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1. Full Text In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization
by Shaw, C. D and Lonchamp, J and Downing, T and Imamura, H and Freeman, T. M and Cotton, J. A and Sanders, M and Blackburn, G and Dujardin, J. C and Rijal, S and Khanal, B and Illingworth, C. J. R and Coombs, G. H and Carter, K. C
Molecular microbiology, ISSN 0950-382X, 03/2016, Volume 99, Issue 6, pp. 1134 - 1148
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Parasitic Sensitivity Tests | Leishmania donovani - drug effects | Lipid Metabolism | Phosphorylcholine - analogs & derivatives | Antimony - pharmacology | Antiprotozoal Agents - pharmacology | Leishmania donovani - metabolism | Animals | Membrane Transport Proteins - genetics | Phosphorylcholine - pharmacology | Female | Leishmania donovani - genetics | Membrane Transport Proteins - metabolism | Leishmaniasis, Visceral - parasitology | Mice | Mice, Inbred BALB C | Mutation | Drug Resistance | Nepal | Antibiotics | Drug resistance | Metabolism | Parasitic diseases | Genomics | Index Medicus | s
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2. Full Text RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon–γ‐primed macrophages
by Flandin, Jean‐Frédéric and Chano, Frédéric and Descoteaux, Albert
European journal of immunology, ISSN 0014-2980, 02/2006, Volume 36, Issue 2, pp. 411 - 420
Innate immunity | Macrophages | Leishmania | Toll‐like receptors | Phagocytosis | Toll-like receptors | Life Sciences & Biomedicine | Immunology | Science & Technology | RNA, Small Interfering - genetics | RNA Interference - drug effects | Toll-Like Receptor 2 - genetics | Interleukin-1 Receptor-Associated Kinases | Intracellular Signaling Peptides and Proteins - immunology | Leishmaniasis, Visceral - immunology | Macrophages - parasitology | Adaptor Proteins, Signal Transducing - immunology | Antineoplastic Agents - pharmacology | Toll-Like Receptor 3 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Cell Line | Nitric Oxide - immunology | Leishmania donovani - immunology | Antineoplastic Agents - immunology | RNA, Small Interfering - pharmacology | Protein-Serine-Threonine Kinases - genetics | Toll-Like Receptor 3 - immunology | Inflammation - immunology | Myeloid Differentiation Factor 88 | Animals | Interferon-gamma - immunology | Leishmaniasis, Visceral - genetics | Inflammation - genetics | Toll-Like Receptor 2 - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Interferon-gamma - pharmacology | Index Medicus
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3. Full Text Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps
by Gabriel, Christelle and McMaster, W. Robert and Girard, Denis and Descoteaux, Albert
The Journal of immunology (1950), ISSN 0022-1767, 10/2010, Volume 185, Issue 7, pp. 4319 - 4327
Life Sciences & Biomedicine | Immunology | Science & Technology | Microscopy, Confocal | Leishmania donovani - immunology | DNA - immunology | Humans | Cells, Cultured | Fluorescent Antibody Technique | Neutrophils - immunology | Leishmania donovani - pathogenicity | Glycosphingolipids - immunology | Metalloendopeptidases - immunology | Index Medicus | Abridged Index Medicus | Life Sciences | Toxicology | Glycosphingolipids | DNA | Leishmania donovani | Neutrophils | Metalloendopeptidases
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4. Full Text Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes
by Boitz, Jan M and Gilroy, Caslin A and Olenyik, Tamara D and Paradis, Dustin and Perdeh, Jasmine and Dearman, Kristie and Davis, Madison J and Yates, Phillip A and Li, Yuexin and Riscoe, Michael K and Ullman, Buddy and Roberts, Sigrid C
Infection and immunity, ISSN 0019-9567, 2017, Volume 85, Issue 1
Polyamines | Arginase | Leishmania | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Ornithine Decarboxylase - metabolism | Cytosol - parasitology | Arginase - metabolism | Cells, Cultured | Leishmania infantum - parasitology | Microbodies - metabolism | Leishmaniasis, Visceral - metabolism | Polyamines - metabolism | Leishmania donovani - metabolism | Animals | Microbodies - parasitology | Cytosol - metabolism | Female | Leishmaniasis, Visceral - parasitology | Mice | Mice, Inbred BALB C | Leishmania infantum - metabolism | Putrescine - metabolism | Index Medicus
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5. Full Text Miltefosine Induces Apoptosis-Like Death in Leishmania donovani Promastigotes
by Caroline Paris and Philippe M. Loiseau and Christian Bories and Jaqueline Bréard
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2004, Volume 48, Issue 3, pp. 852 - 859
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Antiparasitic agents | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Chromatography, Agarose | Apoptosis - drug effects | Leishmania donovani - drug effects | Phosphatidylserines - metabolism | Colorimetry | Phosphorylcholine - analogs & derivatives | Antiprotozoal Agents - pharmacology | Tetrazolium Salts | Protease Inhibitors - pharmacology | Animals | Flow Cytometry | Cell Cycle | Phosphorylcholine - pharmacology | Thiazoles | DNA Fragmentation - drug effects | miltefosine | Index Medicus | Mechanisms of Action | Physiological Effects
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6. Full Text Miltefosine Affects Lipid Metabolism in Leishmania donovani Promastigotes
by M. Rakotomanga and S. Blanc and K. Gaudin and P. Chaminade and P. M. Loiseau
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2007, Volume 51, Issue 4, pp. 1425 - 1430
Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Leishmania donovani - metabolism | Animals | Parasitic Sensitivity Tests | Antiprotozoal Agents - metabolism | Leishmania donovani - drug effects | Phosphorylcholine - pharmacology | Lipid Metabolism - drug effects | Leishmania donovani - genetics | Phosphorylcholine - analogs & derivatives | Phosphorylcholine - metabolism | Antiprotozoal Agents - pharmacology | Index Medicus | Mechanisms of Action | Physiological Effects
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7. Full Text Leishmania promastigotes: building a safe niche within macrophages
by Moradin, Neda and Descoteaux, Albert
Frontiers in cellular and infection microbiology, ISSN 2235-2988, 2012, Volume 2, Issue 2, pp. 121 - 121
Host-Pathogen Interactions | Macrophages - parasitology | Animals | Humans | NADPH Oxidases - antagonists & inhibitors | Leishmania donovani - pathogenicity | Proton-Translocating ATPases - antagonists & inhibitors | Phagosomes - parasitology | Index Medicus | Life Sciences | Human health and pathology | Infectious diseases | macrophage | phagosome | lipophosphoglycan | Leishmania | Virulence
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8. Full Text Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)
by Seifert, Karin and Matu, Sangeeta and Javier Pérez-Victoria, F and Castanys, Santiago and Gamarro, Francisco and Croft, Simon L
International journal of antimicrobial agents, ISSN 0924-8579, 2003, Volume 22, Issue 4, pp. 380 - 387
Miltefosine | Hexadecylphosphocholine | Drug resistance | Leishmania | Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Antiparasitic agents | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Animals | Gene Amplification | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Leishmania donovani - drug effects | Phosphorylcholine - pharmacology | DNA, Protozoan - genetics | Leishmania donovani - genetics | Phosphorylcholine - analogs & derivatives | Antiprotozoal Agents - pharmacology | Drug Resistance | Index Medicus
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9. Full Text Changes in Lipid and Fatty Acid Composition During Intramacrophagic Transformation of Leishmania donovani Complex Promastigotes into Amastigotes
by Bouazizi‐Ben Messaoud, Hana and Guichard, Marion and Lawton, Philippe and Delton, Isabelle and Azzouz‐Maache, Samira
Lipids, ISSN 0024-4201, 05/2017, Volume 52, Issue 5, pp. 433 - 441
Leishmania donovani complex | Lipid variations | Phospholipids | Amastigotes | Fatty acids | Cholesterol | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Cell Line | Macrophages - chemistry | Sterols - analysis | Phospholipids - analysis | Fatty Acids - analysis | Macrophages - cytology | Leishmania donovani - growth & development | Life Cycle Stages | Macrophages - parasitology | Triglycerides - analysis | Animals | Dogs | Mice | Lipids - analysis | Leishmania | Analysis | Phytosterols | Physiological aspects | Lipids | Research | Chemical properties | Health aspects | Ergosterol | Transformation | Promastigotes | Purification | Detritus | Triglycerides | Infections | Parasites | Macrophages | Contamination | Phosphatidylinositol | Fatty acid composition | Sterols | Developmental stages | Microscopy | Internalization | Sphingomyelin | Phosphatidylserine | Index Medicus | Life Sciences | Original
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10. Full Text Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: Complex II inhibition results in increased pentamidine cytotoxicity
by Mehta, Ashish and Shaha, Chandrima
The Journal of biological chemistry, ISSN 0021-9258, 03/2004, Volume 279, Issue 12, pp. 11798 - 11813
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Electron Transport | Leishmania donovani - physiology | Reactive Oxygen Species | Calcium - metabolism | Glutathione - metabolism | Pentamidine - toxicity | Electron Transport Complex II - antagonists & inhibitors | Leishmania donovani - metabolism | Animals | Adenosine Triphosphate - metabolism | Cytosol - metabolism | Leishmania donovani - cytology | Apoptosis | Index Medicus
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11. Full Text Miltefosine (Hexadecylphosphocholine) Inhibits Cytochrome c Oxidase in Leishmania donovani Promastigotes
by Juan Román Luque-Ortega and Luis Rivas
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2007, Volume 51, Issue 4, pp. 1327 - 1332
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Cell Line | Electron Transport Complex IV - antagonists & inhibitors | Animals | Leishmania donovani - drug effects | Phosphorylcholine - pharmacology | Electron Transport Complex IV - drug effects | Leishmania donovani - enzymology | Phosphorylcholine - analogs & derivatives | Leishmania donovani - growth & development | Index Medicus | Mechanisms of Action | Physiological Effects
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