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Blood, ISSN 0006-4971, 2009, Volume 114, Issue 10, pp. 2077 - 2086
In a clinical trial for adeno-associated virus serotype 1 (AAV-1)-mediated gene transfer to muscle for lipoprotein lipase (LPL) deficiency, 1 subject from the... 
RESPONSES | AAV VECTOR | LIPOPROTEIN-LIPASE DEFICIENCY | ADENOASSOCIATED VIRAL VECTOR | LONG-TERM CORRECTION | VIRUS | BENEFICIAL MUTATION | CANINE HEMOPHILIA-B | FACTOR-IX | HEMATOLOGY | LEBERS CONGENITAL AMAUROSIS | Dependovirus - genetics | Genetic Therapy | Dose-Response Relationship, Immunologic | Immunoglobulin G - blood | Humans | Male | Antibodies, Viral - blood | Immunoenzyme Techniques | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Muscle, Skeletal - immunology | Immunoglobulin G - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Capsid - metabolism | Creatine Kinase - immunology | Muscle, Skeletal - enzymology | Transduction, Genetic | Lipoprotein Lipase - genetics | Transgenes - genetics | CD4-Positive T-Lymphocytes - metabolism | Hyperlipoproteinemia Type I - enzymology | Dependovirus - immunology | Lipoprotein Lipase - biosynthesis | Hyperlipoproteinemia Type I - genetics | Capsid - immunology | B-Lymphocytes - immunology | Creatine Kinase - biosynthesis | Hyperlipoproteinemia Type I - immunology | Interferon-gamma - immunology | Lipoprotein Lipase - immunology | Triglycerides - blood | Antibodies, Viral - immunology | Hyperlipoproteinemia Type I - therapy | CD8-Positive T-Lymphocytes - immunology | Transgenes - immunology | Interferon-gamma - biosynthesis | Index Medicus | Abridged Index Medicus | Gene Therapy
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e67748 - e67748
Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that... 
HEPATOCYTES | ACTIVATION | ELIMINATE | INNATE IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-TRANSFER | VECTORS | ADENOVIRUS | T-CELLS | HEMOPHILIA | Recombinant Fusion Proteins - immunology | Dependovirus - genetics | Inflammation - pathology | Liver - pathology | Interleukin-12 - genetics | Hepatocytes - pathology | Liver - immunology | Gene Expression - immunology | Killer Cells, Natural - immunology | Female | Interferon-gamma - genetics | Genetic Vectors - immunology | Mice, Inbred C57BL | Dependovirus - immunology | Inflammation - immunology | Hepatocytes - immunology | Capsid - immunology | Killer Cells, Natural - cytology | Animals | T-Lymphocytes - cytology | Interferon-gamma - immunology | Interleukin-12 - immunology | Inflammation - genetics | Recombinant Fusion Proteins - genetics | Transcription, Genetic - immunology | T-Lymphocytes - immunology | Mice | Transgenes - immunology | Genetic Therapy - methods | Interleukin-12 | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | Dependoviruses | Gene therapy | Transcription | Liver | Cytotoxicity | Viruses | Genomes | Lymphocytes T | Immunity | Immunity (cell-mediated) | Lymphocytes | Hepatology | Interleukin 1 | Deoxyribonucleic acid--DNA | Recombinant | Expression vectors | Medical research | Antigens | Antiinflammatory agents | Immune response | Immunostimulation | Therapeutic applications | Interleukin 12 | Vectors (Biology) | Immune systems | Hepatocytes | γ-Interferon | Interferon | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7379, pp. 81 - 86
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 02/2012, Volume 14, Issue 1, pp. R40 - R40
Introduction: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a key negative costimulatory molecule that displays a wide range of anti-inflammatory properties and... 
Adeno-associated virus (AAV) | Prevention | CTLA4igG fusion protein | Salivary gland dysfunction | Sjögren's syndrome | adeno-associated virus (AAV) | TRANSDUCTION | RHEUMATOLOGY | Sjogren's Syndrome | SALIVARY-GLAND | CTLA4IgG fusion protein | salivary gland dysfunction | REGULATORY T-CELLS | GENE-TRANSFER | AUTOIMMUNE-DISEASE | EXPRESSION | VECTORS | prevention | ABATACEPT | SELF-TOLERANCE | ANTIGEN | Salivary Glands - immunology | Dependovirus - genetics | Salivary Glands - pathology | Sialadenitis - therapy | Genetic Vectors - administration & dosage | Antibodies, Antinuclear - immunology | Dendritic Cells - immunology | Humans | Transforming Growth Factor beta1 - metabolism | Sjogren's Syndrome - immunology | Male | B7 Antigens - immunology | Immunoconjugates - administration & dosage | Salivation - immunology | Sialadenitis - genetics | Drug Delivery Systems | Immunoconjugates - immunology | Transforming Growth Factor beta1 - immunology | Lymphocytes - immunology | Abatacept | Antibodies, Antinuclear - blood | HEK293 Cells | Female | Dendritic Cells - metabolism | Macrophages - immunology | Sjogren's Syndrome - genetics | Cytokines - immunology | Disease Models, Animal | Lymphocytes - metabolism | Cytokines - metabolism | Mice, Inbred C57BL | Lacrimal Apparatus - immunology | Lacrimal Apparatus - metabolism | Genetic Vectors - genetics | B7 Antigens - metabolism | Macrophages - metabolism | Animals | Sjogren's Syndrome - therapy | Immunoconjugates - genetics | Mice, Inbred NOD | Mice | Salivary Glands - metabolism | Sialadenitis - immunology | Sjogren's syndrome | Care and treatment | Usage | Genetic vectors | Immunoglobulin G | Reports | Dosage and administration | Research | Index Medicus | Sjögren's Syndrome
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2013, Volume 21, Issue 9, pp. 1727 - 1737
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5310 - 5318
Journal Article
Blood, ISSN 0006-4971, 08/2007, Volume 110, Issue 4, pp. 1132 - 1140
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2015, Volume 66, pp. 89 - 97
Journal Article