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Hepatology (Baltimore, Md.), ISSN 0270-9139, 2011, Volume 53, Issue 6, pp. 1895 - 1905
Drug‐induced liver injury occurs in general after several weeks and is often unpredictable. It is characterized by a large spectrum of lesions that includes... 
MITOCHONDRIAL BETA-OXIDATION | MICROVESICULAR STEATOSIS | IN-VITRO | DRUG-INDUCED PHOSPHOLIPIDOSIS | LIPID-METABOLISM | EXPRESSION ANALYSIS | HUMAN HEPATOCYTES | CYTOCHROMES P450 | FATTY LIVER-DISEASE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | Fatty Acid Synthase, Type I - genetics | Fatty Liver - pathology | Humans | Fatty Liver - chemically induced | Phosphoproteins - metabolism | Amiodarone - adverse effects | Oleic Acid - pharmacology | Lipogenesis - genetics | Up-Regulation - physiology | Lipid Metabolism - genetics | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Lipogenesis - physiology | Amiodarone - pharmacology | Carrier Proteins | Fatty Liver - metabolism | Membrane Proteins - genetics | Tetracycline - pharmacology | Up-Regulation - genetics | Tetracycline - adverse effects | Phosphoproteins - genetics | Down-Regulation - drug effects | Fatty Acid Synthase, Type I - metabolism | Stearoyl-CoA Desaturase - genetics | Down-Regulation - genetics | Triglycerides - metabolism | Down-Regulation - physiology | Up-Regulation - drug effects | Lipogenesis - drug effects | Carcinoma, Hepatocellular - pathology | Lipid Metabolism - drug effects | Liver Neoplasms - metabolism | Cell Line, Tumor | Stearoyl-CoA Desaturase - metabolism | Perilipin-4 | Lipid Metabolism - physiology | Perilipin-2 | Carcinoma, Hepatocellular - metabolism | Drugs | Fatty acids | Genes | Rodents | Up-Regulation | Hépatology and Gastroenterology | Oleic Acid | Down-Regulation | Lipid Metabolism | Amiodarone | Triglycerides | Liver Neoplasms | Fatty Acid Synthetase Complex, Type I | Tetracycline | Membrane Proteins | Fatty Liver | Life Sciences | Human health and pathology | Stearoyl-CoA Desaturase | Phosphoproteins | Carcinoma, Hepatocellular | Lipogenesis
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 27, pp. 11103 - 11108
Journal Article
Journal Article
Cancer cell, ISSN 1535-6108, 2019, Volume 36, Issue 4, pp. 385 - 401.e8
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an... 
histone methyltransferase | antigen presentation | immune evasion | polycomb | immunotherapy | MHC class I | epigenetic repression | cancer | bivalency | EZH2 | CELL LUNG-CANCER | ESSENTIAL GENES | ONCOLOGY | PD-1 BLOCKADE | DOWN-REGULATION | RESISTANCE | TUMOR-CELLS | EXPRESSION | T-CELLS | REPRESSIVE COMPLEX 2 | INNATE IMMUNITY | CELL BIOLOGY | Polycomb Repressive Complex 2 - antagonists & inhibitors | Tumor Escape - drug effects | DNA Methylation - immunology | Tumor Escape - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Histocompatibility Antigens Class I - metabolism | Histone Code - drug effects | Neoplasms - genetics | Epigenetic Repression - drug effects | Female | Gene Expression Regulation, Neoplastic - drug effects | Histocompatibility Antigens Class I - immunology | Gene Expression Regulation, Neoplastic - immunology | Histocompatibility Antigens Class I - genetics | Antigen Presentation - immunology | Down-Regulation - drug effects | Down-Regulation - genetics | Epigenetic Repression - immunology | Antineoplastic Agents, Immunological - pharmacology | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Antineoplastic Agents, Immunological - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Down-Regulation - immunology | Neoplasms - immunology | Cell Line, Tumor | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | Neoplasms - pathology | Polycomb Repressive Complex 2 - metabolism | Antigens | Epigenetic inheritance | Chromatin | Genes | Genomics | Embryonic stem cells | T cells | Stem cell research | Anopheles | Methyltransferases | Immunotherapy | Physiological aspects | Histones | Genetic engineering | Research institutes | Cancer
Journal Article
BMC plant biology, ISSN 1471-2229, 2014, Volume 14, Issue 1, pp. 116 - 116
Background: Brown algae are sessile macro-organisms of great ecological relevance in coastal ecosystems. They evolved independently from land plants and other... 
Primary metabolism | Copper stress response | Brown algae | ABC transporters | Heavy metal | Oxylipins | MARINE-ALGAE | SPECTROMETRY DATA | MAXIMUM-LIKELIHOOD | LAMINARIA-DIGITATA | FATTY-ACIDS | GENE ONTOLOGY | CELL-DEATH | PLANT SCIENCES | FUCUS-VESICULOSUS | HIGHER-PLANTS | NORTHERN CHILE | Metabolomics | Gas Chromatography-Mass Spectrometry | Humans | Gene Expression Profiling | Chromatography, High Pressure Liquid | Phylogeny | Phaeophyta - genetics | Phaeophyta - physiology | Amino Acids - metabolism | Photosynthesis - genetics | Stress, Physiological - drug effects | Copper - toxicity | Fatty Acids - metabolism | Stress, Physiological - genetics | Oxidative Stress - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Transcriptome - drug effects | Down-Regulation - drug effects | Down-Regulation - genetics | Metabolome - genetics | Discriminant Analysis | Up-Regulation - drug effects | Oxylipins - metabolism | Metabolic Networks and Pathways - genetics | Metabolome - drug effects | Signal Transduction - drug effects | Photosynthesis - drug effects | Least-Squares Analysis | Acclimatization - genetics | Metabolic Networks and Pathways - drug effects | Oxidative Stress - drug effects | Acclimatization - drug effects | Algal Proteins - metabolism | Phaeophyta - drug effects | Cluster Analysis | Physiological aspects | Evolution | Plants | Analysis | Oxidative stress | Discriminant analysis | Ecosystems | Algae | Genomics | Biology | Genomes | Metabolism | Gene expression | Ecosystem biology | Proteins | Studies | Signal transduction | Metabolites | Flowers & plants | Stress response | Photosynthesis | Copper | Up-Regulation | Fatty Acids | Oxidative Stress | Stress, Physiological | Transcriptome | Life Sciences | Signal Transduction | Down-Regulation | Metabolome | Acclimatization | Algal Proteins | Amino Acids | Metabolic Networks and Pathways | Phaeophyta
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 5/2008, Volume 105, Issue 19, pp. 7004 - 7009
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 47, pp. 19408 - 19413
Bromodomain and extra terminal domain (BET) proteins function as epigenetic signaling factors that associate with acetylated histones and facilitate... 
Betting | Cell growth | Messenger RNA | Genes | Cell lines | Cell cycle | Histones | Small interfering RNA | Down regulation | Lung neoplasms | Drug development | Chromatin | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | drug development | C-MYC | BROMODOMAIN INHIBITION | LEUKEMIA | chromatin | TUMORIGENESIS | EXPRESSION | AP-1 | BRD4 | FAMILY | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - pathology | Molecular Targeted Therapy | Gene Knockdown Techniques | Adenocarcinoma - genetics | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Triazoles - therapeutic use | Lung Neoplasms - genetics | Proto-Oncogene Proteins c-fos - metabolism | Nuclear Proteins - metabolism | Signal Transduction - genetics | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Down-Regulation - genetics | Azepines - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Drug Screening Assays, Antitumor | Adenocarcinoma | Epigenetic inheritance | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Health aspects | Cancer | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 08/2015, Volume 112, Issue 32, pp. 10038 - 10043
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits... 
Immunohistochemistry | Up-Regulation | Body Weight | Cell Proliferation | Biological Markers | Male | Mucus | Colony Count, Microbial | Journal Article | Antioxidants | Sulfides | Anti-Bacterial Agents | Microbiota | Ki-67 Antigen | Cell Death | Heme | Colon | Feces | Intestinal Mucosa | Down-Regulation | Mice, Inbred C57BL | Epithelial Cells | Animals | Cell Cycle | Diet | Models, Biological | Research Support, Non-U.S. Gov't | Mucolysis | (Tri)sulfides | Red meat | Mucus barrier | Colorectal cancer | colorectal cancer | MUCIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | red meat | mucus barrier | (tri)sulfides | mucolysis | COLORECTAL-CANCER | CALCIUM | FAT | MICE | INHIBITOR | CYTOTOXICITY | EXPRESSION | Cell Cycle - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Colon - drug effects | Microbiota - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Mucus - drug effects | Intestinal Mucosa - drug effects | Feces - microbiology | Heme - pharmacology | Mucus - metabolism | Sulfides - metabolism | Cell Death - drug effects | Biomarkers - metabolism | Colon - pathology | Epithelial Cells - pathology | Up-Regulation - genetics | Antioxidants - pharmacology | Intestinal Mucosa - microbiology | Down-Regulation - drug effects | Down-Regulation - genetics | Up-Regulation - drug effects | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Colon - microbiology | Cell Cycle - drug effects | Intestinal Mucosa - pathology | Cell proliferation | Colon cancer | Epithelial cells | Physiological aspects | Observations | Health aspects | Biological Sciences | susceptibility | expression | bacterial | inhibitor | mucin | fat | colorectal-cancer | mice | cytotoxicity
Journal Article
American Journal of Psychiatry, ISSN 0002-953X, 10/2016, Volume 173, Issue 10, pp. 1046 - 1046
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2007, Volume 27, Issue 47, pp. 13033 - 13041
Journal Article