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EUROPEAN NEUROPSYCHOPHARMACOLOGY, ISSN 0924-977X, 08/2013, Volume 23, Issue 8, pp. 799 - 813
Currently available treatments have limited pro-cognitive effects for neuropsychiatric disorders, such as schizophrenia, Parkinson's disease and Alzheimer's... 
FREELY MOVING RATS | FOREST-VIRUS SYSTEM | Dopamine D3 receptor | PSYCHIATRY | Dopamine D3 receptor antagonist | HIGH-AFFINITY STATE | Cognition | NEUROSCIENCES | CLINICAL NEUROLOGY | POSITRON-EMISSION-TOMOGRAPHY | MESSENGER-RNA | IN-VIVO | PHARMACOLOGY & PHARMACY | CARD SORTING TEST | HEALTHY-VOLUNTEERS | PARKINSONS-DISEASE | WORKING-MEMORY
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 11/2013, Volume 719, Issue 1-3, pp. 25 - 33
Journal Article
NEUROIMAGE, ISSN 1053-8119, 10/2012, Volume 63, Issue 1, pp. 40 - 46
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal dopamine... 
Neuroimaging | Gambling | Impulsivity | DSM-IV | Dopamine | RELEASE | NEUROSCIENCES | DEPENDENCE | Striatum | FUNCTIONAL SUBDIVISIONS | TRANSMISSION | Addiction | AVAILABILITY | CONTINUOUS-INFUSION | VENTRAL STRIATUM | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | PARKINSONS-DISEASE
Journal Article
DRUG AND ALCOHOL DEPENDENCE, ISSN 0376-8716, 06/2014, Volume 139, pp. 100 - 105
Background: Evidence from animal models and postmortem human studies points to the importance of the dopamine D-3 receptor (D3R) in cocaine dependence (CD).... 
Human | PREFERRING LIGAND | Dopamine | HUMAN BRAIN | PSYCHIATRY | HIGH-AFFINITY STATE | SUBSTANCE ABUSE | D-3 | DRUG-SEEKING | ADDICTION | TRANSMISSION | POSITRON-EMISSION-TOMOGRAPHY | ENDOGENOUS DOPAMINE | Cocaine | [C-11](+)PHNO | BINDING | PET | D3 RECEPTORS
Journal Article
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, ISSN 1461-1457, 10/2017, Volume 20, Issue 10, pp. 788 - 796
Background: Cariprazine, a D-3 -preferring dopamine D-2/D-3 receptor partial agonist, is a new antipsychotic drug recently approved in the United States for... 
TREATMENT-RESISTANT DEPRESSION | CLINICAL-TRIAL | NEGATIVE SYMPTOMS | PSYCHIATRY | antidepressant | CHRONIC MILD STRESS | BIPOLAR I DISORDER | dopamine D-3 receptor | KNOCKOUT MICE | NEUROSCIENCES | CLINICAL NEUROLOGY | ACTIVE-CONTROLLED-TRIAL | anhedonia | PARTIAL AGONIST | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | anxiolytic | cariprazine | ACUTE EXACERBATION
Journal Article
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, ISSN 0028-1298, 02/2013, Volume 386, Issue 2, pp. 155 - 166
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6287 - 6314
Because of the large degree of homology among dopamine D-2-like receptors, discovering ligands capable of discriminating between the D-2, D-3, and D-4 receptor... 
CHEMISTRY, MEDICINAL | ANALOGS | DETERMINANTS | CRYSTAL-STRUCTURE | BIVALENT LIGANDS | PHARMACOLOGY | SEEKING BEHAVIOR | HIGH-AFFINITY | DOPAMINE-D-2 | ANTAGONISTS | ADDICTION
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, pp. 2690 - 2694
As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a... 
Drug addiction | CHEMISTRY, MEDICINAL | Dopamine receptor | D-2 | CHEMISTRY, ORGANIC | COCAINE | D-3 | G-protein coupled receptor (GPCR) | D3 RECEPTOR | BRAIN
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 11/2002, Volume 22, Issue 21, pp. 9595 - 9603
Journal Article
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, ISSN 1461-1457, 08/2012, Volume 15, Issue 7, pp. 989 - 994
In previous research, nicotine-dependent men exhibited lower putamen D-2/D-3 dopamine-receptor availability than non-smokers (Fehr et al. 2008), but parallel... 
nicotine dependence | PSYCHIATRY | NEUROSCIENCES | SPECT | CLINICAL NEUROLOGY | TRANSPORTER AVAILABILITY | D-2 receptors | REFERENCE TISSUE MODEL | PHARMACOLOGY & PHARMACY | [F-18]fallypride | REGISTRATION | dopamine | F-18-FALLYPRIDE | PET | sex differences | BRAIN
Journal Article
by Song, R and Yang, RF and Wu, N and Su, RB and Li, J and Peng, XQ and Li, X and Gaal, J and Xi, ZX and Gardner, EL
ADDICTION BIOLOGY, ISSN 1355-6215, 03/2012, Volume 17, Issue 2, pp. 259 - 273
The dopamine (DA) D3 receptor is posited to be importantly involved in drug reward and addiction, and D3 receptor antagonists have shown extraordinary promise... 
REINFORCING EFFICACY | INDUCED REINSTATEMENT | CONDITIONED PLACE PREFERENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | YQA14 | HIGH-AFFINITY | SUBSTANCE ABUSE | PROGRESSIVE-RATIO | D-3 receptor | self-administration | DRUG-SEEKING BEHAVIOR | Cocaine | ENHANCED BRAIN REWARD | SELECTIVE ANTAGONISM | TRIGGERED RELAPSE | dopamine | SB-277011A | PHARMACOLOGICAL ACTIONS
Journal Article
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, ISSN 1064-1297, 10/2012, Volume 20, Issue 5, pp. 352 - 363
Journal Article
by Song, R and Zhang, HY and Peng, XQ and Su, RB and Yang, RF and Li, J and Xi, ZX and Gardner, EL
NEUROPHARMACOLOGY, ISSN 0028-3908, 09/2013, Volume 72, pp. 82 - 87
The dopamine (DA) D-3 receptor (D3R) has received much attention in medication development for treatment of addiction. However, the functional role of the D3R... 
LOCALIZATION | Dopamine | Conditioned place preference | RHESUS-MONKEYS | KNOCKOUT MICE | NEUROSCIENCES | MUTANT MICE | D-3 receptor | YQA-14 | PHARMACOLOGY | WILD-TYPE MICE | SEEKING BEHAVIOR | PHARMACOLOGY & PHARMACY | Cocaine | Reward | AGONIST 7-OH-DPAT | RAT-BRAIN | ANTAGONISTS
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 01/2016, Volume 36, Issue 3, pp. 785 - 794
Similar to other addiction disorders, the cues inherent in many gambling procedures are thought to play an important role in mediating their addictive nature.... 
COCAINE-SEEKING | BEHAVIOR | addiction | ATTENTIONAL BIAS | NEUROSCIENCES | cues | NUCLEUS-ACCUMBENS | WAITING IMPULSIVITY | DECISION-MAKING | decision making | DRUG-ADDICTION | impulsivity | MEDIAL PREFRONTAL CORTEX | PARKINSON-DISEASE | D-AMPHETAMINE | dopamine
Journal Article
by Zhang, Y and Cheng, CY and He, DF and Shi, WB and Fu, CJ and Wang, XK and Zeng, CY
GENE, ISSN 0378-1119, 04/2016, Volume 580, Issue 2, pp. 89 - 95
Transcriptional gene silencing (TGS) induced by synthetic exogenous short interfering RNAs (siRNAs) that are fully complementary to gene promoters has been... 
TARGET | DIRECTED DNA METHYLATION | Let-7d | MICRORNAS | HISTONE METHYLATION | MAMMALIAN-CELLS | FAMILY | Dopamine D-3 receptor | GENETICS & HEREDITY | DNA methylation | Transcriptional gene silencing | EXPRESSION | TUMORIGENESIS | INTERFERING RNAS
Journal Article
by Chen, Y and Song, R and Yang, RF and Wu, N and Li, J
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 11/2014, Volume 743, pp. 126 - 132
Growing preclinical evidence suggests that dopamine D-3 receptor antagonists are promising for the treatment of addiction. We have previously reported a novel... 
Methamphetamine (METH) | Self-administration | Relapse | REINFORCING EFFICACY | Drug reward | CONDITIONED PLACE PREFERENCE | COCAINE-SEEKING | YQA14 | EMERGING RESEARCH | D3 RECEPTOR | ADDICTION | DEPENDENCE | Dopamine D-3 receptor | REINSTATEMENT | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | EXPRESSION
Journal Article
NEUROPHARMACOLOGY, ISSN 0028-3908, 05/2015, Volume 92, pp. 34 - 43
The dopamine D-3 receptor (D3R) has been shown to mediate many of the behavioral effects of psychostimulants associated with high abuse potential. This study... 
Self-administration | CUE-INDUCED REINSTATEMENT | Methamphetamine | RATS | PG01037 | NEUROSCIENCES | MICE LACKING | DISCRIMINATIVE-STIMULUS | DRUG-SEEKING BEHAVIOR | PHARMACOLOGY & PHARMACY | Cocaine | AGONIST 7-OH-DPAT | UP-REGULATION | Dopamine D-3 receptors | D3 RECEPTORS | BRAIN | Rhesus monkeys
Journal Article
BEHAVIOURAL BRAIN RESEARCH, ISSN 0166-4328, 05/2016, Volume 305, pp. 87 - 99
Elucidating the neurobiological mechanisms underlying individual differences in the extent to which reward cues acquire the ability to act as incentive stimuli... 
Dopamine | RATS | Sign-tracking | D-2 receptor | REWARD | NEUROSCIENCES | PREDICTION | CUE | Goal-tracking | D-3 receptor | INDIVIDUAL-DIFFERENCES | Motivation | INCENTIVE SALIENCE | NUCLEUS | NEURONS | BEHAVIORAL SCIENCES | ACCUMBENS CORE
Journal Article
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