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1. Full Text Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice
by Meng, H and Wang, MY and Liu, HY and Liu, XS and Situ, A and Wu, B and Ji, ZX and Chang, CH and Nel, AE
ACS NANO, ISSN 1936-0851, 04/2015, Volume 9, Issue 4, pp. 3540 - 3557
Recently, a commercial albumin-bound paclitaxel (PTX) nanocarrier (Abraxane) was approved as the first new drug for pancreatic ductal adenocarcinoma in almost... 
SUPPORTED MEMBRANES | paclitaxel | PHYSICAL-PROPERTIES | synergy | mesoporous silica nanoparticle | VIVO | NAB-PACLITAXEL | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | MODEL | CYTIDINE DEAMINASE | CHEMISTRY, MULTIDISCIPLINARY | OVERCOME DRUG-RESISTANCE | co-delivery | pancreatic cancer | IN-VITRO | ratiometric | gemcitabine | BILAYERS PROTOCELLS | NANOTECHNOLOGY | Albumins - chemistry | Deoxycytidine - chemistry | Paclitaxel - pharmacology | Pancreatic Neoplasms - metabolism | Nanoparticles - chemistry | Humans | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Drug Carriers - chemistry | Pancreatic Neoplasms - drug therapy | Albumins - therapeutic use | Paclitaxel - chemistry | Deoxycytidine - therapeutic use | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pancreatic Neoplasms - pathology | Silicon Dioxide - chemistry | Antineoplastic Agents - chemistry | Paclitaxel - therapeutic use | Drug Synergism | Albumins - pharmacology | Animals | Cell Transformation, Neoplastic | Cytidine Deaminase - metabolism | Cell Line, Tumor | Mice | Lipid Bilayers - chemistry | Porosity | Deoxycytidine - analogs & derivatives | Index Medicus | Drugs | Effectiveness | Metabolites | Biocompatibility | Lipids | Nanostructure | Tumors | Cancer
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2. Full Text Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice
by Meng, Huan and Zhao, Yang and Dong, Juyao and Xue, Min and Lin, Yu-Shen and Ji, Zhaoxia and Mai, Wilson X and Zhang, Haiyuan and Chang, Chong Hyun and Brinker, C. Jeffrey and Zink, Jeffrey I and Nel, Andre E
ACS Nano, ISSN 1936-0851, 11/2013, Volume 7, Issue 11, pp. 10048 - 10065
Pancreatic ductal adenocarcinoma (PDAC) elicits a dense stromal response that blocks vascular access because of pericyte coverage of vascular fenestrations. In... 
mesoporous silica nanoparticles | pericyte and stroma | pancreatic cancer | two-wave | nano-engineered approach | TGF-β | gemcitabine | liposome | BREAST-CARCINOMA | DUCTAL ADENOCARCINOMA | NAB-PACLITAXEL | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | VIVO ANTITUMOR-ACTIVITY | CYTIDINE DEAMINASE | CHEMISTRY, MULTIDISCIPLINARY | TGF-beta | GROWTH-FACTOR-BETA | IN-VIVO | PROSTATE-CANCER | Neoplasm Transplantation | Deoxycytidine - chemistry | Nanoparticles - chemistry | Humans | Collagen - chemistry | Polyethylene Glycols - chemistry | Proteoglycans - chemistry | Drug Carriers | Pancreatic Neoplasms - drug therapy | Polyethyleneimine - chemistry | Transforming Growth Factor beta - antagonists & inhibitors | Female | Microscopy, Electron, Transmission | Signal Transduction | Deoxycytidine - administration & dosage | Silicon Dioxide - chemistry | Smad2 Protein - metabolism | Liposomes - chemistry | Animals | Endothelial Cells - cytology | Nanomedicine - methods | Cell Line, Tumor | Laminin - chemistry | Mice | Mice, Inbred BALB C | Deoxycytidine - analogs & derivatives | Drug Combinations | Index Medicus | Drugs | Drug delivery systems | Polyetherimides | Interference | Nitrogen atoms | Nanostructure | Liposomes | Tumors | Cancer | Nano engineered approach | and liposome
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3. Full Text Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging
by Croissant, Jonas G and Zhang, Dingyuan and Alsaiari, Shahad and Lu, Jie and Deng, Lin and Tamanoi, Fuyuhiko and AlMalik, Abdulaziz M and Zink, Jeffrey I and Khashab, Niveen M
Journal of Controlled Release, ISSN 0168-3659, 05/2016, Volume 229, pp. 183 - 191
Functional nanocarriers capable of transporting high drug contents without premature leakage and to controllably deliver several drugs are needed for better... 
Mesoporous silica nanoparticles | Multi-drug delivery | Bovine serum albumin | Gold nanoclusters | Cancer | BRIDGED SILSESQUIOXANE NANOPARTICLES | VITRO | PEGYLATED LIPOSOMAL DOXORUBICIN | COMBINATION | CHEMISTRY, MULTIDISCIPLINARY | GEMCITABINE | BREAST-CANCER | NANOCLUSTERS | RESPONSIVE CONTROLLED-RELEASE | FLUORESCENT-PROBES | PHARMACOLOGY & PHARMACY | ORGANOSILICA NANOPARTICLES | Silicon Dioxide - administration & dosage | Deoxycytidine - chemistry | Gold - administration & dosage | Nanocomposites - chemistry | Nanoparticles - chemistry | Serum Albumin, Bovine - administration & dosage | Humans | Drug Carriers - administration & dosage | Doxorubicin - chemistry | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Serum Albumin, Bovine - chemistry | Doxorubicin - administration & dosage | Gold - chemistry | A549 Cells | Cell Line | Deoxycytidine - administration & dosage | Silicon Dioxide - chemistry | Antineoplastic Agents - chemistry | Neoplasms - diagnostic imaging | Neoplasms - drug therapy | Drug Liberation | Nanoparticles - administration & dosage | Porosity | Deoxycytidine - analogs & derivatives | Nanocomposites - administration & dosage | Nanoparticles | Drugs | Albumin | Precious metal products | Silica | Tumors | Drug delivery systems | Anthracyclines | Pharmaceutical industry | Vehicles | Index Medicus
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4. Full Text Site-specific cross-linking of proteins to DNA: Via a new bioorthogonal approach employing oxime ligation
by Pujari, Suresh S and Zhang, Yi and Ji, Shaofei and Distefano, Mark D and Tretyakova, Natalia Y
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 49, pp. 6296 - 6299
DNA-protein cross-links (DPCs) are super-bulky DNA adducts induced by common chemotherapeutic agents, reactive oxygen species, and aldehydes, and also formed... 
CATALYSIS | CELLS | ALKYLTRANSFERASE | CHEMISTRY, MULTIDISCIPLINARY | REDUCTIVE AMINATION | Cysteine Endopeptidases - chemistry | Aminoacyltransferases - chemistry | Lysine - analogs & derivatives | Oligopeptides - chemical synthesis | Deoxycytidine - chemistry | Cross-Linking Reagents - chemistry | Bacterial Proteins - chemistry | Oligodeoxyribonucleotides - chemical synthesis | Oligodeoxyribonucleotides - chemistry | Oximes - chemical synthesis | Cross-Linking Reagents - chemical synthesis | DNA - chemistry | Single-Domain Antibodies - chemistry | DNA Adducts - chemical synthesis | Lysine - chemical synthesis | Proteins - chemistry | Lysine - chemistry | Oligopeptides - chemistry | Deoxycytidine - analogs & derivatives | Proteins | Biological effects | Peptides | Crosslinking | Construction sites | Conjugation | Lesions | Aldehydes | Deoxyribonucleic acid--DNA | Adducts | Index Medicus
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5. Full Text Gemcitabine-coumarin-biotin conjugates: A target specific theranostic anticancer prodrug
by Maiti, Sukhendu and Park, Nayoung and Han, Ji Hye and Jeon, Hyun Mi and Lee, Jae Hong and Bhuniya, Sankarprasad and Kang, Chulhun and Kim, Jong Seung
Journal of the American Chemical Society, ISSN 0002-7863, 03/2013, Volume 135, Issue 11, pp. 4567 - 4572
We present here, the design, synthesis, spectroscopic characterization, and in vitro biological assessment of a gemcitabine-coumarin-biotin conjugate (5).... 
GOLD NANOPARTICLES | RECEPTOR | RELEASE | DRUG-DELIVERY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Prodrugs - administration & dosage | Cell Survival - drug effects | Fluorescent Dyes - chemistry | Deoxycytidine - chemistry | Deoxycytidine - administration & dosage | Humans | Coumarins - chemistry | Deoxycytidine - pharmacology | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Biotin - chemistry | Deoxycytidine - pharmacokinetics | Prodrugs - pharmacokinetics | Cell Line, Tumor | Sulfhydryl Compounds - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Prodrugs - pharmacology | Deoxycytidine - analogs & derivatives | Drugs | Drug delivery systems | Usage | Analysis | Imaging systems | Chemical bonds | Fluorescence | Research | Vehicles | Index Medicus
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6. Full Text Gemcitabine‐(5′‐phosphoramidate)‐[anti‐IGF‐1R]: molecular design, synthetic organic chemistry reactions, and antineoplastic cytotoxic potency in populations of pulmonary adenocarcinoma (A549)
by Coyne, Cody P and Narayanan, Lakshmi
Chemical Biology & Drug Design, ISSN 1747-0277, 03/2017, Volume 89, Issue 3, pp. 379 - 399
One molecular‐based approach that increases potency and reduces dose‐limited sequela is the implementation of selective ‘targeted’ delivery strategies for... 
synthesis | antineoplastic cytotoxic potency | 1R | synergistic efficacy | margin‐of‐safety | covalent immunochemotherapeutic | IGF | gemcitabine | selective ‘targeted’ delivery | IGF-1R | margin-of-safety | GEMCITABINE CONJUGATE | CHEMISTRY, MEDICINAL | selective 'targeted' delivery | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCLONAL-ANTIBODY | ACUTE MYELOID-LEUKEMIA | P-GLYCOPROTEIN | BREAST-CANCER CELLS | OLIGODEOXYNUCLEOTIDE-DOXORUBICIN CONJUGATE | EPIDERMAL-GROWTH-FACTOR | CHRONIC LYMPHOCYTIC-LEUKEMIA | MULTIDRUG-RESISTANCE | IN-VIVO EVALUATION | Enzyme-Linked Immunosorbent Assay - methods | Lung Neoplasms - drug therapy | Receptor, IGF Type 1 - metabolism | Deoxycytidine - chemistry | Adenocarcinoma - pathology | Chemistry Techniques, Synthetic | Drug Screening Assays, Antitumor - methods | Adenocarcinoma of Lung | Antineoplastic Agents - chemical synthesis | Humans | Polymerization | Lung Neoplasms - pathology | Antineoplastic Agents - chemistry | Adenocarcinoma - drug therapy | Immunoglobulins - chemistry | Drug Design | Receptor, IGF Type 1 - immunology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Carbodiimides - chemistry | Deoxycytidine - analogs & derivatives | Immunoglobulin G - metabolism | Gemcitabine | Chemotherapy | Cancer | Index Medicus | IGF‐1R
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7. Full Text Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy
by Trung Bui, Duc and Maksimenko, Andrei and Desmaële, Didier and Harrisson, Simon and Vauthier, Christine and Couvreur, Patrick and Nicolas, Julien
Biomacromolecules, ISSN 1525-7797, 08/2013, Volume 14, Issue 8, pp. 2837 - 2847
The synthesis of a novel class of polymer prodrug nanoparticles with anticancer activity is reported by using squalene, a naturally occurring isoprenoid, as a... 
CHEMISTRY, ORGANIC | POLYMER SCIENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Deoxycytidine - chemistry | Nanoparticles - chemistry | Colloids | Humans | Deoxycytidine - pharmacology | Polyethylene Glycols - chemistry | Prodrugs - chemistry | Nanocapsules - chemistry | Prodrugs - metabolism | Antineoplastic Agents - metabolism | Terpenes - chemistry | Deoxycytidine - metabolism | Nanoparticles - metabolism | Antineoplastic Agents - pharmacology | Squalene - chemistry | Polymerization | Polymethacrylic Acids - chemical synthesis | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Prodrugs - pharmacology | Deoxycytidine - analogs & derivatives | Index Medicus | Life Sciences | Chemical Sciences
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8. Full Text Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation
by McDaniel, Jonathan R and Bhattacharyya, Jayanta and Vargo, Kevin B and Hassouneh, Wafa and Hammer, Daniel A and Chilkoti, Ashutosh
Angewandte Chemie - International Edition, ISSN 1433-7851, 02/2013, Volume 52, Issue 6, pp. 1683 - 1687
  Nanoparticles on demand: Upon the site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone, chimeric polypeptides... 
self-assembly | biopolymers | distribution coefficient | thermoresponsive nanoparticles | elastin-like polypeptides | ESCHERICHIA-COLI | MICELLES | TUMORS | CHEMISTRY, MULTIDISCIPLINARY | RECOMBINANT PROTEINS | IN-VIVO | PURIFICATION | FUSION PROTEIN | BLOCK-COPOLYMER | EXPRESSION | Amino Acid Sequence | Paclitaxel - chemistry | Deoxycytidine - chemistry | Temperature | Nanoparticles - chemistry | Peptides - chemistry | Pharmaceutical Preparations - chemistry | Hydrophobic and Hydrophilic Interactions | Polymers - chemistry | Deoxycytidine - analogs & derivatives | Drug Carriers - chemistry | Oxycodone - chemistry | Nanoparticles | Universities and colleges | Polymer industry | Peptides | Elastin | Index Medicus | Self assembly | Covalence | Drug delivery systems | Polypeptides | Attachment | Conjugation | Biopolymers
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9. Full Text Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine
by Weiss, Jason T and Dawson, John C and Fraser, Craig and Rybski, Witold and Torres-Sánchez, Carmen and Bradley, Mark and Patton, E. Elizabeth and Carragher, Neil O and Unciti-Broceta, Asier
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2014, Volume 57, Issue 12, pp. 5395 - 5404
Bioorthogonal chemistry has become one of the main driving forces in current chemical biology, inspiring the search for novel biocompatible chemospecific... 
FUNCTIONALIZATION | CHEMISTRY, MEDICINAL | CHEMISTRY | SYSTEMS | PROTECTING GROUPS | ALLYLCARBAMATE CLEAVAGE | PROTEINS | LIVING CELLS | STRATEGIES | Rhodamines - pharmacology | Deoxycytidine - chemistry | Humans | Embryo, Nonmammalian - metabolism | Deoxycytidine - pharmacology | Prodrugs - chemistry | Structure-Activity Relationship | Rhodamines - metabolism | Carbamates - chemistry | Prodrugs - metabolism | Drug Carriers | Carbamates - metabolism | Nanoparticles | Polystyrenes | Antimetabolites, Antineoplastic - pharmacology | Rhodamines - chemistry | Antimetabolites, Antineoplastic - metabolism | Carbamates - pharmacology | Cell Survival - drug effects | Zebrafish | Antimetabolites, Antineoplastic - chemistry | Animals | Cell Line, Tumor | DNA Damage | Palladium - chemistry | Prodrugs - pharmacology | Deoxycytidine - analogs & derivatives | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text Photoswitchable Formation of a DNA Interstrand Cross‐Link by a Coumarin‐Modified Nucleotide
by Haque, Mohammad Mojibul and Sun, Huabing and Liu, Shuo and Wang, Yinsheng and Peng, Xiaohua
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2014, Volume 53, Issue 27, pp. 7001 - 7005
A coumarin‐modified pyrimidine nucleoside ( 1 ) has been synthesized using a Cu I ‐catalyzed click reaction and incorporated into oligodeoxynucleotides (ODNs).... 
click chemistry | nucleosides | cycloaddition | photoswitch | DNA cross‐linking | DNA cross-linking | QUINONE METHIDES | REACTIVITY | LIGATION | HELIX-FORMING OLIGONUCLEOTIDE | CHEMISTRY, MULTIDISCIPLINARY | PROBES | REPAIR | GENE | ALKYLATING-AGENTS | CHEMISTRY | G-QUADRUPLEX | DNA - chemistry | Deoxyadenosines - chemistry | Deoxycytidine - chemistry | Ultraviolet Rays | Pyrimidine Nucleosides - chemistry | Click Chemistry | Base Sequence | Oligodeoxyribonucleotides - chemistry | Coumarins - chemistry | Cycloaddition Reaction | Pyrimidine Nucleosides - chemical synthesis | Thymidine - chemistry | Oligodeoxynucleotides | Crosslinked polymers | DNA | Deoxyribonucleic acid--DNA | Index Medicus | Cycloaddition | Pyrimidines | Deoxyribonucleic acid | Nucleosides | Irradiation | Crosslinking | Formations | Thymidine | Nucleotides
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11. Full Text Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers
by Lu, Kun and Ye, Wenjie and Zhou, Li and Collins, Leonard B and Chen, Xian and Gold, Avram and Ball, Louise M and Swenberg, James A
Journal of the American Chemical Society, ISSN 0002-7863, 03/2010, Volume 132, Issue 10, pp. 3388 - 3399
Exposure to formaldehyde results in the formation of DNA-protein cross-links (DPCs) as a primary genotoxic effect. Although DPCs are biologically important and... 
Oligonucleotides - chemistry | Deoxyadenosines - chemistry | Deoxycytidine - chemistry | Nucleosides - chemistry | Cross-Linking Reagents - chemistry | Formaldehyde - chemistry | Amino Acids - chemistry | Chromatography, High Pressure Liquid | Deoxyguanosine - chemistry | Spectroscopy, Fourier Transform Infrared | Nuclear Magnetic Resonance, Biomolecular - methods | Formic Acid Esters - chemistry | Oligopeptides - chemistry | Tandem Mass Spectrometry - methods | Thymidine - chemistry | Proteins | Usage | DNA | Analysis | Nuclear magnetic resonance spectroscopy | Amino acids | Chemical properties | Structure | Mass spectrometry | Formaldehyde | Index Medicus | DNA-protein crosslink | Structure Elucidation
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12. Full Text Plasmonic nanocarrier grid-enhanced Raman sensor for studies of anticancer drug delivery
by Kurzątkowska, Katarzyna and Santiago, Ty and Hepel, Maria
Biosensors and Bioelectronics, ISSN 0956-5663, 05/2017, Volume 91, pp. 780 - 787
Targeted drug delivery systems using nanoparticle nanocarriers offer remarkable promise for cancer therapy by discriminating against devastating cytotoxicity... 
Gemcitabine drug release | SERS | Plasmonic nanogrid sensor | AuNP nanocarriers | GOLD NANOPARTICLES | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | PANCREATIC-CANCER | CONTROLLED-RELEASE | NANOSCIENCE & NANOTECHNOLOGY | MAGNETIC NANOPARTICLES | LIVE CELLS | CELLULAR UPTAKE | GEMCITABINE | IN-VITRO | BIOPHYSICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SURFACE | SCATTERING | Gold - chemistry | Deoxycytidine - chemistry | Deoxycytidine - administration & dosage | Humans | Metal Nanoparticles - chemistry | Folic Acid - chemistry | Delayed-Action Preparations - chemistry | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Equipment Design | Drug Carriers - chemistry | Drug Delivery Systems | Biosensing Techniques - instrumentation | Glutathione - chemistry | Spectrum Analysis, Raman - instrumentation | Deoxycytidine - analogs & derivatives | Hydrogen-Ion Concentration | Metal Nanoparticles - ultrastructure | Drugs | Chemotherapy | Drug delivery systems | Pancreatic cancer | Sensors | Folic acid | Vehicles | Cancer | Medical screening | Index Medicus
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13. Full Text Silver Ions in Non‐canonical DNA Base Pairs: Metal‐Mediated Mismatch Stabilization of 2′‐Deoxyadenosine and 7‐Deazapurine Derivatives with 2′‐Deoxycytidine and 2′‐Deoxyguanosine
by Yang, Haozhe and Seela, Frank
Chemistry – A European Journal, ISSN 0947-6539, 09/2016, Volume 22, Issue 37, pp. 13336 - 13346
Novel silver‐mediated dA−dC, dA*−dC, and dA*−dG base pairs were formed in a natural DNA double helix environment (dA* denotes 7‐deaza‐dA, 7‐deaza‐7‐iodo‐dA,... 
double-helix stabilization | nucleosides | DNA recognition | silver | base-pair mismatch | CRYSTAL-STRUCTURE | STABILITY | AB-INITIO | basepair mismatch | CHEMISTRY, MULTIDISCIPLINARY | CYTOSINE | MAJOR GROOVE | REPAIR | NMR | OLIGONUCLEOTIDE DUPLEXES | BINDING | PARALLEL | Oligonucleotides - chemistry | Deoxyadenosines - chemistry | Deoxycytidine - chemistry | Adenine - analogs & derivatives | Silver - chemistry | Base Pair Mismatch | Anions - chemistry | Deoxyguanosine - chemistry | Adenine - chemistry | DNA - chemistry | Purines - chemistry | Base Pairing | Nucleosides | Guanine - chemistry | Nucleic Acid Conformation | Solid-Phase Synthesis Techniques - methods | Binding Sites | Silver | Protective coatings | Deoxyribonucleic acid--DNA | Index Medicus | Binding | Stability | Deoxyribonucleic acid | Oligonucleotides | Derivatives | Base metal
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