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Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 517 - 521
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity(1-3). However, the underlying support... 
CYTOCHROME-C-OXIDASE | RAT OLIGODENDROCYTES | OPTIC-NERVE | CELL-DEVELOPMENT | GLUCOSE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | LACTATE | MICE LACKING | BRAIN | DEFICIENCY | Protons | Mitochondria - enzymology | Oligodendroglia - metabolism | Electron Transport Complex IV - antagonists & inhibitors | Demyelinating Diseases - genetics | Alkyl and Aryl Transferases - metabolism | Axons - physiology | Demyelinating Diseases - metabolism | Electron Transport Complex IV - metabolism | Myelin Sheath - metabolism | Action Potentials | Brain - metabolism | Membrane Proteins - deficiency | Oligodendroglia - drug effects | Cell Respiration | Mitochondria - genetics | Time Factors | Alkyl and Aryl Transferases - genetics | Membrane Proteins - metabolism | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Alkyl and Aryl Transferases - deficiency | Brain - cytology | Demyelinating Diseases - enzymology | Magnetic Resonance Spectroscopy | Cell Survival | Membrane Proteins - genetics | Lactic Acid - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Mitochondria - metabolism | Schwann Cells - metabolism | Electron Transport Complex IV - genetics | Mitochondria - pathology | Animals | Glycolysis | Oligodendroglia - enzymology | Mice | Schwann Cells - enzymology | Physiological aspects | Oligodendroglia | Axons | Health aspects | Electrodes | Medical research | Mitochondria | Metabolites | Rodents | Nervous system | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7555, pp. 216 - 220
Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural... 
MYELIN BASIC-PROTEIN | TRANSCRIPTS | GLUCOCORTICOIDS | MULTIPLE-SCLEROSIS | LYSOLECITHIN | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION | OLIGODENDROCYTE PROGENITOR CELLS | Oligodendroglia - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Cerebellum - drug effects | Myelin Sheath - drug effects | Male | Receptors, Glucocorticoid - metabolism | Demyelinating Diseases - metabolism | MAP Kinase Signaling System | Myelin Sheath - metabolism | Oligodendroglia - drug effects | Female | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Germ Layers - drug effects | Germ Layers - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Lysophosphatidylcholines | Pluripotent Stem Cells - cytology | Germ Layers - metabolism | Tissue Culture Techniques | Cerebellum - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cerebellum - pathology | Pluripotent Stem Cells - metabolism | Phenotype | Regeneration - drug effects | Animals | Cell Differentiation - drug effects | Miconazole - pharmacology | Pluripotent Stem Cells - drug effects | Multiple Sclerosis - pathology | Mice | Clobetasol - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Multiple Sclerosis - drug therapy | Medical research | Myelination | Multiple sclerosis | Stem cells | Physiological aspects | Medicine, Experimental | Research | Drugs | Proteins | Blood-brain barrier | Laboratories | Rodents | Clinical trials | FDA approval | Gene expression | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e54722 - e54722
Background: Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory... 
IN-VITRO | MULTIPLE-SCLEROSIS | MICROGLIA | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | DEVELOPING OLIGODENDROCYTES | LIPOPOLYSACCHARIDE | INJURY | REMYELINATION | CENTRAL-NERVOUS-SYSTEM | DEGENERATION | Free Radical Scavengers - pharmacology | Neuritis - metabolism | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Pyruvates - pharmacology | Oxidative Stress | Myelin Sheath - drug effects | Demyelinating Diseases - metabolism | Cerebellum - immunology | Microglia - immunology | Oligodendroglia - physiology | Interleukin-1beta - metabolism | Demyelinating Diseases - immunology | Inflammation Mediators - metabolism | Interleukin-6 - metabolism | Interleukin-1beta - secretion | Cytokines - metabolism | Microglia - drug effects | Myelin Sheath - immunology | Myelin Sheath - pathology | Tissue Culture Techniques | Cerebellum - metabolism | Mice, Inbred C57BL | Tumor Necrosis Factor-alpha - secretion | Interleukin-6 - secretion | Cerebellum - pathology | Animals | Neuritis - immunology | Interferon-beta - pharmacology | Axons - pathology | Lipopolysaccharides - pharmacology | Allopurinol - pharmacology | Mice | Axons - immunology | Nitric Oxide Synthase Type II - metabolism | Oxidases | Oxidative stress | Nervous system diseases | Multiple sclerosis | Hostages | Inflammation | Biological response modifiers | Molybdenum compounds | Tumor necrosis factor | Nitric oxide | Models | Interferon | Mitogens | Cerebellum | Pathogenesis | Nervous system | Damage prevention | Sclerosis | Lipopolysaccharides | Antioxidants | Mitochondria | Neurodegeneration | Neurofilaments | Damage accumulation | Brain diseases | Stresses | Free radicals | Cytokines | Neurodegenerative diseases | Medical treatment | Cultures | Tumor necrosis factor-α | Nitric-oxide synthase | Microglia | Neurological diseases | Inhibitors | Xanthine oxidase | Tumor necrosis factor receptors | Neuroprotection | Reactive oxygen species | Biomedical research | β-Interferon | Pyruvic acid | Activation | Blockage | Interleukin 6 | Demyelination | Rodents | Degeneration | Myelin | Allopurinol | Xanthine | Spheroids | Stress | Brain research | Microscopy | Apoptosis | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 2013, Volume 136, Issue 1, pp. 147 - 167
Journal Article
Nature Neuroscience, ISSN 1097-6256, 01/2013, Volume 16, Issue 1, pp. 48 - 54
After peripheral nerve injury, axons regenerate and become remyelinated by resident Schwann cells. However, myelin repair never results in the original myelin... 
MAINTENANCE | PERIPHERAL-NERVE REGENERATION | MYELIN SHEATH THICKNESS | GROWTH | INJURY | PROLIFERATION | ENSHEATHMENT | MECHANISMS | RECEPTORS | EXPRESSION | NEUROSCIENCES | Electric Stimulation | Recovery of Function - drug effects | Evoked Potentials, Motor - drug effects | Ki-67 Antigen - metabolism | Ganglia, Spinal - cytology | RNA, Messenger - metabolism | Neuregulin-1 - genetics | Time Factors | Statistics, Nonparametric | Neurons - metabolism | Disease Models, Animal | Animals, Newborn | Myelin Basic Protein - metabolism | Neurons - chemistry | Enzyme Inhibitors - pharmacology | Rats | Sciatic Neuropathy - pathology | Mice, Transgenic | S100 Proteins - metabolism | Schwann Cells - metabolism | Signal Transduction - genetics | Schwann Cells - ultrastructure | Signal Transduction - drug effects | Axons - pathology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | Mice | Locomotion - genetics | Evoked Potentials, Motor - physiology | Culture Media, Conditioned - pharmacology | Demyelinating Diseases - metabolism | Myelin Sheath - metabolism | Octamer Transcription Factor-6 - metabolism | Hedgehog Proteins - genetics | Axons - ultrastructure | Sciatic Nerve - cytology | Demyelinating Diseases - etiology | Neurons - drug effects | Schwann Cells - drug effects | Microscopy, Electron, Transmission | Recovery of Function - genetics | Myelin Sheath - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Axons - drug effects | Animals | Neuregulin-1 - metabolism | Early Growth Response Protein 2 - metabolism | Sciatic Neuropathy - physiopathology | Cell Proliferation - drug effects | Myelin P0 Protein - metabolism | Neurons | Schwann cells | Physiological aspects | Genetic aspects | Research | Myelin sheath | Gene expression | Index Medicus
Journal Article
Nature neuroscience, ISSN 1097-6256, 08/2016, Volume 19, Issue 8, pp. 995 - 998
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released... 
DYNAMICS | CELLS | NERVE-FIBERS | MICE | NEUROSCIENCES | DELETION | Brain - metabolism | Microglia - metabolism | Animals | Mice, Inbred C57BL | Mice, Transgenic | Demyelinating Diseases - chemically induced | Demyelinating Diseases - metabolism | Lipofuscin - metabolism | Aging - metabolism | Myelin Sheath - metabolism | Aging | Research | Analysis | Myelin proteins | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76495 - e76495
Multiple sclerosis (MS) is a chronic autoimmune neuroinflammatory disease found mostly in young adults in the western world. Oxidative stress induced neuronal... 
IN-VITRO | INHIBITION | ACID | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | TAU | CENTRAL-NERVOUS-SYSTEM | BLOOD-BRAIN-BARRIER | EXPRESSION | SCLEROSIS PATIENTS | CELL-DEATH | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Demyelinating Diseases - metabolism | Glial Fibrillary Acidic Protein | Th1 Cells - metabolism | CD11b Antigen - genetics | Inflammation - metabolism | Th17 Cells - drug effects | Th17 Cells - metabolism | Inflammation - drug therapy | Apoptosis Regulatory Proteins - genetics | Female | Encephalomyelitis, Autoimmune, Experimental - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Cell Line | Th1 Cells - drug effects | Drugs, Chinese Herbal | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | RNA, Messenger - genetics | Multiple Sclerosis - genetics | Antioxidants - pharmacology | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | T-Box Domain Proteins - genetics | Disease Progression | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Mice | CD11b Antigen - metabolism | Oxidative Stress - drug effects | Multiple Sclerosis - drug therapy | Nitric Oxide Synthase Type II - metabolism | Saponins - pharmacology | Antioxidants | Oxidative stress | Nervous system diseases | Multiple sclerosis | Cytokines | Encephalomyelitis | T cells | Tumor proteins | Neurophysiology | Cell culture | Phosphorylation | Hydrogen peroxide | Bax protein | Bcl-2 protein | Laboratories | Pathogenesis | p53 Protein | Differentiation (biology) | Central nervous system | Lymphocytes T | Chinese medicine | Blood-brain barrier | Neurodegeneration | Rodents | Modulation | Cell cycle | Inhibition | Stresses | Free radicals | Young adults | Inflammation | Gene expression | Cell differentiation | Experimental allergic encephalomyelitis | Nitric-oxide synthase | Molecular chains | Microglia | Tau protein | Nitric oxide | γ-Interferon | Adults | Infiltration | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 11, pp. E2243 - E2252
Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced pluripotent stem cells (iPSC) are currently lacking, but may be a key... 
Myelination | Disease modeling | Forward patterning | Human iPSC | Oligodendrocytes | PROGENITOR CELLS | MUTANT TAU-PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | disease modeling | FRONTOTEMPORAL DEMENTIA | human iPSC | oligodendrocytes | PROCESS OUTGROWTH | PROGRESSIVE MULTIPLE-SCLEROSIS | MESSENGER-RNA | IN-VIVO | myelination | MOUSE SPINAL-CORD | DEVELOPMENTAL-CHANGES | forward patterning | Oligodendroglia - metabolism | Spinal Cord - metabolism | Oxidative Stress | Demyelinating Diseases - genetics | Humans | Transcriptome | tau Proteins - metabolism | Gene Expression Profiling | Demyelinating Diseases - metabolism | Neural Stem Cells - cytology | Spinal Cord - ultrastructure | Myelin Sheath - metabolism | Brain - metabolism | Myelin Basic Protein - genetics | Cell Differentiation - genetics | tau Proteins - genetics | Cell Death - genetics | Spinal Cord - pathology | Brain - ultrastructure | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Induced Pluripotent Stem Cells - cytology | Cell Lineage - genetics | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Myelin Basic Protein - metabolism | Cells, Cultured | Ectopic Gene Expression | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Myelin Sheath - genetics | Biomarkers | Brain - pathology | Mice | Mutation | Neural Stem Cells - metabolism | Cluster Analysis | Cell proliferation | Physiological aspects | Dendritic cells | Observations | Stem cells | Gene expression | Rodents | Medical treatment | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7487, pp. 230 - 234
There are no clinically relevant treatments available that improve function in the growing population of very preterm infants (less than 32 weeks' gestation)... 
MULTIPLE-SCLEROSIS | LOW-BIRTH-WEIGHT | OLIGODENDROCYTE PROGENITORS | MULTIDISCIPLINARY SCIENCES | HYPOXIC INJURY | CENTRAL-NERVOUS-SYSTEM | MOUSE CORPUS-CALLOSUM | PRETERM INFANTS | RAT-BRAIN | WHITE-MATTER ABNORMALITIES | FACTOR RECEPTOR | Epidermal Growth Factor - administration & dosage | Oligodendroglia - metabolism | Receptor, Epidermal Growth Factor - genetics | Demyelinating Diseases - congenital | Brain Injuries - drug therapy | Humans | Brain Injuries - congenital | Male | Stem Cells - cytology | Demyelinating Diseases - metabolism | Epidermal Growth Factor - therapeutic use | Molecular Targeted Therapy | Stem Cells - metabolism | Cell Lineage - drug effects | Hypoxia - metabolism | Receptor, Epidermal Growth Factor - metabolism | Oligodendroglia - drug effects | Time Factors | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Disease Models, Animal | Animals, Newborn | Cell Survival - drug effects | Demyelinating Diseases - prevention & control | Administration, Intranasal | Infant, Premature, Diseases - drug therapy | Cell Division - drug effects | Brain Injuries - prevention & control | Oligodendroglia - pathology | Hypoxia - genetics | Regeneration - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hypoxia - pathology | Stem Cells - drug effects | Hypoxia - physiopathology | Infant, Premature, Diseases - metabolism | Mice | Epidermal Growth Factor - pharmacology | Brain Injuries - pathology | Infant, Premature, Diseases - pathology | Brain | Medical research | Care and treatment | Infants (Premature) | Risk factors | Complications and side effects | Epidermal growth factor | Physiological aspects | Medicine, Experimental | Hypoxia | Diagnosis | Health aspects | Injuries | Attention deficit disorder | Brain damage | Rodents | Apoptosis | Index Medicus
Journal Article
11.