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Cell Death and Differentiation, ISSN 1350-9047, 10/2014, Volume 21, Issue 10, pp. 1511 - 1521
Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as... 
APOPTOSIS | COMPLEX | RIPOPTOSOME | MLKL | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | DOMAIN-LIKE | TNF-ALPHA | CELL-DEATH | CELL BIOLOGY | Protein Kinases - metabolism | Protein Structure, Tertiary | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Phosphorylation | Protein Kinases - genetics | Cell Survival | Humans | Protein Multimerization | Receptors, Tumor Necrosis Factor, Type I | Caspase 8 - metabolism | Imidazoles - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Necrosis - physiopathology | RNA Interference | Indoles - pharmacology | RNA, Small Interfering | Apoptosis - physiology | Enzyme Activation | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Receptor-Interacting Protein Serine-Threonine Kinases/genetics | Protein Kinases/genetics | Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors | Caspase 8/metabolism | Receptor-Interacting Protein Serine-Threonine Kinases/metabolism | Tumor Necrosis Factor-alpha/antagonists & inhibitors | Indoles/pharmacology | Life Sciences | Tumor Necrosis Factor-alpha/metabolism | Imidazoles/pharmacology | Immunology | Apoptosis/physiology | Protein Kinases/metabolism | Necrosis/physiopathology | Original Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 6, pp. E961 - E969
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 43, pp. 31268 - 31279
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 09/2016, Volume 23, Issue 9, pp. 1565 - 1576
Necroptosis is a caspase-independent form of cell death that is triggered by activation of the receptor interacting serine/threonine kinase 3 (RIPK3) and... 
MYOCARDIAL-INFARCTION | RECEPTOR-INTERACTING PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMAIN-LIKE PROTEIN | REPERFUSION INJURY | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | MEDIATES NECROPTOSIS | TNF-ALPHA | NECROPTOTIC CELL-DEATH | NF-KAPPA-B | CELL BIOLOGY | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Protein Kinases - genetics | Sepsis - etiology | Apoptosis - drug effects | Colitis - pathology | Male | Inflammation - metabolism | Sepsis - pathology | Sepsis - metabolism | Colitis - chemically induced | Female | Protein Kinases - deficiency | Reperfusion Injury - metabolism | Disease Models, Animal | Systemic Inflammatory Response Syndrome - metabolism | Lipopolysaccharides - toxicity | Reperfusion Injury - pathology | Mice, Inbred C57BL | Ceruletide - toxicity | Reperfusion Injury - mortality | Pancreatitis - chemically induced | Dextran Sulfate - toxicity | Mice, Knockout | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Systemic Inflammatory Response Syndrome - pathology | Animals | Colitis - metabolism | Pancreatitis - pathology | Systemic Inflammatory Response Syndrome - etiology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Pancreatitis - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Tumor Necrosis Factor alpha-Induced Protein 3 - deficiency | Original Paper
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2015, Volume 589, Issue 12, pp. 1352 - 1358
This study shows that specific microRNAs differentially regulated by ΔNp63α in cisplatin-sensitive and resistant squamous cell carcinoma (SSC) cells of larynx... 
microRNA | Tumor protein p63 | Necroptosis | Cisplatin | Chemoresistance | Cancer | death-assocated protein | TRAF | TRADD | TNF | cylindromatosis | ataxia telangiectasia mutated | UTR | TNF receptor associated factor | RIPK | inhibitor of apoptosis | immunoprecipitation | TNF-related apoptosis-inducing ligand | tumor necrosis factor receptor type 1-associated death domain protein | cisplatin | death-associated protein kinase | NSA | necrostatin | TNFR | autophagy-related protein | necrosulfonamide | TRAIL | MLKL | DAPK | untranslated region | BCL | phosphorylated | CIS | NEC | mixed lineage kinase domain-like | CYLD | SCC | receptor interacting protein kinase | ATG | tumor necrosis factor | IAP | ATM | TNF receptor | B-cell lymphoma | DAP3 | squamous cell carcinoma | CANCER-CELLS | TARGET | APOPTOSIS | NETWORK | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | AUTOPHAGY | CELL BIOLOGY | PLATFORM | RESISTANT | RIPOPTOSOME | NECROSIS | BIOPHYSICS | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Kinases - genetics | MicroRNAs - antagonists & inhibitors | Deubiquitinating Enzyme CYLD | Tumor Suppressor Proteins - antagonists & inhibitors | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Protein Kinases - chemistry | Drug Resistance, Neoplasm | MicroRNAs - metabolism | Necrosis | Protein Processing, Post-Translational - drug effects | Tumor Suppressor Proteins - genetics | Antineoplastic Agents - pharmacology | MicroRNAs - agonists | Cell Death - drug effects | Phosphorylation - drug effects | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Gene Silencing | Recombinant Proteins - chemistry | Transcription Factors - antagonists & inhibitors | Cisplatin - pharmacology | Transcription Factors - genetics | Transcription Factors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Cell Line, Tumor | Genes, Reporter - drug effects | RNA, Small Interfering | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors
Journal Article
Cell death & disease, ISSN 2041-4889, 2013, Volume 4, Issue 1, pp. e465 - e465
Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent... 
INDUCED CELL-DEATH | TARGET | APOPTOSIS | COMPLEX | MIXED LINEAGE KINASE | DOMAIN-LIKE | IDENTIFICATION | TNF | FACTOR RECEPTOR | NF-KAPPA B | CELL BIOLOGY | receptor-interacting protein kinases | smac-mimetic | inhibitor of apoptosis proteins TNF | INHIBITOR | necroptosis | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Caspase Inhibitors - pharmacology | Apoptosis - drug effects | Tumor Necrosis Factor-alpha - genetics | bcl-2 Homologous Antagonist-Killer Protein - deficiency | Caspase 8 - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Receptors, Tumor Necrosis Factor, Type I - metabolism | Recombinant Proteins - biosynthesis | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Quinolines - pharmacology | Necrosis | TNF Receptor-Associated Death Domain Protein - genetics | Caspase 8 - genetics | TNF Receptor-Associated Death Domain Protein - deficiency | Receptors, Tumor Necrosis Factor, Type I - deficiency | Amino Acid Chloromethyl Ketones - pharmacology | bcl-2-Associated X Protein - deficiency | TNF Receptor-Associated Death Domain Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Cell Line | bcl-2-Associated X Protein - metabolism | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Fibroblasts - pathology | Receptors, Tumor Necrosis Factor, Type I - genetics | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Fibroblasts - drug effects | Mice | Original
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 213 - 219
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from... 
CLAN | Caspase 1 | Nod2 | Nod1 | Nuclear factor κB (NF-κB) | Interleukin-1β | nuclear factor kappa B (NF-kappa B) | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | BACTERIAL PEPTIDOGLYCAN | SELF-ASSOCIATION | PROCASPASE-9 | interleukin-1 beta | CARD PROTEIN | SYNDROME | OLIGOMERIZATION | NF-KAPPA-B | Neuronal Apoptosis-Inhibitory Protein | Peptidoglycan - metabolism | Protein Kinases - metabolism | Kidney - embryology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Monocytes - metabolism | NF-kappa B - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Isoforms - metabolism | Cloning, Molecular | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Nod2 Signaling Adaptor Protein | Immunity, Innate | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | CARD Signaling Adaptor Proteins | Nod1 Signaling Adaptor Protein | Interleukin-1 - secretion | Nucleoside-Phosphate Kinase - metabolism | NB-ARC domain, nucleotide-binding domain shared by Apaf-1, certain R gene products and CED-4 | NACHT, NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) | TLR, Toll-like receptor | CARDIAK, CARD-containing interleukin-1β-converting-enzyme-associated kinase | Apaf-1, apoptotic protease-activating factor 1 | RICK, RIP-like interacting CLARP kinase | CLAN, CARD, LRR and NACHT domain-containing protein | interleukin-1β | ECL®, enhanced chemiluminescence | NAC, nucleotide-binding domain and CARD-containing protein | CARD, caspase-recruitment domain | NALP, NACHT, LRR and PYRIN protein 1 | PAN, PAAD- and NACHT-containing protein | NF-κB, nuclear factor κB | ORF, open reading frame | RIP2, receptor-interacting protein | LRR, leucine-rich repeat | IKK, inhibitory κB kinase | PAAD, pyrin, AIM (absent-in-melanoma), ASC (apoptosis-associated speck-like protein containing a CARD) and death-domain-like | PGN, peptidoglycan | LPS, lipopolysaccharide | RACE, rapid amplification of cDNA ends | nuclear factor κB (NF-κB) | PAMP, pathogen-associated molecular pattern | HEK-293T, human embryonic kidney
Journal Article
Journal Article
Journal Article