain reaction | Haplotypes | Aphthous stomatitis | Statistical analysis | Gene frequency | Single-nucleotide polymorphism | Nuclease | Gene polymorphism | Genotypes | Polymorphism
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Loading RightsJournal of Cellular Physiology, ISSN 0021-9541, 05/2004, Volume 199, Issue 2, pp. 227 - 236
The Src homology domain 2 (SH2)‐containing tyrosine phosphatase SHP‐2 has been implicated in the regulation of the phosphatidylinositol 3′‐kinase (PI3K)/Akt...
SIGNAL-TRANSDUCTION | KINASE PATHWAYS | SURVIVAL | ACTIVATION | PHYSIOLOGY | RAS | PHOSPHORYLATION | MECHANISMS | V-SRC | PROTEIN-TYROSINE-PHOSPHATASE | DIRECT TARGET | CELL BIOLOGY | Caspases - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Nucleic Acid Synthesis Inhibitors - pharmacology | Fibroblasts - physiology | Protein-Serine-Threonine Kinases | Immunoblotting | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Somatomedins - pharmacology | Transfection | Caspase 3 | Cells, Cultured | Etoposide - pharmacology | Intracellular Signaling Peptides and Proteins | Enzyme Activation - drug effects | src Homology Domains - physiology | Precipitin Tests | Proto-Oncogene Proteins c-akt | Animals | Fibroblasts - drug effects | Proto-Oncogene Proteins - physiology | SH2 Domain-Containing Protein Tyrosine Phosphatases | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Enzyme Activation - physiology | Protein Tyrosine Phosphatases - physiology
SIGNAL-TRANSDUCTION | KINASE PATHWAYS | SURVIVAL | ACTIVATION | PHYSIOLOGY | RAS | PHOSPHORYLATION | MECHANISMS | V-SRC | PROTEIN-TYROSINE-PHOSPHATASE | DIRECT TARGET | CELL BIOLOGY | Caspases - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Nucleic Acid Synthesis Inhibitors - pharmacology | Fibroblasts - physiology | Protein-Serine-Threonine Kinases | Immunoblotting | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Somatomedins - pharmacology | Transfection | Caspase 3 | Cells, Cultured | Etoposide - pharmacology | Intracellular Signaling Peptides and Proteins | Enzyme Activation - drug effects | src Homology Domains - physiology | Precipitin Tests | Proto-Oncogene Proteins c-akt | Animals | Fibroblasts - drug effects | Proto-Oncogene Proteins - physiology | SH2 Domain-Containing Protein Tyrosine Phosphatases | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Enzyme Activation - physiology | Protein Tyrosine Phosphatases - physiology
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