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Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, pp. 14329 - 14329
Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-alpha(TNF), a proinflammatory... 
APOPTOSIS | SIGNALING PATHWAYS | ACTIVATION | MLKL | PHOSPHORYLATION | TNF-INDUCED NECROPTOSIS | MULTIDISCIPLINARY SCIENCES | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | CELL-DEATH | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 23, pp. 6066 - 6077
Purpose: The induced death signals following oncogene inhibition underlie clinical efficacy of molecular targeted therapies against human cancer, and defects... 
METHYLATION | NECROSIS | ONCOLOGY | PHOSPHORYLATION | MITOCHONDRIAL | DOWNSTREAM | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | GASDERMIN-D | IDENTIFICATION | DFNA5
Journal Article
Journal Article
Journal Article
by Zhang, H and Xu, LJ and Qin, X and Chen, XF and Cong, H and Hu, LM and Chen, L and Miao, ZY and Zhang, WN and Cai, ZY and Zhuang, CL
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 14, pp. 6665 - 6681
Necroptosis, a form of programmed cell death, plays a critical role in various diseases, including inflammatory, infectious, and degenerative diseases. We... 
DESIGN | POTENT | CHEMISTRY, MEDICINAL | NECROSIS | PHOSPHORYLATION | DOWNSTREAM | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | BRAF | DISCOVERY | CELL-DEATH
Journal Article
Cell, ISSN 0092-8674, 05/2014, Volume 157, Issue 5, pp. 1175 - 1188
Journal Article
by Wu, X.-N and Wu, X-N and Yang, Z-H and Yang, Z.-H and Wang, X-K and Wang, X.-K and Zhang, Y and Zhang, Y and Wan, H and Wan, H and Song, Y and Song, Y and Chen, X and Chen, X and Shao, J and Shao, J and Han, J and Han, J
Cell Death and Differentiation, ISSN 1350-9047, 11/2014, Volume 21, Issue 11, pp. 1709 - 1720
Journal Article
Nature Communications, ISSN 2041-1723, 02/2015, Volume 6, Issue 1, pp. 6282 - 6282
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules.... 
RHEUMATOID-ARTHRITIS | NECROPTOSIS | MULTIDISCIPLINARY SCIENCES | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | DEPENDENT APOPTOSIS | CASPASE-8 | TNF-ALPHA | NF-KAPPA-B | INNATE IMMUNITY | Index Medicus
Journal Article
by Zhang, C and Luo, YQ and He, QL and Liu, S and He, AD and Yan, J
CLINICAL SCIENCE, ISSN 0143-5221, 04/2019, Volume 133, Issue 8, pp. 919 - 932
A dramatic increase in the incidence of inflammatory bowel disease (IBD) has been observed in the past two decades, mainly in developed countries and also in... 
INTESTINAL INFLAMMATION | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | INFLAMMATORY-BOWEL-DISEASE | NECROSIS | PERMEABILITY | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | BRAF | CONTRIBUTES
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 43, pp. 31268 - 31279
Journal Article