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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2016, Volume 26, Issue 20, pp. 5103 - 5109
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2015, Volume 14, Issue 1, pp. 111 - 119
The cellular responses to two new temozolomide (TMZ) analogues, DP68 and DP86, acting against glioblastoma multiforme (GBM) cell lines and primary culture... 
ANTITUMOR DRUG TEMOZOLOMIDE | STEM-CELLS | ONCOLOGY | MGMT | DNA | PRODRUGS | REPOPULATION | MISMATCH REPAIR | PROMOTER METHYLATION STATUS | CHEMOTHERAPY | XENOGRAFT MODEL | Antineoplastic Agents, Alkylating - chemical synthesis | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents, Alkylating - administration & dosage | Brain Neoplasms - metabolism | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Dacarbazine - pharmacokinetics | Glioblastoma - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Aniline Compounds - administration & dosage | DNA Damage - drug effects | Dacarbazine - administration & dosage | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Neoplasm Recurrence, Local - metabolism | Mice, Inbred C57BL | Heterocyclic Compounds, 2-Ring - administration & dosage | Antineoplastic Agents, Alkylating - pharmacokinetics | Aniline Compounds - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Brain Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Fanconi Anemia Complementation Group D2 Protein - metabolism | Cell Line, Tumor | Mice | Cell Cycle - drug effects | Glioblastoma - drug therapy | Heterocyclic Compounds, 2-Ring - chemical synthesis | Aniline Compounds - chemical synthesis | Drug Resistance, Neoplasm - drug effects | Index Medicus | glioblastoma | DNA damage response | FANCD2 | ATM | Temozolomide | resistance | ATR
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0123808 - e0123808
Recently approved chemotherapeutic agents to treat colorectal cancer (CRC) have made some impact; however, there is an urgent need for newer targeted agents... 
GLIOMA-CELLS | G ARREST | ADENOMATOUS POLYPOSIS-COLI | BASE EXCISION-REPAIR | LONG-PATCH | GROWTH ARREST | ALKYLATING-AGENTS | MULTIDISCIPLINARY SCIENCES | POLY(ADP-RIBOSE) POLYMERASE-1 | MISMATCH REPAIR | CELLULAR SENESCENCE | Small Molecule Libraries - pharmacology | Sulfhydryl Compounds - pharmacology | Apoptosis - drug effects | Triazoles - chemistry | Humans | Cellular Senescence - drug effects | Toluene - analogs & derivatives | Dacarbazine - pharmacology | Enzyme Inhibitors - chemistry | Dacarbazine - analogs & derivatives | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Sulfhydryl Compounds - chemistry | DNA Polymerase beta - metabolism | Toluene - pharmacology | DNA Repair - drug effects | Sulfonamides - chemistry | Benzothiazoles - pharmacology | HCT116 Cells | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Sulfonamides - pharmacology | Triazoles - pharmacology | Small Molecule Libraries - chemistry | Cell Cycle Checkpoints - drug effects | DNA Damage | Cell Cycle - drug effects | Colorectal Neoplasms - pathology | Senescence | Molecular structure | DNA polymerase | p53 Protein | DNA damage | Genes | Colorectal carcinoma | Colorectal cancer | Cytotoxicity | Drug resistance | Kinases | Cancer therapies | Base excision repair | Alkylation | Metastases | Analogs | Proteins | Cell cycle | Docking | Deoxyribonucleic acid--DNA | Hematology | Blocking | FEN1 protein | Polymerase | Chemotherapy | Displacement activity | Genetic engineering | Temozolomide | DNA-directed DNA polymerase | Cancer | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 04/2019, Volume 54, Issue 4, pp. 1481 - 1495
Melanoma represents a significant challenge in cancer treatment due to the high drug resistance of melanomas and the patient mortality rate. This study... 
vitamin D analogs | vitamin D | DNA-DAMAGE | 25-HYDROXYVITAMIN D | melanoma | EMERGING TARGETED THERAPIES | PROLIFERATION | chemotherapy | BREAST-CANCER | hydroxyvitamin D | IN-VITRO | ONCOLOGY | reactive oxygen species | SKIN | cisplatin | EXPRESSION | oxidative stress | PROGRESSION | dacarbazine | CALCITRIOL
Journal Article
Journal Article
Cancer, ISSN 0008-543X, 01/2011, Volume 117, Issue 2, pp. 268 - 275
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0118702 - e0118702
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2010, Volume 16, Issue 8, pp. 2443 - 2449
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 358, Issue 2, pp. 144 - 151
Highlights • Temozolomide was modified by conjugation to perillyl alcohol. • The resulting novel analog, NEO212, exerted superior activity against melanoma. •... 
Hematology, Oncology and Palliative Medicine | Perillyl alcohol | MGMT | Chemoresistance | O6-methylguanine-DNA methyltransferase | PROMOTER METHYLATION | 06-methylguanine-DNA methyltransferase | PREDICTIVE-VALUE | MALIGNANT-MELANOMA | BREAST-CANCER | RESISTANT GLIOMAS | METASTATIC MELANOMA | PHASE-II TRIAL | ONCOLOGY | PROSTATE-CANCER | MONOTERPENE PERILLYL ALCOHOL | O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | DNA Damage - drug effects | Melanoma - metabolism | Cell Survival - drug effects | Dacarbazine - administration & dosage | Apoptosis - drug effects | Humans | O-Methylguanine-DNA Methyltransferase - metabolism | Antineoplastic Agents, Alkylating - pharmacology | Antineoplastic Agents, Alkylating - administration & dosage | Melanoma - pathology | Dose-Response Relationship, Drug | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Dacarbazine - pharmacology | Antineoplastic Agents, Alkylating - toxicity | Melanoma - drug therapy | Dacarbazine - analogs & derivatives | Cell Line, Tumor | Inhibitory Concentration 50 | Mice | Dacarbazine - toxicity | DNA Methylation - drug effects | Disease Models, Animal | Antimitotic agents | Antineoplastic agents | Melanoma | Therapy | Cell culture | Laboratories | Brain cancer | DNA damage | pOH | Cytotoxicity | Alcohol | Metastasis | Kinases | Cancer therapies | Guanine | Alkylation | Anticancer properties | Proteins | Deoxyribonucleic acid--DNA | Tumor cells | Investigations | Cell death | Antitumor activity | DNA methyltransferase | Temozolomide | Tumors | Apoptosis | Index Medicus
Journal Article
International Journal of Quantum Chemistry, ISSN 0020-7608, 2008, Volume 108, Issue 8, pp. 1380 - 1390
Journal Article
15.