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ChemMedChem, ISSN 1860-7179, 02/2017, Volume 12, Issue 3, pp. 271 - 277
Alpha‐1‐acid glycoprotein (α 1 ‐AGP) is an important blood plasma glycoprotein. Following an acute‐phase reaction such as stress, inflammation, burn, or... 
drug binding | luminescence | chirality | europium | CPL | Index Medicus
Journal Article
Structure, ISSN 0969-2126, 03/2018, Volume 26, Issue 3, pp. 383 - 390.e3
Human carbonic anhydrases (hCAs) play various roles in cells, and have been drug targets for decades. Sequence similarities of hCA isoforms necessitate... 
dorzolamide | hydrogen bonding | drug binding | brinzolamide | ethoxzolamide | perdeuteration | MD simulations | human carbonic anhydrase | neutron crystallography
Journal Article
Journal Article
CLINICAL PHARMACOKINETICS, ISSN 0312-5963, 05/2018, Volume 57, Issue 5, pp. 577 - 589
Background Differences in plasma protein levels observed between children and adults can alter the extent of xenobiotic binding in plasma, resulting in... 
REFERENCE INTERVALS | DRUG-BINDING | PLASMA | PHARMACOKINETICS | INFANTS | PHARMACOLOGY & PHARMACY | TERM | PRETERM | MICROHETEROGENEITY | SERUM-PROTEINS | AGE
Journal Article
2009, Methods in Enzymology, ISBN 9780123749697, Volume 464, 21
Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile tool among model membrane systems to functionally reconstitute membrane... 
MULTIDRUG TRANSPORTER | DRUG-BINDING | PROTEOLIPOSOMES | HUMAN P-GLYCOPROTEIN | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NANOSCALE LIPID-BILAYERS | BIOCHEMICAL RESEARCH METHODS | STATE NMR-SPECTROSCOPY | DETERGENT | NUCLEOTIDE-BINDING | HUMAN CYTOCHROME-P450 3A4
Book Chapter
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 10/2019, Volume 21, pp. 102058 - 102058
Albumin is a serum transport protein, which has been utilized as a carrier for a variety of drugs to improve their delivery efficiency and to obtain favorable... 
Albumin | Phenethyl isothiocyanate | Drug delivery | Drug binding ligand | Binding free energies | Paclitaxel | Index Medicus
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2014, Volume 38, Issue 7, pp. 2964 - 2978
Two dicopper(II) complexes bridged by N-phenolato-N'-[2-(dimethylamino) ethyl] oxamide (H(3)pdmaeox) and end-capped with 2,2'-diamino-4,4'-bithiazole (dabt)... 
DEOXYRIBONUCLEIC-ACID | COPPER(II) COMPLEXES | RUTHENIUM(II) COMPLEXES | FLUORESCENCE | CRYSTAL-STRUCTURE | DRUG BINDING-SITES | CLEAVAGE | CHEMISTRY, MULTIDISCIPLINARY | BOVINE SERUM-ALBUMIN | METAL-COMPLEXES | TETRACOPPER(II) COMPLEX
Journal Article
RSC ADVANCES, ISSN 2046-2069, 07/2019, Volume 9, Issue 35, pp. 19983 - 19992
Vanillic acid is a widely used food additive (flavouring agent, JECFA number: 959) with many reported beneficial biological effects. The same is true for its... 
DRUG-BINDING | HUMAN SERUM-ALBUMIN | PHENOLIC-COMPOUNDS | RATS | APOCYNIN | VANILLIC ACID | CHEMISTRY, MULTIDISCIPLINARY | DIAPOCYNIN
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 12/2014, Volume 39, Issue 1, pp. 386 - 395
In this study, the interaction between (+)-catechin and human serum albumin (HSA) was investigated using isothermal titration calorimetry (ITC), in combination... 
GREEN TEA | CIRCULAR-DICHROISM | DRUG-BINDING | PROTEIN | FLUORESCENCE | (-)-EPIGALLOCATECHIN-3-GALLATE | DOCKING | HSA | FLAVONOIDS | BINDING-SITES | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2015, Volume 39, Issue 1, pp. 386 - 395
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 06/2018, Volume 15, Issue 6, pp. 2174 - 2179
Pharmacokinetics in the posterior eye segment has therapeutic implications due to the importance of retinal diseases in ophthalmology. In principle, drug... 
vitreal binding | vitreous | retinal drug delivery | drug binding | ocular pharmacokinetics | Index Medicus
Journal Article
Biomacromolecules, ISSN 1525-7797, 03/2009, Volume 10, Issue 3, pp. 517 - 521
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 9, pp. 3720 - 3738
Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a lathyrol diterpene isolated from Euphorbia lathyris, were designed by... 
BREAST-CANCER | JATROPHANE DITERPENES | PROTEIN STRUCTURES | CHEMISTRY, MEDICINAL | DRUG-BINDING | MOUSE LYMPHOMA-CELLS | DATABASE | TRANSPORTERS | MACROCYCLIC DITERPENES | GENERATION | DISCOVERY
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 03/2012, Volume 519, Issue 1, pp. 17 - 22
Suramin is a polysulphonated naphthylurea with inhibitory activity against the human secreted group IIA phospholipase A (hsPLA2GIIA), and we have investigated... 
Drug design | PLA | inhibitor | Protein-drug binding
Journal Article
CHEMICAL SCIENCE, ISSN 2041-6520, 03/2018, Volume 9, Issue 11, pp. 2996 - 3003
Luminescence spectroscopy has been used to monitor the selective and reversible binding of pH sensitive, macrocyclic lanthanide complexes, [LnL(1)], to the... 
DRUG-BINDING | SPECTROSCOPY | SERUM-ALBUMIN | ALPHA-1-ACID GLYCOPROTEIN | GENETIC-VARIANTS | SHIFTS | EUROPIUM COMPLEXES | EMISSION | PROTEINS | CHEMISTRY, MULTIDISCIPLINARY | MODULATION
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2019, Volume 43, Issue 8, pp. 3291 - 3302
In this article, Ru(II)-arene-2-pyridinylbenzoxazole complexes [(eta(6)-p-cymene)RuCl(kappa(2)-N,N-5-bromo-2-(pyridine-2-yl)benzo[d]oxazole)] (4) and... 
DNA-BINDING | DRUG BINDING-SITES | BIOLOGY | RUTHENIUM COMPLEXES | CHEMISTRY | PLATINUM | ANTICANCER COMPLEXES | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | METAL-COMPLEXES | CELLULAR UPTAKE
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2019, Volume 141, Issue 29, pp. 11481 - 11488
The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here we have solved an X-ray... 
DRUG-BINDING | VIRUS | PROTEIN | MECHANISM | ADAMANTANE RESISTANCE | TRANSMEMBRANE DOMAIN | AMANTADINE RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | M ION-CHANNEL | HYDROGEN-BONDS | Index Medicus
Journal Article