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Journal of the American Chemical Society, ISSN 0002-7863, 11/2016, Volume 138, Issue 43, pp. 14230 - 14233
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 2102 - 2111
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 1, pp. 191 - 203
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 1, pp. 371 - 383
Background: Lethal mutagenesis is an antiviral strategy. Results: Nucleoside analogue mutagenicity is correlated to base pair stability and the ability to function as a template during reverse transcription. Conclusion... 
ERROR CATASTROPHE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIBONUCLEOSIDE ANALOGS | LETHAL MUTAGENESIS | Lethal | REPLICATION FIDELITY | Reverse Transcription | DEFICIENCY SYNDROME AIDS | Human Immunodeficiency Virus (HIV) | Mutagenesis | HEPATITIS-C VIRUS | RNA VIRUS | IMMUNODEFICIENCY-VIRUS TYPE-1 | Antiviral Agent | Nucleoside | MOUTH-DISEASE VIRUS | Nucleotide Analogue | HIV-1 REVERSE-TRANSCRIPTASE | Anti-HIV Agents - pharmacology | Predictive Value of Tests | Deoxycytidine - chemistry | Mutagens - metabolism | HIV Reverse Transcriptase - antagonists & inhibitors | Molecular Sequence Data | Reverse Transcriptase Inhibitors - pharmacology | Deoxycytidine - pharmacology | HIV Reverse Transcriptase - genetics | Base Pair Mismatch | Reverse Transcriptase Inhibitors - chemistry | Thermodynamics | Deoxycytidine - metabolism | Time Factors | Thymidine - pharmacology | Base Sequence | Drug Design | Anti-HIV Agents - metabolism | Thymidine - chemistry | HIV Reverse Transcriptase - chemistry | Thymidine - metabolism | Mutagens - chemistry | Nucleic Acid Denaturation | HIV-1 - drug effects | Mutagens - pharmacology | High-Throughput Screening Assays - economics | HIV-1 - genetics | Anti-HIV Agents - chemistry | Thymidine - analogs & derivatives | Base Pairing | HIV-1 - enzymology | Reverse Transcriptase Inhibitors - metabolism | Deoxycytidine - analogs & derivatives | Index Medicus | Molecular Biophysics
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 10/2014, Volume 9, Issue 10, pp. 2326 - 2333
...) to track transgenes in cell-based therapies using PET reporter gene/probe pairs. A promising example for such reporter gene/probe pairs are engineered nucleoside kinases that effectively phosphorylate isotopically labeled nucleoside analogues... 
MEDIATED GENE-EXPRESSION | MUTAGENESIS | THERAPY | HUMAN DEOXYCYTIDINE KINASE | TRANSGENE EXPRESSION | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | IMPROVES | SIMULATION | PROTEINS | Deoxycytidine Kinase - chemistry | Nucleosides - chemistry | Phosphorylation | Mutagenesis, Site-Directed | Stereoisomerism | Humans | Substrate Specificity | Positron-Emission Tomography | Mutation - genetics | Deoxycytidine Kinase - metabolism | Computer Simulation | Statistics, Nonparametric | Deoxycytidine Kinase - genetics | Kinetics | Genes, Reporter
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2010, Volume 70, Issue 9, pp. 3606 - 3617
.... We have previously evaluated the bioavailability of novel analogues of curcumin compared with curcumin, and we found that the analogue CDF exhibited greater systemic and pancreatic tissue bioavailability... 
GROWTH-FACTOR RECEPTOR | APOPTOSIS | TO-MESENCHYMAL TRANSITION | INHIBITION | ONCOLOGY | ADENOCARCINOMA | DOWN-REGULATION | ORTHOTOPIC MODEL | FACTOR-KAPPA-B | MICRORNA-21 | LINES | Pancreatic Neoplasms - metabolism | Triterpenes - pharmacology | Apoptosis - drug effects | DNA, Neoplasm - metabolism | Dinoprostone - biosynthesis | Humans | DNA, Complementary - genetics | Apoptosis - genetics | Deoxycytidine - pharmacology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Curcumin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Vascular Endothelial Growth Factor A - secretion | Pancreatic Neoplasms - drug therapy | Transfection | Gene Expression Regulation, Neoplastic - genetics | PTEN Phosphohydrolase - genetics | NF-kappa B - antagonists & inhibitors | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Curcumin - pharmacology | Gene Silencing | MicroRNAs - biosynthesis | Pancreatic Neoplasms - genetics | Drug Synergism | Oligonucleotides, Antisense - genetics | NF-kappa B - genetics | Cell Line, Tumor | MicroRNAs - genetics | DNA, Neoplasm - genetics | Dinoprostone - antagonists & inhibitors | Triterpenes - administration & dosage | Deoxycytidine - analogs & derivatives
Journal Article
Leukemia, ISSN 1476-5551, 2001, Volume 15, Issue 6, pp. 875 - 890
Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine arabinoside... 
Nucleoside transporters | 5′-nucleotidase | Drug resistance | Nucleoside analogues | HUMAN CYTIDINE DEAMINASE | nucleoside transporters | COLONY-STIMULATING FACTOR | DOSE ARA-C | ACUTE MYELOGENOUS LEUKEMIA | MITOCHONDRIAL DEOXYGUANOSINE KINASE | 5'-nucleotidase | ACUTE MYELOID-LEUKEMIA | HAIRY-CELL LEUKEMIA | P53 GENE MUTATION | ONCOLOGY | nucleoside analogues | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | drug resistance | HEMATOLOGY | Deoxycytidine - chemistry | Antimetabolites, Antineoplastic - pharmacokinetics | DNA Replication - drug effects | Neoplastic Stem Cells - drug effects | 2-Chloroadenosine - pharmacology | Humans | 2-Chloroadenosine - analogs & derivatives | Biological Transport | Dioxolanes - pharmacology | Antimetabolites, Antineoplastic - pharmacology | Cytosine - pharmacology | Acute Disease | DNA Repair - drug effects | Arabinonucleosides - pharmacology | Antimetabolites, Antineoplastic - chemistry | Remission Induction | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Leukemia, Myeloid - drug therapy | Antimetabolites, Antineoplastic - therapeutic use | Cytarabine - chemistry | Cytidine Deaminase - metabolism | Hematopoietic Cell Growth Factors - pharmacology | Vidarabine - chemistry | Deoxycytidine - analogs & derivatives | Cytosine - analogs & derivatives | Deoxyadenosines - chemistry | Phosphorylation | Cytarabine - pharmacology | Nucleosides - pharmacokinetics | Deoxycytidine - pharmacology | Deoxycytidine Kinase - metabolism | 2-Chloroadenosine - chemistry | Nucleosides - pharmacology | Nucleosides - therapeutic use | Nucleosides - chemistry | Arabinonucleosides - chemistry | Vidarabine - analogs & derivatives | Cytosine - chemistry | Dioxolanes - chemistry | Vidarabine - pharmacology | Animals | Carrier Proteins - metabolism | Ribonucleotide Reductases - antagonists & inhibitors | Ribonucleotide Reductases - metabolism | Lymphoproliferative Disorders - drug therapy | DNA-Directed DNA Polymerase - metabolism | Deoxyadenosines - pharmacology | 5'-Nucleotidase - metabolism | Drug Resistance, Neoplasm - physiology
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 03/2012, Volume 107, Issue 6, pp. 781 - 790
...), vitamin D-3 and resveratrol alone and in combination with adenosine analogues, 2-chloro-2'-deoxyadenosine (2CdA... 
Promoter methylation | Epigenetic therapy | Phyto-oestrogens | Chemoprevention | Vitamins | PROMOTER HYPERMETHYLATION | APOPTOSIS | DNA METHYLATION | 5-AZA-2'-DEOXYCYTIDINE | PTEN | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | NUTRITION & DIETETICS | PATHWAY | CHRONIC LYMPHOCYTIC-LEUKEMIA | RECEPTOR-BETA | TRANSCRIPTIONAL REGULATION | Humans | Vitamins - metabolism | Stilbenes - pharmacology | Neoplasm Proteins - metabolism | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Breast Neoplasms - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | Breast Neoplasms - enzymology | Adenocarcinoma - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Tretinoin - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Inhibitory Concentration 50 | Antimetabolites, Antineoplastic - pharmacology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Cell Survival - drug effects | PTEN Phosphohydrolase - genetics | DNA (Cytosine-5-)-Methyltransferase 1 | Adenocarcinoma - enzymology | PTEN Phosphohydrolase - metabolism | Adenosine - pharmacology | Antioxidants - pharmacology | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | DNA (Cytosine-5-)-Methyltransferases - genetics | Cholecalciferol - metabolism | Adenosine - analogs & derivatives | Cell Line, Tumor | Antineoplastic Agents, Phytogenic - pharmacology | DNA Methylation - drug effects | DNA methylation | Polyphenols | Breast cancer | Gene expression | Index Medicus
Journal Article