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NATURE REVIEWS DRUG DISCOVERY, ISSN 1474-1776, 03/2017, Volume 16, Issue 3, pp. 203 - 221
In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | LUNG-CANCER | GROWTH-FACTOR-BETA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | POOR-PROGNOSIS | IN-VIVO | DOWN-REGULATION | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | OVARIAN-CANCER | MIR-200 FAMILY
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2019, Volume 104, Issue 5, pp. 1500 - 1507
There is emerging evidence that SHBG is substantially reduced in chronic metabolic diseases, including obesity and nonalcoholic fatty liver disease (NAFLD). We... 
DOWN-REGULATION | ALPHA | PREVALENCE | DISEASE | ENDOCRINOLOGY & METABOLISM
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 02/2019, Volume 202, Issue 4, pp. 1033 - 1038
Intricate life-versus-death decisions are programmed during T cell development, and the regulatory mechanisms that coordinate their activation and repression... 
SURVIVAL | DOWN-REGULATION | IMMUNOLOGY | ROR-GAMMA-T | EXPRESSION | GENES
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 08/2010, Volume 10, Issue 8, pp. 561 - 574
The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance,... 
INDUCED CELL-DEATH | TUMOR-NECROSIS-FACTOR | X-LINKED INHIBITOR | ONCOLOGY | STRUCTURAL BASIS | UBIQUITIN-PROTEIN LIGASE | PANCREATIC-CANCER | ALPHA-DEPENDENT APOPTOSIS | DOWN-REGULATION | TNF-ALPHA | COMPARATIVE GENOMIC HYBRIDIZATION
Journal Article
09/2013
Purpose: To investigate the effects of ursolic acid (UA) on expressions of ERK1, C-Jun, C-Myc and Cyclin D1 in Human Umbilical Vein Endothelial Cells (HUVEC),... 
Vascular endothelial cell | Glioma | Down-regulation | ERK signal pathway | Ursolic acid | Anti-cancer
Web Resource
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 3, pp. 454 - 466
Journal Article
Cancer Research, ISSN 0008-5472, 04/2007, Volume 67, Issue 8, pp. 3853 - 3861
Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. Agents that can either... 
INDUCED CELL-DEATH | APOPTOSIS | IN-VITRO | ACTIVATION | ONCOLOGY | CYCLIN D1 | ENDOTHELIAL-CELLS | DOWN-REGULATION | ADENOCARCINOMA CELLS | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 09/2014, Volume 14, Issue 9, pp. 632 - 641
Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However, during tumour progression and metastasis, cancerous epithelial... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | ACTIVATED PROTEIN-KINASE | ONCOLOGY | DOWN-REGULATION | ANCHORAGE-INDEPENDENT GROWTH | FACTOR-KAPPA-B | EXTRACELLULAR-MATRIX | FACTOR-I RECEPTOR | DOMINANT-NEGATIVE MUTANT | PROMOTES ANOIKIS RESISTANCE
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 04/2011, Volume 13, Issue 4, pp. 434 - U208
The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type2 diabetes mellitus so far remains elusive.... 
CAENORHABDITIS-ELEGANS | LIPID-METABOLISM | SMALL RNAS | AKT/PROTEIN-KINASE-B | DOWN-REGULATION | FAT-METABOLISM | TYPE-2 DIABETES-MELLITUS | GENOME-WIDE ASSOCIATION | RECEPTOR SUBSTRATE-1 | ADIPOSE-TISSUE | CELL BIOLOGY
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5
Background: Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology,... 
CANCER-CELLS | LUNG-CANCER | SUPPRESSOR | THERAPY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DOWN-REGULATION | N-MYC | PHASE-I | EXPRESSION | MYCN ONCOGENE
Journal Article
Organic Letters, ISSN 1523-7060, 03/2017, Volume 19, Issue 5, pp. 1168 - 1171
Furanharzianones A and B (2 and 3), two new harziane-type diterpenoids with a tetrahydrofuran and unusual 4/7/5/6/5 ring system, were obtained from the... 
DITERPENES | DOWN-REGULATION | CHEMISTRY, ORGANIC | COLORIMETRIC ASSAY | TRICHODERMA | GROWTH
Journal Article
Biological Conservation, ISSN 0006-3207, 07/2013, Volume 163, pp. 49 - 57
Preserving large tracts of natural habitats is essential to maintain biodiversity. Nevertheless, even large areas may still suffer from less “visible” impacts... 
Empty forests | Top-down regulation | Herbivory | Maxent | Seed dispersal | Trophic downgrading
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2007, Volume 179, Issue 3, pp. 1634 - 1647
1,25-Dihydroxyvitamin D-3 (1,25(OH)(2)D-3) can modulate immune responses, but whether it directly affects B cell function is unknown. Patients with systemic... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INHIBITION | DENDRITIC CELLS | SECRETING PLASMA-CELLS | P27 ACCUMULATION | GENE-EXPRESSION | DOWN-REGULATION | VITAMIN-D-RECEPTOR | IMMUNOLOGY | T-CELLS | MICROARRAY ANALYSIS
Journal Article