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Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, ISSN 0167-8140, 08/2019
To analyse changes in 2-year overall survival (OS ) with radiotherapy (RT) dose, dose-per-fraction, treatment duration and chemotherapy use, in data compiled... 
Journal Article
Current Medical Research and Opinion, ISSN 0300-7995, 08/2017, Volume 33, Issue 8, pp. 1433 - 1449
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 03/2013, Volume 106, Issue 3, pp. 333 - 340
Background The simultaneous integrated boost (SIB) technique with dose per fraction slightly higher than 2 Gy offers the advantages of shortening the treatment... 
Head and neck carcinoma IMRT Simultaneous integrated boost Dose escalation
Journal Article
12/2010
Background and Purpose: Dose escalation improves local control in prostate cancer. In this study we assess the feasibility of dose escalation to prostate and /... 
dose escalation | intensity-modulated radiotherapy | acute toxicity | Prostate cancer
Web Resource
Radiotherapy and Oncology, ISSN 0167-8140, 06/2016, Volume 119, Issue 3, pp. 398 - 404
Background and purpose Local recurrences after radiotherapy are dose-dependent and occur in the dominant intraprostatic lesion (DIL). The purpose of this study... 
Dose escalation | Toxicity | Intraprostatic lesion | Prostate cancer
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 07/2017, Volume 35, Issue 19, pp. 2216 - 2216
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 02/2010, Volume 28, Issue 5, pp. 780 - 787
Purpose To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics (PKs), pharmacodynamics, and preliminary anticancer activity of ramucirumab... 
LIVER METASTASES | DOSE-ESCALATION | MALIGNANT-TUMORS | ONCOLOGY | TYROSINE KINASE | DAYS ON/7 DAYS | RAF KINASE | REFRACTORY SOLID TUMORS | ANTITUMOR-ACTIVITY | RENAL-CELL CARCINOMA | METASTATIC COLORECTAL-CANCER
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2017, Volume 35, Issue 19, pp. 2215 - 2216
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2008, Volume 70, Issue 1, pp. 96 - 101
The purpose of this study was to characterize the oncologic results and toxicity profile of patients treated with I implants using the dose delivered to 90% of... 
Toxicity profile | Brachytherapy | Dose escalation | Prostate cancer
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2018, Volume 24, Issue 18, pp. 4357 - 4364
A number of novel model-based and model-assisted designs have been proposed to find the MTD in phase I clinical trials, but their differences and relative pros... 
DOSE-ESCALATION | ONCOLOGY | INTERVAL DESIGN | CLINICAL-TRIALS | CONTINUAL REASSESSMENT METHOD | TOXICITY | CANCER
Journal Article
Japanese Journal of Cancer and Chemotherapy, ISSN 0385-0684, 01/2017, Volume 44, Issue 1, pp. 47 - 51
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 11/2014, Volume 113, Issue 2, pp. 204 - 209
Background and purpose Hypoxia-driven intervention (oxygen manipulation or dose escalation) could overcome radiation resistance linked to tumor hypoxia. Here,... 
18 F-FAZA | Carbogen | Dose escalation | EPR | Hypoxia
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 6, pp. 2905 - 2915
Hepatocellular carcinoma (HCC) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Aberrant fibroblast growth factor 19... 
DOSE-ESCALATION | PONATINIB | CHEMISTRY, MEDICINAL | COVALENT INHIBITORS | FGF19 | JNJ-42756493 | PHASE-I | FIBROBLAST-GROWTH-FACTOR-19 | EXPRESSION | DISCOVERY | INSIGHTS
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 1, pp. 64 - 76
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 11/2014, Volume 113, Issue 2, pp. 204 - 209
Hypoxia-driven intervention (oxygen manipulation or dose escalation) could overcome radiation resistance linked to tumor hypoxia. Here, we evaluated the value... 
Hypoxia | Carbogen | 18F-FAZA | Dose escalation | EPR
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 08/2019, Volume 25, Issue 16, pp. 4888 - 4897
Here, we report results of the first phase I study of erdafitinib, a potent, oral pan-FGFR inhibitor. Patients age ≥18 years with advanced solid tumors for... 
MOLECULAR CHARACTERIZATION | DOSE-ESCALATION | ONCOLOGY | FGF RECEPTORS | SENSITIVITY | BLADDER | MUTATIONS | CANCER | GENETIC ALTERATIONS
Journal Article
Journal of Inflammation, ISSN 1476-9255, 2010, Volume 7, Issue 1, pp. 41 - 41
Background: The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II... 
RHEUMATOID-ARTHRITIS | DOSE-ESCALATION | ACTIVATION | SYNOVIAL-FLUID | IMMUNOSUPPRESSION | MONOCLONAL-ANTIBODY | KINASE INHIBITOR | PROINFLAMMATORY CYTOKINES | IMMUNOLOGY | JAK3 | SELECTIVITY
Journal Article
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