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Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
Journal Article
CELLS, ISSN 2073-4409, 01/2019, Volume 8, Issue 1, p. 67
Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological... 
PRPS | DRUG | ADSL | purine metabolism | AMP-deaminase | DISORDERS | purine-associated deficiencies | SACCHAROMYCES-CEREVISIAE | nucleotide synthesis | DOMINANT RETINITIS-PIGMENTOSA | INBORN-ERRORS | CELL BIOLOGY | NUCLEOTIDE | hyperuricemia | MUTANTS | ATIC | GENES | Lesch-Nyhan | AICAR | MUTATIONS | Life Sciences | Lesch–Nyhan
Journal Article
Nutrition and Metabolism, ISSN 1743-7075, 05/2018, Volume 15, Issue 1, pp. 33 - 12
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a... 
Ammonia | Cirrhosis | Cachexia | Diabetes | Nutrition | Glutamine | RAT SKELETAL-MUSCLE | LEUCINE METABOLISM | PROLONGED EXERCISE | PROTEIN-METABOLISM | ALPHA-KETOISOCAPROATE | UREA CYCLE DISORDERS | TUMOR-NECROSIS-FACTOR | DEHYDROGENASE COMPLEX | NUTRITION & DIETETICS | FREE FATTY-ACIDS | GLUTAMINE SYNTHESIS | Branched chain amino acids | Health aspects | Blood plasma
Journal Article
Experimental & molecular medicine, ISSN 1226-3613, 2015, Volume 47, Issue 3, pp. e147 - e147
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-PROTEASOME SYSTEM | CHAPERONE-MEDIATED AUTOPHAGY | ALPHA-SYNUCLEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUALITY CONTROL DEGRADATION | CENTRAL-NERVOUS-SYSTEM | AMYOTROPHIC-LATERAL-SCLEROSIS | SOD1 TRANSGENIC MICE | ENDOPLASMIC-RETICULUM STRESS | END RULE PATHWAY | PARKINSONS-DISEASE | Proteostasis Deficiencies - metabolism | Humans | Ubiquitin - metabolism | tau Proteins - metabolism | Parkinson Disease - drug therapy | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Amyotrophic Lateral Sclerosis - drug therapy | Autophagy - drug effects | DNA-Binding Proteins - metabolism | PrPSc Proteins - metabolism | Lysosomes - metabolism | Proteolysis | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Superoxide Dismutase - metabolism | Prion Diseases - drug therapy | Alzheimer Disease - drug therapy | Neurodegenerative Diseases - metabolism | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | alpha-Synuclein - metabolism | Prion Diseases - metabolism | Review
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2013, Volume 63, pp. 1 - 29
Neurodegenerative disorders are debilitating diseases of the brain, characterized by behavioral, motor and cognitive impairments. Ample evidence underpins... 
Sirtuins | Charcot-Marie-Tooth disease and Friedreich’s ataxia | Mitochondrial dysfunction | Free radicals | Alzheimer’s disease | Neurodegenerative diseases | Amyotrophic lateral sclerosis | Co-Q10 | Huntington’s disease | PGC-1α | Creatine | Parkinson’s disease | Charcot-Marie-Tooth disease and | Parkinson's disease | Huntington's disease | Friedreich's ataxia | Alzheimer's disease | KETOGLUTARATE DEHYDROGENASE COMPLEX | PGC-1 alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | EARLY PARKINSON-DISEASE | NEURONAL CELL-DEATH | AMYOTROPHIC-LATERAL-SCLEROSIS | AMYLOID PRECURSOR PROTEIN | Charcot-Marie-Tooth disease and Friedreich's ataxia | CYTOCHROME-C-OXIDASE | TARGETED ANTIOXIDANT MITOQ | ENDOCRINOLOGY & METABOLISM | PLACEBO-CONTROLLED TRIAL | TRANSGENIC MOUSE MODEL | COMPLEX-I DEFICIENCY | Mitochondrial Diseases - pathology | Friedreich Ataxia - metabolism | Parkinson Disease - pathology | Free Radicals - toxicity | Friedreich Ataxia - pathology | Humans | Huntington Disease - pathology | Nerve Degeneration - physiopathology | Mitochondria - metabolism | Mitochondria - pathology | Charcot-Marie-Tooth Disease - pathology | Huntington Disease - metabolism | Nerve Degeneration - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Amyotrophic Lateral Sclerosis - pathology | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Brain - pathology | Parkinson Disease - metabolism | Charcot-Marie-Tooth Disease - metabolism | Proteins | Nervous system diseases | Mitochondrial DNA | Gene mutations | Analysis | Index Medicus
Journal Article