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Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β... 
STERILE INFLAMMATORY RESPONSE | PROGRAMMED NECROSIS | CASPASE-8 | IL-1-BETA | NLRP3 INFLAMMASOME | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CIAP1 | NALP3 INFLAMMASOME | CELL-DEATH | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 03/2007, Volume 128, Issue 6, pp. 1063 - 1076
Methylation of histones has been regarded as a stable modification defining the epigenetic program of the cell, which regulates chromatin structure and... 
DOMAIN-CONTAINING PROTEINS | METHYLATION | CAENORHABDITIS-ELEGANS | METHYLTRANSFERASE | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCAPES X-INACTIVATION | TRITHORAX | RETINOBLASTOMA-BINDING PROTEIN-2 | TRANSCRIPTIONAL REGULATION | CELL BIOLOGY | Caenorhabditis elegans Proteins - chemistry | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phylogeny | Gene Deletion | Tumor Suppressor Proteins - chemistry | Oxidoreductases, N-Demethylating - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Repressor Proteins - genetics | Caenorhabditis elegans - embryology | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Histone Demethylases | Lysine | Drosophila melanogaster - enzymology | Schizosaccharomyces - enzymology | Mice | Histones - metabolism | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Embryonic Stem Cells - metabolism | Oxidoreductases, N-Demethylating - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | Carrier Proteins - chemistry | Nuclear Proteins - genetics | Genes, Homeobox | Protein Structure, Tertiary | Repressor Proteins - chemistry | Embryonic Stem Cells - enzymology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Oxidoreductases, N-Demethylating - chemistry | Proteins - genetics | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Retinoblastoma-Binding Protein 2 | Proteins - chemistry | Methylation | Jumonji Domain-Containing Histone Demethylases | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2013, Volume 9, Issue 4, pp. e1003256 - e1003256
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1 beta response is mediated by innate receptors in... 
INTERLEUKIN-1 | RNA | RESPIRATORY VIRAL-INFECTION | INNATE IMMUNE-RESPONSE | RIG-I | MICROBIOLOGY | INDUCTION | NS1 PROTEIN | ANTIVIRAL RESPONSES | INTERFERON | VIROLOGY | EPITHELIAL-CELLS | PARASITOLOGY | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Male | Tripartite Motif Proteins | Lung - virology | RNA Interference | Respiratory Mucosa - immunology | HEK293 Cells | Cytoskeletal Proteins - metabolism | Lung - metabolism | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Macrophages - immunology | DEAD Box Protein 58 | Respiratory Mucosa - cytology | Signal Transduction | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ferrets | Toll-Like Receptor 3 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | Interferon-beta - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Cytoskeletal Proteins | Toll-Like Receptor 3 | Interferon-beta | Lung | Macrophages | Life Sciences | Influenza A Virus, H1N1 Subtype | Caspase 1 | Carrier Proteins | Viral Nonstructural Proteins | DEAD-box RNA Helicases | Inflammasomes | Respiratory Mucosa | Epithelial Cells | Virology | Ubiquitin-Protein Ligases | Microbiology and Parasitology | Adaptor Proteins, Signal Transducing | Transcription Factors | Proteins | Medical research | Experiments | Respiratory diseases | Influenza
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2013, Volume 449, Issue 3, pp. 613 - 621
The ASC (apoptosis speck-like protein) is a key component of multimeric protein complexes that mediate inflammation and host defence. Comprising a PYD (Pyrin)... 
Salmonella | Caspase activation and recruitment domain (CARD) | Inflammatory cytokine | Nucleotide-binding domain | Death domain | Signalling platform formation | Innate immunity | Caspase 1 | Inflammasome | Leucine-rich repeat-containing receptor (NLR) | NLR family CARD domain-containing protein 4 (NLRC4) | IMMUNITY | ACTIVATION | CASPASE-1 | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | PYROPTOSOME | IDENTIFICATION | IPAF | caspase activation and recruitment domain (CARD) | CELL-DEATH | inflammatory cytokine | innate immunity | leucine-rich repeat-containing receptor (NLR) | inflammasome | DISEASE | signalling platform formation | death domain | nucleotide-binding domain | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Multiprotein Complexes - genetics | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | HEK293 Cells | Cytoskeletal Proteins - metabolism | Mutant Proteins - immunology | DNA-Binding Proteins | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | CARD Signaling Adaptor Proteins - immunology | Cell Line | Salmonella typhimurium - immunology | Salmonella typhimurium - pathogenicity | Signal Transduction | Inflammasomes - chemistry | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Cytoskeletal Proteins - chemistry | Immunity, Innate | Inflammasomes - genetics | Multiprotein Complexes - chemistry | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | Inflammasomes - immunology | Mutant Proteins - chemistry | CARD Signaling Adaptor Proteins - chemistry | Mice | HeLa Cells | Calcium-Binding Proteins - genetics | Index Medicus | signaling platform formation | inflammatory cytokines | NLRC4 | death domains | CARD | Caspase-1 | Nod-like receptors (NLRs)
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 354 - 357
Journal Article
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, pp. 10791 - 10791
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches... 
AIRWAY EPITHELIAL-CELLS | ASPERGILLUS-FUMIGATUS | III SECRETION APPARATUS | CHRONIC GRANULOMATOUS-DISEASE | ENVIRONMENT INTERACTIONS | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | HOST-DEFENSE | NLRP3 INFLAMMASOME | LUNG INFECTION | IMMUNE RECOGNITION | Immunohistochemistry | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Child, Preschool | Male | Cystic Fibrosis - immunology | Young Adult | Calcium-Binding Proteins - immunology | Autophagy - genetics | Interleukin 1 Receptor Antagonist Protein - pharmacology | Child | Cytokines - genetics | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Respiratory Mucosa - cytology | Cystic Fibrosis - microbiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cystic Fibrosis - genetics | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aspergillus fumigatus | Calcium-Binding Proteins - genetics | Infant | Interleukin 1 Receptor Antagonist Protein - genetics | CARD Signaling Adaptor Proteins - genetics | Autophagy - immunology | Apoptosis Regulatory Proteins - genetics | Adult | Female | Pseudomonas aeruginosa | Lung - metabolism | Macrophages - immunology | Cytokines - immunology | In Situ Nick-End Labeling | CARD Signaling Adaptor Proteins - immunology | Cell Line | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Inflammation | Inflammasomes - genetics | Pseudomonas Infections - immunology | Carrier Proteins - genetics | Animals | Epithelial Cells - immunology | Inflammasomes - immunology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide | Aspergillosis - immunology | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1180 - 12
Oxygenase-catalysed post-translational modifications of basic protein residues, including lysyl hydroxylations and N-epsilon-methyl lysyl demethylations, have... 
SYSTEM | S6 PHOSPHORYLATION | SPECIFICITY | DOMAIN-CONTAINING PROTEIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | 2-OXOGLUTARATE | H3K36ME2 HISTONE DEMETHYLASE | CELL-CYCLE | OXYGENASES | IDENTIFICATION | Stereoisomerism | Humans | Substrate Specificity | Crystallography, X-Ray | Histone Demethylases - genetics | Thermodynamics | Ribosomal Protein S6 - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Carrier Proteins - chemistry | Lysine - metabolism | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Genetic Vectors - chemistry | Hydroxylation | Membrane Proteins - genetics | Histone Demethylases - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ribosomal Protein S6 - genetics | Protein Folding | Arginine - chemistry | Carrier Proteins - genetics | Histone Demethylases - metabolism | Carrier Proteins - metabolism | Membrane Proteins - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | Ribosomal Protein S6 - metabolism | Protein Binding | Kinetics | Lysine - chemistry | Arginine - metabolism | Residues | Peptides | Hydroxylase | Medical treatment | Ribosomal protein S6 | Crystallography | Substrates | Proteins | Oxygenase | Arginine | Condensates | Protein folding | Lysine | Post-translation | Cancer | Index Medicus
Journal Article
Structure, ISSN 0969-2126, 01/2018, Volume 26, Issue 1, pp. 85 - 95.e3
The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities... 
histone methylation | DNMT1 | KDM2A | DNA methylation | TET1 | CFP1 | CpG island | MLL | CXXC domain | epigenetics | METHYLATION | METHYLTRANSFERASE | CHROMATIN-STRUCTURE | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPG-BINDING PROTEIN | TRANSCRIPTION | RESOLUTION | ISLANDS | CELL BIOLOGY | BIOPHYSICS | GENES | MACROMOLECULAR CRYSTALLOGRAPHY | Epigenesis, Genetic | Humans | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | Mixed Function Oxygenases - chemistry | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Jumonji Domain-Containing Histone Demethylases - chemistry | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Binding Sites | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Jumonji Domain-Containing Histone Demethylases - genetics | DNA - genetics | Sequence Homology, Amino Acid | DNA - chemistry | Sequence Alignment | Protein Conformation, beta-Strand | Escherichia coli - genetics | CpG Islands | Protein Binding | Mixed Function Oxygenases - genetics | F-Box Proteins - genetics | Jumonji Domain-Containing Histone Demethylases - metabolism | Protein Isoforms - genetics | Epigenetic inheritance | Chromatin | Methyltransferases | DNA | Crystals | Physiological aspects | Genetic research | Nucleotide sequencing | Methylation | Structure | Protein binding | DNA sequencing | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1844 - 1844
Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it... 
COMPLEX | REPLICATION | INTEGRATION | STRUCTURAL BASIS | PROTEIN-SYNTHESIS SYSTEM | MULTIDISCIPLINARY SCIENCES | INHIBITORS | HIV-1 INFECTION | CELL | EXPRESSION | IMMUNODEFICIENCY-VIRUS VPX | Humans | Proto-Oncogene Proteins c-pim-1 - metabolism | Pyridazines - pharmacology | Proto-Oncogene Proteins c-pim-1 - immunology | Host-Pathogen Interactions - immunology | Recombinant Proteins - isolation & purification | HIV Infections - immunology | Proteolysis - drug effects | Biphenyl Compounds - pharmacology | Protein Processing, Post-Translational - drug effects | SAM Domain and HD Domain-Containing Protein 1 - immunology | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Protein Binding - drug effects | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - immunology | Phosphorylation - immunology | Protein Processing, Post-Translational - immunology | Thiazolidines - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Viral Regulatory and Accessory Proteins - isolation & purification | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Virus Replication - drug effects | SAM Domain and HD Domain-Containing Protein 1 - metabolism | HIV Infections - virology | Immune Tolerance | Virus Replication - immunology | Imidazoles - pharmacology | Protein Binding - immunology | Serine - metabolism | Molecular Dynamics Simulation | Viral Regulatory and Accessory Proteins - metabolism | SAM Domain and HD Domain-Containing Protein 1 - chemistry | Monocytes | Protein Kinase Inhibitors - therapeutic use | HIV-2 - immunology | Proteomics | Cell Line, Tumor | HIV Infections - drug therapy | Protein-Serine-Threonine Kinases - immunology | Protein Kinase Inhibitors - pharmacology | Viral Regulatory and Accessory Proteins - chemistry
Journal Article
Science, ISSN 0036-8075, 3/2002, Volume 295, Issue 5564, pp. 2450 - 2452
Genetic determinants of longevity include the forkhead-related transcription factor DAF-16 in the worm Caenorhabditis elegans and the p66shc locus in mice. We... 
Antioxidants | Oxidative stress | Phosphorylation | Reactive oxygen species | Hydrogen | Cell nucleus | Cell lines | Reports | Peroxides | Gene expression regulation | PC12 cells | SURVIVAL | LIFE-SPAN | OXIDATIVE STRESS | AFX | ELEGANS | MULTIDISCIPLINARY SCIENCES | AKT | TRANSCRIPTION FACTOR | FKHR | Free Radical Scavengers - pharmacology | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Protein-Serine-Threonine Kinases | Adaptor Proteins, Vesicular Transport | PC12 Cells | Blood | Organoselenium Compounds - pharmacology | DNA-Binding Proteins - metabolism | Transfection | Culture Media | Shc Signaling Adaptor Proteins | Proto-Oncogene Proteins - metabolism | Oxidation-Reduction | Signal Transduction | Cells, Cultured | Hydrogen Peroxide - pharmacology | Rats | Transcription Factors - genetics | Azoles - pharmacology | DNA-Binding Proteins - genetics | Hydrogen Peroxide - metabolism | Proteins - genetics | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Proteins - metabolism | Src Homology 2 Domain-Containing, Transforming Protein 1 | Acetylcysteine - pharmacology | Forkhead Box Protein O1 | Mice | Mutation | Forkhead Box Protein O3 | Forkhead Transcription Factors | Aging | Physiological aspects | Cells | Proteins | Genetics | Rodents | Worms | Chemicals | p66shc protein | forkhead proteins | FKHRL1 protein | Index Medicus
Journal Article