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science & technology (530) 530
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life sciences & biomedicine (484) 484
ww domain-containing oxidoreductase (288) 288
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phosphorylation (44) 44
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jumonji domain-containing histone demethylases - metabolism (42) 42
mice, knockout (42) 42
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reactive oxygen species - metabolism (39) 39
protein binding (38) 38
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breast cancer (37) 37
oxidoreductases - physiology (37) 37
protein structure, tertiary (37) 37
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enzymes (28) 28
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1. Full Text Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
by Ives, Annette and Nomura, Johji and Martinon, Fabio and Roger, Thierry and LeRoy, Didier and Miner, Jeffrey N and Simon, Gregoire and Busso, Nathalie and So, Alexander
Nature communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, pp. 6555 - 6555
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Xanthine Dehydrogenase - antagonists & inhibitors | Xanthine Dehydrogenase - genetics | Caspase 1 - immunology | Carrier Proteins - drug effects | Autophagy | Gene Knockdown Techniques | Macrophages - secretion | Xanthine Dehydrogenase - immunology | Reactive Oxygen Species - immunology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Calcium Phosphates - pharmacology | Carrier Proteins - immunology | Macrophages - immunology | Interleukin-1beta - secretion | Signal Transduction | Mice, Inbred C57BL | Peritonitis - immunology | Xanthine Oxidase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Uric Acid - immunology | Monocytes | Animals | Lipopolysaccharides - pharmacology | Mice | In Vitro Techniques | Index Medicus
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2. Full Text The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism
by Abu-Remaileh, Muhannad and Aqeilan, Rami I
Experimental biology and medicine (Maywood, N.J.), ISSN 1535-3702, 3/2015, Volume 240, Issue 3, pp. 345 - 350
hypoxia-inducible transcription factor 1 | tumor suppressor | metabolism | aerobic glycolysis | WW domain-containing oxidoreductase | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Cholesterol, HDL - metabolism | Oxidoreductases - genetics | Humans | Disease Progression | Mice, Knockout | Animals | WW Domain-Containing Oxidoreductase | Tumor Suppressor Proteins - deficiency | Bone and Bones - metabolism | Steroids - metabolism | Tumor Suppressor Proteins - genetics | Cells - metabolism | Glucose - metabolism | Mice | Oxidoreductases - deficiency | Disease Models, Animal | Index Medicus | Minireviews
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3. Full Text Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer
by Bendinelli, Paola and Maroni, Paola and Matteucci, Emanuela and Luzzati, Alessandro and Perrucchini, Giuseppe and Desiderio, Maria Alfonsina
European journal of cancer (1990), ISSN 0959-8049, 2013, Volume 49, Issue 11, pp. 2608 - 2618
Hematology, Oncology and Palliative Medicine | HIF-1 | Hypoxia | Bone metastasis | Hippo pathway | Microenvironment | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Pharmacology. Drug treatments | Tumors | Immunohistochemistry | Cell Hypoxia - physiology | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Humans | Bone Neoplasms - secondary | Tumor Microenvironment | Transcription Factors - genetics | Hypoxia-Inducible Factor 1 - metabolism | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Hypoxia-Inducible Factor 1 - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Transfection | WW Domain-Containing Oxidoreductase | Breast Neoplasms - pathology | PDZ Domains | Female | Bone Neoplasms - genetics | Cell Hypoxia - genetics | COX-2 inhibitors | Breast cancer | Genetic aspects | Genetic transcription | Metastasis | Analysis | Index Medicus
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4. Full Text Novel insights into the PKCβ-dependent regulation of the oxidoreductase p66Shc
by Haller, Martina and Khalid, Sana and Kremser, Leopold and Fresser, Friedrich and Furlan, Tobias and Hermann, Martin and Guenther, Julia and Drasche, Astrid and Leitges, Michael and Giorgio, Marco and Baier, Gottfried and Lindner, Herbert and Troppmair, Jakob
The Journal of biological chemistry, ISSN 0021-9258, 11/2016, Volume 291, Issue 45, pp. 23557 - 23568
RNA, Small Interfering - genetics | Phosphorylation | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Protein Kinase C beta - genetics | Mitochondria - genetics | RNA Interference | Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics | Gene Deletion | Cell Death | HEK293 Cells | Oxidoreductases - metabolism | Oxidoreductases - genetics | Models, Molecular | Serine - genetics | Mitochondria - metabolism | Serine - metabolism | Hydrogen Peroxide - metabolism | Point Mutation | Animals | Protein Kinase C beta - metabolism | Mice | 3T3 Cells | Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism | Index Medicus | redox signaling | Signal Transduction | cell death | PKC | phosphotyrosine binding (PTB) domain | reactive oxygen species (ROS) | p66shc | phosphorylation
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5. Full Text Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling
by Li, Juan and Feng, Xuefei and Li, Canyu and Liu, Jie and Li, Pingping and Wang, Ruiqi and Chen, He and Liu, Peijun
Experimental biology and medicine (Maywood, N.J.), ISSN 1535-3702, 9/2019, Volume 244, Issue 12, pp. 972 - 982
Breast cancer | cell | Hippo | resistance | tamoxifen | WW domain-containing oxidoreductase | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Index Medicus | Original Research
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6. Full Text Role of WW Domain-Containing oxidoreductase WWOX in driving T cell acute lymphoblastic leukemia maturation
by Huang, Shenq-Shyang and Su, Wan-Pei and Lin, Hsin-Pin and Kuo, Hsiang-Ling and Wei, Hsiao-Ling and Chang, Nan-Shan
The Journal of biological chemistry, ISSN 0021-9258, 08/2016, Volume 291, Issue 33, pp. 17319 - 17331
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Multiprotein Complexes - genetics | NF-KappaB Inhibitor alpha - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Multiprotein Complexes - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Proteolysis - drug effects | Phosphorylation - genetics | Cell Nucleus - metabolism | WW Domain-Containing Oxidoreductase | Cell Nucleus - pathology | U937 Cells | Tumor Suppressor Proteins - genetics | HEK293 Cells | Protein Domains | Phosphorylation - drug effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Active Transport, Cell Nucleus - genetics | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Jurkat Cells | Oxidoreductases - genetics | Calcimycin - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Cell Nucleus - genetics | Active Transport, Cell Nucleus - drug effects | NF-KappaB Inhibitor alpha - metabolism | Mice | Index Medicus | extracellular-signal-regulated kinase (ERK) | differentiation | phorbol ester | phosphorylation | tumor suppressor gene | Cell Biology | lymphocyte
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7. Full Text WW domain-containing oxidoreductase in neuronal injury and neurological diseases
by Chang, Hsin-Tzu and Liu, Chan-Chuan and Chen, Shur-Tzu and Yap, Ye Vone and Chang, Nan-Shang and Sze, Chun-I
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 23, pp. 11792 - 11799
WWOX | Neuronal death | WOX1 | Neurites | Transcription factors | Neurodegeneration | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animals | WW Domain-Containing Oxidoreductase | Humans | Mice | Oxidoreductases | Tumor Suppressor Proteins | Nervous System Diseases | Index Medicus
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8. Full Text WW domain-containing oxidoreductase: a candidate tumor suppressor
by Chang, Nan-Shan and Hsu, Li-Jin and Lin, Yee-Shin and Lai, Feng-Jie and Sheu, Hamm-Ming
Trends in molecular medicine, ISSN 1471-4914, 2006, Volume 13, Issue 1, pp. 12 - 22
Pathology | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Protein Structure, Tertiary | Phosphorylation | Tumor Suppressor Proteins - metabolism | Hyaluronoglucosaminidase - metabolism | Oxidoreductases - metabolism | Neoplasm Invasiveness | Oxidoreductases - genetics | Humans | Biomarkers - analysis | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Tumor Protein p73 | WW Domain-Containing Oxidoreductase | Models, Biological | Gene Components | Genes, Tumor Suppressor | Tumors | Index Medicus
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9. Full Text Expression of WW domain–Containing oxidoreductase WWOX in pterygium
by Huang, Yi-Hsun and Chang, Nan-Shan and Tseng, Sung-Huei
Molecular vision, ISSN 1090-0535, 06/2015, Volume 21, pp. 711 - 717
Biochemistry & Molecular Biology | Ophthalmology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Recurrence | Up-Regulation | Phosphorylation | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Humans | Middle Aged | RNA, Messenger - genetics | Male | Pterygium - genetics | RNA, Messenger - metabolism | Oxidoreductases - chemistry | Pterygium - pathology | Case-Control Studies | Disease Progression | WW Domain-Containing Oxidoreductase | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Aged | Pterygium - enzymology | Index Medicus
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10. Full Text The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E‐transformed cells
by Furlan, Tobias and Khalid, Sana and Nguyen, Anh‐Vu and Günther, Julia and Troppmair, Jakob
Molecular oncology, ISSN 1574-7891, 06/2018, Volume 12, Issue 6, pp. 869 - 882
intracellular signaling | BRAFV600E | mitochondria | ROS | vemurafenib resistance | p66Shc | Life Sciences & Biomedicine | Oncology | Science & Technology | NIH 3T3 Cells | Tumor Suppressor Proteins - metabolism | Reactive Oxygen Species - metabolism | Humans | Melanoma - pathology | Mutation - genetics | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Cell Line, Transformed | Isothiocyanates - pharmacology | Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | s
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