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Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 08/2012, Volume 32, Issue 34, pp. 11820 - 11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in... 
DANTROLENE | PRESENILINS | INFLUX | CA2+ RELEASE | CALCIUM-RELEASE | INCREASES | CHANNELS | PRECURSOR PROTEIN | N-TERMINUS | NEUROSCIENCES | I-CRAC | Amyloid Precursor Protein Secretases - genetics | Calcium - metabolism | Embryo, Mammalian | Humans | Calcium Channel Blockers - therapeutic use | Memory Disorders - metabolism | Aminophenols - therapeutic use | RNA, Messenger - metabolism | Phosphorylation - genetics | Endoplasmic Reticulum - drug effects | Muscle Relaxants, Central - pharmacology | Amyloid beta-Peptides - metabolism | Exploratory Behavior - drug effects | Caffeine - pharmacology | Purines - therapeutic use | Phosphorylation - drug effects | Disease Models, Animal | Membrane Potentials - drug effects | Mice, Transgenic | Dantrolene - pharmacology | Mutation - genetics | Enzyme Inhibitors - therapeutic use | Amyloid Precursor Protein Secretases - metabolism | Patch-Clamp Techniques | Memory Disorders - etiology | Analysis of Variance | Ryanodine Receptor Calcium Release Channel - genetics | Cytosol - metabolism | Plaque, Amyloid - metabolism | Mice | Inositol 1,4,5-Trisphosphate Receptors - genetics | Membrane Potentials - genetics | Alzheimer Disease - complications | Cytosol - drug effects | Endoplasmic Reticulum - metabolism | Ryanodine Receptor Calcium Release Channel - metabolism | Endoplasmic Reticulum - pathology | Maleimides - therapeutic use | Transfection | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Reaction Time - drug effects | Amyloid beta-Protein Precursor - metabolism | Neurons - physiology | Membrane Proteins - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Brain - cytology | Peptide Fragments - metabolism | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Cells, Cultured | Maze Learning - drug effects | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Memory Disorders - drug therapy | Recognition (Psychology) - drug effects | Alzheimer Disease - metabolism | Alzheimer Disease - genetics
Journal Article
1993, IPCS/CEC evaluation of antidotes series, ISBN 9780521454599, Volume 14797 EN., xv, 98
Book
Journal of Ethnopharmacology, ISSN 0378-8741, 2004, Volume 90, Issue 2, pp. 205 - 215
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2009, Volume 53, Issue 21, pp. 1993 - 2005
Journal Article
Anesthesia and Analgesia, ISSN 0003-2999, 2010, Volume 110, Issue 2, pp. 498 - 507
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2019, Volume 116, Issue 11, pp. 4810 - 4815
Ca2+ leak via ryanodine receptor type 2 (RyR2) can cause potentially fatal arrhythmias in a variety of heart diseases and has also been implicated in... 
Natural product | Cardiomyocytes | CPVT | Depsipeptide | Ryanodine receptor | depsipeptide | POLYMORPHIC VENTRICULAR-TACHYCARDIA | PROTEIN | DANTROLENE | MALIGNANT HYPERTHERMIA | natural product | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | MIRROR-IMAGE | THERAPEUTIC AGENT | cardiomyocytes | ryanodine receptor | ASYMMETRIC TOTAL-SYNTHESIS | BINDING | CA2+ RELEASE CHANNELS | Membrane Potentials - drug effects | Ryanodine - metabolism | Calcium - metabolism | Stereoisomerism | Anti-Arrhythmia Agents - pharmacology | Calcium Channel Blockers - therapeutic use | Ryanodine Receptor Calcium Release Channel - metabolism | Depsipeptides - pharmacology | Anti-Arrhythmia Agents - chemistry | Anti-Arrhythmia Agents - therapeutic use | Calcium Channel Blockers - pharmacology | Arrhythmias, Cardiac - physiopathology | Arrhythmias, Cardiac - drug therapy | Animals | Calcium Channel Blockers - chemistry | Depsipeptides - therapeutic use | Mice | Dimerization | Depsipeptides - chemistry | Physiological aspects | Causes of | Calcium channels | Arrhythmia | Calcium ions | Brain | Cardiac arrhythmia | Calcium | Leak channels | Hyperactivity | Congeners | Ryanodine receptors | Action potential | Enantiomers | Drug development | Depolarization | Chemical activity | Chemical synthesis | Heart diseases | Tetracaine | Therapeutic applications | Catecholamine | Coronary artery disease | Organic chemistry | Insects | Natural products | Ventricle | Cardiovascular diseases | Biological Sciences | Physical Sciences
Journal Article
Journal Article
Drugs, ISSN 0012-6667, 03/2000, Volume 59, Issue 3, pp. 487 - 495
Journal Article