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Nature, ISSN 0028-0836, 10/2014, Volume 514, Issue 7523, pp. 513 - 517
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 44, pp. 36560 - 36566
Rip1 is required for I kappa B kinase activation in response to tumor necrosis factor alpha (TNF-alpha) and has been implicated in the Toll-like receptor 3... 
TRANSCRIPTION FACTORS | DOMAIN-CONTAINING ADAPTER | RECRUITMENT | SIGNALING PATHWAY | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IFN-BETA PROMOTER | TNF RECEPTOR-1 | CUTTING EDGE | A20
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 4, pp. 1054 - 1067.e10
Background The Nod-like receptor NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and... 
Allergy and Immunology | ibrutinib | Bruton tyrosine kinase | IL-1 | inflammation | inflammasome | NLRP3 | macrophage | X-linked agammaglobulinemia | Muckle-Wells syndrome | Staphylococcus aureus | IMMUNITY | ACTIVATION | IMMUNOLOGY | MASS-SPECTROMETRY | NALP3 INFLAMMASOME | B-CELL | ALLERGY | IN-VIVO | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSION | Inflammasomes - metabolism | Agammaglobulinemia - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Leukocidins - immunology | Molecular Targeted Therapy | Protein-Tyrosine Kinases - genetics | Genetic Diseases, X-Linked - genetics | Bacterial Proteins - immunology | Adaptive Immunity | Cryopyrin-Associated Periodic Syndromes - genetics | Nigericin - immunology | Staphylococcal Infections - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | Immunity, Innate | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Apoptosis Regulatory Proteins | Pyrin Domain - genetics | Agammaglobulinaemia Tyrosine Kinase | Proteomics | Staphylococcus aureus - immunology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Tyrosine | Phenols | Cells | Immunodeficiency | Regulators | Identification methods | Activation | Arthritis | Kinases | Immunity | Caspase-1 | Genotype & phenotype | Bacteria | Protein-tyrosine kinase | Immune system | Cytokines | Secretion | Agammaglobulinemia | Neutrophils | Caspase | Pharmacology | Adaptive immunity | FDA approval | IL-1β | Patients | Ablation | Bruton's tyrosine kinase | Human subjects | Nigericin | Speck | Mutation | Leukocidin | Cancer | Apoptosis
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 6, pp. 1276 - 1282
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 7, pp. 2400 - 2405
Journal Article
Immunology, ISSN 0019-2805, 01/2018, Volume 153, Issue 1, pp. 71 - 83
The Nod‐like receptor protein 3 ( NLRP 3) inflammasome plays roles in host defence against invading pathogens and in the development of autoimmune damage.... 
NLRP | macrophage | 3 inflammasome | Tim‐3 | NLRP3 inflammasome | Tim-3 | HOMEOSTASIS | INHIBITION | IMMUNE-RESPONSES | MACROPHAGES | DISEASE | SECRETION | IMMUNOLOGY | SUPPRESSION | EXPRESSION | Potassium - metabolism | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Hepatitis A Virus Cellular Receptor 2 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Adenosine Triphosphate - biosynthesis | Case-Control Studies | Young Adult | Peritonitis - pathology | Interleukin-1beta - metabolism | Adult | Female | Caspase 1 | Protein Interaction Domains and Motifs | Macrophages - immunology | Disease Models, Animal | Hepatitis A Virus Cellular Receptor 2 - chemistry | Cell Line | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Peritonitis - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Peritonitis - immunology | Macrophages - metabolism | Animals | Inflammasomes - immunology | Protein Binding | Mice | Interleukins | Genetic engineering | T cells | Macrophages | Mitogens | Peritonitis | Efflux | Immunoglobulins | Reactive oxygen species | Interleukin | Aluminum sulfate | Transgenic | Priming | Lymphocytes T | Activation | Cell activation | Mucin | Immune checkpoint | Rodents | Interleukin 1 | Alum | ATP | Original
Journal Article
Journal Article