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American Journal of Hypertension, ISSN 0895-7061, 12/2015, Volume 28, Issue 12, pp. 1409 - 1417
BACKGROUND LCZ696, an angiotensin receptor-neprilysin inhibitor, has recently been demonstrated to exert more beneficial effects on hypertensive or heart... 
angiotensin | blood pressure | cardiovascular protection | neprilysin | dual inhibition | hypertension | METABOLIC SYNDROME | EFFICACY | HEART-FAILURE | RATS | NEUTRAL ENDOPEPTIDASE INHIBITOR | PRESERVED EJECTION FRACTION | NATRIURETIC PEPTIDE SYSTEM | ANGIOEDEMA | BIOLOGY | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | Fibrosis - drug therapy | Tetrazoles - pharmacology | Sodium, Dietary - adverse effects | Angiotensin Receptor Antagonists - pharmacology | Endothelium, Vascular - drug effects | Hypertension - drug therapy | Male | Aminobutyrates - pharmacology | Cyclic GMP - blood | Aminobutyrates - therapeutic use | Hypertension - etiology | Valsartan - pharmacology | Hypertension - blood | Valsartan - therapeutic use | Inflammation - drug therapy | Blood Pressure - drug effects | Vascular Remodeling - drug effects | Drug Evaluation, Preclinical | Rats, Inbred SHR | Cardiomegaly - drug therapy | Sodium, Dietary - urine | Myocardium - pathology | Random Allocation | Animals | Neprilysin - antagonists & inhibitors | Heart - drug effects | Tetrazoles - therapeutic use | Oxidative Stress - drug effects | Angiotensin Receptor Antagonists - therapeutic use | Circadian Rhythm - drug effects | Hypertension | Care and treatment | Cardiac patients | Angiotensin II receptor blockers | Dosage and administration | Cardiovascular diseases | Health aspects | Risk factors
Journal Article
Circulation Research, ISSN 0009-7330, 09/2005, Volume 97, Issue 5, pp. 434 - 442
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 03/2018, Volume 45, Issue 4, pp. 1366 - 1376
Background/Aims: Naive CD4(+) T cells differentiate into T helper cells (Th1 and Th2) that play an essential role in the cardiovascular diseases. However, the... 
Jurkat cells | Th1 differentiation | Angiotensin II | PKA | Proteasome | SYSTEM | PHYSIOLOGY | INJURY | MODEL | CELL BIOLOGY | IMMUNE | INHIBITION | HYPERTENSION | EXPRESSION | Humans | Bortezomib - pharmacology | Interferon-gamma - metabolism | Interleukin-2 - analysis | Angiotensin II Type 1 Receptor Blockers - pharmacology | Protein Subunits - metabolism | STAT1 Transcription Factor - metabolism | Isoquinolines - pharmacology | Ubiquitination - drug effects | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Interferon-gamma - genetics | Protein Subunits - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Interleukin-2 - metabolism | Dual Specificity Phosphatase 1 - genetics | Angiotensin II - pharmacology | Jurkat Cells | Cells, Cultured | Losartan - pharmacology | Sulfonamides - pharmacology | Proteasome Endopeptidase Complex - genetics | Interleukin-2 - genetics | Interferon-gamma - analysis | Signal Transduction - drug effects | T-Lymphocytes - cytology | Cell Differentiation - drug effects | Receptor, Angiotensin, Type 1 - metabolism | Dual Specificity Phosphatase 1 - metabolism | Proteasome Endopeptidase Complex - metabolism | Hypertension | Proteins | Antigens | Enzymes | Transplants & implants | Cytokines | Lymphocytes | Penicillin | Cell cycle | DNA methylation | Gene expression | Kinases
Journal Article
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 5/2015, Volume 93, Issue 5, pp. 547 - 558
Journal Article
Journal of Hypertension, ISSN 0263-6352, 01/2010, Volume 28, Issue 1, pp. 111 - 118
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2012, Volume 302, Issue 3, pp. 801 - 810
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, pp. 3155 - 3160
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2018, Volume 158, pp. 334 - 352
Because of the complex biological networks, many pathologic disorders fail to be treated with a molecule directed towards a single target. Thus, combination... 
Triazole | Chromane | Imidazole | AT1 | PPAR-γ | Designed multiple ligands | METABOLIC SYNDROME | ANTIPROLIFERATIVE ACTIVITY | ALZHEIMERS-DISEASE | DRUG DISCOVERY | AGONISTS | HIGHLY EFFICIENT | PPAR-gamma | lmidazole | DUAL ACTIVITY | ANTAGONISTS | 4-THIAZOLIDINONE DERIVATIVES | CHEMISTRY, MEDICINAL | Medicinal Chemistry | Chemical Sciences
Journal Article