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Journal Article
Postepy Dermatologii i Alergologii, ISSN 1642-395X, 12/2016, Volume 33, Issue 6, pp. 475 - 479
Journal Article
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 05/2004, Volume 339, Issue 1, pp. 145 - 159
A new early-onset form of Alzheimer's disease (AD) was described recently where a point mutation was discovered in codon 693 of the beta-amyloid (Abeta)... 
FIBRIL FORMATION | arctic mutation | DUTCH-TYPE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO | amyloid | BETA-PROTEIN FIBRILLOGENESIS | A-BETA | protofibrils | CENTRAL-NERVOUS-SYSTEM | HCHWA-D | HEREDITARY CEREBRAL-HEMORRHAGE | PRECURSOR PROTEIN | kinetics | Alzheimer's disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2000, Volume 97, Issue 17, pp. 9712 - 9717
Production of amyloid-β protein (Aβ ) is initiated by a β -secretase that cleaves the Aβ precursor protein (APP) at the N terminus of Aβ (the β site). A... 
Proteins | Amyloid plaque | Enzymes | Biological Sciences | HEK293 cells | Active sites | Plasmids | pH | Antibodies | Protein precursors | Genetic mutation | CELLS | DEMENTIA | DUTCH TYPE | GENE | MULTIDISCIPLINARY SCIENCES | MUTATION | FAMILIAL ALZHEIMERS-DISEASE | ANGIOPATHY | HEREDITARY CEREBRAL-HEMORRHAGE | PLAQUES | PEPTIDE | Amyloid beta-Protein Precursor - chemistry | Humans | Molecular Sequence Data | RNA, Messenger - analysis | Substrate Specificity | Gene Expression Profiling | Aspartic Acid Endopeptidases - genetics | Recombinant Fusion Proteins - metabolism | Mutation, Missense - genetics | Netherlands | Sweden | Amyloid beta-Peptides - genetics | Arginine - genetics | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Cloning, Molecular | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Binding Sites | Peptide Fragments - genetics | Amino Acid Sequence | Aspartic Acid Endopeptidases - chemistry | Cell Line | Nervous System - enzymology | Peptide Fragments - metabolism | Phenylalanine - metabolism | RNA, Messenger - genetics | Recombinant Fusion Proteins - chemistry | Sequence Homology, Amino Acid | Peptide Fragments - chemistry | Amyloid beta-Protein Precursor - genetics | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Recombinant Fusion Proteins - genetics | Amino Acid Substitution - genetics | Protein Processing, Post-Translational | Amyloid beta-Peptides - chemistry | Alzheimer Disease - genetics | Endopeptidases | Arginine - metabolism | Hydrogen-Ion Concentration | Neurology | Biology | Mutation | Index Medicus
Journal Article
JNEN: Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 03/2002, Volume 61, Issue 3, pp. 282 - 293
Journal Article
International Journal of Geriatric Psychiatry, ISSN 0885-6230, 07/2006, Volume 21, Issue 7, pp. 681 - 687
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 05/2001, Volume 355, pp. 869 - 877
In a Flemish kindred, an Ala(692) --> Gly amino acid substitution in the amyloid beta -protein precursor (A beta PP) causes a form of early-onset Alzheimer's... 
DUTCH-TYPE | neurotoxicity | PEPTIDES | fibrillogenesis | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | AGGREGATION PROPERTIES | HEREDITARY CEREBRAL-HEMORRHAGE | PRECURSOR PROTEIN | CENTRAL HYDROPHOBIC CLUSTER | SMOOTH-MUSCLE CELLS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 27144 - 27158
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2001, Volume 21, Issue 5, pp. 1619 - 1627
Journal Article
Journal Article
Zywnosc. Nauka. Technologia. Jakosc/Food. Science Technology. Quality, ISSN 1425-6959, 2012, Volume 19, Issue 1, pp. 45 - 59
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2012, Volume 33, Issue 5, pp. 1010.e1 - 1010.e13
Abstract The Arctic (p. E693G) mutation in the amyloid-β precursor protein (AβPP) facilitates amyloid-β (Aβ) protofibril formation and generates clinical... 
Neurology | Internal Medicine | AβPP mutation | N-terminal truncation | Neuropathology | Familial | β-amyloid protein | Alzheimer's disease | Mass spectrometry | ALPHA-SECRETASE | A beta PP mutation | DUTCH-TYPE | SENSITIVE ELISA | beta-amyloid protein | SPASTIC PARAPARESIS | CORE PROTEIN | NEUROSCIENCES | COTTON WOOL PLAQUES | SENILE PLAQUES | GERIATRICS & GERONTOLOGY | ONSET ALZHEIMER-DISEASE | HEREDITARY CEREBRAL-HEMORRHAGE | TRANSGENIC MICE | Alzheimer Disease - physiopathology | Molecular Weight | Plaque, Amyloid - pathology | Amyloid beta-Peptides - biosynthesis | Humans | Middle Aged | Male | Protein Structure, Tertiary - genetics | Peptide Fragments - biosynthesis | Plaque, Amyloid - genetics | Peptide Fragments - chemistry | Amyloid beta-Protein Precursor - genetics | Protein Isoforms - metabolism | Amyloid beta-Peptides - genetics | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Amino Acid Substitution - genetics | Female | Plaque, Amyloid - metabolism | Aged | Amyloid beta-Peptides - chemistry | Alzheimer Disease - genetics | Peptide Fragments - genetics | Protein Isoforms - genetics | Brain | Deposits | Neurodegenerative diseases | Fibrils | Antibodies | Nervous system | beta -Amyloid | Electron microscopy | Cerebral amyloid angiopathy | Aging | Amyloid | Mutation | Plaques | Index Medicus | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Journal Article