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PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0160260 - e0160260
Background Amoxicillin is a commonly used antibiotic which has a short half-life in human. The frequent administration of amoxicillin is often required to keep... 
ACETATE SUCCINATE HPMCAS | IN-VITRO | PERMEABILITY | DRUG-DELIVERY | SPHERONIZATION | MULTIDISCIPLINARY SCIENCES | PARAMETERS | PELLETS | SIMULATION | GRANULES | EXTRUSION/SPHERONIZATION | Models, Theoretical | Microscopy, Electron, Scanning | Area Under Curve | Humans | Half-Life | Male | Methacrylates - chemistry | Amoxicillin - metabolism | Amoxicillin - pharmacokinetics | Animals | Dogs | Drug Compounding | Drug Liberation | Tablets - chemistry | Amoxicillin - chemistry | Polymers - chemistry | ROC Curve | Delayed-Action Preparations | Complications and side effects | Dosage and administration | Research | Pharmacokinetics | Amoxicillin | Drug delivery systems | Compression | Magnesium stearate | Tablets | Extrusion coating | Cellulose | Drug resistance | Drug development | Silicon dioxide | Optimization | Design | Compacting | Modelling | Magnesium | Pharmaceutical industry | Protective coatings | Drug dosages | Controlled release | Pharmaceutical sciences | Pellets | Formulations | Scanning electron microscopy | Chemical industry | Granulation | Computer simulation | Radioactive half-life | Pharmacology | Side effects | Acids | Antibiotics | Engineering research | Concentration time | Granular materials | Pharmacy | Sustained release | In vivo methods and tests | Crafts | In vitro methods and tests | Index Medicus
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 10/2013, Volume 53, Issue 10, pp. 1010 - 1019
Journal Article
Biomacromolecules, ISSN 1525-7797, 09/2014, Volume 15, Issue 9, pp. 3246 - 3252
Multifunctional injectable thermo-/pH-responsive hydrogels as release systems for the oral delivery of small molecule drugs and the local delivery of protein... 
BIODEGRADABLE HYDROGELS | IN-VITRO | POLYMER SCIENCE | CHITOSAN MATERIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | RECENT PROGRESS | SYSTEMS | BIOMEDICAL APPLICATIONS | ORAL DELIVERY | COENZYME-A | MECHANICAL-PROPERTIES | Diclofenac - pharmacology | Adipose Tissue - cytology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Delayed-Action Preparations - chemistry | Hydrogels - pharmacokinetics | Hydrogels - chemical synthesis | Hexuronic Acids - pharmacokinetics | Methacrylates - chemistry | Diclofenac - chemistry | Drug Carriers - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Cattle | Delayed-Action Preparations - pharmacology | Delayed-Action Preparations - pharmacokinetics | Delayed-Action Preparations - chemical synthesis | Serum Albumin, Bovine - chemistry | Hexuronic Acids - chemical synthesis | Glucuronic Acid - chemistry | Alginates - pharmacokinetics | Glucuronic Acid - chemical synthesis | Alginates - pharmacology | Rabbits | Serum Albumin, Bovine - pharmacology | Mesenchymal Stromal Cells - metabolism | Drug Carriers - chemical synthesis | Glucuronic Acid - pharmacokinetics | Hexuronic Acids - chemistry | Diclofenac - pharmacokinetics | Drug Carriers - pharmacology | Glucuronic Acid - pharmacology | Serum Albumin, Bovine - pharmacokinetics | Animals | Alginates - chemical synthesis | Alginates - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Drug Carriers - pharmacokinetics | Hydrogels - pharmacology | Hydrogels - chemistry | Hexuronic Acids - pharmacology | Hydrogen-Ion Concentration | Index Medicus
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 2010, Volume 74, Issue 2, pp. 332 - 339
Ciprofloxacin hydrochloride has a short elimination half-life, a narrow absorption window and is mainly absorbed in proximal areas of GIT. The purpose of this... 
Abdominal X-ray imaging | Gas former | Ciprofloxacin hydrochloride | Release-retarding polymers | Floating gastroretentive tablets | POLYMERS | MICROSPHERES | BEHAVIOR | DRUG-DELIVERY SYSTEM | FORMULATION | ANTIBACTERIAL ACTIVITY | PHARMACOLOGY & PHARMACY | GASTRIC RETENTION | Humans | Tablets - pharmacokinetics | Contrast Media - pharmacokinetics | Methylcellulose - analogs & derivatives | Delayed-Action Preparations - chemistry | Male | Barium Sulfate - pharmacokinetics | Stomach - metabolism | Hexuronic Acids - pharmacokinetics | Calcium Carbonate - chemistry | Delayed-Action Preparations - administration & dosage | Methylcellulose - pharmacokinetics | Time Factors | Chemical Phenomena | Delayed-Action Preparations - pharmacokinetics | Adult | Delayed-Action Preparations - chemical synthesis | Glucuronic Acid - chemistry | Alginates - pharmacokinetics | Radiography, Abdominal | Stomach - diagnostic imaging | Tablets - administration & dosage | Drug Compounding - methods | Drug Stability | Glucuronic Acid - pharmacokinetics | Hexuronic Acids - chemistry | Ciprofloxacin - pharmacokinetics | Methylcellulose - chemistry | Tablets - chemical synthesis | Hypromellose Derivatives | Alginates - chemistry | Tablets - chemistry | Sodium Bicarbonate - chemistry | Drugs | Barium | Drug delivery systems | Salts | Limestone | Sodium bicarbonate | Carbonates | Polymers | Ciprofloxacin | Sulfates | Vehicles | Index Medicus
Journal Article
Journal Article
Journal of Clinical Pharmacology, ISSN 0091-2700, 08/2011, Volume 51, Issue 8, pp. 1152 - 1162
To increase our understanding of important subject characteristics and design variables affecting the performance of oral moxifloxacin in thorough QT studies,... 
Population pharmacokinetics | QT prolongation | exposure-response modeling | thorough QT studies | ICH E14 | moxifloxacin | WOMEN | INTERVAL PROLONGATION | TRAFFICKING | PHARMACOLOGY & PHARMACY | QT/QTC | QUINIDINE | Fluoroquinolones | Aza Compounds - pharmacokinetics | Quinolines - blood | Drugs, Investigational - adverse effects | Anti-Infective Agents - blood | United States | Humans | Middle Aged | Drugs, Investigational - pharmacokinetics | Aza Compounds - adverse effects | Male | Metabolic Clearance Rate | Quinolines - administration & dosage | Drugs, Investigational - analysis | Intestinal Absorption | Delayed-Action Preparations - administration & dosage | Quinolines - pharmacokinetics | Young Adult | Delayed-Action Preparations - pharmacokinetics | Adult | Aza Compounds - blood | Female | United States Food and Drug Administration | Aza Compounds - administration & dosage | Anti-Infective Agents - adverse effects | Administration, Oral | Electrocardiography - drug effects | Clinical Trials as Topic | Animals | Anti-Infective Agents - administration & dosage | Delayed-Action Preparations - adverse effects | Models, Biological | Anti-Infective Agents - pharmacokinetics | Adolescent | Drugs, Investigational - administration & dosage | Aged | Quinolines - adverse effects | Physiological aspects | Moxifloxacin | Research | Demographic aspects | Pharmacokinetics | Index Medicus
Journal Article
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 2011, Volume 77, Issue 1, pp. 11 - 19
The insulin-loaded alginate-chitosan microspheres prepared by SPG membrane emulsification and two-step solidification could realize the pH-sensitive release of... 
Narrow size distribution | Sustained release | Protein or peptide | Alginate–chitosan microspheres | Insulin | Oral administration | Alginate-chitosan microspheres | SYSTEM | PROTEIN DRUGS | RAT | DRUG-DELIVERY | CONTROLLED-RELEASE | SODIUM ALGINATE | CARRIER | PEPTIDE | INTERNAL GELATION | GEL BEADS | PHARMACOLOGY & PHARMACY | Diabetes Mellitus, Experimental - drug therapy | Drug Carriers - therapeutic use | Drug Carriers - administration & dosage | Delayed-Action Preparations - chemistry | Male | Drug Carriers - chemistry | Delayed-Action Preparations - administration & dosage | Diabetes Mellitus, Experimental - blood | Tissue Distribution | Microspheres | Hypoglycemic Agents - administration & dosage | Surface Properties | Delayed-Action Preparations - pharmacokinetics | Glucuronic Acid - chemistry | Hypoglycemic Agents - therapeutic use | Hypoglycemic Agents - pharmacokinetics | Blood Glucose - analysis | Administration, Oral | Drug Stability | Gastric Juice - metabolism | Solubility | Rats | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Hexuronic Acids - chemistry | Rats, Sprague-Dawley | Particle Size | Animals | Chitosan - chemistry | Insulin - chemistry | Alginates - chemistry | Alginates - ultrastructure | Delayed-Action Preparations - therapeutic use | Drug Carriers - pharmacokinetics | Insulin - pharmacokinetics | Insulin - therapeutic use | Hydrogen-Ion Concentration | Index Medicus
Journal Article
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 08/2017, Volume 58, pp. 168 - 180
Injectable hydrogels with pH-responsiveness and self-healing ability have great potential for anti-cancer drug delivery. Herein, we developed a series of... 
Injectable hydrogels | N-Carboxyethyl chitosan | Self-healing | Target release | pH-responsive | POLYMERS | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | DOXORUBICIN | TISSUE | CONTROLLED-RELEASE | COENZYME-A | CANCER | BIOACTIVE MOLECULES | IN-VIVO | BIOMEDICAL APPLICATIONS | Humans | Delayed-Action Preparations - chemistry | Hydrogels - pharmacokinetics | Doxorubicin - chemistry | Carcinoma, Hepatocellular - drug therapy | Esters - chemistry | Delayed-Action Preparations - pharmacology | Delayed-Action Preparations - pharmacokinetics | Chitosan - pharmacology | Liver Neoplasms - pathology | Chitosan - analogs & derivatives | Liver Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Hep G2 Cells | Chitosan - chemistry | Chitosan - pharmacokinetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Esters - pharmacokinetics | Hydrogels - pharmacology | Doxorubicin - pharmacology | Esters - pharmacology | Hydrogels - chemistry | Carcinoma, Hepatocellular - metabolism | Hydrogen-Ion Concentration | Drugs | Schiff bases | Ethylene glycol | Drug delivery systems | Anthracyclines | Care and treatment | Liver | Hepatoma | Vehicles | Analysis | Hydrogen-ion concentration | Health aspects | Cancer | Therapy | Surgical implants | Hydrogels | Ethylene | Cytotoxicity | Hepatocellular carcinoma | Drug delivery | Drug development | pH effects | Doxorubicin | Liver cancer | Hydrogen ions | Aqueous solutions | Imines | Polyethylene glycol | Surgery | Injectability | Toxicity testing | Biocompatibility | Chemical synthesis | Targeted cancer therapy | Michael reaction | Biodegradation | Invasiveness | Gelation | Benzaldehyde | Implantation | Injection | In vivo methods and tests | Chitosan | Rheological properties | Index Medicus
Journal Article