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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 830 - 840
Gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytidine analog, and erlotinib, an epidermal growth factor receptor-tyrosine kinase inhibitor, are used... 
FACTOR RECEPTOR INHIBITORS | ACTIVATED PROTEIN-KINASE | EPIDERMAL-GROWTH-FACTOR | PANCREATIC-CANCER | PHASE-III | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | HOMOLOGOUS RECOMBINATION | MAMMALIAN-CELLS | RADIATION | GEFITINIB IRESSA | Erlotinib Hydrochloride | RNA, Small Interfering - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Ubiquitin - metabolism | Deoxycytidine - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Kinase 1 - genetics | Transfection | Antimetabolites, Antineoplastic - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | MAP Kinase Kinase 2 - genetics | Rad51 Recombinase - metabolism | Cell Survival - drug effects | MAP Kinase Kinase 1 - antagonists & inhibitors | Rad51 Recombinase - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Down-Regulation - genetics | Drug Synergism | Drug Resistance, Neoplasm - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Proteasome Endopeptidase Complex - metabolism | Quinazolines - pharmacology | Deoxycytidine - analogs & derivatives | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2013, Volume 49, Issue 9, pp. 2077 - 2085
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 04/2011, Volume 10, Issue 4, pp. 591 - 602
Checkpoint kinase 1 (CHK1) is an essential serine/threonine kinase that responds to DNA damage and stalled DNA replication. CHK1 is essential for maintenance... 
CANCER-CELLS | PHASE | ACTIVATION | DNA-DAMAGE CHECKPOINT | PRECLINICAL PHARMACOLOGY | ONCOLOGY | PHOSPHORYLATION | ABROGATION | CYCLIN-DEPENDENT KINASE | DISCOVERY | ATR | Protein Kinases - metabolism | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | DNA Replication - drug effects | Humans | Pyridinium Compounds - administration & dosage | Deoxycytidine - pharmacology | Immunoblotting | Pyrimidines - chemistry | Antimetabolites, Antineoplastic - administration & dosage | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | DNA Breaks, Double-Stranded - drug effects | RNA Interference | Antimetabolites, Antineoplastic - pharmacology | Molecular Structure | Cyclin-Dependent Kinases - genetics | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Drug Screening Assays, Antitumor - methods | Pyrimidines - administration & dosage | Protein-Serine-Threonine Kinases - genetics | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Pyrazoles - administration & dosage | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Cell Line, Tumor | Checkpoint Kinase 2 | Checkpoint Kinase 1 | Mice | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Deoxycytidine - analogs & derivatives
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 15, pp. 4027 - 4032
Journal Article
Journal Article
Journal Article
Journal of Surgical Research, ISSN 0022-4804, 2014, Volume 187, Issue 1, pp. 6 - 13
Abstract Background When presenting with advanced stage disease, lung cancer patients have <5% 5-y survival. The overexpression of checkpoint kinase 1 (CHK1)... 
Surgery | Chemosensitivity | Radiosensitivity | CHK1 | NSCLC cell lines | AZD7762 | Combination therapies | SURVIVAL | SURGERY | STEM-CELLS | DNA-DAMAGE RESPONSE | ADENOCARCINOMA | TUMOR-CELLS | GEMCITABINE | CHK1 INHIBITION | TARGETED THERAPIES | CISPLATIN | Protein Kinases - metabolism | Carcinoma, Large Cell - drug therapy | Glutamates - therapeutic use | Lung Neoplasms - drug therapy | Thiophenes - therapeutic use | Protein Kinases - genetics | Guanine - analogs & derivatives | Humans | Lung Neoplasms - metabolism | Deoxycytidine - therapeutic use | Adenocarcinoma - metabolism | Urea - analogs & derivatives | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Guanine - therapeutic use | Lung Neoplasms - genetics | Cell Survival - drug effects | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Adenocarcinoma - drug therapy | Pemetrexed | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Urea - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Checkpoint Kinase 1 | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Lung cancer, Small cell | Chemotherapy | Lung cancer, Non-small cell | Tumor proteins | Nuclear radiation | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. 16856 - 16861
DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of... 
DNA replication | Phosphorylation | Interphase | DNA damage | DNA | Cell cycle | Small interfering RNA | Irradiation | Nucleosides | Cells | CYCLE CHECKPOINT KINASE | ORIGINS | CHK1 | POLYMERASE-ETA | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RNA STABILIZATION | VERTEBRATE S-PHASE | STRESS | FORK PROGRESSION | H2AX PHOSPHORYLATION | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Deoxycytidine - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | MAP Kinase Signaling System | DNA, Single-Stranded - genetics | Ultraviolet Rays | Antimetabolites, Antineoplastic - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA, Single-Stranded - metabolism | Protein-Serine-Threonine Kinases - genetics | p38 Mitogen-Activated Protein Kinases - genetics | DNA Replication | G2 Phase Cell Cycle Checkpoints | Mice, Knockout | Animals | Histones - genetics | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | DNA Damage | Histones - metabolism | Deoxycytidine - analogs & derivatives | Physiological aspects | Research | Health aspects | Mitogen-activated protein kinases | Biological Sciences | Teknik och teknologier | Engineering and Technology | Naturvetenskap | Natural Sciences
Journal Article