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Journal Article
Oncotarget, ISSN 1949-2553, 03/2018, Volume 9, Issue 24, pp. 17104 - 17116
DNA double strand breaks (DSBs) induced by cancer therapeutic agents can lead to DNA damage repair or persistent DNA damage, which can induce apoptotic cell... 
Pharmacodynamic assay | DNA double strand breaks | Immunofluorescence | Multiplex | Apoptosis
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 84 - 96.e1
Background Asthma is related to airway inflammation and oxidative stress. High levels of reactive oxygen and nitrogen species can induce cytotoxic DNA damage.... 
Allergy and Immunology | NU7441 | cell death | House dust mite | asthma | DNA double-strand breaks | BEAS-2B | DNA repair | oxidative stress | DEPENDENT PROTEIN-KINASE | ANTIMALARIAL-DRUG ARTESUNATE | IMMUNOLOGY | MAMMALIAN-CELLS | ALLERGY | ALLERGIC-ASTHMA | NITRIC-OXIDE | HOMOLOGOUS RECOMBINATION | IONIZING-RADIATION | GENETIC-DISEASE | ATAXIA-TELANGIECTASIA | MOLECULAR-MECHANISMS | Asthma - metabolism | Eosinophils - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Caspase 3 - metabolism | Cell Death - immunology | Bronchoalveolar Lavage Fluid - immunology | DNA Breaks, Double-Stranded | Eosinophils - immunology | Respiratory Mucosa - pathology | Antigens, Dermatophagoides - immunology | Allergens - immunology | Cell Death - genetics | Respiratory Mucosa - immunology | Inflammation Mediators - metabolism | Female | Asthma - etiology | Eosinophils - pathology | Lung - metabolism | Disease Models, Animal | Lung - pathology | Cytokines - metabolism | Animals | DNA Repair | Mice | Respiratory Mucosa - metabolism | Lung - immunology | Pyroglyphidae - immunology | Medical colleges | Research institutes | DNA damage | DNA | Asthma | Proteins | Medical research | Allergens | Cell death | Analysis | Medicine, Experimental | Genetic research | B cells | Disease | Pathogenesis | Cytotoxicity | Inflammation | Kinases | Patients | Allergies | Human subjects | Airway management | Lungs | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2006, Volume 21, Issue 2, pp. 201 - 214
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2009, Volume 28, Issue 21, pp. 3413 - 3427
Homologous recombination (HR) and non‐homologous end joining (NHEJ) represent distinct pathways for repairing DNA double‐strand breaks (DSBs). Previous work... 
ataxia telangiectasia | Artemis | homologous recombination | double‐strand breaks | non‐homologous end joining | Double-strand breaks | Ataxia telangiectasia | Homologous recombination | Non-homologous end joining | BIOCHEMISTRY & MOLECULAR BIOLOGY | double-strand breaks | MAMMALIAN-CELLS | CELL BIOLOGY | REPLICATION FORKS | IN-VIVO | non-homologous end joining | GENE CONVERSION | DIRECTED REPAIR | CELL-CYCLE | END RESECTION | IONIZING-RADIATION | DSB REPAIR | SISTER-CHROMATID EXCHANGES | Humans | DNA Breaks, Double-Stranded - radiation effects | DNA-Binding Proteins - metabolism | Heterochromatin - metabolism | Gene Deletion | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | G2 Phase - radiation effects | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | DNA Helicases | Apoptosis Regulatory Proteins | BRCA2 Protein - metabolism | Fibroblasts - radiation effects | G1 Phase - radiation effects | Endonucleases | HeLa Cells | Proteins | Molecular biology | Genetic recombination | DNA repair | Radiation | Index Medicus
Journal Article
11/2013
DNA double-strand breaks (DSBs) are highly cytolethal DNA lesions. To protect genomic integrity and ensure cellular homeostasis, cells initiate a complex... 
DNA damage response | DNA double-strand breaks | chromatin | Molecular | ubiquitylation | Cell
Dissertation
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 54 - 60
Journal Article