Neuron, ISSN 0896-6273, 01/2017, Volume 93, Issue 1, pp. 33 - 47
To decipher neural circuits underlying brain functions, viral tracers are widely applied to map input and output connectivity of neuronal populations. Despite...
transsynaptic/transneuronal tracer | Cre and Flp system | AAV serotypes | superior colliculus | corticofugal projection | intersectional strategy | defensive behavior | mapping neural circuits | flight and freezing | SUPERIOR COLLICULUS | ORGANIZATION | VIRUS | VISUAL-CORTEX | CORPUS-CALLOSUM | IN-VIVO | MOUSE | NEURONS | PROJECTIONS | VECTORS | NEUROSCIENCES | Synapses - physiology | Visual Cortex - cytology | Superior Colliculi - physiology | Behavior, Animal - physiology | Auditory Cortex - physiology | Dependovirus | Cerebral Cortex - cytology | Escape Reaction - physiology | Neural Pathways - physiology | Visual Cortex - physiology | Integrases | Animals | Neural Pathways - cytology | Neurons - physiology | Superior Colliculi - cytology | Freezing Reaction, Cataleptic - physiology | Auditory Cortex - cytology | Cerebral Cortex - physiology | Mice | DNA Nucleotidyltransferases | Medical colleges | Neural circuitry | Gene expression | Neurons | Neurophysiology | Tracers (Biology) | Brain | Data analysis | Rodents | Viruses | Behavior | Labeling
transsynaptic/transneuronal tracer | Cre and Flp system | AAV serotypes | superior colliculus | corticofugal projection | intersectional strategy | defensive behavior | mapping neural circuits | flight and freezing | SUPERIOR COLLICULUS | ORGANIZATION | VIRUS | VISUAL-CORTEX | CORPUS-CALLOSUM | IN-VIVO | MOUSE | NEURONS | PROJECTIONS | VECTORS | NEUROSCIENCES | Synapses - physiology | Visual Cortex - cytology | Superior Colliculi - physiology | Behavior, Animal - physiology | Auditory Cortex - physiology | Dependovirus | Cerebral Cortex - cytology | Escape Reaction - physiology | Neural Pathways - physiology | Visual Cortex - physiology | Integrases | Animals | Neural Pathways - cytology | Neurons - physiology | Superior Colliculi - cytology | Freezing Reaction, Cataleptic - physiology | Auditory Cortex - cytology | Cerebral Cortex - physiology | Mice | DNA Nucleotidyltransferases | Medical colleges | Neural circuitry | Gene expression | Neurons | Neurophysiology | Tracers (Biology) | Brain | Data analysis | Rodents | Viruses | Behavior | Labeling
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2012, Volume 15, Issue 9, pp. 1255 - 1264
Memory formation is thought to be mediated by dendritic-spine growth and restructuring. Myocyte enhancer factor 2 (MEF2) restricts spine growth in vitro,...
DENDRITIC SPINES | LONG-TERM-MEMORY | ANTERIOR CINGULATE CORTEX | AMPA RECEPTOR TRAFFICKING | SPATIAL MEMORY | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | TRANSCRIPTION FACTOR | EXPRESSION | NEUROSCIENCES | MYOCYTE ENHANCER FACTOR-2 | Immunohistochemistry | Male | Luciferases - genetics | Neuronal Plasticity - physiology | Neurons - physiology | Female | MEF2 Transcription Factors | Maze Learning - physiology | Myogenic Regulatory Factors - genetics | Receptors, AMPA - physiology | Conditioning (Psychology) - physiology | Mice, Inbred C57BL | Simplexvirus - genetics | Amygdala - metabolism | Dendritic Spines - physiology | In Situ Hybridization, Fluorescence | Myogenic Regulatory Factors - physiology | Dependovirus | Hippocampus - cytology | Blotting, Western | Endocytosis - physiology | Fear | Learning - physiology | Animals | Mice | Genetic Vectors | Hippocampus - physiology | Amygdala - physiology | Memory - physiology | Neuroplasticity | Physiological aspects | Transcription factors | Research | Memory
DENDRITIC SPINES | LONG-TERM-MEMORY | ANTERIOR CINGULATE CORTEX | AMPA RECEPTOR TRAFFICKING | SPATIAL MEMORY | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | TRANSCRIPTION FACTOR | EXPRESSION | NEUROSCIENCES | MYOCYTE ENHANCER FACTOR-2 | Immunohistochemistry | Male | Luciferases - genetics | Neuronal Plasticity - physiology | Neurons - physiology | Female | MEF2 Transcription Factors | Maze Learning - physiology | Myogenic Regulatory Factors - genetics | Receptors, AMPA - physiology | Conditioning (Psychology) - physiology | Mice, Inbred C57BL | Simplexvirus - genetics | Amygdala - metabolism | Dendritic Spines - physiology | In Situ Hybridization, Fluorescence | Myogenic Regulatory Factors - physiology | Dependovirus | Hippocampus - cytology | Blotting, Western | Endocytosis - physiology | Fear | Learning - physiology | Animals | Mice | Genetic Vectors | Hippocampus - physiology | Amygdala - physiology | Memory - physiology | Neuroplasticity | Physiological aspects | Transcription factors | Research | Memory
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2013, Volume 33, Issue 25, pp. 10405 - 10426
Locomotion and cue-dependent behaviors are modified through corticostriatal signaling whereby short-term increases in dopamine availability can provoke...
DORSOLATERAL STRIATUM | DRUG-ADDICTION | IN-VIVO | CORTICOSTRIATAL TERMINALS | BEHAVIORAL SENSITIZATION | ELECTROPHYSIOLOGICAL PROPERTIES | DOPAMINE NEUROTRANSMISSION | NEOSTRIATAL CHOLINERGIC INTERNEURONS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | PARKINSONS-DISEASE | Dependovirus - genetics | Interneurons - physiology | Motor Activity - physiology | Receptors, Presynaptic - physiology | Neuronal Plasticity - drug effects | Male | Neostriatum - physiology | Excitatory Postsynaptic Potentials - physiology | Neuronal Plasticity - physiology | Receptors, Presynaptic - drug effects | Choline O-Acetyltransferase - physiology | Neostriatum - drug effects | Excitatory Postsynaptic Potentials - genetics | Choline O-Acetyltransferase - genetics | Synapses - drug effects | Neostriatum - cytology | Maze Learning - physiology | Synapses - physiology | Mice, Inbred C57BL | Amphetamine - pharmacology | Glutamic Acid - physiology | Mice, Knockout | Animals | Receptors, Dopamine D1 - physiology | Adrenergic Uptake Inhibitors - pharmacology | Receptors, Dopamine D2 - physiology | Mice | Postural Balance - physiology | Electrophysiological Phenomena | Acetylcholine - physiology | Genetic Vectors | Locomotion - physiology
DORSOLATERAL STRIATUM | DRUG-ADDICTION | IN-VIVO | CORTICOSTRIATAL TERMINALS | BEHAVIORAL SENSITIZATION | ELECTROPHYSIOLOGICAL PROPERTIES | DOPAMINE NEUROTRANSMISSION | NEOSTRIATAL CHOLINERGIC INTERNEURONS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | PARKINSONS-DISEASE | Dependovirus - genetics | Interneurons - physiology | Motor Activity - physiology | Receptors, Presynaptic - physiology | Neuronal Plasticity - drug effects | Male | Neostriatum - physiology | Excitatory Postsynaptic Potentials - physiology | Neuronal Plasticity - physiology | Receptors, Presynaptic - drug effects | Choline O-Acetyltransferase - physiology | Neostriatum - drug effects | Excitatory Postsynaptic Potentials - genetics | Choline O-Acetyltransferase - genetics | Synapses - drug effects | Neostriatum - cytology | Maze Learning - physiology | Synapses - physiology | Mice, Inbred C57BL | Amphetamine - pharmacology | Glutamic Acid - physiology | Mice, Knockout | Animals | Receptors, Dopamine D1 - physiology | Adrenergic Uptake Inhibitors - pharmacology | Receptors, Dopamine D2 - physiology | Mice | Postural Balance - physiology | Electrophysiological Phenomena | Acetylcholine - physiology | Genetic Vectors | Locomotion - physiology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2003, Volume 23, Issue 18, pp. 7093 - 7106
The rod and cone photoreceptors that mediate visual phototransduction in mammals are not required for light-induced circadian entrainment, negative masking of...
Adeno-associated virus | Ventrolateral preoptic nucleus | Retina | Hypothalamus | Suprachiasmatic | Melanopsin | Sleep | Intergeniculate | Entrainment | Subparaventricular | Masking | Pupillary light reflex | Circadian | Ganglion cells | Pretectal | EFFERENT PROJECTIONS | pupillary light reflex | masking | entrainment | CIRCADIAN-RHYTHMS | RETINOHYPOTHALAMIC TRACT | adeno-associated virus | INTERGENICULATE LEAFLET | intergeniculate | ventrolateral preoptic nucleus | pretectal | NEUROSCIENCES | LATERAL GENICULATE-NUCLEUS | melanopsin | sleep | RETINAL GANGLION-CELLS | ADENOASSOCIATED VIRAL VECTORS | circadian | ganglion cells | retina | SUPRACHIASMATIC NUCLEUS | suprachiasmatic | subparaventricular | hypothalamus | Dependovirus - genetics | Green Fluorescent Proteins | Rod Opsins - physiology | Superior Colliculi - physiology | Male | Geniculate Bodies - physiology | Neural Pathways - physiology | Photoreceptor Cells, Vertebrate - physiology | Luminescent Proteins - biosynthesis | Suprachiasmatic Nucleus - physiology | Cerebral Ventricles - physiology | Cerebral Ventricles - anatomy & histology | Dependovirus - physiology | RNA, Messenger - biosynthesis | Retinal Ganglion Cells - cytology | Rod Opsins - genetics | Tectum Mesencephali - anatomy & histology | Tectum Mesencephali - physiology | Light Signal Transduction - physiology | Preoptic Area - physiology | Retinal Ganglion Cells - physiology | Rod Opsins - biosynthesis | Superior Colliculi - anatomy & histology | Geniculate Bodies - anatomy & histology | Rats | Photoreceptor Cells, Vertebrate - cytology | Suprachiasmatic Nucleus - anatomy & histology | Neural Pathways - anatomy & histology | Animals | Cholera Toxin | Luminescent Proteins - genetics | Preoptic Area - anatomy & histology | Cerebral Ventricles - cytology | Behavioral | Systems | Cognitive
Adeno-associated virus | Ventrolateral preoptic nucleus | Retina | Hypothalamus | Suprachiasmatic | Melanopsin | Sleep | Intergeniculate | Entrainment | Subparaventricular | Masking | Pupillary light reflex | Circadian | Ganglion cells | Pretectal | EFFERENT PROJECTIONS | pupillary light reflex | masking | entrainment | CIRCADIAN-RHYTHMS | RETINOHYPOTHALAMIC TRACT | adeno-associated virus | INTERGENICULATE LEAFLET | intergeniculate | ventrolateral preoptic nucleus | pretectal | NEUROSCIENCES | LATERAL GENICULATE-NUCLEUS | melanopsin | sleep | RETINAL GANGLION-CELLS | ADENOASSOCIATED VIRAL VECTORS | circadian | ganglion cells | retina | SUPRACHIASMATIC NUCLEUS | suprachiasmatic | subparaventricular | hypothalamus | Dependovirus - genetics | Green Fluorescent Proteins | Rod Opsins - physiology | Superior Colliculi - physiology | Male | Geniculate Bodies - physiology | Neural Pathways - physiology | Photoreceptor Cells, Vertebrate - physiology | Luminescent Proteins - biosynthesis | Suprachiasmatic Nucleus - physiology | Cerebral Ventricles - physiology | Cerebral Ventricles - anatomy & histology | Dependovirus - physiology | RNA, Messenger - biosynthesis | Retinal Ganglion Cells - cytology | Rod Opsins - genetics | Tectum Mesencephali - anatomy & histology | Tectum Mesencephali - physiology | Light Signal Transduction - physiology | Preoptic Area - physiology | Retinal Ganglion Cells - physiology | Rod Opsins - biosynthesis | Superior Colliculi - anatomy & histology | Geniculate Bodies - anatomy & histology | Rats | Photoreceptor Cells, Vertebrate - cytology | Suprachiasmatic Nucleus - anatomy & histology | Neural Pathways - anatomy & histology | Animals | Cholera Toxin | Luminescent Proteins - genetics | Preoptic Area - anatomy & histology | Cerebral Ventricles - cytology | Behavioral | Systems | Cognitive
Journal Article
5.
Full Text
ALK5-dependent TGF-beta signaling is a major determinant of late-stage adult neurogenesis
NATURE NEUROSCIENCE, ISSN 1097-6256, 07/2014, Volume 17, Issue 7, pp. 943 - 952
The transforming growth factor-beta (TGF-beta) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective...
PROGENITOR CELLS | RAT HIPPOCAMPAL-NEURONS | GROWTH-FACTOR-BETA | PROTEIN | TRANSFORMING GROWTH-FACTOR-BETA-1 | MICE | MECHANISMS | NEURAL STEM-CELL | EXPRESSION | NEUROSCIENCES | BRAIN | Immunohistochemistry | Male | Receptors, Transforming Growth Factor beta - physiology | Luciferases - genetics | Microarray Analysis | Gene Expression - physiology | Neurons - physiology | Fear - psychology | Female | Hippocampus - growth & development | Animals, Newborn | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Transforming Growth Factor beta - physiology | Dependovirus | Blotting, Western | Stereotaxic Techniques | Microscopy, Confocal | Animals | Conditioning (Psychology) | Dentate Gyrus - physiology | Neurogenesis - physiology | Doxycycline - pharmacology | Signal Transduction - physiology | Mice | Genetic Vectors | Hippocampus - physiology | Memory - physiology
PROGENITOR CELLS | RAT HIPPOCAMPAL-NEURONS | GROWTH-FACTOR-BETA | PROTEIN | TRANSFORMING GROWTH-FACTOR-BETA-1 | MICE | MECHANISMS | NEURAL STEM-CELL | EXPRESSION | NEUROSCIENCES | BRAIN | Immunohistochemistry | Male | Receptors, Transforming Growth Factor beta - physiology | Luciferases - genetics | Microarray Analysis | Gene Expression - physiology | Neurons - physiology | Fear - psychology | Female | Hippocampus - growth & development | Animals, Newborn | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Transforming Growth Factor beta - physiology | Dependovirus | Blotting, Western | Stereotaxic Techniques | Microscopy, Confocal | Animals | Conditioning (Psychology) | Dentate Gyrus - physiology | Neurogenesis - physiology | Doxycycline - pharmacology | Signal Transduction - physiology | Mice | Genetic Vectors | Hippocampus - physiology | Memory - physiology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1433 - 1445
Oxidative stress contributes to the loss of neurons in many disease conditions as well as during normal aging; however, small-molecule agents that reduce...
RETINAL DEGENERATION | MEDICINE, RESEARCH & EXPERIMENTAL | DIFFUSIBLE FACTOR | OXIDATIVE STRESS | OPTIC-NERVE | PLACEBO-CONTROLLED PHASE-3 | MOUSE MODEL | AXON REGENERATION | PARTIAL RECOVERY | RETINITIS-PIGMENTOSA | CONE CELL-DEATH | NF-E2-Related Factor 2 - physiology | Dependovirus - genetics | Genetic Therapy | Catalase - therapeutic use | NF-E2-Related Factor 2 - therapeutic use | Oxidative Stress - physiology | Genetic Vectors - therapeutic use | Mice, Mutant Strains | Superoxide Dismutase - physiology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Neurons - physiology | NF-E2-Related Factor 2 - genetics | Optic Nerve Injuries - therapy | Transcription Factors - therapeutic use | Retinal Ganglion Cells - physiology | Transcription Factors - physiology | Catalase - physiology | Mice, Inbred C57BL | Optic Nerve Injuries - physiopathology | Nerve Crush | Retinal Cone Photoreceptor Cells - physiology | Genetic Vectors - genetics | Superoxide Dismutase - therapeutic use | Animals | Retinitis Pigmentosa - therapy | Mice | Nerve Degeneration | Apoptosis | Oxidative stress | Transcription factors | Nervous system | Development and progression | Degeneration | Genetic aspects | Health aspects | Antioxidants | Proteins | Enzymes | Statistical analysis | Optic nerve | Disease | Genes | Lipids | Photoreceptors | Physiology | Genetics | Neuroscience | Ophthalmology | Therapeutics
RETINAL DEGENERATION | MEDICINE, RESEARCH & EXPERIMENTAL | DIFFUSIBLE FACTOR | OXIDATIVE STRESS | OPTIC-NERVE | PLACEBO-CONTROLLED PHASE-3 | MOUSE MODEL | AXON REGENERATION | PARTIAL RECOVERY | RETINITIS-PIGMENTOSA | CONE CELL-DEATH | NF-E2-Related Factor 2 - physiology | Dependovirus - genetics | Genetic Therapy | Catalase - therapeutic use | NF-E2-Related Factor 2 - therapeutic use | Oxidative Stress - physiology | Genetic Vectors - therapeutic use | Mice, Mutant Strains | Superoxide Dismutase - physiology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Neurons - physiology | NF-E2-Related Factor 2 - genetics | Optic Nerve Injuries - therapy | Transcription Factors - therapeutic use | Retinal Ganglion Cells - physiology | Transcription Factors - physiology | Catalase - physiology | Mice, Inbred C57BL | Optic Nerve Injuries - physiopathology | Nerve Crush | Retinal Cone Photoreceptor Cells - physiology | Genetic Vectors - genetics | Superoxide Dismutase - therapeutic use | Animals | Retinitis Pigmentosa - therapy | Mice | Nerve Degeneration | Apoptosis | Oxidative stress | Transcription factors | Nervous system | Development and progression | Degeneration | Genetic aspects | Health aspects | Antioxidants | Proteins | Enzymes | Statistical analysis | Optic nerve | Disease | Genes | Lipids | Photoreceptors | Physiology | Genetics | Neuroscience | Ophthalmology | Therapeutics
Journal Article
7.
Full Text
Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons
Neuron, ISSN 0896-6273, 11/2013, Volume 80, Issue 4, pp. 920 - 933
Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal...
V2-DERIVED INTERNEURONS | CIRCUITS | LEFT-RIGHT COORDINATION | CORD | NEURONAL NETWORKS | COMMISSURAL INTERNEURONS | CENTRAL PATTERN GENERATOR | V2A INTERNEURONS | NEONATAL MOUSE | SPECIFICATION | NEUROSCIENCES | Immunohistochemistry | Dependovirus - genetics | Interneurons - physiology | Motor Neurons - physiology | Gene Silencing | Glutamic Acid - physiology | Male | Axons - physiology | Excitatory Amino Acid Agonists - pharmacology | Optogenetics | Serotonin - pharmacology | Neural Pathways - physiology | N-Methylaspartate - pharmacology | Animals | In Situ Hybridization | Spinal Cord - physiology | Vesicular Glutamate Transport Protein 2 - physiology | Mice | Electrophysiological Phenomena | Spinal Cord - cytology | Homeodomain Proteins - physiology | Locomotion - physiology | Locomotion - drug effects | Neurosciences | Genetic engineering | Analysis | Cells | Proteins | Rhythm | Transcription factors | Behavior | Grants | Neurons | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Fysiologi | Neurovetenskaper
V2-DERIVED INTERNEURONS | CIRCUITS | LEFT-RIGHT COORDINATION | CORD | NEURONAL NETWORKS | COMMISSURAL INTERNEURONS | CENTRAL PATTERN GENERATOR | V2A INTERNEURONS | NEONATAL MOUSE | SPECIFICATION | NEUROSCIENCES | Immunohistochemistry | Dependovirus - genetics | Interneurons - physiology | Motor Neurons - physiology | Gene Silencing | Glutamic Acid - physiology | Male | Axons - physiology | Excitatory Amino Acid Agonists - pharmacology | Optogenetics | Serotonin - pharmacology | Neural Pathways - physiology | N-Methylaspartate - pharmacology | Animals | In Situ Hybridization | Spinal Cord - physiology | Vesicular Glutamate Transport Protein 2 - physiology | Mice | Electrophysiological Phenomena | Spinal Cord - cytology | Homeodomain Proteins - physiology | Locomotion - physiology | Locomotion - drug effects | Neurosciences | Genetic engineering | Analysis | Cells | Proteins | Rhythm | Transcription factors | Behavior | Grants | Neurons | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Fysiologi | Neurovetenskaper
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2013, Volume 16, Issue 9, pp. 1324 - 1330
Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties...
PRIMARY VISUAL-CORTEX | RESPONSE PROPERTIES | ORIENTATION SELECTIVITY | PRIMARY AUDITORY-CORTEX | NEURONS | THALAMIC INPUT | GABA(B) RECEPTORS | NEUROSCIENCES | LATERAL GENICULATE-NUCLEUS | SIMPLE CELLS | RECEPTIVE-FIELDS | Visual Fields - physiology | Mice, Inbred C57BL | Channelrhodopsins | Linear Models | Male | Optogenetics | Orientation - physiology | Cerebral Cortex - cytology | Nerve Net - physiology | Dependovirus - physiology | Visual Pathways - physiology | Animals | Thalamus - physiology | Brain Mapping | Parvalbumins - genetics | Cerebral Cortex - physiology | Female | Luminescent Proteins - genetics | Mice | Photic Stimulation | Luminescent Proteins - metabolism | Excitation (Physiology) | Gene silencing | Genetic transformation | Research | Properties | Neurons
PRIMARY VISUAL-CORTEX | RESPONSE PROPERTIES | ORIENTATION SELECTIVITY | PRIMARY AUDITORY-CORTEX | NEURONS | THALAMIC INPUT | GABA(B) RECEPTORS | NEUROSCIENCES | LATERAL GENICULATE-NUCLEUS | SIMPLE CELLS | RECEPTIVE-FIELDS | Visual Fields - physiology | Mice, Inbred C57BL | Channelrhodopsins | Linear Models | Male | Optogenetics | Orientation - physiology | Cerebral Cortex - cytology | Nerve Net - physiology | Dependovirus - physiology | Visual Pathways - physiology | Animals | Thalamus - physiology | Brain Mapping | Parvalbumins - genetics | Cerebral Cortex - physiology | Female | Luminescent Proteins - genetics | Mice | Photic Stimulation | Luminescent Proteins - metabolism | Excitation (Physiology) | Gene silencing | Genetic transformation | Research | Properties | Neurons
Journal Article
Neuron, ISSN 0896-6273, 11/2013, Volume 80, Issue 4, pp. 997 - 1009
The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we...
NMDA RECEPTORS | POTASSIUM CHANNELS | FIRING PATTERN | IN-VIVO | ANTIPSYCHOTIC-DRUGS | CAG-REPEAT LENGTH | SK CHANNELS | NEUROSCIENCES | SMALL-CONDUCTANCE | PREFRONTAL CORTEX | VENTRAL TEGMENTAL AREA | Immunohistochemistry | Motor Activity - physiology | Small-Conductance Calcium-Activated Potassium Channels - genetics | Calcium Signaling - physiology | Humans | Motor Activity - drug effects | Excitatory Postsynaptic Potentials - drug effects | Psychomotor Performance - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Attention - physiology | Reflex, Startle - drug effects | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Reflex, Startle - physiology | Action Potentials - drug effects | Dopamine - metabolism | Receptors, N-Methyl-D-Aspartate - drug effects | Hallucinogens - pharmacology | Conditioning, Classical - drug effects | N-Methylaspartate - metabolism | Mice, Transgenic | Sensory Gating - physiology | Excitatory Amino Acid Agonists - pharmacology | Dependovirus | Conditioning, Classical - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Action Potentials - physiology | Animals | Calcium Signaling - drug effects | Mice | Electrophysiological Phenomena | In Vitro Techniques | Phenols | Methyl aspartate | Genetic aspects | Dopamine | Neurons | Analysis | Cell culture | Substance abuse treatment | Mental disorders | Parkinsons disease | Schizophrenia | Proteins | Rodents | Addictive behaviors | Physiology | Mutation | Behavior | Localization | Drug dosages
NMDA RECEPTORS | POTASSIUM CHANNELS | FIRING PATTERN | IN-VIVO | ANTIPSYCHOTIC-DRUGS | CAG-REPEAT LENGTH | SK CHANNELS | NEUROSCIENCES | SMALL-CONDUCTANCE | PREFRONTAL CORTEX | VENTRAL TEGMENTAL AREA | Immunohistochemistry | Motor Activity - physiology | Small-Conductance Calcium-Activated Potassium Channels - genetics | Calcium Signaling - physiology | Humans | Motor Activity - drug effects | Excitatory Postsynaptic Potentials - drug effects | Psychomotor Performance - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Attention - physiology | Reflex, Startle - drug effects | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Reflex, Startle - physiology | Action Potentials - drug effects | Dopamine - metabolism | Receptors, N-Methyl-D-Aspartate - drug effects | Hallucinogens - pharmacology | Conditioning, Classical - drug effects | N-Methylaspartate - metabolism | Mice, Transgenic | Sensory Gating - physiology | Excitatory Amino Acid Agonists - pharmacology | Dependovirus | Conditioning, Classical - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Action Potentials - physiology | Animals | Calcium Signaling - drug effects | Mice | Electrophysiological Phenomena | In Vitro Techniques | Phenols | Methyl aspartate | Genetic aspects | Dopamine | Neurons | Analysis | Cell culture | Substance abuse treatment | Mental disorders | Parkinsons disease | Schizophrenia | Proteins | Rodents | Addictive behaviors | Physiology | Mutation | Behavior | Localization | Drug dosages
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7491, pp. 238 - 242
Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of...
POMC NEURONS | LEPTIN | ENERGY-EXPENDITURE | PROTEIN | FOOD-INTAKE | NPY | MULTIDISCIPLINARY SCIENCES | FEEDING-BEHAVIOR | RECEPTORS | CELL-TYPES | HYPOTHALAMUS | Dependovirus - genetics | Paraventricular Hypothalamic Nucleus - physiology | Neural Pathways - drug effects | Neuronal Plasticity - drug effects | Arcuate Nucleus of Hypothalamus - cytology | Male | Neural Pathways - physiology | Cell Tracking | Eating - physiology | Satiety Response - physiology | Hunger - drug effects | Paraventricular Hypothalamic Nucleus - cytology | Clozapine - pharmacology | Thyrotropin-Releasing Hormone - metabolism | Neuronal Plasticity - physiology | Female | Food Deprivation | Integrases - metabolism | Agouti-Related Protein - deficiency | Appetite - physiology | Neurons - metabolism | Neurons - drug effects | Neurons, Afferent - drug effects | Peptide Fragments - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Appetite - drug effects | Clozapine - analogs & derivatives | Agouti-Related Protein - metabolism | Eating - drug effects | Rabies virus - genetics | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Brain Mapping | Mice | Neurons, Afferent - metabolism | Peptide Fragments - deficiency | Hunger - physiology | Physiological aspects | Electrophysiology | Neuropeptides | Physiological research | Hunger | Research | Studies | Brain | Neurons | Experiments | Light | Food
POMC NEURONS | LEPTIN | ENERGY-EXPENDITURE | PROTEIN | FOOD-INTAKE | NPY | MULTIDISCIPLINARY SCIENCES | FEEDING-BEHAVIOR | RECEPTORS | CELL-TYPES | HYPOTHALAMUS | Dependovirus - genetics | Paraventricular Hypothalamic Nucleus - physiology | Neural Pathways - drug effects | Neuronal Plasticity - drug effects | Arcuate Nucleus of Hypothalamus - cytology | Male | Neural Pathways - physiology | Cell Tracking | Eating - physiology | Satiety Response - physiology | Hunger - drug effects | Paraventricular Hypothalamic Nucleus - cytology | Clozapine - pharmacology | Thyrotropin-Releasing Hormone - metabolism | Neuronal Plasticity - physiology | Female | Food Deprivation | Integrases - metabolism | Agouti-Related Protein - deficiency | Appetite - physiology | Neurons - metabolism | Neurons - drug effects | Neurons, Afferent - drug effects | Peptide Fragments - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Appetite - drug effects | Clozapine - analogs & derivatives | Agouti-Related Protein - metabolism | Eating - drug effects | Rabies virus - genetics | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Brain Mapping | Mice | Neurons, Afferent - metabolism | Peptide Fragments - deficiency | Hunger - physiology | Physiological aspects | Electrophysiology | Neuropeptides | Physiological research | Hunger | Research | Studies | Brain | Neurons | Experiments | Light | Food
Journal Article
Neuron, ISSN 0896-6273, 01/2014, Volume 81, Issue 1, pp. 61 - 68
Layer 5 pyramidal neurons comprise at least two subtypes: thick-tufted, subcortically projecting type A neurons, with prominent h-current, and thin-tufted,...
HETEROGENEITY | DENDRITES | SYNAPTIC INTEGRATION | RECEPTOR MODULATION | CELLS | NEOCORTEX | CONNECTIVITY | MICROCIRCUIT | SCHIZOPHRENIA | PATTERNS | NEUROSCIENCES | Electric Stimulation | Calcium - metabolism | Channelrhodopsins | Male | Green Fluorescent Proteins - genetics | Nerve Net - drug effects | Excitatory Postsynaptic Potentials - drug effects | Nerve Net - physiology | Neural Pathways - physiology | Dependovirus - physiology | Neural Inhibition - physiology | Neurotransmitter Agents - pharmacology | Pyramidal Cells - physiology | Female | Pyramidal Cells - drug effects | Action Potentials - drug effects | Green Fluorescent Proteins - metabolism | Transduction, Genetic | Synapses - physiology | Prefrontal Cortex - cytology | Action Potentials - physiology | Patch-Clamp Techniques | Animals | Synapses - classification | Mice | In Vitro Techniques | Neural Inhibition - drug effects | Neurons | Neurosciences | Neurophysiology | Studies | Brain | Medical research | Light
HETEROGENEITY | DENDRITES | SYNAPTIC INTEGRATION | RECEPTOR MODULATION | CELLS | NEOCORTEX | CONNECTIVITY | MICROCIRCUIT | SCHIZOPHRENIA | PATTERNS | NEUROSCIENCES | Electric Stimulation | Calcium - metabolism | Channelrhodopsins | Male | Green Fluorescent Proteins - genetics | Nerve Net - drug effects | Excitatory Postsynaptic Potentials - drug effects | Nerve Net - physiology | Neural Pathways - physiology | Dependovirus - physiology | Neural Inhibition - physiology | Neurotransmitter Agents - pharmacology | Pyramidal Cells - physiology | Female | Pyramidal Cells - drug effects | Action Potentials - drug effects | Green Fluorescent Proteins - metabolism | Transduction, Genetic | Synapses - physiology | Prefrontal Cortex - cytology | Action Potentials - physiology | Patch-Clamp Techniques | Animals | Synapses - classification | Mice | In Vitro Techniques | Neural Inhibition - drug effects | Neurons | Neurosciences | Neurophysiology | Studies | Brain | Medical research | Light
Journal Article
Circulation Research, ISSN 0009-7330, 07/2014, Volume 115, Issue 3, pp. 354 - 363
RATIONALE:Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation....
heart failure | regeneration | myocardial infarction | survival | CELLS | RECOMBINATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ADENOASSOCIATED VIRUS | CARDIOMYOCYTE PROLIFERATION | HIPPO PATHWAY | ORGAN SIZE | HYPERTROPHY | HEART REGENERATION | PERIPHERAL VASCULAR DISEASE | SIZE-CONTROL | HEMATOLOGY | TARGETED EXPRESSION | Dependovirus - genetics | Myocardial Infarction - genetics | Myocardial Infarction - mortality | Cell Proliferation | Humans | Myocardial Contraction - physiology | Transcriptome | Myosin Heavy Chains - genetics | Apoptosis - genetics | Cardiomegaly | Regeneration - genetics | Myocardial Infarction - physiopathology | Phosphoproteins - physiology | Cell Survival - physiology | Disease Models, Animal | Myocytes, Cardiac - cytology | Mice, Transgenic | Survival Rate | Phosphoproteins - genetics | Regeneration - physiology | Adaptor Proteins, Signal Transducing - physiology | Animals | Myocytes, Cardiac - physiology | Adaptor Proteins, Signal Transducing - genetics | Mice | Apoptosis - physiology | YAP | AAV9
heart failure | regeneration | myocardial infarction | survival | CELLS | RECOMBINATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ADENOASSOCIATED VIRUS | CARDIOMYOCYTE PROLIFERATION | HIPPO PATHWAY | ORGAN SIZE | HYPERTROPHY | HEART REGENERATION | PERIPHERAL VASCULAR DISEASE | SIZE-CONTROL | HEMATOLOGY | TARGETED EXPRESSION | Dependovirus - genetics | Myocardial Infarction - genetics | Myocardial Infarction - mortality | Cell Proliferation | Humans | Myocardial Contraction - physiology | Transcriptome | Myosin Heavy Chains - genetics | Apoptosis - genetics | Cardiomegaly | Regeneration - genetics | Myocardial Infarction - physiopathology | Phosphoproteins - physiology | Cell Survival - physiology | Disease Models, Animal | Myocytes, Cardiac - cytology | Mice, Transgenic | Survival Rate | Phosphoproteins - genetics | Regeneration - physiology | Adaptor Proteins, Signal Transducing - physiology | Animals | Myocytes, Cardiac - physiology | Adaptor Proteins, Signal Transducing - genetics | Mice | Apoptosis - physiology | YAP | AAV9
Journal Article