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NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2015, Volume 6
Hepatitis C virus (HCV), a widespread human pathogen, is dependent on a highly structured 50'-untranslated region of its mRNA, referred to as internal ribosome... 
COMPLEX | RNA | CRYSTAL-STRUCTURE | EUKARYOTIC RIBOSOME | MULTIDISCIPLINARY SCIENCES | DOMAIN-II | TRANSLATION INITIATION | HCV | MUTATIONAL ANALYSIS | ENTRY SITES | 80S RIBOSOME
Journal Article
Journal of Integrative Agriculture, ISSN 2095-3119, 05/2019, Volume 18, Issue 5, pp. 1064 - 1071
Cry1Ai-h-loop 2 is a mutant of Cry1Ai constructed by exchanging loop 2 from Cry1Ah protein and shows insecticidal activity against . The toxicity of... 
binding affinity | Helicoverpa armigera | Cry1Ai | Bacillus thuringiensis | Domain II-loop2
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 12/2010, Volume 78, Issue 6, pp. 1124 - 1134
The voltage-gated sodium channel Na-v 1.7 plays a crucial role in pain, and drugs that inhibit hNa(v) 1.7 may have tremendous therapeutic potential. ProTx-II... 
BIOPHYSICAL PROPERTIES | ALPHA-SUBUNIT | SODIUM-CHANNELS | JINGZHAOTOXIN-I | PHARMACOLOGY | DOMAIN-II | PHARMACOLOGY & PHARMACY | PARAMYOTONIA | SCORPION TOXIN | BINDING | EXPRESSION
Journal Article
BLOOD, ISSN 0006-4971, 04/2009, Volume 113, Issue 16, pp. 3792 - 3800
Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated... 
RECOMBINANT IMMUNOTOXIN | HAIRY-CELL LEUKEMIA | PSEUDOMONAS EXOTOXIN-A | PHASE-I TRIAL | GROWTH-FACTOR-ALPHA | DOMAIN-II | RFB4(DSFV)-PE38 BL22 | ANTIGEN PRESENTATION | ANTITUMOR-ACTIVITY | HEMATOLOGY | CATHEPSIN-S
Journal Article
by Liu, MM and Huang, R and Weisman, A and Yu, XY and Lee, SH and Chen, YL and Huang, C and Hu, SH and Chen, XH and Tan, WF and Liu, F and Chen, H and Shea, KJ
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 06/2018, Volume 140, Issue 22, pp. 6853 - 6864
We report a novel strategy for creating abiotic Bacillus thuringiensis (Bt) protein affinity ligands by biomimicry of the recognition process that takes place... 
MANDUCA-SEXTA | ALKALINE-PHOSPHATASE | BOMBYX-MORI MIDGUT | DOMAIN-II | CADHERIN-LIKE RECEPTOR | TRANSGENIC PLANTS | PHAGE DISPLAY | SEXTA BT-R-1 RECEPTOR | IMPRINTED POLYMER | CHEMISTRY, MULTIDISCIPLINARY | RATIONAL DESIGN
Journal Article
Journal Article
CELL, ISSN 0092-8674, 10/2004, Volume 119, Issue 3, pp. 369 - 380
The HCV internal ribosome entry site (IRES) directly regulates the assembly of translation initiation complexes on viral mRNA by a sequential pathway that is... 
ELEMENT | HEPATITIS-C VIRUS | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | 5' NONTRANSLATED REGIONS | DOMAIN-II | SUBUNITS | RIBOSOME ENTRY SITE | INTERNAL INITIATION | MUTATIONAL ANALYSIS | BINDING | CELL BIOLOGY
Journal Article
Nucleic acids research, ISSN 0305-1048, 06/2019, Volume 47, Issue 10, pp. 5307 - 5324
Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with the liver-specific microRNA, miR-122. miR-122 binds to two sites in the 5... 
REPLICATION | HEPATITIS-C VIRUS | CRYSTAL-STRUCTURE | SHAPE-ANALYSIS | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMAIN-II | LONG-RANGE INTERACTIONS | RNA SECONDARY STRUCTURE | TRANSLATION | UNTRANSLATED REGION | RNA and RNA-protein complexes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, ISSN 0005-2736, 05/2017, Volume 1859, Issue 5, pp. 835 - 844
The human voltage-gated sodium channel sub-type 1.7 (hNa(v)1.7) is emerging as an attractive target for the development of potent and sub-type selective novel... 
VENOM | MODIFIER | TARANTULA TOXINS | Gating modifier toxin | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTX-II | SENSOR | Pain therapeutic | Peptide-membrane interactions | NA(V)1.7 | PAIN | BIOPHYSICS | Huwentoxin | DOMAIN-II | Drug design | Venom peptide | ELECTROSTATICS | HUWENTOXIN-IV
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, pp. E1857 - E1865
Voltage-gated sodium channels (Navs) play crucial roles in excitable cells. Although vertebrate Nav function has been extensively studied, the detailed... 
voltage gating | ACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | mu-conotoxin | MU-CONOTOXIN-KIIIA | GATING TRANSITIONS | DOMAIN-II | CHEMICAL-SYNTHESIS | slow inactivation | NA+-CHANNELS | K+ CHANNEL | beta-scorpion toxin | relaxed state | CALCIUM-CHANNEL
Journal Article
VACCINE, ISSN 0264-410X, 04/2017, Volume 35, Issue 18, pp. 2463 - 2472
Plasmodium vivax is the most widely distributed malaria species and the most prevalent species of malaria in America and Asia. Vaccine development against P.... 
ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | METAANALYSIS | Malaria | IMMUNOLOGY | MALARIA VACCINE | Plasmodium vivax | IMMUNIZATION | INVASION | MEROZOITE SURFACE PROTEIN-1 | VACCINE CANDIDATE MSP1 | DOMAIN-II | PICHIA-PASTORIS | EX-VIVO | Recombinant vaccine
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 09/2018, Volume 84, Issue 17
Bacillus thuringiensis Cry1Ca is toxic to different Spodoptera species. The aims of this work were to identify the Cry1Ca-binding proteins in S. frugiperda, to... 
Spodoptera frugiperda | Aminopeptidase | Receptor | Bacillus thuringiensis | Cry1Ca | Mode of action | MANDUCA-SEXTA | LEPIDOPTERA-NOCTUIDAE | mode of action | MICROBIOLOGY | CADHERIN | receptor | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | aminopeptidase | DOMAIN-II | MIDGUT | RESISTANCE | MAIZE | BRUSH-BORDER MEMBRANE | PROTEINS
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2019, Volume 14, Issue 1, pp. 118 - 130
Gating modifier toxins (GMTs) from spider venom can inhibit voltage gated sodium channels (Na(V)s) involved in pain signal transmission, including the Na(V)1.7... 
VENOM | NA(V)1.7 | NMR CHEMICAL-SHIFTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMAIN-II | VOLTAGE SENSOR | CYSTINE KNOT | SODIUM-CHANNEL | LIPID-MEMBRANES | HUWENTOXIN-IV | BINDING
Journal Article