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1. Full Text Antiretroviral drug exposure in the female genital tract: Implications for oral pre- and post-exposure prophylaxis
by Dumond, Julie B and Yeh, Rosa F and Patterson, Kristine B and Corbett, Amanda H and Jung, Byung Hwa and Rezk, Naser L and Bridges, Arlene S and Stewart, Paul W and Cohen, Myron S and Kashuba, Angela D.M
AIDS (London), ISSN 0269-9370, 09/2007, Volume 21, Issue 14, pp. 1899 - 1907
Women | Genital tract | HIV | Prophylaxis | Sexual transmission | Pharmacokinetics | Antiretroviral therapy | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Virology | Antiviral agents | General aspects | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Antibiotics. Antiinfectious agents. Antiparasitic agents | Epidemiology. Vaccinations | Lamivudine - administration & dosage | Humans | Deoxycytidine - blood | Zidovudine - administration & dosage | Tenofovir | Deoxycytidine - pharmacokinetics | HIV Protease Inhibitors - pharmacokinetics | Atazanavir Sulfate | Genitalia, Female - metabolism | Emtricitabine | HIV Infections - blood | HIV Protease Inhibitors - blood | Adenine - analogs & derivatives | Pyridines - administration & dosage | Benzoxazines - administration & dosage | Administration, Oral | Anti-Retroviral Agents - pharmacokinetics | Deoxycytidine - administration & dosage | Lopinavir | HIV Protease Inhibitors - administration & dosage | Adenine - pharmacokinetics | Pyrimidinones - blood | Anti-Retroviral Agents - administration & dosage | Oligopeptides - administration & dosage | Pyrimidinones - administration & dosage | Zidovudine - blood | Deoxycytidine - analogs & derivatives | Reverse Transcriptase Inhibitors - blood | Zidovudine - pharmacokinetics | Pyridines - pharmacokinetics | Reverse Transcriptase Inhibitors - administration & dosage | Adenine - blood | Reverse Transcriptase Inhibitors - pharmacokinetics | Benzoxazines - pharmacokinetics | Adult | Benzoxazines - blood | Female | Organophosphonates - blood | Anti-Retroviral Agents - blood | Drug Therapy, Combination | Oligopeptides - blood | Oligopeptides - pharmacokinetics | Lamivudine - blood | Lamivudine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Pyridines - blood | Pyrimidinones - pharmacokinetics | HIV Infections - drug therapy | Index Medicus | AIDS/HIV | genital tract | sexual transmission | antiretroviral therapy | pharmacokinetics | prophylaxis | women
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2. Full Text Oral and intravenous pharmacokinetics of 5-fluoro-2′-deoxycytidine and THU in cynomolgus monkeys and humans
by Holleran, Julianne L and Beumer, Jan H and McCormick, David L and Johnson, William D and Newman, Edward M and Doroshow, James H and Kummar, Shivaani and Covey, Joseph M and Davis, Myrtle and Eiseman, Julie L
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 10/2015, Volume 76, Issue 4, pp. 803 - 811
Toxicokinetics | Medicine & Public Health | Toxicity | Oncology | Cancer Research | Monkeys | Pharmacology/Toxicology | Tetrahydrouridine | DNA methylation inhibitor | Fluorodeoxycytidine | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Cytidine Deaminase - antagonists & inhibitors | Antimetabolites, Antineoplastic - pharmacokinetics | Enzyme Inhibitors - blood | Humans | Half-Life | Macaca fascicularis | Biological Availability | Male | Metabolic Clearance Rate | Deoxycytidine - blood | Antimetabolites, Antineoplastic - administration & dosage | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Deoxycytidine - pharmacokinetics | Antimetabolites, Antineoplastic - blood | Enzyme Inhibitors - pharmacokinetics | Biotransformation | Female | Drug Evaluation, Preclinical | Tetrahydrouridine - pharmacokinetics | Administration, Oral | Tetrahydrouridine - blood | Deoxycytidine - administration & dosage | Tetrahydrouridine - administration & dosage | Pilot Projects | Animals | Infusions, Intravenous | Deoxycytidine - analogs & derivatives | Drug Combinations | Cohort Studies | Metabolites | Methylation | Analysis | Index Medicus | toxicity | monkeys | toxicokinetics | fluorodeoxycytidine | tetrahydouridine
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3. Assessment of nutritional status in cancer - the relationship between body composition and pharmacokinetics
by Prado, Carla M. M and Maia, Yara L. M and Ormsbee, Michael and Sawyer, Michael B and Baracos, Vickie E
Anti-cancer agents in medicinal chemistry, ISSN 1871-5206, 2013, Volume 13, Issue 8, pp. 1197 - 1203
Nutritional assessment | Cancer prognosis | Chemotherapy treatment | Pharmacokinetics | Body composition | Nutritional status | Cancer | Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Body Composition | Body Mass Index | Neoplasms - metabolism | Niacinamide - analogs & derivatives | Fluorouracil - analogs & derivatives | Capecitabine | Deoxycytidine - administration & dosage | Humans | Antineoplastic Agents - administration & dosage | Neoplasms - drug therapy | Niacinamide - administration & dosage | Deoxycytidine - pharmacokinetics | Fluorouracil - administration & dosage | Phenylurea Compounds - administration & dosage | Niacinamide - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Nutritional Status | Phenylurea Compounds - pharmacokinetics | Neoplasms - physiopathology | Fluorouracil - pharmacokinetics | Nutritional Support | Deoxycytidine - analogs & derivatives | Index Medicus
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4. Full Text Clinical Pharmacokinetics of Capecitabine
by Reigner B and Blesch K and Weidekamm E
2001, Volume 40, Issue 2, 20
Capecitabine, pharmacokinetics | Paclitaxel, drug interactions | Antineoplastics, pharmacokinetics | Capecitabine, drug interactions | Docetaxel, drug interactions | Warfarin, drug interactions | Drug food interactions | Drug interactions | Antacids, drug interactions | Folinic acid, drug interactions | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Chemotherapy | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Paclitaxel - metabolism | Leucovorin - metabolism | Antimetabolites, Antineoplastic - pharmacokinetics | Fluorouracil - analogs & derivatives | Capecitabine | Humans | Paclitaxel - analogs & derivatives | Intestinal Absorption | Dose-Response Relationship, Drug | Antacids - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Deoxycytidine - pharmacokinetics | Deoxycytidine - therapeutic use | Deoxycytidine - metabolism | Drug Interactions | Taxoids | Colorectal Neoplasms - drug therapy | Protein Binding | Liver Diseases - metabolism | Antimetabolites, Antineoplastic - metabolism | Deoxycytidine - analogs & derivatives | Food | Index Medicus
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5. Full Text Population pharmacokinetics and exposure–response analyses of trastuzumab in patients with advanced gastric or gastroesophageal junction cancer
by Cosson, Valérie F and Ng, Vivian W and Lehle, Michaela and Lum, Bert L
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 4/2014, Volume 73, Issue 4, pp. 737 - 747
Population pharmacokinetics | Gastroesophageal junction cancer | Medicine & Public Health | Exposure–response | Oncology | Cancer Research | Pharmacology/Toxicology | Gastric cancer | Trastuzumab | Exposure-response | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Pharmacology. Drug treatments | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Tumors | Esophagus | Receptor, ErbB-2 - genetics | Capecitabine | Esophageal Neoplasms - blood | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Receptor, ErbB-2 - metabolism | Stomach Neoplasms - metabolism | Male | Stomach Neoplasms - pathology | Cisplatin - administration & dosage | Esophageal Neoplasms - pathology | Young Adult | Antibodies, Monoclonal, Humanized - administration & dosage | Fluorouracil - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Antibodies, Monoclonal, Humanized - blood | Esophageal Neoplasms - metabolism | Aged, 80 and over | Adult | Female | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Esophagogastric Junction - metabolism | Esophagogastric Junction - pathology | Stomach Neoplasms - drug therapy | Stomach Neoplasms - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged | Esophageal Neoplasms - drug therapy | Deoxycytidine - analogs & derivatives | Antimitotic agents | Care and treatment | Chemotherapy | Epidermal growth factor | Analysis | Cancer | Index Medicus
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6. Full Text Population pharmacokinetics and exposure–overall survival analysis of the transforming growth factor-β inhibitor galunisertib in patients with pancreatic cancer
by Gueorguieva, Ivelina and Tabernero, Josep and Melisi, Davide and Macarulla, Teresa and Merz, Valeria and Waterhouse, Timothy H and Miles, Colin and Lahn, Michael M and Cleverly, Ann and Benhadji, Karim A
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 11/2019, Volume 84, Issue 5, pp. 1003 - 1015
Pharmacodynamics | Medicine & Public Health | Anticancer drugs | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacokinetics | Randomized controlled trial | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Deoxycytidine - administration & dosage | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Half-Life | Male | Quinolines - administration & dosage | Randomized Controlled Trials as Topic | Pancreatic Neoplasms - drug therapy | Young Adult | CA-19-9 Antigen - metabolism | Pyrazoles - administration & dosage | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Deoxycytidine - analogs & derivatives | Statistical analysis | Gemcitabine | Transforming growth factor | Exposure | Pharmacology | Dosage | Patients | Survival | Survival analysis | Pancreatic cancer | Growth factors | Cancer | Index Medicus
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7. Full Text Pharmacokinetics and exposure–effect relationships of capecitabine in elderly patients with breast or colorectal cancer
by Daher Abdi, Z and Lavau-Denes, S and Prémaud, A and Urien, S and Sauvage, F L and Martin, J and Leobon, S and Marquet, P and Tubiana-Mathieu, N and Rousseau, A
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 6/2014, Volume 73, Issue 6, pp. 1285 - 1293
Response | Medicine & Public Health | Capecitabine | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacokinetics | Elderly | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Pharmacology. Drug treatments | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Tumors | Age Factors | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antimetabolites, Antineoplastic - administration & dosage | Breast Neoplasms - metabolism | Deoxycytidine - pharmacokinetics | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Deoxycytidine - adverse effects | Female | Colorectal Neoplasms - metabolism | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Breast Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Antimetabolites, Antineoplastic - adverse effects | Aged | Colorectal Neoplasms - pathology | Fluorouracil - pharmacokinetics | Deoxycytidine - analogs & derivatives | Antimitotic agents | Cancer patients | Chemotherapy | Metabolites | Analysis | Colorectal cancer | Aged patients | Breast cancer | Cancer | Index Medicus | elderly | Antineoplastic Combined Chemotherapy Protocols | Breast Neoplasms | capecitabine | Deoxycytidine | response | pharmacokinetics | Antimetabolites, Antineoplastic | Colorectal Neoplasms | Fluorouracil
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8. Population pharmacokinetics of gemcitabine and its metabolite in japanese cancer patients: Impact of genetic polymorphisms
by Sugiyama, Emiko and Kaniwa, Nahoko and Kim, Su-Ryang and Hasegawa, Ryuichi and Saito, Yoshiro and Ueno, Hideki and Okusaka, Takuji and Ikeda, Masafumi and Morizane, Chigusa and Kondo, Shunsuke and Yamamoto, Noboru and Tamura, Tomohide and Furuse, Junji and Ishii, Hiroshi and Yoshida, Teruhiko and Saijo, Nagahiro and Sawada, Jun-Ichi
Clinical pharmacokinetics, ISSN 0312-5963, 2010, Volume 49, Issue 8, pp. 549 - 558
genetic-polymorphism | antineoplastics | gemcitabinepharmacokinetics | pharmacokinetics | pharmacokinetic-modelling | population-pharmacokinetics | metabolites | genotype | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Floxuridine - analogs & derivatives | Antimetabolites, Antineoplastic - pharmacokinetics | Cytidine Deaminase - genetics | Humans | Middle Aged | Equilibrative Nucleoside Transporter 1 - genetics | Floxuridine - pharmacokinetics | Male | Deoxycytidine - blood | Neoplasms - drug therapy | Polymorphism, Genetic | Asian Continental Ancestry Group | Deoxycytidine - pharmacokinetics | Antimetabolites, Antineoplastic - blood | Computer Simulation | Adult | Female | Aged | Polymorphism, Single Nucleotide | Deoxycytidine Kinase - genetics | Deoxycytidine - analogs & derivatives | Index Medicus
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9. Full Text Pharmacokinetics of Gemcitabine in Japanese Cancer Patients: The Impact of a Cytidine Deaminase Polymorphism
by Emiko Sugiyama and Nahoko Kaniwa and Su-Ryang Kim and Ruri Kikura-Hanajiri and Ryuichi Hasegawa and Keiko Maekawa and Yoshiro Saito and Shogo Ozawa and Jun-ichi Sawada and Naoyuki Kamatani and Junji Furuse and Hiroshi Ishii and Teruhiko Yoshida and Hideki Ueno and Takuji Okusaka and Nagahiro Saijo
Journal of clinical oncology, ISSN 0732-183X, 01/2006, Volume 25, Issue 1, pp. 32 - 42
Biological and medical sciences | Medical sciences | Tumors | Pharmacogenetics | Antimetabolites, Antineoplastic - pharmacokinetics | Cytidine Deaminase - genetics | Humans | Japan | Middle Aged | Genotype | Male | Cytidine Deaminase - blood | Linkage Disequilibrium | Neoplasms - drug therapy | Polymorphism, Genetic | Deoxycytidine - pharmacokinetics | Deoxycytidine - toxicity | Antimetabolites, Antineoplastic - toxicity | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Infusions, Intravenous | Deoxycytidine - analogs & derivatives | Index Medicus
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10. Full Text Pharmacokinetics and Bioavailability of an Integrase and Novel Pharmacoenhancer-Containing Single-Tablet Fixed-Dose Combination Regimen for the Treatment of HIV
by German, Polina and Warren, David and West, Steve and Hui, James and Kearney, Brian P
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 11/2010, Volume 55, Issue 3, pp. 323 - 329
pharmacokinetics | fixed-dose combination | elvitegravir | pharmacoenhancer | integrase inhibitor | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Humans | Tablets - pharmacokinetics | Biological Availability | Male | HIV Integrase Inhibitors - administration & dosage | Anti-HIV Agents - administration & dosage | Tenofovir | HIV Integrase | Deoxycytidine - pharmacokinetics | Quinolones - pharmacokinetics | Adult | Female | Emtricitabine | Tablets - administration & dosage | Adenine - analogs & derivatives | Administration, Oral | Deoxycytidine - administration & dosage | HIV Integrase Inhibitors - pharmacokinetics | Adenine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Quinolones - administration & dosage | Anti-HIV Agents - pharmacokinetics | Plasma - chemistry | HIV Infections - drug therapy | Deoxycytidine - analogs & derivatives | Drug Combinations | Drugs | Pharmacology | Bioavailability | Drug therapy | Drug dosages | Human immunodeficiency virus--HIV | Index Medicus | AIDS/HIV
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11. Full Text Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR ®: Biodistribution, pharmacokinetic features and in vivo antitumor activity
by Paolino, Donatella and Cosco, Donato and Racanicchi, Leda and Trapasso, Elena and Celia, Christian and Iannone, Michelangelo and Puxeddu, Efisio and Costante, Giuseppe and Filetti, Sebastiano and Russo, Diego and Fresta, Massimo
Journal of controlled release, ISSN 0168-3659, 2010, Volume 144, Issue 2, pp. 144 - 150
Unilamellar PEGylated liposomes | ARO cell xenograft model | Gemcitabine | Biodistribution | Pharmacokinetic | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Unilamellar Liposomes | Floxuridine - analogs & derivatives | Polyethylene Glycols | Half-Life | Deoxycytidine - pharmacology | Raloxifene Hydrochloride | Mice, SCID | Chemistry, Pharmaceutical | Tissue Distribution | Deoxycytidine - pharmacokinetics | Animals | Mice, Inbred NOD | Antineoplastic Agents - pharmacokinetics | Mice | Deoxycytidine - analogs & derivatives | Liposomes - pharmacokinetics | Index Medicus
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