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FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
Journal Article
Neuroscience, ISSN 0306-4522, 2006, Volume 141, Issue 3, pp. 1163 - 1170
Journal Article
Protein Science, ISSN 0961-8368, 02/2001, Volume 10, Issue 2, pp. 423 - 433
The rapid increase in protein synthesis during the mitogenic stimulation of human peripheral blood lymphocyte is the result of global and specific... 
MALDI‐TOF, matrix‐assisted laser desorption/ionization time‐of‐flight | CID, collision‐induced ionization | Translation | lymphocytes | CHX, cycloheximide | FBS, fetal bovine serum | T cells, peripheral blood T lymphocytes | I + P, ionomycin and PMA | protein synthesis | mRNA | [35S]Met, [35S]methionine | T cells | LC/ESI/MS/MS, liquid chromatography/electrospray ionization/mass spectrometry/mass spectrometry | EST, expressed sequence tag | PAmRNAs, polysome‐associated mRNAs | SDS–PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis | proteins | nRRL, nuclease‐treated rabbit reticulocyte lysates | RNP, ribonucleoprotein | PMA, phorbol myristate acetate | gene expression | ActD, actinomycin D | DRB, dichloro 1‐β ribofuranoside benzimide | Proteins | Lymphocytes | Protein synthesis | Gene expression | Lymphocytes - metabolism | Rabbits | Up-Regulation | Gene Expression | Protein Biosynthesis | Biotinylation | Nucleic Acid Synthesis Inhibitors - pharmacology | Lymphocyte Activation | Down-Regulation | Electrophoresis, Polyacrylamide Gel | Humans | Repressor Proteins | RNA, Messenger - metabolism | Reticulocytes - metabolism | Dose-Response Relationship, Drug | Animals | Streptavidin - metabolism | Time Factors | Mass Spectrometry | Polyribosomes - metabolism | Protein Binding | Lysine - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Proteins - chemistry | CELLS | ACTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTINOMYCIN | MEMBRANE-BOUND POLYSOMES | CYTOSKELETAL | MESSENGER-RNA | PROHIBITIN | translation | TUBULIN | ANTIGEN RECEPTOR
Journal Article
FEBS Letters, ISSN 0014-5793, 02/2006, Volume 580, Issue 3, pp. 988 - 994
Protein kinase CKII (CKII) plays a critical role in cell growth and proliferation. In this study, we examine how CKII activity is regulated during cellular... 
Gene silencing | Senescence | Rat tissue | Human lung fibroblast | Protein kinase CKII | PBS | SDS | population doubling level | siRNA | phosphate-buffered saline | senescent-associated β-galactosidase | small-interfering RNA | SA-β-gal | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole | DRB | CKII | PDL | sodium dodecyl sulfate | PCR | polymerase chain reaction | protein kinase CKII (also known as casein kinase II) | rat tissue | CATALYTIC SUBUNIT | CASEIN KINASE-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | human lung fibroblast | ESCHERICHIA-COLI | gene silencing | protein kinase CKII | CK2 | TUMORS | CELL BIOLOGY | senescence | BIOPHYSICS | NUCLEAR-MATRIX | IN-VIVO | HUMAN FIBROBLASTS | EXPRESSION | CYCLE | Gene Expression Regulation, Enzymologic - drug effects | RNA, Small Interfering - genetics | Transcription, Genetic - drug effects | Oxidants - pharmacology | Gene Silencing - drug effects | Liver - enzymology | Tumor Suppressor Protein p53 - biosynthesis | Humans | Rats, Inbred F344 | Cellular Senescence - drug effects | Male | Casein Kinase II - genetics | Dichlororibofuranosylbenzimidazole - pharmacology | Gene Expression Regulation, Enzymologic - physiology | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Testis - enzymology | Cell Line | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Casein Kinase II - biosynthesis | Testis - cytology | RNA, Small Interfering - pharmacology | Casein Kinase II - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Cellular Senescence - physiology | Rats | Down-Regulation - drug effects | Down-Regulation - physiology | Transcription, Genetic - physiology | Animals | Aging - physiology | Liver - cytology | Polymerase chain reaction | Cell research | Messenger RNA | Casein | Surface active agents | Tumor proteins | Sulfates | Protein kinases
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2009, Volume 583, Issue 17, pp. 2893 - 2898
We examined whether transcription elongation factors control constitutive transcription of the and genes. Chromatin immunoprecipitaion demonstrated positive... 
Transcription elongation factor | Histone H1 | GAPDH | Promoter-proximal pausing | CDK | ChIP | DSIF | chromatin immunoprecipitation | P-TEFb | DRB sensitivity inducing factor | NELF | C-terminal domain | immediate early gene | glyceraldehyde-3-phosphate dehydrogenase | negative elongation factor | positive transcription elongation factor b | IEG | CTD | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole | DRB | MKP-1 | cyclin-dependent kinase | RNA polymerase II | MAP kinase phosphatase-1 | pol II | RNA-POLYMERASE-II | POL-II | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK | STIMULATED TRANSCRIPTION | CELL BIOLOGY | BIOPHYSICS | MESSENGER-RNA | IN-VIVO | NEUROENDOCRINE CELLS | IMMEDIATE-EARLY GENES | EXPRESSION | Gene Expression Regulation | Rats | Nuclear Proteins - metabolism | Glyceraldehyde-3-Phosphate Dehydrogenases - genetics | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | Transcription Factors - genetics | Positive Transcriptional Elongation Factor B - genetics | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Histones - genetics | Cell Line, Tumor | Transcription, Genetic | Transcriptional Elongation Factors - genetics | Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism | Histones - metabolism | Nuclear Proteins - genetics | Phosphates | Chromatin | Phosphatases | RNA
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2011, Volume 585, Issue 21, pp. 3360 - 3366
► CKII inhibition induced acetylation of p53 at K382 in HCT116 and HEK293 cells. ► This acetylation was suppressed by SIRT1 activation. ► CKII interacted with... 
Senescence | Tumor suppression | p53 Acetylation | SIRT1 | Protein kinase CKII | phosphate-buffered saline | senescent-associated β-galactosidase | phenylmethylsulfonyl fluoride | SA-β-gal | Sir2 | silent information regulator 2 | NADPH oxidase | CKII | reactive oxygen species | sodium dodecyl sulfate | MBP | protein kinase CKII (also known as casein kinase II) | PBS | SDS | siRNA | small-interfering RNA | histone deacetylase | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole | DRB | PMSF | NOX | ROS | maltose binding protein | HDAC | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CK2 | P16(INK4A) | CELL BIOLOGY | PREMATURE SENESCENCE | BIOPHYSICS | ONCOGENIC RAS | HUMAN FIBROBLASTS | INHIBITORS | TUMORIGENESIS | Sirtuin 1 - metabolism | Cellular Senescence - genetics | RNA, Small Interfering - genetics | HCT116 Cells | Humans | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - drug effects | Casein Kinase II - genetics | Sirtuin 1 - antagonists & inhibitors | Down-Regulation - genetics | Protein Subunits - metabolism | Acetylation - drug effects | Phosphorylation - genetics | RNA Interference | Protein Stability - drug effects | Casein Kinase II - deficiency | HEK293 Cells | Histone Deacetylase Inhibitors - pharmacology | Lysine - metabolism | Tumor Suppressor Protein p53 - chemistry | Phosphorylation - drug effects | Casein Kinase II - metabolism
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 11613 - 14
In recent years, immune repertoire profiling with high-throughput sequencing (HTS) has advanced our understanding of adaptive immunity. However, fast progress... 
CLASS-II DRB | MHC CLASS-I | GENE | BIAS | MULTIDISCIPLINARY SCIENCES | DISEASE | T-CELL-RECEPTOR | DIVERSITY | DUPLICATION | BANK VOLE | BALANCING SELECTION | T-cell receptor | Orthology | Next-generation sequencing | Adaptive immunity | Lymphocytes T | Ribonucleic acid--RNA | Bioinformatics | Complementarity-determining region 3
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2008, Volume 122, Issue 6, pp. 1426 - 1429
Recently, we identified a nucleoside analog named ARC (4‐amino‐6‐hydrazino‐7‐β‐D‐ribofuranosyl‐7H‐Pyrrolo[2,3‐d]pyrimidine‐5‐carboxamide), which has the... 
Mcl‐1 | survivin | apoptosis | ARC | Akt | DRB | Mcl-1 | Survivin | Apoptosis | P53 | TRIAL | ARREST | PHASE | ONCOLOGY | INHIBITOR | EXPRESSION | FLAVOPIRIDOL | Colonic Neoplasms - genetics | Apoptosis - drug effects | Colonic Neoplasms - pathology | Humans | Cell Line, Tumor | Nucleosides - pharmacology | Blotting, Western | Cell Division - drug effects | Drug Screening Assays, Antitumor | Genes, APC
Journal Article
Human Immunology, ISSN 0198-8859, 2016, Volume 77, Issue 12, pp. 1275 - 1279
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2006, Volume 400, Issue 3, pp. 449 - 456
The elongation of transcription of HIV RNA at the TAR (transactivation-response element) is highly regulated by positive and negative factors. The cellular... 
Negative elongation factor E (NELF E) | NMR structure | RNA-binding protein | Transactivation-response element (TAR) | HIV termination/anti-termination | POLYMERASE-II ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | transactivation-response element (TAR) | P-TEFB | negative elongation | PULSED-FIELD GRADIENTS | DISTANCE RESTRAINTS | PROTEIN STRUCTURES | COMPLEX-FORMATION | NMR | DIPOLAR COUPLINGS | factor E (NELF E) | BINDING | 3-DIMENSIONAL STRUCTURES | Humans | Transcriptional Elongation Factors - chemistry | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Nuclear Proteins - metabolism | HIV-1 - genetics | Nuclear Proteins - chemistry | Amino Acid Motifs | Transcriptional Elongation Factors - metabolism | Gene Expression Regulation, Viral | Base Sequence | Protein Binding | Protein Conformation | Transcription, Genetic | Transcription Factors | RNA - metabolism | RMSD, root mean square deviation | pTEFb, positive transcription elongation factor b | TAR, transactivation-response element | negative elongation factor E (NELF E) | FAM, 6-carboxyfluorescein | RDC, residual dipolar coupling | HIV-1, HIV type 1 | HIV termination | NOE, nuclear Overhauser effect | DTT, dithiothreitol | anti-termination | RRM, RNA-recognition motif | HSQC, heteronuclear single-quantum coherence | IPTG, isopropyl β-D-thiogalactoside | Pol II, polymerase II | DSIF, DRB (5,6-dichloro-1β-D-ribofuranosylbenzimidazole)-sensitivity-inducing factor | MEXICO, measurement of exchange rates in isotopically labelled compounds | NELF, negative elongation factor | C12E5, penta(ethylene glycol)monododecyl ether
Journal Article