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Pain, ISSN 0304-3959, 06/2011, Volume 152, Issue 6, pp. 1317 - 1326
The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether... 
Nociception | GABA | Sensitization | Inhibition | Dorsal horn
Journal Article
PAIN, ISSN 0304-3959, 05/2019, Volume 160, Issue 5, pp. 987 - 988
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2018, Volume 38, Issue 49, pp. 10489 - 10504
Mechanical allodynia, a widespread pain symptom that still lacks effective therapy, is associated with the activation of a dorsally directed polysynaptic... 
Inflammation | Pain | Serotonin | PKC-gamma | Medullary dorsal horn | 5-HT2A
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 06/2017, Volume 95, Issue 6, pp. 1307 - 1318
Neuronal inhibition mediated by GABAA receptors constrains nociceptive processing in the spinal cord, and loss of GABAergic inhibition can produce allodynia... 
GABA | inhibition | nociception | sensitization | dorsal horn
Journal Article
Neuroscience, ISSN 0306-4522, 08/2018, Volume 384, pp. 329 - 339
Clinical and basic science research have revealed persistent effects of early-life injury on nociceptive processing and resulting pain sensitivity. While... 
inhibition | pain | synapse | metabotropic | dorsal horn | Dorsal horn
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 08/2019, Volume 20, Issue 17, p. 4177
Diverse transcriptional controls in the dorsal horn have been observed in pain hypersensitivity. However, the understanding of the exact causes and mechanisms... 
CDK9 | Hes1 | neuropathic pain | RNAPII | dorsal horn
Journal Article
NATURE, ISSN 0028-0836, 01/2008, Volume 451, Issue 7176, pp. 330 - U6
Inflammatory diseases and neuropathic insults are frequently accompanied by severe and debilitating pain, which can become chronic and often unresponsive to... 
PERIPHERAL-NERVE INJURY | NEUROPATHIC PAIN | CORD | SUPERFICIAL DORSAL HORN | INHIBITION | RAT | ANION GRADIENT | MULTIDISCIPLINARY SCIENCES | NEURONS | HYPERALGESIA | BENZODIAZEPINES
Journal Article
06/2012
The mammalian central nervous system maintains a delicate balance between neuronal excitation and inhibition. Conventional synaptic inhibition is mediated... 
tonic inhibition | gabapentin | dorsal horn | GABA | nociception | 0719 | neuronal excitability | 0317
Dissertation
NATURE, ISSN 0028-0836, 08/2003, Volume 424, Issue 6950, pp. 778 - 783
Pain after nerve damage is an expression of pathological operation of the nervous system 1,2, one hallmark of which is tactile allodynia-pain hypersensitivity... 
CORD | CYTOKINES | PAIN | RAT | MULTIDISCIPLINARY SCIENCES | ATP P-2X RECEPTORS | INVOLVEMENT | SYNAPTIC TRANSMISSION | RELEASE | DORSAL HORN NEURONS | BRAIN
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 06/2012, Volume 209, Issue 6, pp. 1121 - 1134
Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level.... 
MEDICINE, RESEARCH & EXPERIMENTAL | MOLECULAR-DYNAMICS | CANNABIDIOL | SENSITIZATION | SPINAL-CORD | DELTA-TETRAHYDROCANNABINOL | MICE | HYPERALGESIA | IMMUNOLOGY | NERVE INJURY | DORSAL-HORN | MODULATION
Journal Article
Journal Article
Gene, ISSN 0378-1119, 11/2019, Volume 719, p. 144080
Trigeminal neuropathic pain is seen as a huge clinical challenge. Although numerous drugs have been developed to treat the condition, some patients have shown... 
PTEN | JAK2 | Trigeminal neuropathic pain | Medullary dorsal horn | Dexmedetomidine
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 04/2009, Volume 29, Issue 13, pp. 4076 - 4088
Neuropathic pain results from damage to the peripheral sensory nervous system, which may have a number of causes. The calcium channel subunit alpha(2)delta-1... 
INDUCED TACTILE ALLODYNIA | ROOT GANGLION NEURONS | INJURED RATS | SUPERFICIAL DORSAL-HORN | SYNAPTIC-TRANSMISSION | GENE-EXPRESSION | SPINAL-CORD | PERIPHERAL NEUROPATHY | GATED CA2+ CHANNELS | UP-REGULATION | NEUROSCIENCES
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 139, Issue 2, pp. 267 - 284
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 05/2008, Volume 28, Issue 20, pp. 5189 - 5194
Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries, plays an essential role in the induction and maintenance of... 
proinflammatory cytokines | ACTIVATION | GABAERGIC INHIBITION | RAT | PERSISTENT PAIN | INFLAMMATORY PAIN HYPERSENSITIVITY | PICs | NEUROSCIENCES | DORSAL-HORN | SENSORY NEURONS | FACTOR-ALPHA | NEUROPATHIC PAIN | soluble IL-6 receptor | IPSC | glycine | GABA | SUBSTANTIA-GELATINOSA | EPSC | disinhibition
Journal Article