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1. Full Text Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis
by Qiu, Xiaolan and Li, Zhi and Han, Xuedong and Zhen, Linlin and Luo, Chao and Liu, Minmin and Yu, Kun and Ren, Yi
Theranostics, ISSN 1838-7640, 2019, Volume 9, Issue 9, pp. 2618 - 2636
Tumor-derived nanovesicles have been widely used as a biomarker or therapeutic target in various tumor types. However, these nanovesicles have limited use in... 
Lung metastasis | Kupffer cells | flux | Breast cancer | DOTAP/DOPE liposome | Cell surface | Nucleolin | Tumor-derived nanovesicles | Phagocytosis | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | HUMAN MACROPHAGES | MOUSE | OXIDIZED LDL | MICRORNAS | BREAST-CANCER | Ca2+ flux | CD36 | PHOSPHATIDYLSERINE | CD44
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2. Full Text Immunization with a T cell-dependent protein antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies
by Akkaya, Munir and Akkaya, Billur and Sheehan, Patrick W and Miozzo, Pietro and Pena, Mirna and Qi, Chen-Feng and Manzella-Lapeira, Javier and Bolland, Silvia and Pierce, Susan K
European journal of immunology, ISSN 0014-2980, 11/2017, Volume 47, Issue 11, pp. 1890 - 1899
The development of vaccines for infectious diseases for which we currently have none, including HIV, will likely require the use of adjuvants that strongly... 
TLR 9 | CpG | DOTAP | Affinity maturation | Germinal center
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3. Full Text B cells produce type 1 interferons in response to the Toll-like receptor 9 agonist CpG-A conjugated to cationic lipids
by Akkaya, Munir and Akkaya, Billur and Miozzo, Pietro and Rawat, Mukul and Pena, Mirna and Sheehan, Patrick W and Kim, Ann S and Kamenyeva, Olena and Kabat, Juraj and Bolland, Silvia and Chaturvedi, Akanksha and Pierce, Susan K
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 8/2017, Volume 199, Issue 3, pp. 931 - 940
B cells express the innate receptor, toll-like receptor 9 (TLR9), which signals in response to unmethylated CpG sequences in microbial DNA. Of the two major... 
TLR 9 | Interferon | CpG | B cells | DOTAP
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4. Treatment of lung cancer using nanoparticle drug delivery systems
by Chandolu, Vijay and Dass, Crispin R
Current Drug Discovery Technologies, ISSN 1570-1638, 06/2013, Volume 10, Issue 2, pp. 170 - 176
Drug delivery | PEG | DOTAP | SiRNA | Cisplatin | Apoptosis
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5. Full Text Role of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) in β-lactoglobulin aggregation
by Ma, Baoliang and Wang, Xiaofei and Liu, Yujie and Li, Zhihong and Zhang, Fan
Chemistry and Physics of Lipids, ISSN 0009-3084, 01/2018, Volume 210, pp. 76 - 81
Protein aggregation is a prevalent phenomenon. It is important to study protein aggregation under different solution conditions. In this study, using... 
Critical micelle concentration (CMC) | 1,2-dioleoyl-3-trimethylammonium-propane(DOTAP) | Spherical aggregation | Amyloid aggregation | β-lactoglobulin (β-LG) | BIOPHYSICS | PROTEIN AGGREGATION | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID FIBRIL FORMATION | 1,2-dioleoy1-3-trimethylammonium-propane (DOTAP) | beta-lactoglobulin (beta-LG)
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6. Full Text Membrane protein assembly into Nanodiscs
by Bayburt, Timothy H and Sligar, Stephen G
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 9, pp. 1721 - 1727
Nanodiscs are soluble nanoscale phospholipid bilayers which can self-assemble integral membrane proteins for biophysical, enzymatic or structural... 
Nanodisc | Membrane protein | Self-assembly | dipalmitoylphosphatidylcholine | octylglucoside | DDM | dodecylmaltoside | phosphatidylcholine | POPC | 1,2-dioleoyl-3-trimethylammonium-propane | DMPC | DPPC | size exclusion chromatography | dimyristoylphosphatidylcholine | membrane scaffold protein | rHDL | MSP | SAXS | SEC | phosphatidylserine | phosphatidylethanolamine | reconstituted high density lipoprotein | 1-palmitoyl-2-oleoyl phosphatidylcholine | DOTAP | phospholipid | small angle X-ray scattering | phosphatidylglycerol | ACTIVATION | DRUG-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | MOLECULE HEIGHT MEASUREMENTS | CYTOCHROME-P450 3A4 | APOLIPOPROTEIN | CELL BIOLOGY | NMR INVESTIGATIONS | LIPID-BILAYERS | BIOPHYSICS | RHODOPSIN | RECONSTITUTION | Humans | Models, Molecular | Membrane Lipids - chemistry | Animals | Membrane Proteins - chemistry | Membrane Proteins - physiology | Models, Biological | Protein Multimerization - physiology | Surface Properties | Membrane Lipids - metabolism | Nanostructures - chemistry | Membrane Proteins - metabolism | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Membrane Proteins | Self-Assembly | Nanodiscs
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7. Full Text A novel “in-feed” delivery platform applied for oral DNA vaccination against IPNV enables high protection in Atlantic salmon ( Salmon salar )
by Reyes, Miguel and Ramírez, Cesar and Ñancucheo, Ivan and Villegas, Ricardo and Schaffeld, Guillermo and Kiman, Luis and Gonzalez, Javier and Oyarzun, Patricio
Vaccine, ISSN 0264-410X, 2016, Volume 35, Issue 4, pp. 626 - 632
Abstract Background DNA vaccination has emerged as a promising tool against infectious diseases of farmed fish. Oral delivery allows stress-free administration... 
Allergy and Immunology | DNA vaccine | Salmon salar | Oral delivery | Liposome | Atlantic salmon | DOTAP | IPNV | Feed
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8. Full Text Amyloid-β aggregation on model lipid membranes: An atomic force microscopy study
by Hane, Francis and Drolle, Elizabeth and Gaikwad, Ravi and Faught, Erin and Leonenko, Zoya
Journal of Alzheimer's Disease, ISSN 1387-2877, 2011, Volume 26, Issue 3, pp. 485 - 494
Amyloid fibril formation is generally associated with many neurodegenerative disorders, including Alzheimer's disease (AD). Although fibril plaque formation is... 
1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC | 1,2-dioleoyl-3-trimethylammonium-propane, DOTAP | 1,2-dioleoyl-sn-glycero-3- phosphocholine, DOPC | amyloid fibril formation | amyloid-lipid interactions | 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol), DOPG | atomic force microscopy | Alzheimer's disease | FIBRIL FORMATION | DOPG | PROTEIN | ALZHEIMERS-DISEASE | 1,2-dioleoyl-sn-glycero-3-phospho-(1 '-rac-glycerol) | 1,2-dioleoyl-sn-glycero-3-phosphocholine DOPC | TOXICITY | BILAYERS | FIBRILLOGENESIS | NEUROTOXICITY | NEUROSCIENCES | OLIGOMERS | 1-40 PEPTIDE | amyloid-beta(1-42) | 1,2-dioleoyl-3-trimethylammonium-propane | DOTAP | ION CHANNELS | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine | DPPC | Gels | Membranes, Artificial | Phosphatidylcholines - chemistry | Quaternary Ammonium Compounds - chemistry | Membrane Lipids - chemistry | Peptide Fragments - chemistry | Phosphatidylglycerols - chemistry | Image Processing, Computer-Assisted | Lipid Bilayers | Microscopy, Atomic Force | Fatty Acids, Monounsaturated - chemistry | 1,2-Dipalmitoylphosphatidylcholine - chemistry | Software | Amyloid beta-Peptides - chemistry
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9. Full Text Enhancement of tumor suppressor RAR- protein expression by cationic liposomal-ATRA treatment in benzo(a)pyrene-induced lung cancer mice model
by Viswanathan, S and Grace, VMB and Danisha, JP
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, ISSN 0028-1298, 04/2019, Volume 392, Issue 4, pp. 415 - 426
Targeting the specific molecular proteins or genes which are responsible for the suppression of cancer growth is currently an emerging molecular method to... 
CELLS | APOPTOSIS | GROWTH-INHIBITION | METASTASIS | BETA EXPRESSION | Lung cancer | INDUCTION | Tumor suppressor | RAR-beta | CARCINOGENESIS | PHARMACOLOGY | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | RETINOIC-ACID-RECEPTOR | Liposomes | DOTAP | ATRA
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10. Full Text RNAi-based nanomedicines for targeted personalized therapy
by Daka, Ala and Peer, Dan
Advanced Drug Delivery Reviews, ISSN 0169-409X, 10/2012, Volume 64, Issue 13, pp. 1508 - 1521
RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in order for RNAi to serve as an ideal personalized therapeutics and... 
Nanoparticles | Clinical trials | In vivo | Short interfering RNA (siRNA) | Systemic delivery | Personalized medicine | RES | RNA | DsRNA | EPR | CNT | MAb | MPS | CME | TLR | ApoB | DOTMA | DOPE | RISC | DC-6-14 | MiRNA | P.I | I.V | ShRNA | PEG | PEI | DOTAP | SNALP | IN-VIVO DELIVERY | CHEMICAL-MODIFICATION | SIRNA DELIVERY-SYSTEM | CARBON NANOTUBES | MACROMOLECULAR THERAPEUTICS | SMALL INTERFERING RNA | SHORT HAIRPIN RNA | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | ANTISENSE OLIGONUCLEOTIDES | LIPID-LIKE MATERIALS | Animals | RNA Interference | Humans | Nanoparticles - administration & dosage | RNA, Small Interfering - administration & dosage | Nanomedicine | Precision Medicine | Drugs | Monoclonal antibodies | Drug delivery systems | Permeability | Vehicles
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11. Full Text Powerful anti-colon cancer effect of modified nanoparticle-mediated IL-15 immunogene therapy through activation of the host immune system
by Liu, Xiaoxiao and Li, Yanyan and Sun, Xiaodong and Muftuoglu, Yagmur and Wang, Bilan and Yu, Ting and Hu, Yuzhu and Ma, Lu and Xiang, Mingli and Guo, Gang and You, Chao and Gao, Xiang and Wei, Yuquan
Theranostics, ISSN 1838-7640, 2018, Volume 8, Issue 13, pp. 3490 - 3503
Rationale: Colorectal cancer (CRC) is the third most commonly diagnosed cancer around the world. Over the past several years, immunotherapy has demonstrated... 
Interleukin-15 | DOTAP | MPEG-PLA | Immunotherapy | Colorectal cancer | REGRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | colorectal cancer | EFFICACY | CYTOKINE | COMBINATION | interleukin-15 | NK CELLS | COLORECTAL-CANCER | immunotherapy | POTENTIAL ROLE | EXPRESSION
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12. Full Text Synthesis of NBD-Labeled DOTAP Analog to Track Intracellular Delivery of Liposome
by Kyung Oh Doh and and Bieong Kil Kim and Tae Jin Lee and Jong Won Park and Young Bae Seu
Journal of Microbiology and Biotechnology, ISSN 1017-7825, 2013, Volume 23, Issue 1, pp. 131 - 135
A DOTAP analog labeled by NBD on the head group (DTNBD) was designed and synthesized to label DOTAP liposome. The structure was confirmed by 1H NMR and FAB-MS,... 
DOTAP | fluorescent Lipid | cationic Liposome | transfection
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13. Full Text Diacylglycerol in Cationic Nanoparticles Stimulates Oxidative Stress‐Mediated Death of Cancer Cells
by Bae, Chun‐Sik and Ahn, Taeho
Lipids, ISSN 0024-4201, 11/2018, Volume 53, Issue 11-12, pp. 1059 - 1067
Previous reports have suggested that cargo‐free cationic nanoparticles (cNP) consisting of cationic monovalent lipids, such as... 
Nonlamellar | Reactive oxygen species | DOTAP | Cell death | Nanoparticle | Diacylglycerol | APOPTOSIS | FUSION | MITOCHONDRIAL | VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | INDUCTION | DELIVERY | TARGETED NANOPARTICLES | TRANSMISSION | NUTRITION & DIETETICS | LIPOSOMES | Index Medicus
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14. Full Text Enhancement of tumor suppressor RAR-β protein expression by cationic liposomal-ATRA treatment in benzo(a)pyrene-induced lung cancer mice model
by Viswanathan, S and Viswanathan, S and Berlin Grace, V M and Berlin Grace, V M and Danisha, J Perinba and Danisha, J Perinba
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 4/2019, Volume 392, Issue 4, pp. 415 - 426
Targeting the specific molecular proteins or genes which are responsible for the suppression of cancer growth is currently an emerging molecular method to... 
Neurosciences | Biomedicine | Lung cancer | Liposomes | RAR- β | DOTAP | Pharmacology/Toxicology | ATRA | Tumor suppressor | Immunohistochemistry | Liver | Benzo(a)pyrene | Cholesterol | Western blotting | Thin films | Proteins | Pyrene | Receptors | Tumor suppressor genes | Protein expression | Mice | Cations | Cancer | Tumors
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15. Full Text Association between Cationic Liposomes and Low Molecular Weight Hyaluronic Acid
by Gasperini, Antonio A. M and Puentes-Martinez, Ximena E and Balbino, Tiago Albertini and de Paula Rigoletto, Thais and de Sá Cavalcanti Corrêa, Gabriela and Cassago, Alexandre and Portugal, Rodrigo Villares and de La Torre, Lucimara Gaziola and Cavalcanti, Leide P
Langmuir, ISSN 0743-7463, 03/2015, Volume 31, Issue 11, pp. 3308 - 3317
This work presents a study of the association between low molecular weight hyaluronic acid (16 kDa HA) and cationic liposomes composed of egg... 
CELLS | MATERIALS SCIENCE, MULTIDISCIPLINARY | COMPLEXES | EPC/DOTAP/DOPE | CHEMISTRY, PHYSICAL | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | NANOPARTICLES | PROGRESS | GENE-THERAPY | CD44 | PROSPECTS | Liposomes - chemistry | Cations - chemistry | Molecular Weight | Phosphatidylethanolamines - chemistry | Hyaluronic Acid - chemistry
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16. Full Text Pharmacokinetics and therapeutic efficiency of a novel cationic liposome nano-formulated all trans retinoic acid in lung cancer mice model
by Berlin Grace, V.M and Viswanathan, S
Journal of Drug Delivery Science and Technology, ISSN 1773-2247, 06/2017, Volume 39, pp. 223 - 236
The externally given all retinoic acid (ATRA) for the treatment of certain solid cancers faces challenges such as stability, persistence, and effective... 
Nano-scale | Liposomes | DOTAP | Dialysis membrane | ATRA | Cholesterol | CELLS | STABILITY | IMMUNOSTIMULATION | COMBINATION | DELIVERY | INHIBITION | CISPLATIN | LIVER | PHARMACOLOGY & PHARMACY
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17. Immunopotentiation of cationic liposome DOTAP as an adjuvant of hepatitis B vaccine
by Yu, Gang and Hao, Peng-Liang and Han, Xi-Xin and Han, Jing and Zhao, Wei and Huang, Xiao-Yuan and Yang, Xiao-Ming
Chinese Journal of Biologicals, ISSN 1004-5503, 10/2016, Volume 29, Issue 10, pp. 1017 - 1026
Cationic liposome liposome | Antibody | Adjuvant | DOTAP | Hepatitis b vaccine
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18. Full Text Increasing cellular immune response in liposomal formulations of DOTAP encapsulated by fusion protein Hspx, PPE44, And Esxv, as a potential tuberculosis vaccine candidate
by Mansury, Davood and Ghazvini, Kiarash and Jamehdar, Saeid Amel and Badiee, Ali and Tafaghodi, Mohsen and Nikpoor, Amin Reza and Amini, Yousef and Jaafari, Mahmoud Reza
Reports of Biochemistry and Molecular Biology, ISSN 2322-3480, 2019, Volume 7, Issue 2, pp. 156 - 166
Due to the ineffectiveness of the BCG vaccine, especially in adult pulmonary tuberculosis (TB), and variable efficacies against childhood forms of TB,... 
Fusion Protein | Mycobacterium tuberculosis | 6'-Dibehenate | Trehalose 6 | DOTAP | Liposomes | Vaccines | 6’-Dibehenate | Original
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19. Full Text Mechanistic profiling of the siRNA delivery dynamics of lipid–polymer hybrid nanoparticles
by Colombo, Stefano and Cun, Dongmei and Remaut, Katrien and Bunker, Matt and Zhang, Jianxin and Martin-Bertelsen, Birte and Yaghmur, Anan and Braeckmans, Kevin and Nielsen, Hanne M and Foged, Camilla
Journal of Controlled Release, ISSN 0168-3659, 03/2015, Volume 201, pp. 22 - 31
Understanding the delivery dynamics of nucleic acid nanocarriers is fundamental to improve their design for therapeutic applications. We investigated the... 
Sustained release | siRNA | Drug delivery | PLGA | DOTAP | Nanomedicine | RNA INTERFERENCE | GENE DELIVERY | QUANTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | CATIONIC LIPIDS | PROTEIN CORONA | DNA COMPLEXES | RT-PCR | IN-VIVO | PHARMACOLOGY & PHARMACY | SUSTAINED-RELEASE | PLGA NANOPARTICLES | RNA, Small Interfering - chemistry | Lactic Acid - chemistry | Nanoparticles - chemistry | Humans | Polyglycolic Acid - chemistry | Cell Line, Tumor | Fatty Acids, Monounsaturated - chemistry | Green Fluorescent Proteins - genetics | Nanoparticles - administration & dosage | Quaternary Ammonium Compounds - chemistry | RNA, Small Interfering - administration & dosage | Nanoparticles | Atomic force microscopy | Genetic engineering | Polymer industry | Polymers | Analysis | Drugs | Phosphates | Drug delivery systems | Nucleic acids | Vehicles
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