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1. Full Text Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
by Ives, Annette and Nomura, Johji and Martinon, Fabio and Roger, Thierry and LeRoy, Didier and Miner, Jeffrey N and Simon, Gregoire and Busso, Nathalie and So, Alexander
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, p. 6555
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present... 
ALLOPURINOL | OXIDASE | IL-1-BETA PRODUCTION | CONVERSION | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | HYPERTENSION | INHIBITOR | URIC-ACID | DEHYDROGENASE | NALP3 INFLAMMASOME | Phosphorylation | Calcium - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Xanthine Dehydrogenase - antagonists & inhibitors | Xanthine Dehydrogenase - genetics | Caspase 1 - immunology | Carrier Proteins - drug effects | Autophagy | Gene Knockdown Techniques | Macrophages - secretion | Xanthine Dehydrogenase - immunology | Reactive Oxygen Species - immunology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Calcium Phosphates - pharmacology | Carrier Proteins - immunology | Macrophages - immunology | Interleukin-1beta - secretion | Signal Transduction | Mice, Inbred C57BL | Peritonitis - immunology | Xanthine Oxidase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Uric Acid - immunology | Monocytes | Animals | Lipopolysaccharides - pharmacology | Mice | In Vitro Techniques
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2. Full Text Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk
by Lee, HL and Cheng, HL and Liu, YF and Chou, MC and Yang, SF and Chou, YE
PLOS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0176141
Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been... 
APOPTOSIS | LUNG | PROTEIN | MULTIDISCIPLINARY SCIENCES | FRAGILE GENES | TUMOR-SUPPRESSOR | OVARIAN | EXPRESSION | CANCER | BREAST | CELL-DEATH | Amino Acid Sequence | Genetic Predisposition to Disease | Liver Neoplasms - genetics | Oxidoreductases - genetics | Humans | Middle Aged | Genotype | Male | Oxidoreductases - chemistry | Sequence Homology, Amino Acid | WW Domain-Containing Oxidoreductase | Carcinoma, Hepatocellular - genetics | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Alleles | Aged, 80 and over | Adult | Female | Aged | Biomarkers, Tumor - genetics | Polymorphism, Single Nucleotide | Liver cancer | Genetic variation | Amino acids | Genetic aspects | Single nucleotide polymorphisms | Research | Chemical properties | Biological markers | Oral cancer | Oxidoreductase | Lung cancer | Risk | Hepatocellular carcinoma | Alcohol | Single-nucleotide polymorphism | Hepatitis | Cell cycle | DNA methylation | Bioindicators | Deoxyribonucleic acid--DNA | Alanine | Breast cancer | Genetic diversity | Gene expression | Patients | Medicine | Studies | Genetic variance | Hospitals | Alanine transaminase | Biomarkers | Tumor suppressor genes | Prostate cancer | Tumors | Apoptosis | Polymorphism | Deoxyribonucleic acid | DNA
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3. Full Text The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism
by Abu-Remaileh, Muhannad and Aqeilan, Rami I
Experimental Biology and Medicine, ISSN 1535-3702, 3/2015, Volume 240, Issue 3, pp. 345 - 350
The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is frequently altered in cancer. WWOX binds several proteins and thus is... 
hypoxia-inducible transcription factor 1 | tumor suppressor | metabolism | aerobic glycolysis | WW domain-containing oxidoreductase | MEDICINE, RESEARCH & EXPERIMENTAL | TUMORIGENICITY | CANCER | DELETION | INACTIVATION | GLUCOSE-METABOLISM | PROTEIN EXPRESSION | metabolism aerobic glycolysis | GENE-EXPRESSION | FREQUENT LOSS | ASSOCIATION | FRA16D | Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Cholesterol, HDL - metabolism | Oxidoreductases - genetics | Humans | Disease Progression | Mice, Knockout | Animals | WW Domain-Containing Oxidoreductase | Tumor Suppressor Proteins - deficiency | Bone and Bones - metabolism | Steroids - metabolism | Tumor Suppressor Proteins - genetics | Cells - metabolism | Glucose - metabolism | Mice | Oxidoreductases - deficiency | Disease Models, Animal | Minireviews
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4. Full Text Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer
by Bendinelli, Paola and Maroni, Paola and Matteucci, Emanuela and Luzzati, Alessandro and Perrucchini, Giuseppe and Desiderio, Maria Alfonsina
European Journal of Cancer, ISSN 0959-8049, 2013, Volume 49, Issue 11, pp. 2608 - 2618
Abstract The hypoxic microenvironment of bone marrow favours the bone metastasis process. Hypoxia inducible factor (HIF)-1α is hallmark for hypoxia,... 
Hematology, Oncology and Palliative Medicine | HIF-1 | Hypoxia | Bone metastasis | Hippo pathway | Microenvironment | PROTEIN | CARCINOMA CELLS | HEPATOCYTE GROWTH-FACTOR | NICHE | THERAPY | HIF-1 ACTIVITY | ONCOLOGY | EXPRESSION | MET | Immunohistochemistry | Cell Hypoxia - physiology | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Humans | Bone Neoplasms - secondary | Tumor Microenvironment | Transcription Factors - genetics | Hypoxia-Inducible Factor 1 - metabolism | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Hypoxia-Inducible Factor 1 - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Transfection | WW Domain-Containing Oxidoreductase | Breast Neoplasms - pathology | PDZ Domains | Female | Bone Neoplasms - genetics | Cell Hypoxia - genetics | COX-2 inhibitors | Breast cancer | Genetic aspects | Genetic transcription | Metastasis | Analysis
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5. Full Text Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity
by Fini, Mehdi A and Gaydos, Jeanette and McNally, Alicia and Karoor, Vijaya and Burnham, Ellen L
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2017, Volume 313, Issue 6, pp. L1047 - L1057
Acute respiratory distress syndrome (ARDS) is a common and devastating disorder. Alcohol use disorders (AUDs) increase ARDS risk and worsen outcomes through... 
Bronchoscopy | Human | Inflammasome | Cyclooxygenase-2 | OXIDATIVE STRESS | PHYSIOLOGY | CLINICAL-TRIAL | cyclooxygenase-2 | NLRP3 INFLAMMASOME ACTIVATION | ACUTE LUNG INJURY | N-ACETYLCYSTEINE | GLUTATHIONE HOMEOSTASIS | bronchoscopy | RESPIRATORY-DISTRESS-SYNDROME | DANGER SIGNALS | RESPIRATORY SYSTEM | inflammasome | USE DISORDERS | human | URIC-ACID | Respiratory Distress Syndrome, Adult - pathology | Xanthine Dehydrogenase - metabolism | Alcoholism - pathology | Lung - pathology | Lipopolysaccharides - toxicity | Oxidative Stress | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Middle Aged | Cells, Cultured | Bronchoalveolar Lavage | Male | Lung - enzymology | Alcoholism - enzymology | Interleukin-1beta - metabolism | Cyclooxygenase 2 - metabolism | Adult | Female | Respiratory Distress Syndrome, Adult - enzymology | Acute respiratory distress syndrome | Complications and side effects | Alcoholism | Physiological aspects | Oxidoreductases | Xanthine | Risk factors
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6. Full Text Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling
by Li, Juan and Feng, Xuefei and Li, Canyu and Liu, Jie and Li, Pingping and Wang, Ruiqi and Chen, He and Liu, Peijun
Experimental Biology and Medicine, ISSN 1535-3702, 9/2019, Volume 244, Issue 12, pp. 972 - 982
Acquired tamoxifen-resistance is an important cause of death in patients with hormone-dependent breast tumors. Therefore, understanding the molecular... 
Breast cancer | cell | Hippo | resistance | tamoxifen | WW domain-containing oxidoreductase | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN EXPRESSION VARIES | P38 MAPK | YAP | PROLIFERATION | BREAST-CANCER | GENE | PATHWAY | GROWTH | TUMOR-SUPPRESSOR PROTEIN | ASSOCIATION
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7. Full Text Role of WW Domain-Containing oxidoreductase WWOX in driving T cell acute lymphoblastic leukemia maturation
by Huang, Shenq-Shyang and Su, Wan-Pei and Lin, Hsin-Pin and Kuo, Hsiang-Ling and Wei, Hsiao-Ling and Chang, Nan-Shan
Journal of Biological Chemistry, ISSN 0021-9258, 08/2016, Volume 291, Issue 33, pp. 17319 - 17331
Whether tumor suppressor WWOX (WW domain-containing oxidoreductase) stimulates immune cell maturation is largely unknown. Here, we determined that... 
THYMOCYTE DEVELOPMENT | differentiation | phorbol ester | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR WWOX | lymphocyte | TIAF1 SELF-AGGREGATION | extracellular-signal-regulated kinase (ERK) | IN-VITRO | POSITIVE SELECTION | phosphorylation | NF-KAPPA-B | POTENTIAL ROLE | PHYSICALLY INTERACTS | tumor suppressor gene | Tetradecanoylphorbol Acetate - pharmacology | Humans | Multiprotein Complexes - genetics | NF-KappaB Inhibitor alpha - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Multiprotein Complexes - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Proteolysis - drug effects | Phosphorylation - genetics | Cell Nucleus - metabolism | WW Domain-Containing Oxidoreductase | Cell Nucleus - pathology | U937 Cells | Tumor Suppressor Proteins - genetics | HEK293 Cells | Protein Domains | Phosphorylation - drug effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Active Transport, Cell Nucleus - genetics | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Jurkat Cells | Oxidoreductases - genetics | Calcimycin - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Cell Nucleus - genetics | Active Transport, Cell Nucleus - drug effects | NF-KappaB Inhibitor alpha - metabolism | Mice | Cell Biology
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8. Full Text WW domain-containing oxidoreductase: a candidate tumor suppressor
by Chang, Nan-Shan and Hsu, Li-Jin and Lin, Yee-Shin and Lai, Feng-Jie and Sheu, Hamm-Ming
Trends in Molecular Medicine, ISSN 1471-4914, 2006, Volume 13, Issue 1, pp. 12 - 22
Common fragile site gene WWOX encodes a candidate tumor suppressor WW domain-containing oxidoreductase. Alteration of this gene, along with dramatic... 
Pathology | MEDICINE, RESEARCH & EXPERIMENTAL | CHROMOSOMAL FRAGILE SITE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE WWOX | NECROSIS-FACTOR CYTOTOXICITY | CELL BIOLOGY | BREAST-CANCER | LUNG-CANCER | IN-VIVO | SQUAMOUS-CELL CARCINOMA | POTENTIAL ROLE | HEMATOPOIETIC MALIGNANCIES | Protein Structure, Tertiary | Phosphorylation | Tumor Suppressor Proteins - metabolism | Hyaluronoglucosaminidase - metabolism | Oxidoreductases - metabolism | Neoplasm Invasiveness | Oxidoreductases - genetics | Humans | Biomarkers - analysis | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Tumor Protein p73 | WW Domain-Containing Oxidoreductase | Models, Biological | Gene Components | Genes, Tumor Suppressor | Tumors
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9. Full Text Expression of WW domain–Containing oxidoreductase WWOX in pterygium
by Huang, Yi-Hsun and Chang, Nan-Shan and Tseng, Sung-Huei
Molecular Vision, ISSN 1090-0535, 06/2015, Volume 21, pp. 711 - 717
Purpose: Pterygium was traditionally regarded as a degenerative disease, but certain characteristics suggest that pterygium is probably premalignant tissue.... 
BREAST-CANCER | APOPTOSIS | IN-VITRO | P53 EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | SQUAMOUS-CELL CARCINOMA | DOWN-REGULATION | OPHTHALMOLOGY | WOX1 | FRAGILE SITE FRA16D | POTENTIAL ROLE | Immunohistochemistry | Recurrence | Up-Regulation | Phosphorylation | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Humans | Middle Aged | RNA, Messenger - genetics | Male | Pterygium - genetics | RNA, Messenger - metabolism | Oxidoreductases - chemistry | Pterygium - pathology | Case-Control Studies | Disease Progression | WW Domain-Containing Oxidoreductase | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Aged | Pterygium - enzymology
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10. Full Text Novel insights into the PKCβ-dependent regulation of the oxidoreductase p66Shc
by Haller, Martina and Khalid, Sana and Kremser, Leopold and Fresser, Friedrich and Furlan, Tobias and Hermann, Martin and Guenther, Julia and Drasche, Astrid and Leitges, Michael and Giorgio, Marco and Baier, Gottfried and Lindner, Herbert and Troppmair, Jakob
Journal of Biological Chemistry, ISSN 0021-9258, 11/2016, Volume 291, Issue 45, pp. 23557 - 23568
Dysfunctional mitochondria contribute to the development of many diseases and pathological conditions through the excessive production of reactive oxygen... 
RNA, Small Interfering - genetics | Phosphorylation | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Protein Kinase C beta - genetics | Mitochondria - genetics | RNA Interference | Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics | Gene Deletion | Cell Death | HEK293 Cells | Oxidoreductases - metabolism | Oxidoreductases - genetics | Models, Molecular | Serine - genetics | Mitochondria - metabolism | Serine - metabolism | Hydrogen Peroxide - metabolism | Point Mutation | Animals | Protein Kinase C beta - metabolism | Mice | 3T3 Cells | Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism | redox signaling | Signal Transduction | cell death | PKC | phosphotyrosine binding (PTB) domain | reactive oxygen species (ROS) | p66shc | phosphorylation
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11. Full Text WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3Β
by Wang, H.-Y and Juo, L.-I and Lin, Y.-T and Hsiao, M and Lin, J.-T and Tsai, C.-H and Tzeng, Y.-H and Chuang, Y.-C and Chang, N.-S and Yang, C.-N and Lu, P.-J
Cell Death and Differentiation, ISSN 1350-9047, 06/2012, Volume 19, Issue 6, pp. 1049 - 1059
WW domain-containing oxidoreductase (WWOX), a putative tumour suppressor, is suggested to be involved in the hyperphosphorylation of Alzheimer's Tau. Tau is a... 
GSK3β | SH-SY5Y | WWOX | Tau | PROTEIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GSK-3 | CELL BIOLOGY | RETINOIC ACID | GSK3-BETA | GSK3 beta | EXPRESSION | ASSOCIATION | Oxidoreductases - antagonists & inhibitors | Phosphorylation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Neurons - cytology | Oxidoreductases - chemistry | Microtubules - metabolism | tau Proteins - genetics | RNA Interference | WW Domain-Containing Oxidoreductase | Tumor Suppressor Proteins - chemistry | Neurogenesis - drug effects | Neurons - metabolism | Binding Sites | tau Proteins - antagonists & inhibitors | Tretinoin - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Oxidoreductases - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 - metabolism | Molecular Dynamics Simulation | Amino Acid Motifs | Glycogen Synthase Kinase 3 - genetics | Cell Line, Tumor | Protein Binding | RNA, Small Interfering - metabolism | Immunoprecipitation | Neurodegenerative diseases | Axonogenesis | Neurons | Glycogen synthase kinase 3 | Data processing | Alcohol dehydrogenase | reductase | Molecular modelling | Tau protein | Microtubule-associated proteins | Differentiation | Immunofluorescence | oxidoreductase | Alzheimer's disease | Bioinformatics | Retinoic acid | Original Paper
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12. Full Text WW domain-containing oxidoreductase in neuronal injury and neurological diseases
by Chang, Hsin-Tzu and Liu, Chan-Chuan and Chen, Shur-Tzu and Yap, Ye Vone and Chang, Nan-Shang and Sze, Chun-I
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 23, pp. 11792 - 11799
WWOX | Neuronal death | WOX1 | Neurites | Transcription factors | Neurodegeneration
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13. Full Text Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro: A potential role in Alzheimer's disease
by Sze, Chun-I and Su, Meng and Pugazhenthi, Subbiah and Jambal, Purevsuren and Hsu, Li-Jin and Heath, John and Schultz, Lori and Chang, Nan-Shan
Journal of Biological Chemistry, ISSN 0021-9258, 07/2004, Volume 279, Issue 29, pp. 30498 - 30506
Numerous enzymes hyperphosphorylate Tau in vivo, leading to the formation of neurofibrillary tangles (NFTs) in the neurons of Alzheimer's disease ( AD).... 
NEUROFIBRILLARY TANGLES | APOPTOSIS | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | PAIRED HELICAL FILAMENTS | TUMOR-SUPPRESSOR GENE | PROLYL ISOMERASE PIN1 | BINDING-PROTEIN | ESTROGEN | NEUROBLASTOMA CELL-LINE | Immunohistochemistry | Phosphorylation | Temperature | Threonine - chemistry | Humans | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Oxidoreductases - chemistry | Alzheimer Disease - pathology | Retroviridae - genetics | Time Factors | WW Domain-Containing Oxidoreductase | Flavonoids - pharmacology | Neurons - metabolism | Tyrosine - chemistry | Oxidoreductases - biosynthesis | Protein Structure, Tertiary | Cell Line | Estradiol - metabolism | Down-Regulation | Enzyme Inhibitors - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Serine - chemistry | Anthracenes - pharmacology | Precipitin Tests | Hippocampus - metabolism | Two-Hybrid System Techniques | Animals | Alzheimer Disease - metabolism | Brain - pathology | Cell Line, Tumor | Protein Binding | Anisomycin - pharmacology | Mice | Genetic Vectors | In Vitro Techniques | COS Cells | Microscopy, Fluorescence | Tumor Suppressor Proteins | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism
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14. Full Text Xanthine oxidoreductase activation is implicated in the onset of metabolic arthritis
by Aibibula, Zulipiya and Ailixiding, Maierhaba and Iwata, Munetaka and Piao, Jinying and Hara, Yasushi and Okawa, Atsushi and Asou, Yoshinori
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 26 - 32
A metabolic syndrome (MetS) is accompanied by hyperuricemia, during which xanthine oxidoreductase (XOR) catalyzes the production of uric acid. In the cohort... 
Metabolic syndrome | Osteoarthritis | Xanthine oxidoreductase | Infrapatellar fat pad | KNEE | APOPTOSIS | CYTOKINES | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVERWEIGHT | URIC-ACID | Xanthine Dehydrogenase - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Xanthine Dehydrogenase - antagonists & inhibitors | Diet, High-Fat - adverse effects | Synovial Membrane - pathology | Male | Metabolic Syndrome - metabolism | Hyperuricemia - metabolism | RNA, Messenger - metabolism | Febuxostat - pharmacology | Adipose Tissue - metabolism | Osteophyte - pathology | Osteoarthritis - pathology | Hyperuricemia - complications | Chondrocytes - pathology | Uric Acid - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Osteoarthritis - metabolism | Metabolic Syndrome - complications | Carrier Proteins - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Mice | Enzyme Activation | Metabolic Syndrome - pathology | Adipose Tissue - drug effects | Osteoarthritis - etiology | Apoptosis | Oxidases | Uric acid | Molybdenum compounds
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15. Full Text WW-Domain-Containing Oxidoreductase Is Associated with Low Plasma HDL-C Levels
by Lee, Jenny C and Weissglas-Volkov, Daphna and Kyttälä, Mira and Dastani, Zari and Cantor, Rita M and Sobel, Eric M and Plaisier, Christopher L and Engert, James C and van Greevenbroek, Marleen M.J and Kane, John P and Malloy, Mary J and Pullinger, Clive R and Huertas-Vazquez, Adriana and Aguilar-Salinas, Carlos A and Tusie-Luna, Teresa and de Bruin, Tjerk W.A and Aouizerat, Bradley E and van der Kallen, Carla C.J and Croce, Carlo M and Aqeilan, Rami I and Marcil, Michel and Viikari, Jorma S.A and Lehtimäki, Terho and Raitakari, Olli T and Kuusisto, Johanna and Laakso, Markku and Taskinen, Marja-Riitta and Genest, Jacques and Pajukanta, Päivi
The American Journal of Human Genetics, ISSN 0002-9297, 08/2008, Volume 83, Issue 2, pp. 180 - 192
Low serum HDL-cholesterol (HDL-C) is a major risk factor for coronary artery disease. We performed targeted genotyping of a 12.4 Mb linked region on 16q to... 
DENSITY-LIPOPROTEIN CHOLESTEROL | CHROMOSOME 16Q | GENETICS & HEREDITY | FAMILIAL COMBINED HYPERLIPIDEMIA | LOCI | SERUM-LIPID LEVELS | FINNISH FAMILIES | APOLIPOPROTEIN-B | LINKAGE | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Genetics, Population | Cholesterol, HDL - biosynthesis | Cardiovascular Diseases - ethnology | Oxidoreductases - genetics | Humans | Middle Aged | Child, Preschool | Male | Oxidoreductases - physiology | Cardiovascular Diseases - genetics | Polymorphism, Genetic | Tumor Suppressor Proteins - physiology | WW Domain-Containing Oxidoreductase | Tumor Suppressor Proteins - genetics | Adolescent | Alleles | Finland | Adult | Female | Mexico | Aged | Child | Cohort Studies | Evaluation | Cholesterol, HDL | Analysis | Genetic aspects | Oxidoreductases | Research | Gene expression | Population genetics
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