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by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e95037 - e95037
Journal Article
Journal Article
Nature communications, ISSN 2041-1723, 05/2018, Volume 9, Issue 1, p. 1864
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
Lumican - metabolism | Glaucoma, Open-Angle - genetics | Humans | Corneal Diseases - metabolism | Corneal Dystrophies, Hereditary - ethnology | Corneal Diseases - genetics | Ehlers-Danlos Syndrome - genetics | Corneal Dystrophies, Hereditary - pathology | Loeys-Dietz Syndrome - metabolism | Mendelian Randomization Analysis | Fibrillin-1 - metabolism | Cornea - pathology | Keratoconus - pathology | Corneal Diseases - pathology | Decorin - genetics | Gene Expression | Eye Diseases, Hereditary - pathology | Lumican - genetics | ADAMTS Proteins - metabolism | Proteoglycans - metabolism | Ehlers-Danlos Syndrome - ethnology | European Continental Ancestry Group | Myopia - pathology | Cornea - metabolism | Myopia - ethnology | Loeys-Dietz Syndrome - pathology | Corneal Diseases - ethnology | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Cornea - abnormalities | Quantitative Trait Loci | Proteoglycans - genetics | ADAMTS Proteins - genetics | Transforming Growth Factor beta2 - metabolism | Corneal Dystrophies, Hereditary - genetics | Glaucoma, Open-Angle - pathology | Keratoconus - metabolism | Loeys-Dietz Syndrome - ethnology | Glaucoma, Open-Angle - ethnology | Myopia - metabolism | Ehlers-Danlos Syndrome - pathology | Marfan Syndrome - ethnology | Keratoconus - genetics | Glaucoma, Open-Angle - metabolism | Fibrillin-1 - genetics | Eye Diseases, Hereditary - ethnology | Genome-Wide Association Study | Quantitative Trait, Heritable | Corneal Dystrophies, Hereditary - metabolism | Marfan Syndrome - genetics | Eye Diseases, Hereditary - genetics | Myopia - genetics | Asian Continental Ancestry Group | Keratoconus - ethnology | Ehlers-Danlos Syndrome - metabolism | Loeys-Dietz Syndrome - genetics | Polymorphism, Single Nucleotide | Transforming Growth Factor beta2 - genetics | Genome, Human | Decorin - metabolism | Eye Diseases, Hereditary - metabolism | Cornea | Decorin | Corneal Dystrophies, Hereditary | Myopia | Corneal Diseases | Marfan Syndrome | Keratoconus | ADAMTS Proteins | Lumican | Transforming Growth Factor beta2 | Ehlers-Danlos Syndrome | Glaucoma, Open-Angle | Fibrillin-1 | Eye Diseases, Hereditary | Proteoglycans | Wellcome Trust Case Control Consortium 2 (WTCCC2) | Blue Mountains Eye Study—GWAS group | Loeys-Dietz Syndrome | NEIGHBORHOOD Consortium
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2012, Volume 8, Issue 5, pp. e1002711 - e1002711
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0184028 - e0184028
Journal Article
Science Signaling, ISSN 1945-0877, 11/2011, Volume 4, Issue 199, pp. ra75 - ra75
The mechanisms linking immune responses and inflammation with tumor development are not well understood. Here, we show that the soluble form of the... 
BREAST-CANCER | GROWTH-FACTOR-BETA | TGF-BETA | PROTEIN | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PDCD4 | TOLL-LIKE RECEPTORS | CELL-DEATH 4 | EXPRESSION | PROGRAMMED CELL-DEATH-4 | CELL BIOLOGY | Inflammation - pathology | Toll-Like Receptor 2 - genetics | Humans | Transforming Growth Factor beta1 - metabolism | MicroRNAs - metabolism | Inflammation - metabolism | Sepsis - metabolism | Toll-Like Receptor 4 - agonists | Decorin - genetics | Apoptosis Regulatory Proteins - immunology | Signal Transduction | RNA-Binding Proteins - immunology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | MicroRNAs - immunology | Toll-Like Receptor 4 - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Mice, Nude | Neoplasms - immunology | Interleukin-10 - genetics | Cell Line, Tumor | Toll-Like Receptor 2 - immunology | Mice | MicroRNAs - genetics | Macrophages, Peritoneal - metabolism | Interleukin-10 - immunology | RNA-Binding Proteins - metabolism | Neoplasms - metabolism | Neoplasm Transplantation | RNA-Binding Proteins - genetics | Toll-Like Receptor 2 - agonists | Macrophages, Peritoneal - pathology | Transplantation, Heterologous | Transforming Growth Factor beta1 - immunology | Decorin - immunology | Sepsis - pathology | Neoplasms - genetics | Apoptosis Regulatory Proteins - genetics | Interleukin-10 - metabolism | Sepsis - immunology | Inflammation - immunology | Transforming Growth Factor beta1 - genetics | Mice, Inbred C3H | Sepsis - genetics | Animals | Inflammation - genetics | Neoplasms - pathology | Decorin - metabolism | Index Medicus | Life Sciences | Cellular Biology
Journal Article
PloS one, 2017, Volume 12, Issue 8, p. e0184028
Journal Article
Oncogene, ISSN 0950-9232, 11/2001, Volume 20, Issue 50, pp. 7437 - 7446
Gene expression studies were undertaken in normal pancreas and pancreatic adenocarcinomas to determine new candidate genes that can potentially be used as... 
Desmoplasia | Expression profiling | Microarray | Pancreatic cancer | APOPTOSIS | CELLS | desmoplasia | expression profiling | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | TUMORS | CELL BIOLOGY | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | DECORIN | pancreatic cancer | microarray | ONCOLOGY | GENETICS & HEREDITY | EXTRACELLULAR-MATRIX | PROTEINS | Sialoglycoproteins - genetics | Decorin | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Stromal Cells - pathology | Cell Count | Humans | Gene Expression Profiling | Sialoglycoproteins - biosynthesis | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Extracellular Matrix Proteins | Phosphoric Monoester Hydrolases - biosynthesis | Neoplastic Stem Cells - pathology | Collagen - biosynthesis | Dishevelled Proteins | Neoplasm Proteins - genetics | Receptors, Fibroblast Growth Factor | Phosphoproteins - biosynthesis | Membrane Proteins - genetics | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinases - biosynthesis | Proteoglycans - biosynthesis | Reverse Transcriptase Polymerase Chain Reaction | Adaptor Proteins, Signal Transducing | Membrane Proteins - biosynthesis | Fibrosis | Computer Systems | Mitogen-Activated Protein Kinases - genetics | Biomarkers, Tumor - genetics | Biopsy, Needle | Internet | Proteoglycans - genetics | Receptors, Cell Surface - genetics | Ribosomal Proteins - biosynthesis | Adenocarcinoma - genetics | Collagen - genetics | Receptors, Cell Surface - biosynthesis | Phosphoric Monoester Hydrolases - genetics | Gene Library | Neoplasm Proteins - biosynthesis | Ribosomal Proteins - genetics | Stromal Cells - metabolism | Pancreatic Neoplasms - genetics | Phosphoproteins - genetics | Mitogen-Activated Protein Kinase 9 | Protein Isoforms - biosynthesis | rac1 GTP-Binding Protein - biosynthesis | Biomarkers, Tumor - biosynthesis | Protein Isoforms - genetics | rac1 GTP-Binding Protein - genetics | RNA | Oncology, Experimental | Analysis | Genetic aspects | Research | Gene expression | Cancer | Rac 1 gene | RPL-13a gene | Wnt5A gene | RPS9 gene | NEDD5 gene | GLG1 gene | stromal desmoplasia | Index Medicus
Journal Article
Human Gene Therapy, ISSN 1043-0342, 08/2017, Volume 28, Issue 8, pp. 667 - 680
In advanced and metastatic stages of colorectal cancer (CRC), reduced sensitivity to conventional strategies is still a major obstacle to successful... 
Research Articles | oncolytic adenovirus | colorectal cancer | immune | decorin | GM-CSF | MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC DELIVERY | CELLS | FACTOR-BETA | TGF-BETA | CANCER | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | MEDIATED INHIBITION | PHASE-I | EXPRESSION | T-Lymphocyte Subsets - immunology | Genetic Therapy | Genetic Vectors - administration & dosage | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Colorectal Neoplasms - genetics | Humans | Cytopathogenic Effect, Viral | Carcinogenesis - metabolism | Colorectal Neoplasms - therapy | Epithelial-Mesenchymal Transition | Adenoviridae - genetics | Transgenes | Gene Order | Colorectal Neoplasms - metabolism | Decorin - genetics | Disease Models, Animal | Gene Expression | Transduction, Genetic | Cytokines - metabolism | Signal Transduction | Immunomodulation | Carcinogenesis - genetics | Oncolytic Viruses - genetics | Genetic Vectors - genetics | Oncolytic Virotherapy | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Xenograft Model Antitumor Assays | Animals | Colorectal Neoplasms - immunology | Virus Replication | T-Lymphocyte Subsets - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Decorin - metabolism | Decorin | Mesenchyme | Toxicity | CD8 antigen | Transforming growth factor-b | Colorectal carcinoma | Lung | Colorectal cancer | Clinical trials | Cytotoxicity | Lymphocytes T | Infections | Metastasis | Tissues | Macrophages | Blood | Metastases | Angiogenesis | Granzyme B | Granulocytes | Lymphocytes | Coding | Xenografts | Oncolysis | Colony-stimulating factor | Inhibition | Perforin | Vascular endothelial growth factor | Growth factors | Activation analysis | Spleen | Medical research | Immune response | Granulocyte-macrophage colony-stimulating factor | Colonies | Gene expression | Patients | Adenoviruses | Antitumor activity | Leukocytes (granulocytic) | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article
Human Gene Therapy, ISSN 1043-0342, 12/2015, Volume 26, Issue 12, pp. 813 - 825
The development of novel therapies for breast cancer bone metastasis is a major unmet medical need. Toward that end, we have constructed an oncolytic... 
Research Articles | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | CARCINOMA CELLS | MITOPHAGY | AUTOPHAGY | GROWTH-FACTOR-BETA | MICROENVIRONMENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | DYNAMICS | EXTRACELLULAR-MATRIX | MEDIATED INHIBITION | Proto-Oncogene Proteins c-met - metabolism | Bone and Bones - pathology | Luciferases - metabolism | Bone Neoplasms - therapy | Humans | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Vascular Endothelial Growth Factor A - metabolism | Mammary Neoplasms, Experimental - metabolism | Vascular Endothelial Growth Factor A - genetics | Mammary Neoplasms, Experimental - genetics | Bone Neoplasms - metabolism | Luciferases - genetics | Bone Resorption - genetics | Bone and Bones - metabolism | Mammary Neoplasms, Experimental - pathology | Adenoviridae - genetics | Bone Resorption - metabolism | Female | Bone Neoplasms - genetics | Transgenes | Decorin - genetics | Genes, Reporter | Genetic Vectors - chemistry | Signal Transduction | Genetic Vectors - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Mammary Neoplasms, Experimental - therapy | Proto-Oncogene Proteins c-met - genetics | Bone Resorption - prevention & control | Oncolytic Virotherapy - methods | Animals | Mice, Nude | Bone Resorption - pathology | Mice | Adenoviridae - metabolism | Decorin - metabolism | Index Medicus
Journal Article