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Journal Article
by Raphael, Benjamin J and Hruban, Ralph H and Aguirre, Andrew J and Moffitt, Richard A and Yeh, Jen Jen and Stewart, Chip and Robertson, A. Gordon and Cherniack, Andrew D and Gupta, Manaswi and Getz, Gad and Gabriel, Stacey B and Meyerson, Matthew and Cibulskis, Carrie and Fei, Suzanne S and Hinoue, Toshinori and Shen, Hui and Laird, Peter W and Ling, Shiyun and Lu, Yiling and Mills, Gordon B and Akbani, Rehan and Loher, Phillipe and Londin, Eric R and Rigoutsos, Isidore and Telonis, Aristeidis G and Gibb, Ewan A and Goldenberg, Anna and Mezlini, Aziz M and Hoadley, Katherine A and Collisson, Eric and Lander, Eric and Murray, Bradley A and Hess, Julian and Rosenberg, Mara and Bergelson, Louis and Zhang, Wei and Zhang, Hailei and Zhang, Jiashan (Julia) and Zhang, Lizhi and Cho, Juok and Tiao, Grace and Kim, Seong Hoon and Kim, Hark and Kim, Jaegil and Kim, Paula and Kim, Yong Hoon and Livitz, Dimitri and Leshchiner, Ignaty and Reardon, Brendan and Van Allen, Eliezer and Kamburov, Atanas and Beroukhim, Rameen and Saksena, Gordon and Schumacher, Steven E and Noble, Michael S and Heiman, David I and Gehlenborg, Nils and Lawrence, Michael S and Adsay, Volkan and Petersen, Gloria and Klimstra, David and Bardeesy, Nabeel and Leiserson, Mark D.M and Bowlby, Reanne and Kasaian, Katayoon and Birol, Inanc and Mungall, Andrew J and Mungall, Karen L and Sadeghi, Sara and Weinstein, John N and Spellman, Paul T and Liu, Yuexin and Liu, Jia and Amundadottir, Laufey T and Tepper, Joel and Singhi, Aatur D and Dhir, Rajiv and Paul, Drwiega and Smyrk, Thomas and Bowen, Jay and Frick, Jessica and Gastier-Foster, Julie M and Gerken, Mark and Lau, Kevin and Leraas, Kristen M and Lichtenberg, Tara M and Ramirez, Nilsa C and Renkel, Jeremy and Sherman, Mark and Wise, Lisa and Yena, Peggy and Zmuda, Erik and Shih, Juliann and Ally, Adrian and Balasundaram, Miruna and Carlsen, Rebecca and Chu, Andy and Chuah, Eric and Clarke, Amanda and Dhalla, Noreen and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu and Cancer Genome Atlas Research Network
Cancer Cell, ISSN 1535-6108, 08/2017, Volume 32, Issue 2, pp. 185 - 203.e13
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 397, pp. 72 - 82
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. To identify potential effective therapeutic drugs for PDAC, we... 
Hematology, Oncology and Palliative Medicine | Epithelial–stromal interaction | Microenvironment | Indirubin 3′-oximes | Pancreatic ductal adenocarcinoma | APOPTOSIS | Epithelial-stromal interaction | ACTIVATION | CHINESE ANTILEUKEMIA MEDICINE | Indirubin 3 '-oximes | HUMAN CANCER-CELLS | INHIBITS TUMOR-GROWTH | HUMAN NEUROBLASTOMA | CYCLIN-DEPENDENT KINASES | LUNG-CANCER | ONCOLOGY | ENDOTHELIAL-CELL | DERIVATIVES | CDC2 Protein Kinase | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Carcinoma, Pancreatic Ductal - metabolism | Male | Cyclin B1 - metabolism | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | G2 Phase Cell Cycle Checkpoints - drug effects | Time Factors | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - pathology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Oximes - pharmacology | Mice, Inbred BALB C | Adenocarcinoma | Medical colleges | Microbiology | Cell death | Analysis | Pancreatic cancer | Biochemistry | Biotechnology | Immunoglobulins | Lung cancer | Leukemia | Kinases | Cancer therapies | Studies | Cell growth | Chemotherapy | Medical prognosis | Rodents | Cell cycle | Fibroblasts | Software | Apoptosis | Cancer | Index Medicus
Journal Article
Journal Article
Gut, ISSN 0017-5749, 06/2018, Volume 67, Issue 6, pp. 1112 - 1123
Journal Article
by Pérez-Mancera, Pedro A and Rust, Alistair G and Van Der Weyden, Louise and Kristiansen, Glen and Li, Allen and Sarver, Aaron L and Silverstein, Kevin A. T and Grützmann, Robert and Aust, Daniela and Rümmele, Petra and Knösel, Thomas and Herd, Colin and Stemple, Derek L and Kettleborough, Ross and Brosnan, Jacqueline A and Li, Ang and Morgan, Richard and Knight, Spencer and Yu, Jun and Stegeman, Shane and Collier, Lara S and Ten Hoeve, Jelle J and De Ridder, Jeroen and Klein, Alison P and Goggins, Michael and Hruban, Ralph H and Chang, David K and Biankin, Andrew V. Wessels and Grimmond, Sean M and Wessels, Lodewyk F. A and Wood, Stephen A and Iacobuzio-Donahue, Christine A and Pilarsky, Christian and Largaespada, David A and Adams, David J and Tuveson, David A and Bienkin, Andrew V and Johns, Amber L and Mawson, Amanda and Cheng, David K and Brancato, Mary-Anne L and Rowe, Sarah J and Simpson, Skye L and Martyn-Smith, Mona and Chantrill, Lorraine A and Chin, Venessa T and Chou, Angela and Cowley, Mark J and Humphris, Jeremy L and Jones, Marc D and Scott Mead, R and Nagrial, Adnan M and Pajic, Marina and Pettit, Jessica and Pinese, Mark and Rooman, Ilse and Wu, Jianmin and Daly, Roger J and Musgrove, Elizabeth A and Sutherland, Robert L and Grimond, Sean M and Waddell, Nicola and Kassahn, Karin S and Miller, David K and Wilson, Peter J and Patch, Ann-Marie and Song, Sarah and Harliwong, Ivon and Idrisoglu, Senel and Nourse, Craig and Nourbakhsh, Ehsan and Manning, Suzanne and Wani, Shivangi and Gongora, Milena and Anderson, Matthew and Holmes, Oliver and Leonard, Conrad and Taylor, Darrin and Wood, Scott and Xu, Christina and Nones, Katia and Lynn Fink, J and Christ, Angelika and Bruxner, Tim and Cloonan, Nicole and Newell, Felicity and Pearson, John V and Samra, Jaswinder S and Gill, Anthony J and Pavlakis, Nick and Guminski, Alex and Toon, Christopher and Blankin, Andrew V and Asghari, Ray and Merrett, Neil D and Pavey, Darren A and Das, Amithabad and Cosman, Peter H and Ismail, Kasim and O'Connor, Chelsie and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7402, pp. 266 - 270
Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much progress concerning its molecular characterization. PDA tumours harbour four...