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Pharmacological Research, ISSN 1043-6618, 09/2016, Volume 111, pp. 757 - 766
G protein-coupled receptor 55 (GPR55) possesses pro-oncogenic activity and its function can be competitively inhibited with ( )-4⿲-methoxy-1-naphthylfenoterol... 
Cancer biomarkers | β-Catenin | Hypoxia-inducible factor 1α (HIF-1α) | Pyruvate kinase M2 (PKM2) | Multidrug resistance (MDR) | GPR55 | PKM2 | PHOSPHORYLATION | INVOLVEMENT | P-GLYCOPROTEIN EXPRESSION | GROWTH-FACTOR RECEPTOR | INHIBITION | Hypoxia-inducible factor 1 alpha (HIF-1 alpha) | beta-Catenin | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | LYSOPHOSPHATIDYLINOSITOL | PROMOTES | AGONIST | Phosphorylation | Pancreatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | Humans | Deoxycytidine - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Mitogen-Activated Protein Kinase Kinases - metabolism | Deoxycytidine - metabolism | MCF-7 Cells | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Biomarkers, Tumor - metabolism | Antimetabolites, Antineoplastic - pharmacology | Doxorubicin - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Antimetabolites, Antineoplastic - metabolism | Fenoterol - pharmacology | Pancreatic Neoplasms - pathology | Fenoterol - analogs & derivatives | beta Catenin - metabolism | Carrier Proteins - metabolism | Signal Transduction - drug effects | Thyroid Hormones - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | Antibiotics, Antineoplastic - metabolism | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gerontology | Cancer | Benzoic acid | Drug resistance in microorganisms | Anthracyclines | Epidermal growth factor | Pancreatic cancer | Cancer cells | G proteins | Membrane proteins | hypoxia-inducible factor 1α (HIF-1α) | β-catenin
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 114 - 118
Cells require nucleotides to support DNA replication and repair damaged DNA. In addition to de novo synthesis, cells recycle nucleotides from the DNA of dying... 
GLYCOSYLASE | REPLICATION | 5-METHYL-2'-DEOXYCYTIDINE | 5-METHYLCYTOSINE | DNA | MULTIDISCIPLINARY SCIENCES | HUMAN-LEUKEMIC CELLS | 5-HYDROXYMETHYLCYTOSINE | MONOPHOSPHATE KINASE | EXPRESSION | 5-FORMYLCYTOSINE | Neoplasms - metabolism | Phosphotransferases - metabolism | Cytosine - analogs & derivatives | Up-Regulation | Epigenesis, Genetic | Humans | Uridine - analogs & derivatives | Gene Expression Regulation, Neoplastic | Cytidine - pharmacology | Substrate Specificity | Deoxycytidine - pharmacology | Cytidine - analogs & derivatives | Nucleotides - chemistry | Deoxycytidine - metabolism | Neoplasms - genetics | Cytosine - metabolism | Nucleotides - pharmacology | DNA - biosynthesis | Cytosine - pharmacology | Cell Death - drug effects | Uridine - chemistry | DNA Damage - drug effects | Cytidine - chemistry | Oxidation-Reduction | Cytidine Deaminase - genetics | Cytosine - chemistry | Nucleotides - metabolism | Neoplasms - drug therapy | Gene Expression Regulation, Enzymologic | DNA - chemistry | Animals | 5-Methylcytosine - metabolism | 5-Methylcytosine - pharmacology | Cytidine Deaminase - metabolism | Cell Line, Tumor | Cytidine - metabolism | Uridine - metabolism | Mice | DNA-Directed DNA Polymerase - metabolism | Deoxycytidine - analogs & derivatives | Enzymes | Epigenetic inheritance | Care and treatment | Nucleosides | Genetic aspects | Metabolism | Health aspects | Methods | Cancer | DNA polymerase | Epigenetics | Cytotoxicity | Kinases | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Gut, ISSN 0017-5749, 12/2015, Volume 64, Issue 12, pp. 1936 - 1948
ObjectiveCancer stem cells (CSCs) represent the root of many solid cancers including pancreatic ductal adenocarcinoma, are highly chemoresistant and represent... 
DOWNSTREAM TARGET | SOLID TUMORS | PATHWAY | SELF-RENEWAL | PROLIFERATION | TUMORIGENICITY | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | MICRORNA CLUSTER | TBX3 | Cyclin-Dependent Kinase Inhibitor p57 - metabolism | MicroRNAs - antagonists & inhibitors | Pancreatic Neoplasms - metabolism | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Transforming Growth Factor beta1 - metabolism | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Activins - metabolism | Deoxycytidine - pharmacology | MicroRNAs - metabolism | Nodal Protein - metabolism | Carcinoma, Pancreatic Ductal - genetics | Gene Knockdown Techniques | Pancreatic Neoplasms - drug therapy | Cell Self Renewal | Deoxycytidine - therapeutic use | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Neoplastic Stem Cells - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antimetabolites, Antineoplastic - pharmacology | Female | Signal Transduction | Down-Regulation | Pancreatic Neoplasms - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Carcinoma, Pancreatic Ductal - drug therapy | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Animals | Cell Cycle Checkpoints - drug effects | Cell Transformation, Neoplastic | Mice, Nude | Mice | MicroRNAs - genetics | Deoxycytidine - analogs & derivatives | Care and treatment | MicroRNA | Pancreatic cancer | Patient outcomes | Analysis | Stem cells | Research | Metastasis | Risk factors | International organizations | Medical research | Biomedical research | Cell cycle | Tumors | CELL CYCLE CONTROL | PANCREATIC CANCER | DRUG RESISTANCE | STEM CELLS | Pancreas | 1506 | INTRACELLULAR SIGNALING
Journal Article
Gastroenterology, ISSN 0016-5085, 02/2018, Volume 154, Issue 3, pp. 675 - 688
Cells of the monocyte lineage contribute to tumor angiogenesis. Interleukin 35 (IL35) is a member of the IL12 family produced by regulatory, but not effector,... 
Infiltration | Immune Cell Migration | Anti-tumor Immune Response | Tumor Progression | PATHWAYS | METASTASIS | MACROPHAGES | RECEPTOR | MYELOID CELLS | CANCER | TRIAL | ANTICANCER THERAPIES | ENDOTHELIAL-CELLS | GASTROENTEROLOGY & HEPATOLOGY | PLUS BEVACIZUMAB | Interleukin-12 Subunit p35 - metabolism | Pancreatic Neoplasms - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Pancreatic Neoplasms - blood supply | Carcinoma, Pancreatic Ductal - metabolism | Microvessels - metabolism | Neovascularization, Pathologic | Microvessels - pathology | Deoxycytidine - pharmacology | Monocytes - metabolism | Interleukins - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Interleukin-12 Subunit p35 - antagonists & inhibitors | Pancreatic Neoplasms - drug therapy | Interleukins - genetics | Transfection | Chemotaxis, Leukocyte - drug effects | RNA Interference | Time Factors | Minor Histocompatibility Antigens - genetics | Female | Chemokine CCL5 - metabolism | Interleukin-8 - metabolism | Chemokine CXCL1 - metabolism | Paracrine Communication | Signal Transduction | Pancreatic Neoplasms - pathology | Microvessels - drug effects | Antibodies, Neutralizing - pharmacology | Interleukin-12 Subunit p35 - genetics | Tumor Burden | Mice, SCID | Carcinoma, Pancreatic Ductal - pathology | Interleukins - antagonists & inhibitors | Monocytes - drug effects | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Macrophages - metabolism | Minor Histocompatibility Antigens - metabolism | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Carcinoma, Pancreatic Ductal - blood supply | Deoxycytidine - analogs & derivatives | Adenocarcinoma | Interleukins | Endothelial growth factors | Growth | Analysis | Pancreatic cancer | T cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 8, pp. 2473 - 2478
The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, which forces proliferating tumor cells to... 
PROTEIN | MULTIDISCIPLINARY SCIENCES | GLYCOLYSIS | pancreatic cancer | PATHWAY | PROSTATE-CANCER | LIPID RAFTS | cholesterol | S-PHASE | metabolism | gemcitabine | CELL-CYCLE | KRAS | ACCUMULATION | SIMVASTATIN | LDLR | Adenocarcinoma - pathology | Epithelial Cells - metabolism | Gene Silencing - drug effects | Pancreatic Neoplasms - metabolism | Prognosis | Epithelial Cells - drug effects | Humans | Deoxycytidine - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Adenocarcinoma - metabolism | Lipoproteins - metabolism | Clone Cells | Gene Expression Regulation, Neoplastic - drug effects | Receptors, LDL - genetics | Pancreatic Neoplasms - pathology | Adenocarcinoma - enzymology | Pancreatic Neoplasms - enzymology | Receptors, LDL - metabolism | Epithelial Cells - pathology | Up-Regulation - genetics | Cholesterol - metabolism | Adenocarcinoma - drug therapy | Up-Regulation - drug effects | Metabolic Networks and Pathways - genetics | Phenotype | Animals | MAP Kinase Signaling System - drug effects | Cell Compartmentation - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Metabolic Networks and Pathways - drug effects | Deoxycytidine - analogs & derivatives | Pancreatic cancer | Carcinoma, Ductal | Development and progression | Genetic aspects | Genetic transcription | Cholesterol metabolism | Health aspects | Biological Sciences
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 7, pp. 1932 - 1943.e9
Background & Aims A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug delivery to... 
Gastroenterology and Hepatology | Tumor Microenvironment | Stroma | Pancreatic Cancer | Drug Delivery | DUCTAL ADENOCARCINOMA | STELLATE CELLS | RECEPTOR | SRC KINASE | MASS-SPECTROMETRY | INHIBITION | GROWTH | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | CARCINOMA | PROGRESSION | Receptors, Transforming Growth Factor beta - genetics | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Stromal Cells - pathology | Humans | Carcinoma, Pancreatic Ductal - metabolism | Drug Resistance, Neoplasm | Pyrimidines - metabolism | Carcinoma, Pancreatic Ductal - genetics | Gene Knockdown Techniques | Time Factors | Carcinoma, Pancreatic Ductal - mortality | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | STAT3 Transcription Factor - genetics | Antineoplastic Combined Chemotherapy Protocols - metabolism | Pancreatic Neoplasms - pathology | Osteonectin - metabolism | Mice, Transgenic | Pyrimidines - pharmacology | Tumor Burden | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Deoxycytidine - analogs & derivatives | Phosphorylation | Deoxycytidine - pharmacology | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Deoxycytidine - metabolism | Transfection | Stromal Cells - drug effects | Pancreatic Neoplasms - mortality | STAT3 Transcription Factor - metabolism | Pyrazoles - pharmacology | Mice, Inbred C57BL | Stromal Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Pancreatic Neoplasms - genetics | Pyrazoles - metabolism | Transcription Factors - genetics | Carcinoma, Pancreatic Ductal - pathology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Collagen - metabolism | Animals | Neoplasm Staging | STAT3 Transcription Factor - antagonists & inhibitors | Drugs | Drug delivery systems | Pancreatic cancer | Genetic transcription | Drug therapy | Health aspects | Biomedical engineering | Vehicles
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2013, Volume 19, Issue 1, pp. 57 - 64
Chemotherapeutic agents are widely used for cancer treatment. In addition to their direct cytotoxic effects, these agents harness the host's immune system,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER-CHEMOTHERAPY | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GEMCITABINE | BETA | CELL BIOLOGY | 5-FLUOROURACIL | INHIBITION | MICROENVIRONMENT | ANTITUMOR IMMUNITY | BEARING MICE | T-CELLS | Neoplasms - metabolism | Cell Proliferation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cathepsin B - genetics | Humans | Caspase 1 - metabolism | Deoxycytidine - pharmacology | Signal Transduction - immunology | Neoplasms - genetics | RNA Interference | Female | Antineoplastic Agents - pharmacology | Interleukin-1beta - biosynthesis | Dendritic Cells - metabolism | bcl-2-Associated X Protein - genetics | Interleukin-17 - secretion | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cathepsin B - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Cell Line, Tumor | Fluorouracil - pharmacology | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Receptors, Interleukin-1 - antagonists & inhibitors | Deoxycytidine - analogs & derivatives | Chemotherapy | Gemcitabine | Cathepsins | Physiological aspects | Dosage and administration | Research | Health aspects | Fluorouracil | Cancer | Cells | Inflammatory diseases | Tumors | Engineering Sciences | Automatic
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7598, pp. 245 - 249
Journal Article
Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, 09/2018, Volume 32, Issue 9, pp. 1485 - 1491
Background Koebnerized non‐melanoma skin cancer following skin trauma represents a rare and obscure event. Objectives To study molecular pathological... 
FUMARIC-ACID ESTERS | METASTASIS | GLUTATHIONE | DNA | AZATHIOPRINE | KERATOACANTHOMA | TRANSPLANT RECIPIENTS | MESENCHYMAL TRANSITION | CANCER | P53 | DERMATOLOGY | Cell Cycle - genetics | Azathioprine - therapeutic use | Proto-Oncogene Proteins p21(ras) - genetics | Skin - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Epigenesis, Genetic | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | ErbB Receptors - genetics | Carcinoma, Squamous Cell - surgery | Ki-67 Antigen - metabolism | Male | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Deoxycytidine - metabolism | Skin Physiological Phenomena - genetics | Female | Skin Neoplasms - surgery | Proto-Oncogene Proteins - metabolism | Neoplasm Recurrence, Local - metabolism | Tumor Suppressor Protein p53 - metabolism | Skin Neoplasms - metabolism | 5-Methylcytosine - metabolism | Dimethyl Fumarate - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Skin Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Isocitrate Dehydrogenase - metabolism | Neoplasm Recurrence, Local - genetics | Deoxycytidine - analogs & derivatives | Multiple Sclerosis - drug therapy | Immunohistochemistry | Medical research | Epigenetic inheritance | Enzymes | Squamous cell carcinoma | Multiple sclerosis | Melanoma | Skin cancer | Analysis | Cell cycle | Medicine, Experimental | Skin | Tumor proteins | Papillomavirus infections
Journal Article