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1. Full Text Experimental analysis of development of compulsive behavioural disorders due to intravenous fentanyl self-administration
by Chkhikvishvili, N and Naneishvili, T and Dashniani, M and Burjanadze, M
European Neuropsychopharmacology, ISSN 0924-977X, 2019, Volume 29, pp. S183 - S184
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2. Full Text A glutamatergic insular-striatal projection regulates the reinstatement of cue-associated morphine-seeking behavior in mice
by Zhang, Rui and Jia, Wei and Wang, Huaning and Wang, Yunpeng and Zhu, Yongsheng and Liu, Feihu and Liu, Fei and Li, Baojun and Tan, Qingrong
Brain Research Bulletin, ISSN 0361-9230, 10/2019, Volume 152, pp. 257 - 264
Recently, the insular cortex (IC) was identified as part of the neuronal circuit responsible for the reward expectations in cue-triggered behaviours. Moreover,... 
Drug-seeking | Nucleus accumbens | Morphine | insular cortex
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3. Full Text Drug Cues, Conditioned Reinforcement, and Drug Seeking: The Sequelae of a Collaborative Venture With Athina Markou
by Everitt, Barry John
ISSN 0006-3223, 2018
Athina Markou spent a research period in my laboratory, then in the Department of Anatomy in Cambridge University, in 1991 to help us establish a... 
Alcohol | Cocaine | Drug Seeking | Conditioned reinforcement | Habits | Heroin
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4. Full Text Systemic and Central Amygdala Injections of the mGluR2/3 Agonist LY379268 Attenuate the Expression of Incubation of Cocaine Craving
by Lu, Lin and Uejima, Jamie L and Gray, Sarah M and Bossert, Jennifer M and Shaham, Yavin
Biological Psychiatry, ISSN 0006-3223, 2007, Volume 61, Issue 5, pp. 591 - 598
Background We and others reported time-dependent increases in cue-induced cocaine seeking after withdrawal, suggesting that craving incubates over time.... 
Psychiatry | Basolateral amygdala | drug seeking | reinstatement | relapse | glutamate
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5. NOP-Related Mechanisms in Substance Use Disorders
by Ciccocioppo, Roberto and Borruto, Anna Maria and Domi, Ana and Teshima, Koji and Cannella, Nazzareno and Weiss, Friedbert
Handbook of experimental pharmacology, ISSN 0171-2004, 04/2019, Volume 254, pp. 187 - 212
Nociceptin/orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995 and has been widely studied since. The role of the N/OFQ system in drug... 
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6. Full Text From the ventral to the dorsal striatum: Devolving views of their roles in drug addiction
by Everitt, Barry J and Robbins, Trevor W
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 11/2013, Volume 37, Issue 9, pp. 1946 - 1954
â–ş Addictive behaviour involves the development of drug seeking habits. â–ş Habitual drug seeking and taking depend upon dorsolateral striatum. â–ş Compulsive drug... 
Drug addiction | Cocaine | Ventral striatum | Prefrontal cortex | Dorsal striatum | COCAINE-SEEKING BEHAVIOR | OLFACTORY TUBERCLE | RESPONSE PERSEVERATION | NEUROSCIENCES | DECISION-MAKING | NUCLEUS-ACCUMBENS CORE | BEHAVIORAL SCIENCES | CONDITIONED REINFORCEMENT | DOPAMINE-RECEPTORS | ORBITOFRONTAL CORTEX | PERSONALITY-TRAITS | Animals | Corpus Striatum - physiopathology | Drug-Seeking Behavior - physiology | Humans | Brain Mapping - methods | Behavior, Addictive - physiopathology | Substance-Related Disorders - physiopathology | Drug abuse
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7. Full Text The Cystine/Glutamate Antiporter System x(c)(-) in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
by Lewerenz, J and Hewett, SJ and Huang, Y and Lambros, M and Gout, PW and Kalivas, PW and Massie, A and Smolders, I and Methner, A and Pergande, M and Smith, SB and Ganapathy, V and Maher, P
ANTIOXIDANTS & REDOX SIGNALING, ISSN 1523-0864, 02/2013, Volume 18, Issue 5, pp. 522 - 555
The antiporter system x(c)(-) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1: 1 counter-transport of glutamate. It is... 
HYPOXIC NEURONAL INJURY | PROMOTES TUMOR-GROWTH | AMINO-ACID-TRANSPORT | HUMAN-DIPLOID FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | NERVE-CELL DEATH | INDUCED DRUG-SEEKING | OXIDATIVE GLUTAMATE TOXICITY | GLUTATHIONE-RELATED ENZYMES | MOUSE PERITONEAL-MACROPHAGES | RETINAL-PIGMENT EPITHELIUM | Animals | Oxidation-Reduction | Cystine - metabolism | Humans | Amino Acid Transport Systems - physiology | Glutamic Acid - metabolism | Phylogeny | Amino Acid Transport Systems - metabolism | Index Medicus
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8. Full Text Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On
by Everitt, Barry J and Robbins, Trevor W
Annual Review of Psychology, ISSN 0066-4308, 1/2016, Volume 67, Issue 1, pp. 23 - 50
A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits,... 
endophenotype | vulnerability | striatum | insula | prefrontal cortex | inhibitory control | Striatum | Insula | Inhibitory control | Vulnerability | Prefrontal cortex | Endophenotype | COCAINE-SEEKING BEHAVIOR | BETA-ADRENERGIC-RECEPTORS | DORSOLATERAL STRIATUM | REACTION-TIME-TASK | PSYCHOLOGY | PSYCHOLOGY, MULTIDISCIPLINARY | VENTROMEDIAL PREFRONTAL CORTEX | DECISION-MAKING | NUCLEUS-ACCUMBENS CORE | DORSAL STRIATUM | MEMORY RECONSOLIDATION | DEPENDENT INDIVIDUALS | Animals | Compulsive Behavior - psychology | Conditioning (Psychology) - physiology | Brain - physiopathology | Drug-Seeking Behavior - physiology | Humans | Compulsive Behavior - physiopathology | Substance-Related Disorders - psychology | Substance-Related Disorders - therapy | Substance-Related Disorders - physiopathology | Habits | Drug abuse | Public health administration | Forecasts and trends | Health behavior | Care and treatment | Substance abuse
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9. Full Text Decoding Neural Circuits that Control Compulsive Sucrose Seeking
by Nieh, Edward H and Matthews, Gillian A and Allsop, Stephen A and Presbrey, Kara N and Leppla, Christopher A and Wichmann, Romy and Neve, Rachael and Wildes, Craig P and Tye, Kay M
Cell, ISSN 0092-8674, 01/2015, Volume 160, Issue 3, pp. 528 - 541
The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop... 
MEDIAL FOREBRAIN-BUNDLE | DOPAMINE NEURONS | GLUTAMATERGIC NEURONS | SELF-STIMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LATERAL HYPOTHALAMIC NEURONS | POSITIVE REINFORCEMENT | HORSERADISH-PEROXIDASE | SUBSTANTIA-NIGRA | DRUG SEEKING | VENTRAL TEGMENTAL AREA | CELL BIOLOGY | Sucrose | gamma-Aminobutyric Acid - metabolism | Hypothalamic Area, Lateral - cytology | Neurons - cytology | Ventral Tegmental Area - physiology | Neural Pathways | Behavior, Animal | Animals | Hypothalamic Area, Lateral - physiology | Feedback | Mice | Models, Neurological | Reward | GABA | Sugars | Neural circuitry
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10. Full Text Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
by Ellen Y. T. Chien and Wei Liu and Qiang Zhao and Vsevolod Katritch and Gye Won Han and Michael A. Hanson and Lei Shi and Amy Hauck Newman and Jonathan A. Javitch and Vadim Cherezov and Raymond C. Stevens
Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6007, pp. 1091 - 1095
Dopamine modulates movement cognition, and emotion through activation of dopamine G protein–coupled receptors in the brain. The crystal structure of the human... 
Receptors | Salts | Hydrogen bonds | REPORTS | Ligands | Amides | Bridge engineering | Pharmacology | Grants | Binding sites | Crystal structure | ANGSTROM CRYSTAL-STRUCTURE | INDUCED REINSTATEMENT | IONIC LOCK | 2ND EXTRACELLULAR LOOP | D-3 RECEPTOR | COCAINE-SEEKING | MULTIDISCIPLINARY SCIENCES | BINDING-SITE CREVICE | PROTEIN-COUPLED RECEPTORS | DRUG-SEEKING BEHAVIOR | BETA-ADRENERGIC RECEPTOR | Cell Line | Humans | Receptors, Dopamine D3 - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Crystallography, X-Ray | Arginine - chemistry | Spodoptera | Animals | Salicylamides - chemistry | Protein Conformation | Receptors, Dopamine D3 - antagonists & inhibitors | Binding Sites | Dopamine Antagonists - chemistry | Dopamine D2 Receptor Antagonists | Physiological aspects | G proteins | Properties | Dopamine receptors | Proteins | Ions | Dopamine | Neurons | Human | Binding | Pocket | Activation | Locks | Cognition
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