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Neuron, ISSN 0896-6273, 2006, Volume 49, Issue 4, pp. 603 - 615
Increased activity of D2 receptors (D2Rs) in the striatum has been linked to the pathophysiology of schizophrenia. To determine directly the behavioral and... 
DELAYED-RESPONSE | C957T POLYMORPHISM | WORKING-MEMORY DEFICITS | BASAL GANGLIA | IN-VIVO | ANTIPSYCHOTIC-DRUGS | SPATIAL MEMORY | D-2 RECEPTORS | SCHIZOPHRENIC SUBJECTS | NEUROSCIENCES | DOUBLE-BLIND PET | Gene Expression - drug effects | Dopamine Antagonists - pharmacokinetics | Humans | Prefrontal Cortex - physiopathology | Male | Memory, Short-Term - physiology | Receptors, Dopamine D2 - metabolism | Corpus Striatum - metabolism | Dose-Response Relationship, Drug | Carbon Isotopes - pharmacokinetics | Time Factors | Gene Expression - physiology | Protein Binding - drug effects | Radioligand Assay - methods | Deoxyglucose - pharmacokinetics | In Situ Hybridization - methods | Disease Models, Animal | Dopamine Agonists - pharmacology | Cognition Disorders - physiopathology | Mice, Inbred C57BL | Prefrontal Cortex - abnormalities | Proto-Oncogene Proteins c-fos - metabolism | Behavior, Animal - physiology | Mice, Transgenic | Cognition Disorders - genetics | Adenylyl Cyclases - metabolism | Reaction Time - genetics | Spiperone - pharmacokinetics | Receptors, Dopamine D2 - genetics | Immunohistochemistry - methods | Animals | Excitatory Amino Acid Agonists - toxicity | Analysis of Variance | Prefrontal Cortex - injuries | Prefrontal Cortex - metabolism | Glucose - metabolism | Doxycycline - pharmacology | Mice | Tritium - pharmacokinetics | N-Methylaspartate - toxicity | Medical colleges | Dopamine | Neurons | Analysis | Medical societies | Physiological aspects | Schizophrenia | Phenols | Studies | Mental disorders | Disease | Pathogenesis | Rodents | Memory | Digital video | Animal cognition | Index Medicus
Journal Article
BBA Clinical, ISSN 2214-6474, 06/2016, Volume 5, pp. 120 - 123
Bioenergetics and bioenergetic-related functions are altered in Alzheimer's disease (AD) subjects. These alterations represent therapeutic targets and provide... 
Clinical trial | Mitochondria | Oxaloacetate | Pharmacokinetics | Alzheimer's disease
Journal Article
Journal Article
Journal Article
Journal Article
Epilepsia, ISSN 0013-9580, 04/2009, Volume 50, Issue 4, pp. 664 - 677
Increased blood-brain barrier (BBB) permeability is radiologically detectable in regions affected by drug-resistant epileptogenic lesions. Brain penetration of... 
Drug delivery | Drug design | Pharmacokinetics | MRI | Phenytoin | Multiple drug resistance | NERVOUS-SYSTEM | TEMPORAL-LOBE EPILEPSY | WHITE-MATTER | RAT | PERMEABILITY | CEREBRAL EDEMA | STATUS EPILEPTICUS | CLINICAL NEUROLOGY | DISRUPTION | SEIZURE | DIFFUSION | Tissue Distribution - physiology | Deoxyglucose - metabolism | Chromatography, High Pressure Liquid - methods | Capillary Permeability - drug effects | Male | Blood-Brain Barrier - injuries | Blood Proteins - metabolism | Diazepam - pharmacokinetics | Carbon Isotopes - pharmacokinetics | Time Factors | Radioligand Assay - methods | Sucrose - metabolism | Anticonvulsants - pharmacokinetics | Tissue Distribution - drug effects | Brain Edema - metabolism | Brain Edema - pathology | Rats | Diuretics, Osmotic - administration & dosage | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Brain - drug effects | Animals | Analysis of Variance | Models, Biological | Mannitol - administration & dosage | Electrochemistry - methods | In Vitro Techniques | Hippocampus | Phenytoin - pharmacokinetics | Tritium - pharmacokinetics | Drugs | Brain | Drug delivery systems | Neurosciences | Epilepsy | Permeability | Drug resistance | Vehicles | Analysis | Brain damage | Diazepam | Blood proteins | Protein binding | Index Medicus
Journal Article
Journal Article
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 12/2007, Volume 48, Issue 12, pp. 2056 - 2062
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2006, Volume 72, Issue 4, pp. 446 - 454
Journal Article
Journal Article
Journal Article