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Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2176 - 15
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic... 
AICARDI-GOUTIERES-SYNDROME | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVE ENZYME | MAMMALIAN DNA | MULTIDISCIPLINARY SCIENCES | ALPHA | INFLAMMATORY DISEASE | DEOXYRIBONUCLEASE-II | MUTATIONS | EXONUCLEASE TREX1 | NUCLEIC-ACIDS | Endodeoxyribonucleases - immunology | Phosphorylation | Deoxyribonucleases - deficiency | Humans | RNA, Messenger - analysis | Male | Gene Expression Profiling | Erythroblasts - immunology | Signal Transduction - immunology | Deoxyribonucleases - immunology | STAT1 Transcription Factor - metabolism | Female | Endodeoxyribonucleases - deficiency | Child | STAT3 Transcription Factor - metabolism | Interferon-alpha - metabolism | Antiviral Agents - pharmacology | Hereditary Autoinflammatory Diseases - blood | Hereditary Autoinflammatory Diseases - enzymology | Hereditary Autoinflammatory Diseases - immunology | Interferon-alpha - immunology | Up-Regulation - drug effects | Deoxyribonucleases - genetics | Hematopoiesis - immunology | Endodeoxyribonucleases - genetics | Sequence Analysis, RNA | Interferon-alpha - blood | Adolescent | Mutation | Hereditary Autoinflammatory Diseases - genetics | Glomerulonephritis | Neonates | Deformation | Liver | Antibodies | α-Interferon | Microorganisms | Lymphocytes | Hematopoiesis | Peripheral blood | Anti-DNA antibodies | Stat1 protein | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Deoxyribonuclease | Hematology | Anemia | Stat3 protein | Nucleic acids | Ribonucleic acid--RNA | Hemopoiesis | Signaling | Monocytes | Erythroblasts | Fibrosis | Interferon | Endonuclease | Life Sciences | Immunology
Journal Article
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 09/2014, Volume 411, pp. 55 - 65
Effects of exosomes present in human plasma on immune cells have not been examined in detail. Immunological studies with plasma-derived exosomes require their... 
Exosome isolation | Immunological studies | Size-exclusion chromatography | Human plasma | Exosome characteristics | BIOCHEMICAL RESEARCH METHODS | MICROVESICLES | T-CELL | INDUCE APOPTOSIS | IMMUNOLOGY | IDENTIFICATION | SUPPRESSION | EXTRACELLULAR VESICLES | PROTEINS | CD24 | Exosomes - metabolism | Antigens, CD - immunology | Ribonucleases - chemistry | Antigens, CD - biosynthesis | Humans | Gene Expression Regulation, Neoplastic | Lectins, C-Type - immunology | Neoplasm Proteins - immunology | Male | Lectins, C-Type - biosynthesis | CD4-Positive T-Lymphocytes - pathology | Neoplasm Proteins - metabolism | Lectins, C-Type - chemistry | CD4-Positive T-Lymphocytes - immunology | Blood Buffy Coat - metabolism | Neoplasms - blood | Exosomes - immunology | Antigens, Differentiation, T-Lymphocyte - chemistry | Female | Antigens, CD - chemistry | Deoxyribonucleases - chemistry | Exosomes - ultrastructure | Microscopy, Electron, Transmission | Antigens, Differentiation, T-Lymphocyte - immunology | Blood Buffy Coat - pathology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Neoplasm Proteins - chemistry | Blood Buffy Coat - immunology | Hyaluronoglucosaminidase - chemistry | Neoplasms - immunology | Exosomes - chemistry | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Neoplasms - pathology | immunological studies | size-exclusion chromatography | human plasma | exosome characteristics
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2013, Volume 190, Issue 9, pp. 4621 - 4626
TAK1, a member of MAPK kinase kinase (MAPKK-K) family, can activate JNK, p38 MAPK, and NF-kappa B signaling pathways. Although targeted gene disruption studies... 
PROTEIN | JNK | INFLAMMATION | N-TERMINAL KINASE | STRESS-INDUCED APOPTOSIS | JUN NH2-TERMINAL KINASE | DEATH | IMMUNOLOGY | TRANSDUCTION PATHWAYS | I-KAPPA-B | LYMPHOCYTES | Proto-Oncogene Proteins c-bcl-2 - immunology | Caspases - immunology | Apoptosis - drug effects | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Mitogen-Activated Protein Kinase Kinases - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Deoxyribonucleases - metabolism | Lactones - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Signal Transduction - immunology | Deoxyribonucleases - immunology | Lymphocyte Activation - immunology | Caspases - metabolism | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Receptors, Antigen, T-Cell - immunology | Phosphorylation - immunology | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Cells, Cultured | Receptors, Interleukin-2 - metabolism | MAP Kinase Kinase Kinases - metabolism | Receptors, Interleukin-2 - immunology | MAP Kinase Kinase Kinases - immunology | Immunosuppression | Animals | Apoptosis - immunology | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Mice
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 02/2016, Volume 99, Issue 2, pp. 265 - 278
Clinical Review for Basic Researchers: NETs in autoimmune diseases, their potential as disease markers and therapeutic targets. Neutrophil extracellular traps... 
autoimmunity | type I IFN | systemic lupus erythematosus | Autoimmunity | Type I IFN | Systemic lupus erythematosus | WEGENERS-GRANULOMATOSIS | MAMMALIAN TARGET | ALPHA MONOCLONAL-ANTIBODY | SYSTEMIC-LUPUS-ERYTHEMATOSUS | NETTING NEUTROPHILS | PEPTIDYLARGININE DEIMINASE INHIBITION | MICROSCOPIC POLYANGIITIS | IMMUNOLOGY | ANTIPHOSPHOLIPID SYNDROME | CELL BIOLOGY | DOUBLE-BLIND | HEMATOLOGY | PHASE-I | Lupus Erythematosus, Systemic - complications | Humans | Immunosuppressive Agents - therapeutic use | Deoxyribonuclease I - therapeutic use | Antibodies, Monoclonal - therapeutic use | Molecular Targeted Therapy | Thrombophilia - etiology | Thrombophilia - immunology | Atherosclerosis - etiology | Extracellular Traps - immunology | Protein Processing, Post-Translational - drug effects | Extracellular Traps - drug effects | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Female | Acetylcysteine - therapeutic use | Thrombosis - prevention & control | Translational Medical Research - methods | Autoimmune Diseases - drug therapy | Interferon-alpha - biosynthesis | Interferon-alpha - antagonists & inhibitors | Neutrophils - drug effects | Autoimmune Diseases - immunology | Neutrophils - immunology | Antimalarials - therapeutic use | Translational Medical Research - trends | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy | Pregnancy | Apoptosis - immunology | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology | Autoantigens - immunology | Biomarkers | Pregnancy Complications - prevention & control | Vitamin D - therapeutic use | Atherosclerosis - prevention & control | Protein-Arginine Deiminases | Hydrolases - antagonists & inhibitors | Pregnancy Complications - immunology | Paired Basic‐Translational Reviews
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 7, pp. 3522 - 3531
Journal Article
Immunobiology, ISSN 0171-2985, 2015, Volume 221, Issue 2, pp. 228 - 235
Abstract Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which is the causative agent of paracoccidioidomycosis, a... 
Allergy and Immunology | Advanced Basic Science | Innate immunity | Neutrophil | Neutrophil extracellular traps | Dectin-1 receptor | Paracoccidioides brasiliensis | IMMUNITY | HUMAN NEUTROPHILS | TRAPS | ANTIFUNGAL ACTIVITY | CALPROTECTIN | INTERLEUKIN-10 | IMMUNOLOGY | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | YEAST-CELLS | GROWTH | HOST-DEFENSE | Paracoccidioides - immunology | Toll-Like Receptor 2 - genetics | Extracellular Traps - metabolism | Humans | Paracoccidioides - ultrastructure | Lectins, C-Type - immunology | Neutrophil Activation - drug effects | Neutrophils - ultrastructure | Lectins, C-Type - genetics | Pancreatic Elastase - immunology | Extracellular Traps - immunology | Receptors, Mitogen - immunology | Extracellular Traps - drug effects | Deoxyribonucleases - pharmacology | Phagocytosis - drug effects | DNA - immunology | Histones - immunology | Signal Transduction | Neutrophils - drug effects | Gene Expression Regulation | Neutrophils - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Toll-Like Receptor 4 - genetics | Pancreatic Elastase - metabolism | Toll-Like Receptor 4 - immunology | DNA - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Toll-Like Receptor 2 - immunology | Paracoccidioides - pathogenicity | Histones - metabolism | Interferon-gamma - pharmacology | Receptors, Mitogen - genetics | Proteins | Mycoses | Virulence (Microbiology)
Journal Article