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NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 10/2007, Volume 32, Issue 10, pp. 2125 - 2134
Converging evidence supports a role for mesocorticolimbic dopaminergic systems in a subject's ability to shift behavior in response to changing stimulus-reward... 
EXCITOTOXIC LESIONS | RHESUS-MONKEYS | PSYCHIATRY | PERFORMANCE | D-2-like receptors | FRONTAL-CORTEX | learning | PREFRONTAL SEROTONIN DEPLETION | D1 RECEPTORS | NEUROSCIENCES | CAUDATE-NUCLEUS | raclopride | reversal | COGNITIVE INFLEXIBILITY | PHARMACOLOGY & PHARMACY | visual-discrimination | dopamine | MARMOSET | WORKING-MEMORY
Journal Article
CHEMBIOCHEM, ISSN 1439-4227, 10/2002, Volume 3, Issue 10, pp. 946 - 961
The dopamine D-3 receptor has been recognized to play an important role in the molecular mechanisms of various neuropsychiatric disorders. The development of... 
PARTIAL AGONISTS | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-AFFINITY | dopamines | antagonist | G-protein-coupled receptors | D3 RECEPTOR | BEHAVIORAL PROFILE | COMPETITIVE ANTAGONIST | POTENT | neurotransmitters | LIMBIC SELECTIVITY | ANTIPSYCHOTIC-DRUGS | RAT IN-VIVO | medicinal chemistry
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 10/2013, Volume 23, Issue 20, pp. 5586 - 5591
A series of new 1,4-disubstituted triazoles was prepared from appropriate arylacetylenes and aminoalkylazides using click chemistry methodology. These... 
CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | SCHIZOPHRENIA | DISORDERS | D-3-RECEPTOR ANTAGONISTS | ANTIPARKINSONIAN DRUGS | AGONISTS | LEVODOPA | 1,2,3-Triazoles | CYCLOADDITION | LINKING | Synthesis | Click chemistry | Binding assays | DERIVATIVES | Microwaves | Dopamine receptors
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 03/2009, Volume 34, Issue 4, pp. 1078 - 1086
The dopamine D-2 receptors exist in two states: a high-affinity state (D-2(high)) that is linked to second messenger systems, is responsible for functional... 
D-2/3 AGONIST | INTACT-CELLS | HUMAN BRAIN | PSYCHIATRY | D-2 | high-affinity state | schizophrenia | D-3 | NEUROSCIENCES | psychosis | POSITRON-EMISSION-TOMOGRAPHY | [C-11]-(+)-PHNO | IN-VIVO | D2(HIGH) RECEPTORS | ENDOGENOUS DOPAMINE | PHARMACOLOGY & PHARMACY | AGONIST RADIOTRACER | BINDING | AMPHETAMINE
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 01/1999, Volume 20, Issue 1, pp. 60 - 80
The dopamine D-2 and D-3 receptors are members of the D-2 subfamily that includes the D-2, D-3 and D-4 receptor. In the mt, the D-3 receptor exhibits a... 
dopamine D-2 receptor | PSYCHIATRY | ALZHEIMERS-DISEASE | dopamine D-3 receptor | NEUROSCIENCES | LATERAL GENICULATE-NUCLEUS | ORGANIZATION | MESSENGER-RNAS | D2 RECEPTORS | nonisotopic in situ hybridization | human brain | PRIMATE SUBSTANTIA-NIGRA | receptor binding | HUMAN-BRAIN | PHARMACOLOGY & PHARMACY | BASAL FOREBRAIN | RAT-BRAIN | VENTRAL STRIATUM
Journal Article
PHYSIOLOGY & BEHAVIOR, ISSN 0031-9384, 05/2019, Volume 203, pp. 25 - 32
Eating a high fat laboratory chow enhances sensitivity of rats to the behavioral effects of drugs that act on dopamine systems (e.g., cocaine). Further, in... 
Dopamine | Rats | Sex differences | LOCOMOTOR-ACTIVITY | COCAINE | High fat diet | ADOLESCENT | SUPPLEMENTATION | RESPONSES | CHOW | Addiction | D2 RECEPTOR | SYSTEMS | BEHAVIORAL SCIENCES | PSYCHOLOGY, BIOLOGICAL | ANTAGONISTS
Journal Article
Psychopharmacology, ISSN 0033-3158, 2015, Volume 232, Issue 7, pp. 1279 - 1289
The dopamine (DA) D-2 and D-3 receptors have been associated with cocaine abuse. A recent study with the D-3 receptor (D3R) partial agonist PG619 found that it... 
Self-administration | Cocaine | Monkeys | Dopamine D 3 receptors | Methamphetamine | TRANSPORTER | PSYCHIATRY | INVOLVEMENT | RATS | DISORDERS | AGONISTS | NEUROSCIENCES | DEPENDENCE | TRIAL | PHARMACOLOGY & PHARMACY | CYNOMOLGUS MONKEYS | ANTAGONISTS | AMPHETAMINE | Dopamine D-3 receptors
Journal Article
Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, 11/2015, Volume 35, Issue 11, pp. 1812 - 1818
Positron emission tomography with antagonist radiotracers has showed that striatal dopamine D-2/3 receptor (D2/3R) availability decreases with age. However, no... 
C]-(+)-PHNO | receptor | aging | positron emission tomography | dopamine | C]-Raclopride | HUMANS | D-2 receptor | SUBSTANTIA-NIGRA | NEUROSCIENCES | DECLINE | DENSITY | D-3 receptor | [C-11]-(+)-PHNO | ENDOCRINOLOGY & METABOLISM | HUMAN-BRAIN | LIGAND | HEMATOLOGY | BINDING | [C-11]-Raclopride | PET | AGONIST
Journal Article
by Cho, DI and Zheng, M and Kim, KM
ARCHIVES OF PHARMACAL RESEARCH, ISSN 0253-6269, 10/2010, Volume 33, Issue 10, pp. 1521 - 1538
Journal Article
by Xing, B and Kong, H and Meng, X and Wei, S.G and Xu, M and Li, S.B
Neuroscience, ISSN 0306-4522, 2010, Volume 169, Issue 4, pp. 1511 - 1519
Abstract Experimental evidence suggests the involvement of the brain dopaminergic system in learning and memory processes, although the associated molecular... 
Neurology | II MUTANT MICE | MOLECULAR-BIOLOGY | signaling | Morris water maze | ACTIVATED PROTEIN-KINASE | spatial learning | ELEMENT-BINDING PROTEIN | KNOCKOUT MICE | SYNAPTIC PLASTICITY | NEUROSCIENCES | mitogen-activated protein kinase | dopamine receptors | GENE-EXPRESSION | LONG-TERM POTENTIATION | D1 RECEPTOR | Brain
Journal Article
PHARMACOLOGY & THERAPEUTICS, ISSN 0163-7258, 11/2010, Volume 128, Issue 2, pp. 229 - 273
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 02/2013, Volume 60, pp. 42 - 50
A series of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole was synthesized to explore the influence of two structural features -... 
Isoquinoline-sulfonamides | DESIGN | CHEMISTRY, MEDICINAL | Dopamine | Serotonin | BEHAVIOR | Schizophrenia | Depression | D-2 partial agonist | D-3 | Aripiprazole | 5-HT2A antagonist | DISCOVERY | Long-chain arylpiperazines | 2,3-Dichlorophenylpiperazine | LIGANDS | AFFINITY | 5-HT7 RECEPTOR | DISORDER | AGENTS | Quinoline-sulfonamides | 5-HT7 antagonist
Journal Article
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, ISSN 0362-4803, 02/2016, Volume 59, Issue 2, pp. 48 - 53
There is still no efficient fluorine-18-labeled dopamine D-3 subtype selective receptor ligand for studies with positron emission tomography. We aim at... 
SUBTYPE | CHEMISTRY, ANALYTICAL | CHEMISTRY, MEDICINAL | nucleophilic aromatic F-18-fluorination | ANALOGS | BIOCHEMICAL RESEARCH METHODS | phenylazocarboxylic esters | dopamine D-3 receptor | D3 RECEPTOR | FUNCTIONALIZED LINKING CHAINS | THERAPEUTIC AGENTS | positron emission tomography | ANTAGONISTS | PET | ALCOHOLISM
Journal Article
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 02/2013, Volume 128, Issue 1-2, pp. 52 - 57
Background: Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging... 
Cannabis | Raclopride | receptor | Dopamine | D | Marijuana | Positron emission tomography | MONOAMINE-OXIDASE | PSYCHIATRY | SUBSTANCE ABUSE | D-2 receptor | RELEASE | NUCLEUS-ACCUMBENS | POSITRON-EMISSION-TOMOGRAPHY | DOPAMINE D2 RECEPTORS | IN-VIVO | HUMAN-BRAIN | RAT-BRAIN | BINDING | ALCOHOL DEPENDENCE
Journal Article
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 10/2004, Volume 176, Issue 1, pp. 57 - 65
Rationale: The dopamine (DA) D-3 receptor is preferentially expressed in the mesolimbic system. We have previously shown that selective D-3 receptor blockade... 
accumbens | stress | HEROIN-SEEKING | cocaine | relapse | RHESUS-MONKEYS | PSYCHIATRY | addiction | MEDICATION DEVELOPMENT | D-3 antagonist | NEUROSCIENCES | PREFRONTAL CORTEX | D3 RECEPTOR | NUCLEUS-ACCUMBENS | INDUCED RELAPSE | reinstatement | self-administration | CORTICOTROPIN-RELEASING FACTOR | PHARMACOLOGY & PHARMACY | AGONIST 7-OH-DPAT | dopamine | SB-277011A | INSITU HYBRIDIZATION HISTOCHEMISTRY
Journal Article
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 05/2008, Volume 197, Issue 4, pp. 549 - 556
Introduction Cannabis users have been reported to have decreased regional cerebral glucose metabolism after short periods of abstinence. The purpose of this... 
LOCALIZATION | ACTIVATION | PSYCHIATRY | cannabis | MARIJUANA USERS | D-2/D-3 receptor | NEUROSCIENCES | ADDICTION | ABUSERS | [18F]-FDG center dot [11C]-raclopride | DOPAMINE | dependence | HUMAN-BRAIN | PHARMACOLOGY & PHARMACY | glucose metabolism | BINDING | ASSOCIATION | PET
Journal Article
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, ISSN 0028-1298, 02/2013, Volume 386, Issue 2, pp. 167 - 176
Growing evidence indicates that dopamine (DA) D-3 receptors are involved in the control of drug-seeking behavior and may play an important role in the... 
Dopamine | COCAINE-SEEKING BEHAVIOR | CUE-INDUCED REINSTATEMENT | HIGH-AFFINITY | Selective antagonists | D3 receptor | Substance use disorders | PROGRESSIVE-RATIO | POSITRON-EMISSION-TOMOGRAPHY | Addiction | Impulse control disorders | IN-VIVO | DRUG-ADDICTION | PHARMACOLOGY & PHARMACY | ENHANCED BRAIN REWARD | POTENTIAL ANTIPSYCHOTIC AGENT
Journal Article
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, ISSN 0271-0749, 02/2005, Volume 25, Issue 1, pp. 6 - 11
Risperidone is an atypical antipsychotic agent with efficacy for both positive and negative symptoms of schizophrenia. Risperidone is a potent dopamine D-3... 
CLOZAPINE | ASSOCIATION ANALYSIS | STIMULATION | ANTAGONIST | PSYCHIATRY | GENDER DIFFERENCES | PHARMACOLOGY & PHARMACY | DOPAMINE D3 RECEPTOR | CHRONIC-SCHIZOPHRENIA | PHARMACOGENETICS | TARDIVE-DYSKINESIA | GENE POLYMORPHISM
Journal Article
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