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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 10, pp. 1701 - 1707
Three major organosulfur compounds of aged garlic extract, S-allyl-L-cysteine (SAC), S-methyl-L-cysteine (SMC), and trans-S-1-propenyl-L-cysteine (S1PC), were... 
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2013, Volume 61, Issue 12, pp. 1248 - 1263
We describe herein the design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based... 
Journal Article
Yakugaku zasshi, ISSN 0031-6903, 2019, Volume 139, Issue 3, pp. 437 - 460
In this review, 9 compounds with insufficient absorption characteristics, safety or efficacy were selected from among the compounds for which the author was in... 
new-drug development | drug absorption | pharmacodynamic | pharmacokinetic | drug-drug interaction
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2014, Volume 29, Issue 4, pp. 317 - 324
[Summary]: Hypothesis: Simotinib hydrochloride (SIM6802), which is a new epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is often... 
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2014, Volume 29, Issue 1, pp. 52 - 60
[Summary] The natural variant of the cytochrome P450 enzyme CYP2D6.1, CYP2D6.17, is most common in African populations, has three amino acid substitutions... 
Journal Article
Yakugaku zasshi, ISSN 0031-6903, 2017, Volume 137, Issue 6, pp. 697 - 705
Since more than 70% of clinically used drugs are excreted from the body through metabolic processes, drug metabolism is a key determinant of pharmacokinetics,... 
microRNA | polymorphism | cytochrome P450 | drug-drug interaction | non-P450 enzyme | interindividual variability
Journal Article
薬剤学, ISSN 0372-7629, 2013, Volume 73, Issue 4, pp. 254 - 264
Lapatinib (LAP) is metabolized mainly by CYP3A4/5 and this metabolic pathway is inhibited by ketoconazole (KTZ), a strong CYP3A4 inhibitor. LAP is not only a... 
lapatinib | ketoconazole | drug-drug interactions | quantitative prediction
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2012, Volume 27, Issue 4, pp. 368 - 378
[Summary]: Cyclosporin A (CsA) causes a number of clinically relevant drug-drug interactions (DDIs) by inhibiting OATP1B1 and OATP1B3. In the present study,... 
Journal Article
Yakugaku zasshi, ISSN 0031-6903, 2016, Volume 136, Issue 6, pp. 905 - 911
Iguratimod (IGU), a disease-modifying antirheumatic drug launched in September 2012, has been reported to carry a risk of severe hemorrhages through a... 
drug-drug interaction | iguratimod, disease-modifying antirheumatic drug | warfarin
Journal Article
Yakugaku zasshi, ISSN 0031-6903, 2018, Volume 138, Issue 3, pp. 347 - 351
Drug-drug interactions mediated by drug metabolizing enzymes are serious, clinically relevant issues. Prediction and evaluation of the probability and... 
enzyme induction | drug-drug interaction | multi-level physiological modeling & simulation platform | physiologically based pharmacokinetics
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2012, Volume 27, Issue 5, pp. 513 - 519
[Summary]: Fibrate drugs, the peroxisome proliferator-activated receptor alpha (PPARα) agonists, are widely prescribed for the treatment of hyperlipidemia. The... 
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2008, Volume 23, Issue 2, pp. 95 - 100
Summary:Plasma digoxin concentrations are increased by the coadministration of anticholinergic drugs, such as propantheline, which decrease gastrointestinal... 
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2007, Volume 22, Issue 6, pp. 409 - 418
Summary:Nateglinide is an antidiabetic agent metabolized by CYP2C9 and CYP3A4;hence inhibitors of these CYP isozymes may interact with nateglinide. There are,... 
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2007, Volume 30, Issue 11, pp. 2185 - 2190
A systematic analysis to examine the effects of peroxisome proliferator-activated receptor (PPAR)α agonists on the expression levels of all the nutrient/drug... 
Journal Article
The Journal of the Dental Association of Thailand, ISSN 0045-9917, 03/1990, Volume 40, Issue 2, p. 83
Journal Article
Journal Article
The Journal of the Dental Association of Thailand, ISSN 0045-9917, 09/1978, Volume 28, Issue 5, p. 208
Journal Article
Yakugaku zasshi, ISSN 0031-6903, 2012, Volume 132, Issue 2, pp. 237 - 241
We used a mobile electrocardiograph to manage the adverse effects and interactions of drugs, especially QT-prolonging drugs, in a community pharmacy setting.... 
donepezil | risk management | mobile electrocardiograph | community pharmacy | QT-prolongation | drug-drug interaction
Journal Article
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