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Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 6, pp. 569 - 576
  Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
Genetic research | Nucleases | Genetic aspects | Genetic engineering | Zinc finger proteins | Research | Biotechnology | Enzymes | Mutation | Genomics
Journal Article
Journal Article
Science, ISSN 0036-8075, 8/2012, Volume 337, Issue 6096, pp. 816 - 821
Journal Article
CMLS Cellular and Molecular Life Sciences, ISSN 1420-682X, 3/2005, Volume 62, Issue 6, pp. 685 - 707
Type II restriction endonucleases are components of restriction modification systems that protect bacteria and archaea against invading foreign DNA. Most are... 
Life Sciences | Biochemistry, general | mechanism of phosphodiester bond hydrolysis | protein engineering | Life Sciences, general | Protein-nucleic acid interaction | DNA cleavage | DNA recognition | evolution | facilitated diffusion | Biomedicine general | Cell Biology | Protein engineering | Mechanism of phosphodiester bond hydrolysis | Evolution | Facilitated diffusion | protein-nucleic acid interaction | COLI RNASE HI | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTRATE-ASSISTED CATALYSIS | PATCH REPAIR ENDONUCLEASE | NONSPECIFIC DNA-SEQUENCES | ECO-RI ENDONUCLEASE | SITE-DIRECTED MUTAGENESIS | 2 RECOGNITION SITES | CELL BIOLOGY | METAL-ION BINDING | Archaeal Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Ions - chemistry | Protein Structure, Secondary | Archaeal Proteins - chemistry | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Deoxyribonucleases, Type II Site-Specific - genetics | Sequence Homology, Amino Acid | Deoxyribonucleases, Type II Site-Specific - metabolism | Sequence Alignment | Deoxyribonucleases, Type II Site-Specific - chemistry | Metals - chemistry | Protein Binding | Archaeal Proteins - genetics | Bacterial Proteins - metabolism | Molecular Structure | Deoxyribonucleases, Type II Site-Specific - classification | Nucleases | Bioengineering | Proteins | Enzymes | Catalysis | Deoxyribonucleic acid--DNA
Journal Article