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Schweizer Archiv fur Neurologie und Psychiatrie, ISSN 0258-7661, 2013, Volume 164, Issue 5, pp. 153 - 157
Journal Article
Epilepsy Research, ISSN 0920-1211, 11/2019, Volume 157, p. 106182
: To describe the use of a population pharmacokinetic (PopPK) model incorporating weight and ontogeny to identify effective clobazam (CLB) dosing for use in a... 
Pharmacometrics | Pediatric dosing | Clobazam | Epilepsy | Population pharmacokinetic modeling | Dravet syndrome
Journal Article
Epilepsy Research, ISSN 0920-1211, 08/2019, Volume 154, pp. 8 - 12
Anti-seizure drugs (ASDs) are widely used and known to increase inhibitory tone on neuro-circuits and reduce aberrant synchronous firing in epilepsy. Some ASDs... 
GABRG2(Q390X) mutation | Stiripentol | Electroencephalogram | Epilepsy | Dravet syndrome | Benzodiazepine
Journal Article
EPILEPSY & BEHAVIOR, ISSN 1525-5050, 02/2019, Volume 91, pp. 1 - 3
Journal Article
Salus, ISSN 1316-7138, 12/2015, Volume 19, Issue 3, pp. 27 - 30
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 12/2019, Volume 132, p. 104583
Dravet syndrome (DS) is an early onset refractory epilepsy typically caused by de novo heterozygous variants in encoding the α-subunit of the neuronal sodium... 
Chromatin architecture | Neural differentiation | Nav1.1 | Dravet syndrome | iPSC | Neurodevelopment | SCN1A
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 34, pp. E8077 - E8085
Spider venom is a rich source of peptides, many targeting ion channels. We assessed a venom peptide, Hm1a, as a potential targeted therapy for Dravet syndrome,... 
Targeted drug therapy | Spider venom | Genetic epilepsy | Dravet syndrome | Seizures | Biological Sciences | PNAS Plus | targeted drug therapy | genetic epilepsy | seizures | spider venom
Journal Article
Neuroscience, ISSN 0306-4522, 02/2019, Volume 398, pp. 1 - 11
Dravet syndrome (DS) is a disease that is primarily caused by the inactivation of the SCN1A-encoded voltage-gated sodium channel alpha subunit (Nav1.1). In... 
epilepsy | genomics | CRISPR/Cas9 | RNA-seq | Dravet syndrome | SCN1A | GENE | CYTOSCAPE | NEUROSCIENCES
Journal Article
Epilepsy Research, ISSN 0920-1211, 08/2019, Volume 154, pp. 13 - 20
Background: Since 2014, patients with severe treatment-resistant epilepsies (TREs) have been receiving add-on cannabidiol (CBD) in an ongoing, expanded access... 
Expanded access program | Lennox-Gastaut syndrome | Dravet syndrome | Cannabidiol | Efficacy | Tolerability | Treatment-resistant epilepsy | Seizures
Journal Article
Turk pediatri arsivi, ISSN 1306-0015, 12/2018, Volume 53, Issue 4, pp. 259 - 262
Dravet syndrome is a catastrophic progressive epileptic syndrome. De novo loss of function mutations on the SCN1A gene coding voltage-gated sodium channels are... 
Journal Article
Epilepsia, ISSN 0013-9580, 04/2011, Volume 52, Issue 2, pp. 76 - 78
The anticonvulsant stiripentol (Diacomittm) has been shown to have a positive impact on control of seizures for many patients with Dravet syndrome. As with... 
Patch‐clamp | Dravet syndrome | Recombinant | Patch-clamp | recombinant | Dravet Syndrome | patch-clamp
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2019, Volume 29, Issue 6, pp. 815 - 820
The voltage-gated sodium channel, Na 1.1, is predominantly expressed in parvalbumin-positive fast spiking interneurons and has been genetically linked to... 
Nav1.1 activator | Voltage-gated sodium channels | Slow current decay of inactivation | Dravet syndrome | BBB penetration
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 03/2019, Volume 29, Issue 6, pp. 815 - 820
The voltage-gated sodium channel, Na 1.1, is predominantly expressed in parvalbumin-positive fast spiking interneurons and has been genetically linked to... 
1.1 activator | Slow current decay of inactivation | Voltage-gated sodium channels | BBB penetration | Dravet syndrome
Journal Article
Developmental Medicine & Child Neurology, ISSN 0012-1622, 07/2018, Volume 60, Issue 7, pp. 718 - 723
The ketogenic diet was effective in children with epilepsy associated with an acquired structural aetiology. This article is commented on by Auvin on page 644... 
DRAVET SYNDROME | EFFICACY | ILAE COMMISSION | CLASSIFICATION | TERMINOLOGY | PEDIATRICS | CHILDHOOD EPILEPSY | CLINICAL NEUROLOGY
Journal Article
Journal of Pediatric Neurosciences, ISSN 1817-1745, 04/2018, Volume 13, Issue 2, pp. 273 - 275
Journal Article
Journal Article